CN114848745A - Chicory and gardenia beverage and preparation method thereof - Google Patents

Chicory and gardenia beverage and preparation method thereof Download PDF

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Publication number
CN114848745A
CN114848745A CN202210314002.2A CN202210314002A CN114848745A CN 114848745 A CN114848745 A CN 114848745A CN 202210314002 A CN202210314002 A CN 202210314002A CN 114848745 A CN114848745 A CN 114848745A
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chicory
gardenia
parts
drink
preparation
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李英
李欣
李艳
张辉
梁超
明平幸
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Shanxi Zhendong Wuhe Medicinal Tea Technology Co ltd
Shanxi Zhendong Wuhe Medical Care Hall Co ltd
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Shanxi Zhendong Wuhe Medicinal Tea Technology Co ltd
Shanxi Zhendong Wuhe Medical Care Hall Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/52—Juglandaceae (Walnut family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8967—Lilium, e.g. tiger lily or Easter lily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention discloses a chicory and gardenia drink and a preparation method thereof, belonging to the technical field of traditional Chinese medicine tea drinks. The chicory and gardenia drink for reducing uric acid index and relieving gout symptoms is prepared by compounding chicory, gardenia, kudzu root, mulberry leaf, sweet lily and cyclocarya paliurus. The tea drink is used as a food with homology of medicine and food, has scientific ingredients, is safe and has no toxic or side effect; the product can reduce uric acid index, relieve gout symptoms, has the effects of inducing diuresis to reduce edema, clearing liver and benefiting gallbladder, is beneficial to reducing blood pressure, reducing blood fat, improving immunity, and can relieve pain caused by arthritis, rheumatoid arthritis, scapulohumeral periarthritis and other inflammations. Therefore, the chicory gardenia drink provided by the invention is suitable for being popularized and applied in the market.

Description

Chicory and gardenia beverage and preparation method thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicine tea drinks, particularly relates to a chicory and gardenia drink and a preparation method thereof, and particularly relates to a chicory and gardenia drink for reducing uric acid indexes and relieving gout symptoms and a preparation method thereof.
Background
Hyperuricemia is a metabolic disease mainly manifested by uric acid abnormality. Along with the gradual improvement of the living standard of people, the incidence rate of hyperuricemia is increased day by day, and because the uric acid metabolism of patients is unbalanced, uric acid in the bodies is difficult to be discharged in time to form uric acid deposition, so a series of complications such as gout and the like are caused, so that the patients suffer pain and the life quality is seriously influenced. Uric acid is deposited on joints to form gout, gout is one of main diseases affecting the health and daily life of people at present, gout patients suffer from long-term pain and need to take medicines regularly, the economic burden is heavy, and the cure difficulty of the gout is extremely high. At present, hyperuricemia is mainly prevented and treated clinically from three aspects of reducing uric acid production, promoting uric acid excretion and promoting uric acid oxidation, so that the effect of the medicine is realized through the three ways.
Clinically, the commonly used drugs for inhibiting the synthesis of uric acid comprise xanthine oxidase inhibitors such as allopurin and febuxostat; clinically, the medicines for promoting uric acid excretion such as URAT1 inhibitors like sulpirenone and the like, and one medicine has the main function of promoting uric acid oxidation, so that at present, the clinically available medicines are few, only Labraziase is available, and other medicines are not clinically used and are still in the development stage. Western medicines have certain effects on preventing and treating hyperuricemia, but have large side effects, the health of patients can be damaged due to excessive taking, certain contraindications are provided on use, some medicines cannot be taken for a long time, some medicines are forbidden for patients with renal insufficiency, renal calculus and the like, and once the medicines are taken by mistake, serious consequences can be caused, so that the search for safe and effective medicines which can be used for a long time is urgent needs of the current medical field and patients with hyperuricemia.
At present, although western medicines have short-term curative effects on hyperuricemia and gout, the recurrence rate is high, the dependence is strong, and the western medicines have obvious toxic and side effects after long-term administration. The traditional Chinese medicine has a certain curative effect on treating and preventing hyperuricemia and gout attack, fully develops the concept of 'treating the disease' of the traditional Chinese medicine, takes prevention as the main part and treatment as the auxiliary part, and fully exerts the advantages of the traditional Chinese medicine.
