CN105831751B - 补气健脑的中药保健组合物、制备方法及其使用方法 - Google Patents
补气健脑的中药保健组合物、制备方法及其使用方法 Download PDFInfo
- Publication number
- CN105831751B CN105831751B CN201610240827.9A CN201610240827A CN105831751B CN 105831751 B CN105831751 B CN 105831751B CN 201610240827 A CN201610240827 A CN 201610240827A CN 105831751 B CN105831751 B CN 105831751B
- Authority
- CN
- China
- Prior art keywords
- parts
- health
- composition
- tonifying
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 85
- 210000004556 brain Anatomy 0.000 title claims abstract description 42
- 239000003814 drug Substances 0.000 title claims abstract description 42
- 238000005728 strengthening Methods 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims description 22
- 238000000034 method Methods 0.000 title claims description 11
- 241000007126 Codonopsis pilosula Species 0.000 claims abstract description 15
- 241000222336 Ganoderma Species 0.000 claims abstract description 14
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 14
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 14
- 241000405414 Rehmannia Species 0.000 claims abstract description 14
- 235000006533 astragalus Nutrition 0.000 claims abstract description 14
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 14
- 235000011477 liquorice Nutrition 0.000 claims abstract description 14
- 241000045403 Astragalus propinquus Species 0.000 claims abstract description 13
- 241000112528 Ligusticum striatum Species 0.000 claims abstract description 13
- 240000006766 Cornus mas Species 0.000 claims abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 51
- 230000036541 health Effects 0.000 claims description 44
- 239000000706 filtrate Substances 0.000 claims description 41
- 238000001914 filtration Methods 0.000 claims description 34
- 238000002156 mixing Methods 0.000 claims description 24
- 239000000843 powder Substances 0.000 claims description 24
- 241000756943 Codonopsis Species 0.000 claims description 23
- 239000002994 raw material Substances 0.000 claims description 23
- 239000000284 extract Substances 0.000 claims description 22
- 239000000463 material Substances 0.000 claims description 19
- 229920001353 Dextrin Polymers 0.000 claims description 10
- 239000004375 Dextrin Substances 0.000 claims description 10
- 229920002472 Starch Polymers 0.000 claims description 5
