CN105832820B - Chinese toon leaf auxiliary blood sugar reducing decoction pieces and preparation method thereof - Google Patents
Chinese toon leaf auxiliary blood sugar reducing decoction pieces and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a toona sinensis leaf auxiliary blood sugar reducing decoction piece and a preparation method thereof, belonging to the field of medical health products. The decoction pieces are prepared from the following raw materials in parts by weight: by mass, 6-9% of the toona sinensis leaf extract, 12-14% of maltodextrin, 0.5-0.75% of a lubricant and the balance of a filler. The old toona sinensis leaves are subjected to room-temperature soaking, low-temperature soaking, room-temperature standing, ultrasonic extraction and purification to obtain a toona sinensis leaf extract, and the toona sinensis leaf extract, maltodextrin and a filling agent are subjected to processes of uniformly mixing, sieving, soft material preparation, granulation, drying, lubricant addition, tabletting and the like to prepare the toona sinensis leaf auxiliary blood sugar reduction decoction piece. The extraction method adopted by the invention has high extraction rate of total flavonoids, can effectively maintain the active ingredients of the extract, simultaneously improves the utilization rate and the added value of Chinese toon resources by reasonably developing and utilizing the old Chinese toon leaves, and the provided decoction pieces are convenient to eat, have obvious auxiliary hypoglycemic effect and can effectively prevent diabetic complications.
Description
Technical Field
The invention belongs to the field of medical health-care products, and particularly relates to a toona sinensis leaf auxiliary blood sugar reducing decoction piece and a preparation method thereof.
Background
Cedrela, Meliaceae, is a deciduous tree widely distributed in yellow river and Yangtze river basin, and has been cultivated in China for over 2000 years. The cedrela sinensis tender shoots and tender leaves are strong in fragrance and unique in taste, are woody vegetables unique to China and are deeply loved by people. The Chinese toon is not only rich in nutrition, but also can be used as a medicine. The old leaves of Chinese toon are rich in active substances such as polyphenol, flavone and saponin. The flavonoids have the effects of resisting oxidation and virus, softening blood vessels, enhancing vascular tension and improving blood circulation, so the flavonoids have good prevention effect on diabetic complications such as diabetic lipid metabolism disorder, cardiovascular diseases and the like. In addition, the toona sinensis leaves also contain terpenoids and lactones, and the terpenoids not only have the effects of resisting bacteria and diminishing inflammation, relieving fever and eliminating phlegm, but also have the effect of bidirectionally regulating blood sugar. A plurality of researches show that the Chinese toon leaf extract has obvious effects of resisting oxidation, resisting tumors, reducing blood sugar, resisting viruses and the like.
The tender shoots and leaves of toona sinensis are often used for fresh eating or processed into salted products, dehydrated products, frozen products or canned products, and at present, the extract of tender leaves of toona sinensis is reported to be supplemented with other materials to be processed into preparations for reducing blood sugar or blood fat. However, most of the old leaves of Chinese toon are not reasonably utilized and still in self-life, thereby causing resource waste and being not beneficial to environmental cleaning. In addition, the yield of the young leaves of the Chinese toon is low, the old leaves of the Chinese toon are byproducts in the production of the Chinese toon, and the yield of the old leaves of the Chinese toon is higher than that of the young leaves. In the prior art, the extraction method of active substances such as flavone and the like in the toona sinensis leaves mainly comprises an enzymolysis method, an ultrasonic wave method, a microwave method, a semi-bionic method, an immersion method and the like, but has the problem of low extraction rate. Therefore, the invention utilizes the waste old leaves of the Chinese toon as the raw material, the old leaves of the Chinese toon are pretreated before ultrasonic extraction, the extraction rate of active ingredients of the old leaves of the Chinese toon is expected to be improved, meanwhile, the extracted active ingredients and other auxiliary materials are utilized to prepare the Chinese toon leaf-assisted hypoglycemic decoction pieces, the old leaves of the Chinese toon are changed into valuable, and the invention has important significance for scientifically utilizing Chinese toon resources and improving the utilization rate and the additional value of the Chinese toon.
Disclosure of Invention
The invention aims to provide a toona sinensis leaf auxiliary blood sugar reducing decoction piece and a preparation method thereof.