CN 111973704A Botrytis cinerea composition and its preparation method and application: the invention relates to a vine tea chicory composition and a preparation method and application thereof. The Ampelopsis grossedentata and chicory composition is prepared from Ampelopsis grossedentata leaves, chicory, cape jasmine, mulberry leaves, kudzu roots and sweet lilies. The composition takes medicinal and edible medicinal materials as raw materials, is reasonably proportioned according to the theory of traditional Chinese medicine, medicine properties and dosage, is in the best of pathogenesis, treats based on syndrome differentiation, and has obvious curative effect on dampness-heat blockage type uricemia (symptoms such as proteinuria, hematuria, edema, uric acid stone, glycolipid metabolic disorder and the like). In addition, the formula of the invention has no toxic or side effect, and is safe, reliable and convenient to take.
CN 108902980A is a health-preserving combined food for preventing and treating hyperuricemia and gout and a preparation method thereof, wherein the health-preserving combined food comprises the following components: the invention discloses a health-care combined food for preventing and treating hyperuricemia and gout and a preparation method thereof, belongs to the technical field of health-care foods, inherits the ideas of traditional Chinese medicine health care and disease prevention and treatment, takes homology of medicine and food as a main body, combines new resource food raw materials and other disciplines, and is prepared into the health-care food for preventing and treating gout by matching, and is used for improving gout symptoms, preventing relapse and assisting in treating gout. The composite food comprises gout health preserving granules and gout health preserving tea; the gout health preserving granule comprises 5-15 parts of cogongrass rhizome, 5-15 parts of chicory, 5-15 parts of cape jasmine fruit and 2-10 parts of sunflower disc extract. The product is prepared by matching traditional Chinese medicine health-preserving granules with pure health-preserving tea drinks, has synergistic effect, has fragrant taste, can be taken for a long time, and is convenient to carry. The purposes of preserving health, expelling toxin, conditioning symptoms such as hyperuricemia, gout and the like, intervening in early stage of gout and avoiding development of diseases to the final stage are achieved through food therapy.
Although the prior art has records on the treatment of hyperuricemia and gout and has certain curative effect, few economic, effective and safe medicines are available on the market, and some medicines can bring other side effects after being taken for a long time. How to provide a medicament which can effectively reduce uric acid and has no side effect and is suitable for daily drinking of people is a problem which is difficult to solve in the prior art.
Therefore, the development of a chicory gardenia drink which has obvious efficacy, is convenient and practical, can reduce the uric acid index and relieve gout symptoms is a problem to be solved by the technical personnel in the field.
Disclosure of Invention
In view of the above, the invention provides a chicory gardenia drink and a preparation method thereof, and the chicory gardenia drink can reduce uric acid indexes and relieve gout symptoms.
In order to achieve the purpose, the invention adopts the following technical scheme:
a chicory gardenia drink is prepared from the following raw materials in parts by weight:
4-10 parts of chicory, 2-8 parts of gardenia, 2-7 parts of kudzu root, 1-7 parts of mulberry leaf, 1-8 parts of sweet lily, 1-8 parts of cyclocarya paliurus, 2-7 parts of erythritol, 5-12 parts of honey, 0.05-0.4 part of sodium carboxymethylcellulose, 0.001-0.007 part of sucralose and 0.01-0.03 part of potassium sorbate.
Preferably, the chicory gardenia drink is prepared from the following raw materials in parts by weight:
7 parts of chicory, 5 parts of cape jasmine, 4 parts of kudzu root, 5 parts of mulberry leaf, 4 parts of sweet lily, 4 parts of cyclocarya paliurus, 4 parts of erythritol, 8 parts of honey, 0.2 part of sodium carboxymethylcellulose, 0.004 part of sucralose and 0.02 part of potassium sorbate.
The chicory gardenia drink prepared by the method disclosed by the invention is used as a food with homology of medicine and food, is scientific in ingredients, safe and free of toxic and side effects; the product can reduce uric acid index, relieve gout symptoms, promote urination, reduce swelling, clear liver and promote gallbladder, is helpful for reducing blood pressure, reducing blood lipid, improving immunity, and relieving pain caused by arthritis, rheumatoid diseases, scapulohumeral periarthritis and other inflammations.