- 239000002131 composite material Substances 0.000 claims description 5
- 235000019425 dextrin Nutrition 0.000 claims description 5
- 235000013402 health food Nutrition 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- 239000008107 starch Substances 0.000 claims description 5
- 235000012149 noodles Nutrition 0.000 claims description 3
- 241000157352 Uncaria Species 0.000 claims description 2
- 235000013312 flour Nutrition 0.000 claims description 2
- 235000002566 Capsicum Nutrition 0.000 claims 1
- 235000003365 Ilex pubescens Nutrition 0.000 claims 1
- 241001100932 Ilex pubescens Species 0.000 claims 1
- 241001506304 Kadsura japonica Species 0.000 claims 1
- 239000006002 Pepper Substances 0.000 claims 1
- 235000016761 Piper aduncum Nutrition 0.000 claims 1
- 235000017804 Piper guineense Nutrition 0.000 claims 1
- 244000203593 Piper nigrum Species 0.000 claims 1
- 235000008184 Piper nigrum Nutrition 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 27
- 235000009508 confectionery Nutrition 0.000 abstract description 12
- 210000003734 kidney Anatomy 0.000 abstract description 12
- 239000008280 blood Substances 0.000 abstract description 11
- 210000004369 blood Anatomy 0.000 abstract description 11
- 230000006870 function Effects 0.000 abstract description 11
- 210000004185 liver Anatomy 0.000 abstract description 10
- 235000019640 taste Nutrition 0.000 abstract description 10
- 230000001737 promoting effect Effects 0.000 abstract description 7
- 230000001105 regulatory effect Effects 0.000 abstract description 4
- 201000010099 disease Diseases 0.000 abstract description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 3
- 235000013305 food Nutrition 0.000 abstract description 3
- 235000016709 nutrition Nutrition 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 108010082495 Dietary Plant Proteins Proteins 0.000 abstract description 2
- 150000001413 amino acids Chemical class 0.000 abstract description 2
- 230000008859 change Effects 0.000 abstract description 2
- 230000002124 endocrine Effects 0.000 abstract description 2
- 239000004615 ingredient Substances 0.000 abstract description 2
- 230000007774 longterm Effects 0.000 abstract description 2
- 230000002265 prevention Effects 0.000 abstract description 2
- 229940088594 vitamin Drugs 0.000 abstract description 2
- 229930003231 vitamin Natural products 0.000 abstract description 2