The invention is realized by the following technical scheme:
the Chinese toon leaf auxiliary blood sugar reducing decoction pieces comprise the following raw materials in parts by mass: 6 to 9 percent of Chinese toon leaf extract, 12 to 14 percent of maltodextrin, 0.5 to 0.75 percent of lubricant and the balance of filler.
Preferably, the filler is starch and xylitol, and the weight ratio of the starch to the xylitol is 2: 1.
Preferably, the lubricant is magnesium stearate.
The preparation method of the toona sinensis leaf auxiliary blood sugar reducing decoction pieces comprises the following steps:
(1) drying and crushing the old leaves of the Chinese toon in the shade, taking edible alcohol as an extracting solution, soaking for 4-8h at room temperature, then soaking for 1-3h at the low temperature of-35 to-5 ℃, standing for 1-2h at room temperature, pretreating the old leaves of the Chinese toon, performing ultrasonic extraction, filtering, evaporating the filtrate under reduced pressure to remove alcohol, and drying in an oven to obtain a crude extract of the Chinese toon leaves;
(2) dissolving the crude extract obtained in the step (1) with water, separating and purifying by adopting macroporous resin, removing alcohol by reduced pressure evaporation, and drying in an oven to obtain a toona sinensis leaf extract;
(3) and (3) uniformly mixing the toona sinensis leaf extract obtained in the step (2), maltodextrin and a filling agent, sieving, preparing a soft material, granulating, drying, adding a lubricant, and tabletting to obtain the toona sinensis leaf auxiliary blood sugar reduction decoction pieces.
Preferably, in the preparation method of the toona sinensis leaf auxiliary blood sugar reducing decoction pieces, in the step (1), the edible alcohol concentration is 55-65%, and the material-liquid ratio is 1:10-1: 20; the ultrasonic extraction parameters are as follows: the extraction power is 175W, the extraction temperature is 45-60 ℃, and the extraction time is 35-50 min; the parameters of reduced pressure evaporation are as follows: evaporating at 46 deg.C under 0.01MPa until no alcohol is evaporated; the drying temperature of the oven is 45 ℃, and the oven is dried to constant weight.
Preferably, in the preparation method of the toona sinensis leaf-assisted hypoglycemic decoction pieces, the conditions of separation and purification by macroporous resin in the step (2) are as follows: the model of the macroporous resin is NKA-9, the mass concentration of the crude extract of the Chinese toon leaves is 7mg/mL, the volume is 70mL, the sample loading speed is 2BV/h, 80mL of 60% edible alcohol is used as an eluent, and the elution flow rate is 2 BV/h; the parameters of reduced pressure evaporation are as follows: evaporating at 46 deg.C under 0.01MPa until no alcohol is evaporated; the drying temperature of the oven is 45 ℃, and the oven is dried to constant weight.
Preferably, in the preparation method of the toona sinensis leaf auxiliary blood sugar reducing decoction pieces, the components in the step (3) are mixed uniformly and then are sieved by a 100-mesh sieve, so that a soft material which is held by hand to be agglomerated and is slightly pressed to be dispersed is prepared.
Preferably, in the preparation method of the toona sinensis leaf-assisted hypoglycemic decoction pieces, after granulation in the step (3), drying conditions are as follows: the temperature is 60 ℃, and the drying time of the oven is 2-3 h.
The invention has the following advantages:
according to the preparation method of the toona sinensis leaf-assisted hypoglycemic decoction pieces, the old toona sinensis leaves are subjected to pretreatment of room-temperature soaking, low-temperature soaking and room-temperature standing, so that the chemical properties of active substances in the toona sinensis leaves are effectively maintained, and the extraction rate of total flavonoids is increased through ultrasonic extraction.
According to the invention, the old toona sinensis leaves are reasonably utilized, are extracted and processed with other auxiliary materials to prepare the decoction pieces for assisting in reducing blood sugar, are easy to store and convenient to eat, have the effects of reducing blood sugar and preventing diabetic complications such as diabetic lipid metabolism disorder, cardiovascular diseases and the like, are scientifically and reasonably utilized, and the utilization rate and the additional value of toona sinensis resources are improved.
Detailed Description
The invention is further described by the following specific examples in order to facilitate a clear and complete understanding of the disclosure.
