CN105832820A - Chinese toon leaf decocting pieces assisting in blood glucose reduction and preparation method of decocting pieces - Google Patents
Chinese toon leaf decocting pieces assisting in blood glucose reduction and preparation method of decocting pieces Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
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Abstract
The invention relates to Chinese toon leaf decocting pieces assisting in blood glucose reduction and a preparation method of the decocting pieces, and belongs to the field of a medical health-care product. The decocting pieces comprise the following components, by mass, 6-9% of a toon leaf extract, 12-14% of maltodextrin, and 0.5-0.75% of a lubricant, with the balance being a filling agent. The decocting pieces are prepared by performing room-temperature soaking, low-temperature soaking, room-temperature standing, ultrasonic extraction, and purification to old Chinese toon leaves to obtain the toon leaf extract; uniformly mixing the toon leaf extract, maltodextrin, and the filling agent, and carrying out sieving, soft material preparation, granulation, drying, addition of the lubrication and tabletting. Through the method, the general flavones extraction ratio is high, and active components of the extract can be effectively kept. Meanwhile, old Chinese toon leaves are subjected to reasonable exploitation and utilization, thereby increasing the use ratio and additional value of Chinese toon resources. The provided decocting pieces are convenient to eat, have an obvious effect on assisting blood glucose reduction, and can effectively prevent diabetic complications.
Description
Technical field
The invention belongs to Medicines and Health Product field, particularly to a kind of Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice and preparation side thereof
Method.
Background technology
Cedrela Meliaceae Cedrela, is a kind of deciduous tree, is distributed widely in the Yellow River and the Yangtze river basin, existing in China
The cultivation history of more than 2000 year.Chinese toon tender shoots and tender leaf give off a strong fragrance, mouthfeel unique, are the distinctive woody vegetables of China, are deeply subject to
People like.Chinese toon is the most nutritious, but also can be used as medicine.Chinese toon old leaf is rich in polyphenol, flavones and saponin(e isoreactivity thing
Matter.Flavonoid substances can anti-oxidant, antiviral, softening blood vessel, enhancing antiotasis, improve blood circulation, therefore to glycosuria
The sick diabetic complication such as disorders of lipid metabolism and angiocardiopathy has good prevention effect.It addition, possibly together with terpene in Chinese Toon Leaves
Compounds and lactone, terpenoid not only has anti-inflammation, antipyretic effect eliminated the phlegm, also has bidirectional modulation blood sugar
Effect.Many research shows, Chinese Toon Leaves extract has the effects such as the most anti-oxidant, antitumor, hypoglycemic, antiviral.
Chinese toon tender shoots and tender leaf are usually used in eating or be processed into salt soaking foodstuff, dehydrated products, quick frozen product or bottle stored product, mesh raw
Before, have been reported and be aided with other materials with the extract of Chinese toon tender leaf, be processed into hypoglycemic or blood-fat-reducing preparation.But, Chinese toon is old
This resource of leaf is the most not yet used appropriately, and in running its course, thus causes the wasting of resources, is also unfavorable for that environment is clear
Clean.It addition, the yielding poorly of Chinese toon tender leaf, Chinese toon old leaf is the accessory substance during Chinese toon produces, and its yield is higher than tender leaf.Prior art
In, in Chinese Toon Leaves, the extracting method of flavones isoreactivity material mainly has enzymatic isolation method, supercritical ultrasonics technology, microwave method, half biomimetic method, dipping
Method etc., but there is the problem that recovery rate is low.So, the present invention utilize discarded Chinese toon old leaf for raw material, right before ultrasonic extraction
Chinese toon old leaf pre-processes, it is desirable to improve the recovery rate of its active component, utilize simultaneously the active ingredient of extraction in addition other
Auxiliary material is prepared as a kind of Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice, is turned waste into wealth by Chinese toon old leaf, to scientific utilization Chinese toon resource, raising
Utilization rate and the added value of Chinese toon are significant.