- 235000013343 vitamin Nutrition 0.000 abstract description 2
- 239000011782 vitamin Substances 0.000 abstract description 2
- 240000008866 Ziziphus nummularia Species 0.000 abstract 1
- 230000015654 memory Effects 0.000 description 13
- 241000209020 Cornus Species 0.000 description 12
- 241001465754 Metazoa Species 0.000 description 12
- 210000000952 spleen Anatomy 0.000 description 12
- 230000007812 deficiency Effects 0.000 description 11
- 241001247821 Ziziphus Species 0.000 description 10
- 230000013016 learning Effects 0.000 description 9
- 210000004072 lung Anatomy 0.000 description 9
- 230000032683 aging Effects 0.000 description 8
- 241000699666 Mus <mouse, genus> Species 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 7
- 210000002216 heart Anatomy 0.000 description 7
- 206010011224 Cough Diseases 0.000 description 5
- 206010033557 Palpitations Diseases 0.000 description 5
- 206010012735 Diarrhoea Diseases 0.000 description 4
- 206010062717 Increased upper airway secretion Diseases 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 230000007087 memory ability Effects 0.000 description 4
- 230000027939 micturition Effects 0.000 description 4
- 208000026435 phlegm Diseases 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 3
- 208000009205 Tinnitus Diseases 0.000 description 3
- 208000031971 Yin Deficiency Diseases 0.000 description 3
- 206010003549 asthenia Diseases 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 206010022437 insomnia Diseases 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 230000035900 sweating Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 231100000886 tinnitus Toxicity 0.000 description 3
- 230000002936 tranquilizing effect Effects 0.000 description 3
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 2
- 208000000044 Amnesia Diseases 0.000 description 2
- 208000031091 Amnestic disease Diseases 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 208000008967 Enuresis Diseases 0.000 description 2
- 241000893536 Epimedium Species 0.000 description 2
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 2
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 2
- 206010059013 Nocturnal emission Diseases 0.000 description 2
- 244000131316 Panax pseudoginseng Species 0.000 description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 description 2