Example 1
(1) Drying and crushing 10kg of old toona sinensis leaves in the shade, adding 55% edible alcohol according to the material-liquid ratio of 1:10, soaking for 4h at room temperature, then soaking for 1h at-35 ℃, standing for 1h at room temperature, performing ultrasonic extraction with the ultrasonic power of 175W and the temperature of 45 ℃, extracting for 35min, filtering, evaporating the obtained filtrate under reduced pressure at the temperature of 46 ℃ under the pressure of 0.01MPa until no alcohol is evaporated, and drying at the temperature of 45 ℃ until the weight is constant to obtain the crude extract of the toona sinensis leaves.
(2) Dissolving the crude extract obtained in the step (1) with water, and separating and purifying by adopting NKA-9 macroporous resin under the conditions that: 70mL of crude extract of the Chinese toon leaves with the mass concentration of 7mg/mL, the sampling speed is 2BV/h, 80mL of 60 percent edible alcohol is used as an eluent, the elution is carried out at the flow rate of 2BV/h, the eluent is collected, the pressure is reduced and the evaporation is carried out under the conditions of 0.01MPa and 46 ℃ until no alcohol is evaporated, and then the drying is carried out under the condition of 45 ℃ until the weight is constant, thus obtaining the extract of the Chinese toon leaves.
(3) Weighing the following raw material components in percentage by weight: 6% of Chinese toon leaf extract, 12% of maltodextrin, 0.5% of magnesium stearate, 54.33% of starch and 27.17% of xylitol.
(4) And (3) uniformly mixing the toona sinensis leaf extract, maltodextrin, starch and xylitol in the weight ratio in the step (3), sieving by a 100-mesh sieve to prepare a soft material which is held by a hand to be conglobated and slightly pressed to be dispersed, granulating, drying in an oven for 2 hours at the temperature of 60 ℃, adding 0.5% of magnesium stearate, uniformly mixing, and tabletting to obtain the toona sinensis leaf auxiliary blood sugar reducing decoction piece.
Example 2
(1) Drying 10kg of old toona sinensis leaves in the shade, crushing, adding 60% edible alcohol according to the material-liquid ratio of 1:15, soaking for 6h at room temperature, then soaking for 2h at-20 ℃, standing for 1.5h at room temperature, then carrying out ultrasonic extraction with the ultrasonic power of 175W and the temperature of 50 ℃, extracting for 40 min, filtering, evaporating the obtained filtrate under reduced pressure at the temperature of 46 ℃ under the pressure of 0.01MPa until no alcohol is evaporated, and then drying at the temperature of 45 ℃ until the weight is constant to obtain the crude extract of the toona sinensis leaves.
(2) Dissolving the crude extract of the toona sinensis leaves obtained in the step (1) by using water, and separating and purifying by using NKA-9 macroporous resin, wherein the conditions are as follows: 70mL of crude extract of the Chinese toon leaves with the mass concentration of 7mg/mL, the sampling speed is 2BV/h, 80mL of 60 percent edible alcohol is used as an eluent, the elution is carried out at the flow rate of 2BV/h, the eluent is collected, the pressure is reduced and the evaporation is carried out under the conditions of 0.01MPa and 46 ℃ until no alcohol is evaporated, and then the drying is carried out under the condition of 45 ℃ until the weight is constant, thus obtaining the extract of the Chinese toon leaves.
(3) Weighing the following raw material components in percentage by weight: 8% of Chinese toon leaf extract, 13% of maltodextrin, 0.75% of magnesium stearate, 52.17% of starch and 26.08% of xylitol.
(4) And (3) uniformly mixing the toona sinensis leaf extract, maltodextrin, starch and xylitol in the weight ratio in the step (3), sieving by a 100-mesh sieve to prepare a soft material which is held by a hand to be conglobated and slightly pressed to be dispersed, granulating, drying in an oven for 2 hours at the temperature of 60 ℃, adding 0.75% of magnesium stearate, uniformly mixing, and tabletting to obtain the toona sinensis leaf auxiliary blood sugar reducing decoction piece.