Summary of the invention
It is an object of the invention to provide a kind of Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice and preparation method thereof, this medicine materical crude slice is with natural
The extract of plant Chinese toon old leaf is active component, adds other auxiliary materials, reduces blood sugar, prevention lipids metabolic disturbance in diabetes mellitus
With the effect of the complication such as angiocardiopathy, improve the utilization rate of Chinese toon resource simultaneously.
The present invention is achieved by the following technical solutions:
A kind of Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice, by mass, its raw material components proportioning is as follows: Chinese Toon Leaves extract 6%-9%, wheat
Bud dextrin 12%-14%, lubricant 0.5%-0.75%, remaining is filler.
Preferably, described filler is starch and xylitol, and the weight ratio of starch and xylitol is 2:1.
Preferably, described lubricant is magnesium stearate.
The preparation method of a kind of above-mentioned Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice comprises the steps of:
(1) Chinese toon old leaf is dried in the shade pulverizing, with edible alcohol as extract, soaking at room temperature 4-8h, then at-35 ~-5 DEG C of low temperature
Soak 1-3h, Chinese toon old leaf is pre-processed under conditions of standing 1-2h by room temperature, ultrasonic extraction, filtration, filtrate decompression evaporation
Removing alcohol, oven drying obtains Chinese Toon Leaves crude extract；
(2) crude extract water step (1) obtained dissolves, and uses macroreticular resin isolated and purified, is evaporated under reduced pressure and removes alcohol, dries
Case is dried to obtain Chinese Toon Leaves extract；
(3) the Chinese Toon Leaves extract that step (2) obtained, maltodextrin and filler mixing, through sieving, softwood processed, granulation, dry
Dry, interpolation lubricant, compressing tablet, obtain Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice.
Preferably, in the preparation method of described Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice, edible alcohol concentration in step (1)
55%-65%, solid-liquid ratio 1:10-1:20；Ultrasonic extracting parameter is: extracts power 175 W, Extracting temperature 45 DEG C-60 DEG C, extract
Time 35 min-50 min；Reduction vaporization parameter is: 0.01MPa, 46 DEG C, is evaporated to alcohol-free steaming；Oven drying temperature is
45 DEG C, dry to constant weight.
Preferably, in the preparation method of described Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice, the macroreticular resin of step (2) separates pure
Change condition is: macroreticular resin model is NKA-9, and the mass concentration of Chinese Toon Leaves crude extract is 7 mg/mL, volume is 70 mL, loading
Speed 2 BV/h, with 80 mL 60% edible alcohols as eluant, eluent, elution flow rate 2 BV/h；Reduction vaporization parameter is: 0.01MPa,
46 DEG C, it is evaporated to alcohol-free steaming；Oven drying temperature is 45 DEG C, dries to constant weight.
Preferably, in the preparation method of described Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice, after the component mixing in step (3),
Cross 100 mesh sieves, make and hold the softwood that agglomerating light pressure i.e. dissipates.
Preferably, in the preparation method of described Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice, in step (3) after granulation, dried strip
Part is: temperature 60 DEG C, oven drying time 2-3 h.
The invention have the advantages that
The present invention provide Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice preparation method in, Chinese toon old leaf through soaking at room temperature, low temperature soak,
The pretreatment that room temperature stands, effectively maintains the chemical property of active material in Chinese Toon Leaves, then through ultrasonic extraction, general flavone carries
The rate that takes increases.
The present invention is by Chinese toon old leaf Appropriate application, and it is through extracting, and the processing of other auxiliary materials is prepared as auxiliary hyperglycemic
Medicine materical crude slice, it is easy to preserve, instant edible, not only has reduction blood sugar, the prevention sugar such as lipids metabolic disturbance in diabetes mellitus and angiocardiopathy
Effect of the sick complication of urine, and Chinese toon old leaf is carried out scientific and reasonable utilization, improves the utilization rate of Chinese toon resource and attached
Value added.
Detailed description of the invention
Below by instantiation, the invention will be further described, to help clearly and completely understanding present invention.