- 240000001341 Reynoutria japonica Species 0.000 description 2
- 235000018167 Reynoutria japonica Nutrition 0.000 description 2
- 244000097577 Rhus javanica Species 0.000 description 2
- 235000010889 Rhus javanica Nutrition 0.000 description 2
- 206010039966 Senile dementia Diseases 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- 230000003187 abdominal effect Effects 0.000 description 2
- 230000006986 amnesia Effects 0.000 description 2
- 208000022531 anorexia Diseases 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 235000015895 biscuits Nutrition 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 208000010877 cognitive disease Diseases 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 235000018905 epimedium Nutrition 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 210000000232 gallbladder Anatomy 0.000 description 2
- 235000008434 ginseng Nutrition 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 2
- 229960002646 scopolamine Drugs 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000012549 training Methods 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- GXFZCDMWGMFGFL-KKXMJGKMSA-N (+)-Tubocurarine chloride hydrochloride Chemical compound [Cl-].[Cl-].C([C@H]1[N+](C)(C)CCC=2C=C(C(=C(OC3=CC=C(C=C3)C[C@H]3C=4C=C(C(=CC=4CC[NH+]3C)OC)O3)C=21)O)OC)C1=CC=C(O)C3=C1 GXFZCDMWGMFGFL-KKXMJGKMSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241001061264 Astragalus Species 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 206010007882 Cellulitis Diseases 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 241001111317 Chondrodendron tomentosum Species 0.000 description 1
- 239000008709 Curare Substances 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- 206010020741 Hyperpyrexia Diseases 0.000 description 1
- 208000004044 Hypesthesia Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 208000019255 Menstrual disease Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 238000012347 Morris Water Maze Methods 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- GMZVRMREEHBGGF-UHFFFAOYSA-N Piracetam Chemical compound NC(=O)CN1CCCC1=O GMZVRMREEHBGGF-UHFFFAOYSA-N 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 206010038084 Rectocele Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 241000304195 Salvia miltiorrhiza Species 0.000 description 1