Specifically, the chicory is a common traditional Chinese medicine, can be used as a medicine part, namely roots or dry overground parts of plants, has good medicinal value, can be directly eaten, is rich in inulin and aromatic substances at the roots, can extract specific substances by a chemical extraction method, is used for preparing substitute coffee, and can enhance the digestion function of a human body. The chicory can be eaten for a long time, is harmless to human bodies, and even can become a delicious food on dining tables of people, so that the aim of preventing and treating diseases is fulfilled by daily correct and reasonable eating of the chicory. As a traditional Chinese medicine used as both medicine and food, chicory avoids side effects to a certain extent when the medicine is not properly used or the compatibility is wrong. The root of chicory is called chicory root, the aerial part is called chicory, the chicory can be used as a medicine, the traditional Chinese medicine is bitter in taste, is generally used for inducing diuresis to reduce edema, clearing heat and removing toxicity, and has a certain effect on invigorating stomach, and modern pharmacological studies find that the chicory has obvious curative effect on hyperuricemia. Research shows that chicory can reduce uric acid by reducing the activity of uric acid metabolic enzymes and key reaction enzymes, such as xanthine oxidase, and can also start with excretion from kidney and intestinal tract, inhibit reabsorption, regulate intestinal environment and balance uric acid metabolism. The most main uric acid reducing medicines in chicory can be aesculin, chlorogenic acid and chicoric acid, and the substances are nontoxic and cannot cause serious liver and kidney function damage.
The fruit of gardenia is a traditional Chinese medicine, belongs to the 1 st batch of medical and edible dual-purpose resources issued by the ministry of health, has the functions of protecting liver, benefiting gallbladder, reducing blood pressure, tranquilizing, stopping bleeding, reducing swelling and the like, and is commonly used for treating diseases such as icteric hepatitis, sprain and contusion, hypertension, diabetes and the like in the clinical traditional Chinese medicine.
The mulberry leaf contains flavonoid compounds, alkaloid compounds, polysaccharide compounds, sterol compounds, polyphenol compounds, volatile oil, amino acids, vitamins and the like, and has the effects of reducing blood sugar, blood fat, blood pressure, oxidation resistance, tumor resistance, virus resistance, organism immunity enhancement and the like.
Cyclocarya paliurus leaves contain various chemical components such as saccharides, flavonoids, terpenes, phenolic acids and the like, and particularly cyclocarya paliurus polysaccharide is more and more focused on people. The study shows that cyclocarya paliurus polysaccharide has the effects of resisting oxidation, reducing blood sugar, resisting cancer and bacteria and improving immunity.
A preparation method of a chicory gardenia drink is characterized by comprising the following steps:
(1) preparing materials: weighing chicory, gardenia, kudzu root, mulberry leaf, sweet lily and cyclocarya paliurus according to the formula ratio for later use;
(2) and (3) extraction and concentration: soaking radix Puerariae and Bulbus Lilii in water, extracting with herba Cichorii, fructus Gardeniae and folium Mori in water, sieving, and concentrating to obtain concentrated solution;
(3) centrifuging: centrifuging the concentrated solution, and taking a supernatant for later use;
(4) blending: adding sucralose, erythritol, honey and a thickening agent into the supernatant, uniformly stirring until the sucralose, erythritol, honey and the thickening agent are fully dissolved, and then carrying out constant volume, filling and sterilization to obtain the chicory and gardenia beverage.
Preferably, the water is added in the step (2) for soaking for 1h, and the ratio of leaching materials to leaching liquids is 1: 8; the leaching times are 2 times, the extraction time is 2 hours, and the mixture is sieved by a 200-mesh sieve.
Preferably, the concentrated solution obtained in the step (2) is concentrated to a volume of half of the formula amount, and is refrigerated and kept stand for 24 hours at 4 ℃ to obtain the concentrated solution.
Preferably, the centrifugal speed in the step (3) is 4000r/min, and the centrifugal time is 30 min.