Embodiment 1
(1) taking Chinese toon old leaf 10kg to dry in the shade pulverizing, adding concentration according to solid-liquid ratio 1:10 is the edible alcohol of 55%, soaking at room temperature
4h, then soaks after 1h at-35 DEG C, and room temperature stands 1h, then carries out ultrasonic extraction, ultrasonic power is 175 W, temperature 45 C,
Extraction time 35 min, filtration, by the filtrate of gained in 0.01MPa, be evaporated under reduced pressure under the conditions of 46 DEG C and steam, then to the most alcohol-free
It is dried to constant weight under the conditions of 45 DEG C, obtains Chinese Toon Leaves crude extract.
(2) crude extract water step (1) obtained dissolves, and uses NKA-9 macroreticular resin isolated and purified, and its condition is:
70 mL mass concentrations are the Chinese Toon Leaves CE of 7 mg/mL, loading speed 2 BV/h, with 80 mL 60% edible alcohols are
Eluant, eluent, elutes with the flow velocity of 2 BV/h, collects eluent, is evaporated under reduced pressure to alcohol-free steaming in 0.01MPa, under the conditions of 46 DEG C
Go out, be then dried to constant weight under the conditions of 45 DEG C, obtain Chinese Toon Leaves extract.
(3) each material component is weighed by following percentage by weight: Chinese Toon Leaves extract 6%, maltodextrin 12%, magnesium stearate
0.5%, starch 54.33%, xylitol 27.17%.
(4) the Chinese Toon Leaves extract of step (3) described weight ratio, maltodextrin, starch and xylitol mixed, cross 100
Mesh sieve, make hold agglomerating light pressure and i.e. dissipate softwood, granulation, under the conditions of 60 DEG C, be dried 2h in an oven after, add 0.5%
Magnesium stearate, mixing, compressing tablet, i.e. obtain Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice.
Embodiment 2
(1) taking Chinese toon old leaf 10kg to dry in the shade pulverizing, adding concentration according to solid-liquid ratio 1:15 is the edible alcohol of 60%, soaking at room temperature
6h, after then soaking 2h at-20 DEG C, room temperature stands 1.5h, then carries out ultrasonic extraction, and ultrasonic power is 175 W, temperature 50
DEG C, extraction time 40 min, filtration, by the filtrate of gained in 0.01MPa, be evaporated under reduced pressure under the conditions of 46 DEG C and steam to the most alcohol-free,
Then it is dried to constant weight under the conditions of 45 DEG C, obtains Chinese Toon Leaves crude extract.
(2) Chinese Toon Leaves crude extract water step (1) obtained dissolves, and uses NKA-9 macroreticular resin isolated and purified, its
Part is: 70 mL mass concentrations are the Chinese Toon Leaves CE of 7 mg/mL, loading speed 2 BV/h, with 80 mL 60% edible wines
Essence is eluant, eluent, elutes with the flow velocity of 2 BV/h, collects eluent, is evaporated under reduced pressure to the most alcohol-free in 0.01MPa, under the conditions of 46 DEG C
Steam, be then dried to constant weight under the conditions of 45 DEG C, obtain Chinese Toon Leaves extract.
(3) each material component is weighed by following percentage by weight: Chinese Toon Leaves extract 8%, maltodextrin 13%, magnesium stearate
0.75%, starch 52.17%, xylitol 26.08%.
(4) the Chinese Toon Leaves extract of step (3) described weight ratio, maltodextrin, starch and xylitol mixed, cross 100
Mesh sieve, make hold agglomerating light pressure and i.e. dissipate softwood, granulation, under the conditions of 60 DEG C, be dried 2h in an oven after, add 0.75%
Magnesium stearate, mixing, compressing tablet, i.e. obtain Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice.
Embodiment 3
(1) taking Chinese toon old leaf 10kg to dry in the shade pulverizing, adding concentration according to solid-liquid ratio 1:20 is the edible alcohol of 65%, soaking at room temperature
8h, after then soaking 3h at-5 DEG C, room temperature stands 2h, and ultrasonic power is 175 W, temperature 60 C, extraction time 50min, mistake
Filter, by the filtrate of gained in 0.01MPa, be evaporated under reduced pressure under the conditions of 46 DEG C and steam to the most alcohol-free, be then dried under the conditions of 45 DEG C
To constant weight, obtain Chinese Toon Leaves crude extract.