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010041497 Spermatorrhoea Diseases 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 210000004958 brain cell Anatomy 0.000 description 1
- 230000003925 brain function Effects 0.000 description 1
- 229940046011 buccal tablet Drugs 0.000 description 1
- 239000006189 buccal tablet Substances 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000003727 cerebral blood flow Effects 0.000 description 1
- 201000004559 cerebral degeneration Diseases 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 231100000895 deafness Toxicity 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 229930182486 flavonoid glycoside Natural products 0.000 description 1
- 150000007955 flavonoid glycosides Chemical class 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 208000018997 giddiness Diseases 0.000 description 1
- 229940089161 ginsenoside Drugs 0.000 description 1
- 229930182494 ginsenoside Natural products 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000016354 hearing loss disease Diseases 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 208000034783 hypoesthesia Diseases 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000006386 memory function Effects 0.000 description 1
- 206010027175 memory impairment Diseases 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 208000027061 mild cognitive impairment Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 235000021395 porridge Nutrition 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 230000006886 spatial memory Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000004233 talus Anatomy 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
本发明公开了一种补气健脑的中药保健组合物,包括党参10‑40份、山茱萸9‑25份、熟地黄10‑25份、生枣仁10‑15份、灵芝3‑10份、柏子仁3‑9份、川芎15‑30份、黄芪15‑30份、甘草10‑30份、知母15‑30份、益智仁10‑20份;所述保健组合物的成分性味多属甘平,甘则能补能缓,具有补养、缓和作用;平则寒凉温热不甚明显,作用平和,长期服用亦几无毒副作用;其含有多种氨基酸、植物蛋白、维生素等营养成分,具有健脑补血、益智、补气的成分,能达到调和气血、健脑固本、调节内分泌、滋补肝肾等的功效,对脑功能减退性等疾病具有一定的防治功能,起到防微杜渐的保健作用,保证老年人的生活质量。
Description
技术领域
本发明涉及一种保健品,特别涉及一种具有改善记忆、益智功能的补气健脑的中药保健组合物、制备方法及其使用方法。
背景技术