Example 3
(1) Drying 10kg of old toona sinensis leaves in the shade, crushing, adding 65% edible alcohol according to the material-liquid ratio of 1:20, soaking for 8h at room temperature, then soaking for 3h at-5 ℃, standing for 2h at room temperature, carrying out extraction for 50min at the temperature of 60 ℃ under the ultrasonic power of 175W, filtering, evaporating the obtained filtrate under reduced pressure at the temperature of 46 ℃ under the pressure of 0.01MPa until no alcohol is evaporated, and drying at the temperature of 45 ℃ until the weight is constant to obtain the crude extract of the toona sinensis leaves.
(2) Dissolving the crude extract of the toona sinensis leaves obtained in the step (1) by using water, and separating and purifying by using NKA-9 macroporous resin, wherein the conditions are as follows: 70mL of crude extract of the Chinese toon leaves with the mass concentration of 7mg/mL, the sampling speed is 2BV/h, 80mL of 60 percent edible alcohol is used as an eluent, the elution is carried out at the flow rate of 2BV/h, the eluent is collected, the pressure is reduced and the evaporation is carried out under the conditions of 0.01MPa and 46 ℃ until no alcohol is evaporated, and then the drying is carried out under the condition of 45 ℃ until the weight is constant, thus obtaining the extract of the Chinese toon leaves.
(3) Weighing the following raw material components in percentage by weight: 9% of Chinese toon leaf extract, 14% of maltodextrin, 0.5% of magnesium stearate, 51% of starch and 25.5% of xylitol.
(4) And (3) uniformly mixing the toona sinensis leaf extract, maltodextrin, starch and xylitol in the weight ratio in the step (3), sieving by a 100-mesh sieve to prepare a soft material which is held by a hand to be conglobated and lightly pressed to be dispersed, granulating, drying in an oven at the temperature of 60 ℃ for 3 hours, adding 0.5% of magnesium stearate, uniformly mixing, and tabletting to obtain the toona sinensis leaf auxiliary blood sugar reducing decoction piece.
TABLE 1 extraction ratio of total flavonoids from old leaves of Toona sinensis in examples 1-3
The control group is the old leaves of the Chinese toon which are not soaked at room temperature, soaked at low temperature and kept standing at room temperature, and other conditions are kept the same as the embodiment. Rutin is used as a standard solution, and the extraction rate of total flavonoids in the old leaves of the Chinese toon is measured by an aluminum nitrate color development method, and the result is shown in table 1. After the pretreatment of room temperature soaking, low temperature soaking and room temperature standing, the extraction rate of the total flavone is obviously increased.
Animal experiments
TABLE 2 weight, blood sugar and serum insulin water for diabetic miceInfluence of flatness (
±S，n=10）
Comparison with the control group:a P < 0.05，b P <0.01; comparison with model groups:c P < 0.05，d P < 0.01。
TABLE 3 Effect of the invention on blood lipid levels in diabetic mice: (
±S，n=10）
Comparison with the control group:a P < 0.05，b P <0.01; comparison with model groups:c P < 0.05，d P < 0.01。
the experiment successfully establishes a type 2 diabetes mouse model by adopting a method of high-fat feed plus alloxan small-dose single intraperitoneal injection. The invention has the advantages that the weight of the mouse is obviously reduced (P <0.01), and the blood sugar and the serum insulin level are obviously reduced (P <0.01) after the prognosis. In the experiment, the levels of TC, TG and LDL of the model control group type 2 diabetes mouse are obviously increased (P is less than 0.01), and the relative content of HDL (HDL/LDL) is also obviously reduced (P is less than 0.01), which indicates that the type 2 diabetes mouse has the characteristics of dyslipidemia and hyperglycemia and hyperlipidemia occur together. After the invention is used for dry prognosis, TC, TG and LDL-C of the mouse are reduced, HDL relative content (HDL/LDL) is increased, hyperlipidemia is relieved to a certain extent, and the effect is enhanced along with the increase of the dosage. Type 2 diabetes patients are often accompanied by high TC, TG, LDL-C levels and low HDL-C levels, and excessive blood lipid levels cause further decrease in insulin sensitivity in peripheral organs, aggravate insulin resistance, and induce cardiovascular diseases, and thus effective control of hyperlipidemia is one of the important measures for alleviating insulin resistance. The experimental results show that the invention has good effects of reducing blood sugar and preventing diabetes complications such as hyperlipidemia, cardiovascular diseases and the like.