Preferably, the mass concentration of the thickening agent in the step (4) is 1%,
and the preparation steps of the thickening agent are as follows: weighing 4g of sodium carboxymethylcellulose solution in 400ml of purified water, and fully dissolving, swelling and moistening to obtain a 1% sodium carboxymethylcellulose solution.
Preferably, the filling sterilization temperature in the step (4) is 105 ℃, and the sterilization time is 30 min.
According to the technical scheme, compared with the prior art, the invention discloses the chicory and gardenia drink and the preparation method thereof, and the chicory and gardenia drink has the following different excellent effects:
the chicory and gardenia drink disclosed by the invention defines the functional effects and effective functional components of chicory, gardenia, kudzu root, mulberry leaf, sweet lily and cyclocarya paliurus, and is compounded according to the characteristics of medicinal materials to form the chicory and gardenia drink for reducing the uric acid index and relieving gout symptoms. The chicory gardenia drink provided by the invention has better drinking taste, is convenient to carry, and is suitable for popularization and application.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.
Figure 1 shows the content of uric acid in zebrafish after chicory gardenia drink treatment is compared with that in the model control group, p is less than 0.01, p is less than 0.001.
FIG. 2 is a diagram of efficacy evaluation of chicory gardenia drink for assisting in reducing uric acid.
Detailed Description
The technical solutions disclosed in the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The present invention will be further illustrated by the following examples for better understanding, but the invention is not to be construed as being limited thereto, and certain insubstantial modifications and adaptations of the invention by those skilled in the art based on the foregoing disclosure are intended to be included within the scope of the invention.
Example 1:
a chicory gardenia beverage comprises the following raw materials in parts by weight:
4g of chicory, 2g of cape jasmine, 2g of kudzu root, 1g of mulberry leaf, 1g of sweet lily, 1g of cyclocarya paliurus, 2g of erythritol, 5g of honey, 0.05g of sodium carboxymethylcellulose, 0.001g of sucralose and 0.01g of potassium sorbate.
The preparation method of the chicory gardenia drink for reducing uric acid indexes and relieving gout symptoms comprises the following steps:
(1) extracting and concentrating
Weighing chicory, gardenia, kudzu root, mulberry leaf, sweet lily and cyclocarya paliurus according to the formula amount, firstly adding water to soak kudzu root and sweet lily for 1h, filtering out water, then adding 8 times of water to extract the kudzu root and sweet lily together with the rest medicinal materials for 2h, carrying out the second extraction under the same condition as the first extraction, sieving by a 200-mesh sieve, concentrating to the volume of half of the formula amount, refrigerating at 4 ℃ and standing for 24h
(2) Centrifugation
Centrifuging the concentrated solution at 4000r/min for 30min, and collecting supernatant
(3) Preparation of thickening agent
Weighing thickener, and preparing into 1% solution
(4) Blending
Adding sucralose, erythritol, honey and a thickening agent, stirring uniformly until the sucralose, erythritol, honey and thickening agent are fully dissolved, and fixing the volume to the formula amount
(5) Filling and sterilizing
Sterilizing the chicory and gardenia beverage at 105 ℃ for 30min in a bottle of 30mL to obtain the chicory and gardenia beverage.
Example 2:
a chicory gardenia beverage comprises the following raw materials in parts by weight:
5g of chicory, 5g of cape jasmine, 6g of kudzu root, 6g of mulberry leaf, 7g of sweet lily, 5g of cyclocarya paliurus, 5g of erythritol, 8g of honey, 0.1g of sodium carboxymethylcellulose, 0.005g of sucralose and 0.01g of potassium sorbate.