(2) Chinese Toon Leaves crude extract water step (1) obtained dissolves, and uses NKA-9 macroreticular resin isolated and purified, its
Part is: 70 mL mass concentrations are the Chinese Toon Leaves CE of 7 mg/mL, loading speed 2 BV/h, with 80 mL 60% edible wines
Essence is eluant, eluent, elutes with the flow velocity of 2 BV/h, collects eluent, is evaporated under reduced pressure to the most alcohol-free in 0.01MPa, under the conditions of 46 DEG C
Steam, be then dried to constant weight under the conditions of 45 DEG C, obtain Chinese Toon Leaves extract.
(3) each material component is weighed by following percentage by weight: Chinese Toon Leaves extract 9%, maltodextrin 14%, magnesium stearate
0. 5%, starch 51%, xylitol 25.5%.
(4) the Chinese Toon Leaves extract of step (3) described weight ratio, maltodextrin, starch and xylitol mixed, cross 100
Mesh sieve, make hold agglomerating light pressure and i.e. dissipate softwood, granulation, under the conditions of 60 DEG C, be dried 3h in an oven after, add 0.5%
Magnesium stearate, mixing, compressing tablet, i.e. obtain Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice.
The recovery rate of general flavone in Chinese toon old leaf in table 1 embodiment 1-3
Control group is that Chinese toon old leaf soaks without soaking at room temperature, low temperature, room temperature stands, and other conditions keep phase with embodiment
With.With rutin as titer, using the recovery rate of general flavone in aluminum nitrate determination of color Chinese toon old leaf, result is as shown in table 1.
Through soaking at room temperature, low temperature soaks and after the pretreatment of room temperature standing, the recovery rate of general flavone is significantly raised.
Zoopery
Table 2 present invention on diabetic mice body weight, blood sugar, serum insulin level impact (± S, n=10)
Compare with control group:aP < 0.05,bP < 0.01；Compare with model group:cP < 0.05,d P < 0.01。
Table 3 present invention on the impact of diabetic mice blood lipid level (± S, n=10)
Compare with control group:aP < 0.05,bP < 0.01；Compare with model group:cP < 0.05,d P < 0.01。
This experiment uses the method that high lipid food adds alloxan low dose single intraperitoneal injection, has been successfully established 2 type sugar
The sick mouse model of urine.After the present invention intervenes, Mouse Weight significantly alleviate (P < 0.01), blood sugar and serum insulin level notable under
Fall (P < 0.01).In this experiment, TC, TG, LDL level of model control group 2 patients with type Ⅰ DM mouse significantly raise (P <
0.01), and HDL relative amount (HDL/LDL) the most significantly reduces (P < 0.01), shows that 2 patients with type Ⅰ DM mouse have blood fat
The feature of metabolic disorder, hyperglycemia and hyperlipemia occur in the lump.And after the present invention intervenes, TC, TG, LDL-C fall of mouse
Low, HDL relative amount (HDL/LDL) raises, and hyperlipemia has certain alleviation, and effect strengthens along with the increase of pharmaceutical quantities.2
Diabetes mellitus type is often with high TC, TG, LDL-C level and low HDL-C level, and too high blood lipid level causes periphery device
The sensitiveness of insulin is reduced by official further, increases the weight of insulin resistance, and can induce angiocardiopathy, therefore, effectively controls
Hyperlipemia processed is one of important measures alleviating insulin resistance.Above-mentioned test result indicate that, the present invention is to hypoglycemic and pre-
The diabetic complications such as anti-high fat of blood, angiocardiopathy have good effect.
Claims (8)
1. a Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice, it is characterised in that: by mass, its raw material components proportioning is as follows: Chinese Toon Leaves
Extract 6%-9%, maltodextrin 12%-14%, lubricant 0.5%-0.75%, remaining is filler.
A kind of Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice the most according to claim 1, it is characterised in that: described filler is starch
With xylitol, starch is 2:1 with the weight ratio of xylitol.
A kind of Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice the most according to claim 1, it is characterised in that: described lubricant is stearic
Acid magnesium.