记忆功能减退是老年性痴呆的最早期症状和必要特征,其本质是轻度认知损害的标志症状。目前,全世界60岁以上老年人口总数已达6亿,有60多个国家的老年人口达到或超过人口总数的10%,进入了人口老龄化社会行列。人口老龄化的迅速发展,引起了联合国及世界各国政府的重视和关注。有资料表明我国已初步进入老龄化社会。伴随老龄化的进程,尤以脑功能老化而出现学习记忆和认知功能障碍最为显著,严重影响老年人的生活质量。延缓衰老、保证老年人的生活质量已成为全社会关注的一个重点问题。改善记忆功能可以在一定程度上扭转脑老化的发展趋势,对痴呆等脑功能减退性疾病的防治,具有防微杜渐的作用。传统中医药在改善记忆、增智健脑等方面具有数千年的历史,积累了大量行之有效的实践经验。中医认为脾肾两虚、元气不足、痰蒙清窍是AD的主要病理病机之一,固本培元、脾肾双补、化痰开窍法是防治老年性痴呆的有效方法。因此,运用中医药特有的理论体系和思维方法防治健忘,已经成为一种潮流。现有技术中,中国专利如CN201410708558“具有健脑固本功能的组合物及其制剂和应用”、CN201410268182“改善记忆力的保健食品”、CN201410032469“一种改善记忆力的益智胶囊及制备方法”、CN201310743375“一种改善记忆力的中药组合物及其制备方法”、CN201310622919“一种改善记忆力的天然营养粥及其生产方法”、CN201310601935“具有改善记忆力的功能食品及其制备方法”、CN201310510762“一种改善记忆力的保健食品”等公开了改善记忆力及制备方法,上述专利或成药所公开的药物均有一定效果,但效果甚微,或是具有一定的副作用。
发明内容
有鉴于此,本发明的目的在于提供一种补气健脑的中药保健组合物、制备方法及其使用方法,利用中药制成中药保健食品的形式来达到补气健脑、改善记忆、益智、延缓衰老的目的。
本发明的补气健脑的中药保健组合物,所述保健组合物原料按重量份包括以下组分:
党参10-40份、山茱萸9-25份、熟地黄10-25份、生枣仁10-15份、灵芝3-10份、柏子仁3-9份、川芎15-30份、黄芪15-30份、甘草10-30份、知母15-30份、益智仁10-20份;
进一步,所述保健组合物原料按重量份包括以下组分:
党参15-25份、山茱萸13-20份、熟地黄15-25份、生枣仁10-15份、灵芝3-10份、柏子仁3-9份、川芎18-30份、黄芪18-30份、甘草15-26份、知母18-30份、益智仁10-20份;
进一步,所述组合物原料按重量份包括以下组分:
党参20份、山茱萸15份、熟地黄18份、生枣仁13份、灵芝7份、柏子仁6份、川芎22份、黄芪23份、甘草20份、知母23份、益智仁15份;
进一步,还包括辅料,所述辅料淀粉或糊精中的一种或两种;所述辅料重量占保健组合物总量的10%-30%;
进一步,该组合物可加入医学或食品学或保健品学上能够接受的载体制成制剂;
进一步,改组合物可加入一种或多种用于改善或治疗兼证的中药。
本发明还公开一种的补气健脑的中药保健组合物的制备方法,包括以下步骤:
a.将党参按设定重量份的1/2粉碎成粉末;
b.将剩余的党参与原料中的其他组分混合加水煎煮3次,其中第1次加水量是保健组合物总量的12-16倍,煎煮0.8-1.2小时,过滤收集滤液;第2次加水量是保健组合物总量的8-12倍,煎煮0.8-1.2小时,过滤收集滤液;第3次加水量是保健组合物总量的6-10倍,煎煮0.8-1.2小时,过滤收集滤液;合并三次收集的滤液浓缩至相对密度1.1-1.3的浸膏;
c.将党参粉末与浸膏混合;
进一步,步骤b中,第1次加水量是保健组合物总量的15倍,煎煮1小时,过滤收集滤液;第2次加水量是保健组合物总量的10倍,煎煮1小时,过滤收集滤液;第3次加水量是保健组合物总量的8倍,煎煮1小时。
本发明还公开一种补气健脑的中药保健组合物的使用方法,将保健组合物的原料的提取液与党参粉末和辅料混合制成保健食品;
进一步,将提取液与党参粉和面粉混合做成面条。
本发明的有益效果:本发明的补气健脑的中药保健组合物、制备方法及其使用方法,所述保健组合物的成分性味多属甘平,甘则能补能缓,具有补养、缓和作用;平则寒凉温热不甚明显,作用平和,长期服用亦几无毒副作用;其含有多种氨基酸、植物蛋白、维生素等营养成分,具有健脑补血、益智、补气的成分,能达到调和气血、健脑固本、调节内分泌、滋补肝肾等的功效,对脑功能减退性等疾病具有一定的防治功能,起到防微杜渐的保健作用,保证老年人的生活质量,现代药理学研究表明上述诸药共同起到调整、改善机体细胞免疫和体液免疫功能,增强人体抗病能力,提高机体适应性,调节中枢神经系统功能,以及促进物质代谢、提高思维活动和体力劳动能力等功能,且完全采用大自然药食两用中药,是真正绿色天然中药保健品。
党参性味甘,性平;归脾、肺经。具有健脾益肺,养血生津的功效。用于脾肺气虚,气血不足,面色萎黄,心悸气短,是补气健脾之要药。
所述山茱萸味酸、涩,性微温;归肝、肾经。具有补益肝肾,收涩固脱。用于眩晕耳呜,腰膝酸痛,阳痿遗精,遗尿尿频,崩漏带下,大汗虚脱,内热消渴。
所述熟地黄味甘,性微温;归经肝经、肾经。具有补血滋润,益精填髓的功效。用于血虚萎黄,心悸怔忡,肝肾阴虚,腰膝酸软,耳鸣耳聋,头目昏花,眩晕,耳鸣,须发早白。
所述生枣仁味甘、酸,性平;归肝、胆、心经。具有养心补肝,宁心安神,敛汗,生津的功效。用于虚烦不眠,惊悸多梦。
所述灵芝味甘,性平;归心、肺、肝、肾经。具有补气安神,止咳平喘。用于心神不宁.失眠心悸,肺虚咳喘,虚劳短气,不思饮食。
所述柏子仁味甘,性平;归心、肾、大肠经。具有养心安神,止汗,润肠的功效。用于虚烦失眠,心悸怔忡,阴虚盗汗,肠燥便秘。
所述川芎味辛,性温;归肝、胆、心包经。具有活血行气,祛风止痛。用于胸痹心痛,胸胁刺痛,跌扑肿痛,月经不调,经闭痛经,瘕瘕腹痛,头痛,风湿痹痛。
所述黄芪味甘,性微温;归肺、脾经。具有补气固表,利尿托毒,排脓,敛疮生肌的功效。用于气虚乏力,食少便溏,中气下陷,久泻脱肛,便血崩漏,表虚自汗,气虚水肿,内热消渴,血虚萎黄,半身不遂,痹痛麻木,痈疽难溃,久溃不敛。
所述甘草味甘,性平;归心、肺、脾、胃经。具有补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药。用于脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急疼痛,痈肿疮毒,缓解药物毒性、烈性。