The preparation method of the chicory gardenia drink for reducing uric acid indexes and relieving gout symptoms comprises the following steps:
(1) extracting and concentrating
Weighing chicory, gardenia, kudzu root, mulberry leaf, sweet lily and cyclocarya paliurus according to the formula amount, firstly adding water to soak kudzu root and sweet lily for 1h, filtering out water, then adding 8 times of water to extract the kudzu root and sweet lily together with the rest medicinal materials for 2h, carrying out the second extraction under the same condition as the first extraction, sieving by a 200-mesh sieve, concentrating to the volume of half of the formula amount, refrigerating at 4 ℃ and standing for 24h
(2) Centrifugation
Centrifuging the concentrated solution at 4000r/min for 30min, and collecting supernatant
(3) Preparation of thickening agent
Weighing thickener, and preparing into 1% solution
(4) Blending
Adding sucralose, erythritol, honey and a thickening agent, stirring uniformly until the sucralose, erythritol, honey and thickening agent are fully dissolved, and fixing the volume to the formula amount
(5) Filling and sterilizing
Sterilizing the chicory and gardenia beverage at 105 ℃ for 30min in a bottle of 30mL to obtain the chicory and gardenia beverage.
Example 3:
a chicory gardenia beverage comprises the following raw materials in parts by weight:
8g of chicory, 8g of cape jasmine, 6g of kudzu root, 7g of mulberry leaf, 8g of sweet lily, 6g of cyclocarya paliurus, 4g of erythritol, 10g of honey, 0.2g of sodium carboxymethylcellulose, 0.005g of sucralose and 0.01g of potassium sorbate.
The preparation method of the chicory gardenia beverage for reducing uric acid indexes and relieving gout symptoms comprises the following steps:
(1) extracting and concentrating
Weighing chicory, gardenia, kudzu root, mulberry leaf, sweet lily and cyclocarya paliurus according to the formula amount, firstly adding water to soak kudzu root and sweet lily for 1h, filtering out water, then adding 8 times of water to extract the kudzu root and sweet lily together with the rest medicinal materials for 2h, carrying out the second extraction under the same condition as the first extraction, sieving by a 200-mesh sieve, concentrating to the volume of half of the formula amount, refrigerating at 4 ℃ and standing for 24h
(2) Centrifugation
Centrifuging the concentrated solution at 4000r/min for 30min, and collecting supernatant
(3) Preparation of thickening agent
Weighing thickener, and preparing into 1% solution
(4) Blending
Adding sucralose, erythritol, honey and a thickening agent, stirring uniformly until the sucralose, erythritol, honey and thickening agent are fully dissolved, and fixing the volume to the formula amount
(5) Filling and sterilizing
Sterilizing the chicory and gardenia beverage at 105 ℃ for 30min in a bottle of 30mL to obtain the chicory and gardenia beverage.
Example 4:
a chicory gardenia beverage comprises the following raw materials in parts by weight:
7g of chicory, 5g of cape jasmine, 4g of kudzu root, 5g of mulberry leaf, 4g of sweet lily, 4g of cyclocarya paliurus, 4g of erythritol, 8g of honey, 0.2g of sodium carboxymethylcellulose, 0.004g of sucralose and 0.02g of potassium sorbate.
The preparation method of the chicory gardenia drink for reducing uric acid indexes and relieving gout symptoms comprises the following steps:
(1) extracting and concentrating
Weighing chicory, gardenia, kudzu root, mulberry leaf, sweet lily and cyclocarya paliurus according to the formula amount, firstly adding water to soak kudzu root and sweet lily for 1h, filtering out water, then adding 8 times of water to extract the kudzu root and sweet lily together with the rest medicinal materials for 2h, carrying out the second extraction under the same condition as the first extraction, sieving by a 200-mesh sieve, concentrating to the volume of half of the formula amount, refrigerating at 4 ℃ and standing for 24h
(2) Centrifugation
Centrifuging the concentrated solution at 4000r/min for 30min, and collecting supernatant
(3) Preparation of thickening agent
Weighing thickener, and preparing into 1% solution
(4) Blending
Adding sucralose, erythritol, honey and a thickening agent, stirring uniformly until the sucralose, erythritol, honey and thickening agent are fully dissolved, and fixing the volume to the formula amount
(5) Filling and sterilizing
Sterilizing the chicory and gardenia beverage at 105 ℃ for 30min in a bottle of 30mL to obtain the chicory and gardenia beverage.