Claims (6)
1. The Chinese toon leaf auxiliary blood sugar reducing decoction piece is characterized in that: the raw materials comprise the following components by mass: 6 to 9 percent of Chinese toon leaf extract, 12 to 14 percent of maltodextrin, 0.5 to 0.75 percent of lubricant and the balance of filler;
wherein the Chinese toon leaf extract is prepared by the following method:
(1) drying and crushing old toona sinensis leaves in the shade, taking edible alcohol as an extracting solution, soaking for 4-8h at room temperature, then soaking for 1-3h at the low temperature of-35 to-5 ℃, standing for 1-2h at room temperature for pretreatment, performing ultrasonic extraction, filtering, evaporating the filtrate under reduced pressure to remove alcohol, and drying in an oven to obtain a crude toona sinensis leaf extract;
(2) dissolving the crude extract obtained in the step (1) with water, separating and purifying by adopting macroporous resin, removing alcohol by reduced pressure evaporation, and drying in an oven to obtain a toona sinensis leaf extract;
the filler is starch and xylitol, and the weight ratio of the starch to the xylitol is 2: 1;
the lubricant is magnesium stearate.
2. The preparation method of the toona sinensis leaf auxiliary blood sugar reducing decoction pieces, which are disclosed by claim 1, is characterized by comprising the following steps of: comprises the following steps:
(1) drying and crushing old toona sinensis leaves in the shade, taking edible alcohol as an extracting solution, soaking for 4-8h at room temperature, then soaking for 1-3h at the low temperature of-35 to-5 ℃, standing for 1-2h at room temperature for pretreatment, performing ultrasonic extraction, filtering, evaporating the filtrate under reduced pressure to remove alcohol, and drying in an oven to obtain a crude toona sinensis leaf extract;
(2) dissolving the crude extract obtained in the step (1) with water, separating and purifying by adopting macroporous resin, removing alcohol by reduced pressure evaporation, and drying in an oven to obtain a toona sinensis leaf extract;
(3) and (3) uniformly mixing the toona sinensis leaf extract obtained in the step (2), maltodextrin and a filling agent, sieving, preparing a soft material, granulating, drying, adding a lubricant, and tabletting to obtain the toona sinensis leaf auxiliary blood sugar reduction decoction pieces.
3. The preparation method of the toona sinensis leaf auxiliary blood sugar reducing decoction pieces as claimed in claim 2, wherein the preparation method comprises the following steps: in the step (1), the concentration of edible alcohol is 55-65% (v/v), and the ratio of material to liquid is 1:10-1:20 (g/mL); the ultrasonic extraction parameters are as follows: the extraction power is 175W, the extraction temperature is 45-60 ℃, and the extraction time is 35-50 min; the parameters of reduced pressure evaporation are as follows: evaporating at 46 deg.C under 0.01MPa until no alcohol is evaporated; the drying temperature of the oven is 45 ℃, and the oven is dried to constant weight.
4. The preparation method of the toona sinensis leaf auxiliary blood sugar reducing decoction pieces as claimed in claim 2, wherein the preparation method comprises the following steps: the conditions for separating and purifying the macroporous resin in the step (2) are as follows: the model of the macroporous resin is NKA-9, the mass concentration of the crude extract of the Chinese toon leaves is 7mg/mL, the volume is 70mL, the sample loading speed is 2BV/h, 80mL60% edible alcohol is used as an eluent, and the elution flow rate is 2 BV/h; the parameters of reduced pressure evaporation are as follows: evaporating at 46 deg.C under 0.01MPa until no alcohol is evaporated; the drying temperature of the oven is 45 ℃, and the oven is dried to constant weight.
5. The preparation method of the toona sinensis leaf auxiliary blood sugar reducing decoction pieces as claimed in claim 2, wherein the preparation method comprises the following steps: and (4) uniformly mixing the components in the step (3), and sieving the mixture by a 100-mesh sieve to prepare a soft material which is held by hand to be agglomerated and is slightly pressed to be dispersed.
6. The preparation method of the toona sinensis leaf auxiliary blood sugar reducing decoction pieces as claimed in claim 2, wherein the preparation method comprises the following steps: after granulation in the step (3), the drying conditions are as follows: the temperature is 60 ℃, and the drying time of the oven is 2-3 h.
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