所述知母味苦、甘,性寒;归肺、胃、肾经。具有清热泻火,滋阴润燥。用于外感热病,高热烦渴,肺热燥咳,骨蒸潮热,内热消渴,肠燥便秘。
所述益智仁味辛,性温;归脾、肾经。具有暖肾固精缩尿,温脾止泻摄唾的功效。用于肾虚遗尿,小便频数,遗精白浊,脾寒泄泻,腹中冷痛,口多唾涎。
附图说明
下面结合附图和实施例对本发明作进一步描述:
图1为空白对照组的定位航行检测图;
图2为给药组的定位航检测行图;
图3为模型组的定位航检测行图。
具体实施方式
实施例一
本实施例的补气健脑的中药保健组合物,所述保健组合物原料按重量份包括以下组分:
党参10份、山茱萸9份、熟地黄10份、生枣仁10份、灵芝3份、柏子仁3份、川芎15份、黄芪15份、甘草10份、知母15份、益智仁10份;
本实施例中,还包括辅料,所述辅料淀粉或糊精中的一种或两种;所述辅料重量占保健组合物总量的10%。
本实施例的补气健脑的中药保健组合物的制备方法,包括以下步骤:
a.将党参按设定重量份的1/2粉碎成粉末;
b.将剩余的党参与原料中的其他组分混合加水煎煮3次,其中第1次加水量是保健组合物总量的12倍,煎煮0.8小时,过滤收集滤液;第2次加水量是保健组合物总量的8倍,煎煮0.8小时,过滤收集滤液;第3次加水量是保健组合物总量的6倍,煎煮0.8小时,过滤收集滤液;合并三次收集的滤液浓缩至相对密度1.1的浸膏;
c.将党参粉末与浸膏混合。
实施例二
本实施例的补气健脑的中药保健组合物,所述保健组合物原料按重量份包括以下组分:
党参40份、山茱萸25份、熟地黄25份、生枣仁15份、灵芝10份、柏子仁9份、川芎30份、黄芪30份、甘草30份、知母30份、益智仁20份;
本实施例中,还包括辅料,所述辅料淀粉或糊精中的一种或两种;所述辅料重量占保健组合物总量的30%。
本实施例的补气健脑的中药保健组合物的制备方法,包括以下步骤:
a.将党参按设定重量份的1/2粉碎成粉末;
b.将剩余的党参与原料中的其他组分混合加水煎煮3次,其中第1次加水量是保健组合物总量的16倍,煎煮1.2小时,过滤收集滤液;第2次加水量是保健组合物总量的12倍,煎煮1.2小时,过滤收集滤液;第3次加水量是保健组合物总量的10倍,煎煮1.2小时,过滤收集滤液;合并三次收集的滤液浓缩至相对密度1.3的浸膏;
c.将党参粉末与浸膏混合。
实施例三
本实施例的补气健脑的中药保健组合物,所述保健组合物原料按重量份包括以下组分:
党参10份、山茱萸25份、熟地黄10份、生枣仁15份、灵芝3份、柏子仁9份、川芎15份、黄芪30份、甘草10份、知母30份、益智仁10份;
本实施例中,还包括辅料,所述辅料淀粉或糊精中的一种或两种;所述辅料重量占保健组合物总量的15%。
本实施例的补气健脑的中药保健组合物的制备方法,包括以下步骤:
a.将党参按设定重量份的1/2粉碎成粉末;
b.将剩余的党参与原料中的其他组分混合加水煎煮3次,其中第1次加水量是保健组合物总量的13倍,煎煮0.9小时,过滤收集滤液;第2次加水量是保健组合物总量的12倍,煎煮0.8小时,过滤收集滤液;第3次加水量是保健组合物总量的9倍,煎煮1.2小时,过滤收集滤液;合并三次收集的滤液浓缩至相对密度1.1的浸膏;
c.将党参粉末与浸膏混合。
实施例四
本实施例的补气健脑的中药保健组合物,所述保健组合物原料按重量份包括以下组分:
党参15份、山茱萸13份、熟地黄15份、生枣仁10份、灵芝3份、柏子仁3份、川芎18份、黄芪18份、甘草15份、知母18份、益智仁10份;
本实施例的补气健脑的中药保健组合物的制备方法,包括以下步骤:
a.将党参按设定重量份的1/2粉碎成粉末;
b.将剩余的党参与原料中的其他组分混合加水煎煮3次,其中第1次加水量是保健组合物总量的13倍,煎煮1.1小时,过滤收集滤液;第2次加水量是保健组合物总量的10倍,煎煮0.8小时,过滤收集滤液;第3次加水量是保健组合物总量的7倍,煎煮0.8小时,过滤收集滤液;合并三次收集的滤液浓缩至相对密度1.1的浸膏;
c.将党参粉末与浸膏混合。
实施例五
本实施例的补气健脑的中药保健组合物,所述保健组合物原料按重量份包括以下组分:
党参25份、山茱萸20份、熟地黄25份、生枣仁15份、灵芝10份、柏子仁9份、川芎30份、黄芪30份、甘草26份、知母30份、益智仁20份;
本实施例的补气健脑的中药保健组合物的制备方法,包括以下步骤:
a.将党参按设定重量份的1/2粉碎成粉末;
b.将剩余的党参与原料中的其他组分混合加水煎煮3次,其中第1次加水量是保健组合物总量的15倍,煎煮1小时,过滤收集滤液;第2次加水量是保健组合物总量的12倍,煎煮1小时,过滤收集滤液;第3次加水量是保健组合物总量的7倍,煎煮1小时,过滤收集滤液;合并三次收集的滤液浓缩至相对密度1.1-1.3的浸膏;
c.将党参粉末与浸膏混合。
实施例六
本实施例的补气健脑的中药保健组合物,所述保健组合物原料按重量份包括以下组分:
党参25份、山茱萸13份、熟地黄18份、生枣仁14份、灵芝5份、柏子仁9份、川芎25份、黄芪28份、甘草15份、知母30份、益智仁12份;
本实施例的补气健脑的中药保健组合物的制备方法,包括以下步骤:
a.将党参按设定重量份的1/2粉碎成粉末;
b.将剩余的党参与原料中的其他组分混合加水煎煮3次,其中第1次加水量是保健组合物总量的14倍,煎煮0.9小时,过滤收集滤液;第2次加水量是保健组合物总量的11倍,煎煮1小时,过滤收集滤液;第3次加水量是保健组合物总量的10倍,煎煮1小时,过滤收集滤液;合并三次收集的滤液浓缩至相对密度1.2的浸膏;