Example 5:
a chicory gardenia beverage comprises the following raw materials in parts by weight:
10g of chicory, 8g of cape jasmine, 7g of kudzu root, 7g of mulberry leaf, 8g of sweet lily, 8g of cyclocarya paliurus, 7g of erythritol, 12g of honey, 0.4g of sodium carboxymethylcellulose, 0.007g of sucralose and 0.03g of potassium sorbate.
The preparation method of the chicory gardenia drink for reducing uric acid indexes and relieving gout symptoms comprises the following steps:
(1) extracting and concentrating
Weighing chicory, gardenia, kudzu root, mulberry leaf, sweet lily and cyclocarya paliurus according to the formula amount, firstly adding water to soak kudzu root and sweet lily for 1h, filtering out water, then adding 8 times of water to extract the kudzu root and sweet lily together with the rest medicinal materials for 2h, carrying out the second extraction under the same condition as the first extraction, sieving by a 200-mesh sieve, concentrating to the volume of half of the formula amount, refrigerating at 4 ℃ and standing for 24h
(2) Centrifugation
Centrifuging the concentrated solution at 4000r/min for 30min, and collecting supernatant
(3) Preparation of thickening agent
Weighing thickener, and preparing into 1% solution
(4) Blending
Adding sucralose, erythritol, honey and a thickening agent, stirring uniformly until the sucralose, erythritol, honey and thickening agent are fully dissolved, and fixing the volume to the formula amount
(5) Filling and sterilizing
Sterilizing the chicory and gardenia beverage at 105 ℃ for 30min in a bottle of 30mL to obtain the chicory and gardenia beverage.
In order to further verify the excellent effect of the chicory gardenia drink prepared by the invention, the inventor also carries out the following experiments:
first, animal experiment
Randomly selecting 5dpf wild AB strain zebra fish in a 6-hole plate, and treating 30 zebra fish in each hole (experimental group); respectively dissolving with water to give chicory gardenia drink with concentrations of 15.6, 31.2, 62.5, 125 and 250 muL/mL, setting a model control group and a normal control group with a capacity of 3mL per hole, and giving a positive control group with an allopurinol concentration of 136 mug/mL; except for the normal control group, all the other experimental groups are dissolved in water and then are given potassium oxonate and xanthine sodium salt to establish a zebra fish hyperuricemia model.
After the treatment is finished: 1) observing and counting the death number and the toxic reaction condition of the zebra fish of each experimental group, and determining the MTC of the chicory gardenia drink; 2) taking three concentration groups of MTC and the following, a positive control group, a model control group and a normal control group, respectively homogenizing each group, taking supernatant, and detecting the content (S) of uric acid in the zebra fish body by using a high performance liquid chromatograph.
Wherein, the chromatographic conditions are as follows: detector wavelength: -288 nm; a chromatographic column: shimadzu C18(5 μm 4.6X 250 mm); mobile phase: water (0.2% acetic acid): methanol (V: V) ═ 94: 6; flow rate: 1.0 mL/min; column temperature: 30 ℃; sample introduction amount: 10 μ L.
And evaluating the effect of the chicory gardenia drink for assisting in reducing uric acid by using the statistical analysis result of the uric acid content. Statistical treatment results are expressed as mean ± SE. The calculation formula of the auxiliary uric acid reducing effect is as follows:
Figure BDA0003568269570000101
statistical analysis using analysis of variance and Dunnett's T-test indicated significant differences with p < 0.05.
1. The result of the detection
(1)MTC
Under the experimental conditions, the MTC of the chicory gardenia drink on the high-uric-acid zebra fish is 62.5 mu L/mL. See table 1 for details.
Table 1. experiment result of concentration of efficacy of chicory gardenia drink for assisting in reducing uric acid (n ═ 30)
Figure BDA0003568269570000111
(2) Auxiliary uric acid reduction efficacy evaluation
Under the experimental condition, the chicory gardenia drink has obvious effect of assisting in reducing uric acid. See table 2, fig. 1 and fig. 2 for details.
TABLE 2 auxiliary uric acid reducing effect of zebra fish after chicory gardenia drink treatment (n ═ 2)
Figure BDA0003568269570000112
P <0.01, p <0.001, compared to model controls.