4. the preparation method of any one Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice described in claim 1-3, it is characterised in that:
Comprise the steps of:
(1) Chinese toon old leaf is dried in the shade pulverizing, with edible alcohol as extract, soaking at room temperature 4-8h, then at-35 ~-5 DEG C of low temperature
Soak 1-3h, room temperature pre-processes under conditions of standing 1-2h, removes wine through ultrasonic extraction, filtration, filtrate decompression evaporation
Essence, oven drying obtains Chinese Toon Leaves crude extract；
(2) crude extract water step (1) obtained dissolves, and uses macroreticular resin isolated and purified, is evaporated under reduced pressure and removes alcohol, dries
Case is dried to obtain Chinese Toon Leaves extract；
(3) the Chinese Toon Leaves extract that step (2) obtained, maltodextrin and filler mixing, through sieving, softwood processed, granulation, dry
Dry, interpolation lubricant, compressing tablet, obtain Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice.
The preparation method of a kind of Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice the most according to claim 4, it is characterised in that: step
(1) in, edible alcohol concentration 55%-65%(v/v), solid-liquid ratio 1:10-1:20(g/mL)；Ultrasonic extracting parameter is: extract power
175 W, Extracting temperature 45 DEG C-60 DEG C, extraction time 35 min-50 min；Reduction vaporization parameter is: 0.01MPa, 46 DEG C,
It is evaporated to alcohol-free steaming；Oven drying temperature is 45 DEG C, dries to constant weight.
The preparation method of a kind of Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice the most according to claim 4, it is characterised in that: step
(2) in, macroreticular resin purification condition is: macroreticular resin model is NKA-9, and the mass concentration of Chinese Toon Leaves crude extract is 7 mg/
ML, volume are 70 mL, loading speed 2 BV/h, with 80 mL 60% edible alcohols as eluant, eluent, and elution flow rate 2 BV/h；Decompression
Vaporous parameter is: 0.01MPa, 46 DEG C, is evaporated to alcohol-free steaming；Oven drying temperature is 45 DEG C, dries to constant weight.
The preparation method of a kind of Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice the most according to claim 4, it is characterised in that: step
(3), after the component mixing in, cross 100 mesh sieves, make and hold the softwood that agglomerating light pressure i.e. dissipates.
The preparation method of a kind of Chinese Toon Leaves auxiliary hyperglycemic medicine materical crude slice the most according to claim 4, it is characterised in that: step
(3) in after granulation, drying condition is: temperature 60 DEG C, oven drying time 2-3 h.
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| CN201610233469.9A CN105832820B (en) | 2016-04-15 | 2016-04-15 | Chinese toon leaf auxiliary blood sugar reducing decoction pieces and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106962839A (en) * | 2017-02-21 | 2017-07-21 | 河南省农业科学院 | A kind of preparation method of nutrition leisure Chinese toon chewable tablets |
| CN108272762A (en) * | 2018-03-15 | 2018-07-13 | 西南大学 | Chinese toon old leaf total flavones dispersible tablet and preparation method thereof |
| CN108392518A (en) * | 2018-03-13 | 2018-08-14 | 阜阳师范学院 | Chinese toon extract and preparation method thereof and purposes |
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| CN102188003A (en) * | 2010-03-17 | 2011-09-21 | 叶娅雯 | Sugar-free wheat-element chewing and drinking tablet |
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| CN102188003A (en) * | 2010-03-17 | 2011-09-21 | 叶娅雯 | Sugar-free wheat-element chewing and drinking tablet |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106962839A (en) * | 2017-02-21 | 2017-07-21 | 河南省农业科学院 | A kind of preparation method of nutrition leisure Chinese toon chewable tablets |
| CN108392518A (en) * | 2018-03-13 | 2018-08-14 | 阜阳师范学院 | Chinese toon extract and preparation method thereof and purposes |
| CN108392518B (en) * | 2018-03-13 | 2021-10-26 | 阜阳师范学院 | Toona sinensis extract and preparation method and application thereof |
| CN108272762A (en) * | 2018-03-15 | 2018-07-13 | 西南大学 | Chinese toon old leaf total flavones dispersible tablet and preparation method thereof |
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| CN105832820B (en) | 2021-07-09 |
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