Claims (8)

1. The chicory gardenia drink is characterized by being prepared from the following raw materials in parts by weight:
4-10 parts of chicory, 2-8 parts of gardenia, 2-7 parts of kudzu root, 1-7 parts of mulberry leaf, 1-8 parts of sweet lily, 1-8 parts of cyclocarya paliurus, 2-7 parts of erythritol, 5-12 parts of honey, 0.05-0.4 part of sodium carboxymethylcellulose, 0.001-0.007 part of sucralose and 0.01-0.03 part of potassium sorbate.
2. The chicory gardenia drink as claimed in claim 1, which is prepared from the following raw materials in parts by weight:
7 parts of chicory, 5 parts of cape jasmine, 4 parts of kudzu root, 5 parts of mulberry leaf, 4 parts of sweet lily, 4 parts of cyclocarya paliurus, 4 parts of erythritol, 8 parts of honey, 0.2 part of sodium carboxymethylcellulose, 0.004 part of sucralose and 0.02 part of potassium sorbate.
3. A method for preparing a chicory gardenia drink as claimed in claim 1, which comprises the following steps:
(1) preparing materials: weighing chicory, gardenia, kudzu root, mulberry leaf, sweet lily and cyclocarya paliurus according to the formula for later use;
(2) and (3) extraction and concentration: soaking radix Puerariae and Bulbus Lilii in water, extracting with herba Cichorii, fructus Gardeniae and folium Mori in water, sieving, and concentrating to obtain concentrated solution;
(3) centrifuging: centrifuging the concentrated solution, and taking a supernatant for later use;
(4) blending: adding sucralose, erythritol, honey and a thickening agent into the supernatant, uniformly stirring until the sucralose, erythritol, honey and the thickening agent are fully dissolved, and then carrying out constant volume, filling and sterilization to obtain the chicory and gardenia beverage.
4. The preparation method of chicory gardenia drink as claimed in claim 3, wherein the water soaking time in the step (2) is 1h, and the ratio of the leaching materials to the leaching solution is 1: 8; the leaching times are 2 times, the extraction time is 2 hours, and the mixture is sieved by a 200-mesh sieve.
5. The preparation method of chicory gardenia drink as claimed in claim 3 or 4, characterized in that the concentrated solution is obtained by concentrating the chicory gardenia drink in the step (2) to a volume of half of the formula amount and refrigerating and standing the concentrated solution at 4 ℃ for 24 hours.
6. The preparation method of chicory gardenia drink as claimed in claim 3, wherein the centrifugation speed in step (3) is 4000r/min and the centrifugation time is 30 min.
7. The preparation method of the chicory gardenia drink as claimed in claim 3, wherein the mass concentration of the thickener in the step (4) is 1%.
8. The preparation method of chicory gardenia drink as claimed in claim 3 or 7, wherein the filling sterilization temperature in the step (4) is 100-121 ℃, and the sterilization time is 10-30 min.
CN202210314002.2A 2022-03-28 2022-03-28 Chicory and gardenia beverage and preparation method thereof Pending CN114848745A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115252728A (en) * 2022-09-06 2022-11-01 广州市致仁医药科技有限公司 Heat-clearing, dampness-removing and lipid-lowering tea and preparation method thereof

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CN111973704A (en) * 2020-08-11 2020-11-24 中山市中智药业集团有限公司 Ampelopsis grossedentata and chicory composition as well as preparation method and application thereof
CN113181307A (en) * 2021-05-18 2021-07-30 山西振东五和健康科技股份有限公司 Radix puerariae and chicory tea substitute drink and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN108159312A (en) * 2018-01-04 2018-06-15 大连美通生物技术有限公司 A kind of composite plant activity drink and preparation method that can treat gout
CN111973704A (en) * 2020-08-11 2020-11-24 中山市中智药业集团有限公司 Ampelopsis grossedentata and chicory composition as well as preparation method and application thereof
CN113181307A (en) * 2021-05-18 2021-07-30 山西振东五和健康科技股份有限公司 Radix puerariae and chicory tea substitute drink and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115252728A (en) * 2022-09-06 2022-11-01 广州市致仁医药科技有限公司 Heat-clearing, dampness-removing and lipid-lowering tea and preparation method thereof

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