c.将党参粉末与浸膏混合。
实施例七
本实施例的补气健脑的中药保健组合物,所述保健组合物原料按重量份包括以下组分:
党参20份、山茱萸15份、熟地黄18份、生枣仁13份、灵芝7份、柏子仁6份、川芎22份、黄芪23份、甘草20份、知母23份、益智仁15份。
本实施例的补气健脑的中药保健组合物的制备方法,包括以下步骤:
a.将党参按设定重量份的1/2粉碎成粉末;
b.将剩余的党参与原料中的其他组分混合加水煎煮3次,其中第1次加水量是保健组合物总量的15倍,煎煮1小时,过滤收集滤液;第2次加水量是保健组合物总量的10倍,煎煮1小时,过滤收集滤液;第3次加水量是保健组合物总量的8倍,煎煮1小时,过滤收集滤液;合并三次收集的滤液浓缩至相对密度1.2的浸膏;
c.将党参粉末与浸膏混合。
上述实施例中,中药组合物使用时可加入一种或多种用于改善或治疗兼证的中药;如可加入1-3份绿茶、3-6份蝉蜕、5-10败酱草、2-4份细辛、4-6份夜交藤;用于改善睡眠,治疗失眼多梦、健忘易怒;加入4-10份的丹参,改善脑缺血,抑制凝血,降低血黏度、血脂,延缓动脉粥状硬化形成,防止血栓形成,改善微循环;可加入2-10份人参、1-5份淫羊藿、5-10份首乌、2-6份鸦胆子,人参中人参皂苷能明显增加脑内蛋白质量,促进蛋白质、核糖核酸和脱氧核糖核酸的合成;淫羊藿中黄酮苷对简箭毒处理的大鼠,在停止人工呼吸、缺血缺氧条件下,均能使脑电图消失的时间延缓,对脑细胞有保护作用;首乌能改善中枢神经系统功能;鸦胆子乳剂可对抗颅内压升高;加入1-3份海风藤、1-3份毛冬青增加脑血流量;可加入4-10份钩藤,抑制脑神经细胞蛋白异常活化,预防和治疗脑退化症。
上述实施例中,该可加入医学能够接受的药物载体制成制剂。
上述所述例中,可将原料分别精选、清洁后煎煮、过滤后即可得到提取液,进一步稀释而成口服液;或加工成颗粒剂、胶囊剂(包括软硬胶囊)、含片、各类糕点饼干、各类麦片、各类面条。
实施例八
实验例:党参200g打粉;另取党参200g,山茱萸180g,熟地200g,生枣仁100g,灵芝50g,柏子仁50g,川芎160g,黄芪200g,甘草250g,知母150g,益智仁100g洗净,晾干,加水煎煮3次,第1次加水量24600mL,煎煮1小时,过滤;第2次加水量16400mL,煎煮1小时,过滤;第3次加水量13120mL,煎煮1小时,过滤。合并三次滤液,浓缩至相对密度1.25的浸膏,与党参200g粉末一起,按比例加入糕点原料中,混合均匀,制作成饼干和蛋糕。
本发明的保健食品组合物在记忆障碍小鼠中的应用:训练前24h将小鼠放入水迷宫中自由游泳3min以熟悉迷宫环境,然后开始定位航行的训练,每只小鼠分别随机从水池三个象限(北、西、南)面壁放入水池。小鼠寻找到隐匿平台的时间为逃避潜伏期,以60s为限,如果60s仍找不到平台,可引导其找到平台,每只小鼠在平台滞留15s,每天上、下午训练2次,连续5d。记录第5d各组动物逃避潜伏期。然后淘汰出逃避潜伏期有显著差异的小鼠后,除正常组注射生理盐水外,其余均注射东莨菪碱造成小鼠记忆障碍模型,注射量为2mg·kg-1;低剂量组和高剂量组在注射东莨菪碱前分别灌服低剂量具有补气健脑功能的组合物药液和高剂量具有补气健脑功能的组合物药液,脑复康组每天按0.1mL·10g-1给予脑复康混悬液,连续灌胃28d,造模成功后进行水迷宫测试。最后统计数据,数据采用均数±标准差表示,采用SPSS11.0统计软件进行分析,逃避潜伏期反映动物空间参照学习记忆情况。检测结果:
注:*与模型组比较p<0.05;#与正常组比较p<0.05
表1显示,Morris水迷宫检测中,搜索持续时间即逃避潜伏期和搜索路径长度反映空间记忆获得能力,与正常组比较,各造模组动物找到平台的时间明显延长(p<0.05),说明模型动物其记忆能力没有自动恢复;与模型组比较,高剂量组动物逃避潜伏期和平均游程低于模型组,差异有统计学意义(p<0.05),其中高剂量组疗效最好,说明有改善记忆的作用。提示模型组动物学习能力相对较弱,正常组和各给药组均较空模组学习快,高剂量组差别有显著意义(p<0.05)。各给药组与空模组的比较提示各给药组均能显著改善模型鼠的学习能力;各给药组与正常组比较提示各给药组无法使模型鼠的学习能力改善到正常水平,但可以使模型鼠学习能力得到改善,其中高剂量组优于低给药组,高剂量组和脑康组疗效无显著差异。
从穿越目标平台的次数看,除低剂量组外,正常组和高给药组动物穿越平台的次数均明显高于模型组(p<0.05),见表1,反映模型组动物学习记忆能力明显受损,经采用药物治疗后,模型动物的学习记忆能力有所提高,高剂量组效果最好,与正常组无显著差异(p>0.05),说明该组动物的记忆能力基本接近正常,这一结果与定位航行检测结果基本吻合。
最后说明的是,以上实施例仅用以说明本发明的技术方案而非限制,尽管参照较佳实施例对本发明进行了详细说明,本领域的普通技术人员应当理解,可以对本发明的技术方案进行修改或者等同替换,而不脱离本发明技术方案的宗旨和范围,其均应涵盖在本发明的权利要求范围当中。
Claims (7)
1.一种补气健脑的中药保健组合物,其特征在于: 所述保健组合物原料由以下组分制成:
党参10-40份、山茱萸9-25份、熟地黄10-25份、生枣仁10-15份、灵芝3-10份、柏子仁3-9份、川芎15-30份、黄芪15-30份、甘草10-30份、知母15-30份、益智仁10-20份、1-3份海风藤、1-3份毛冬青、4-10份钩藤。
2.根据权利要求1所述的补气健脑的中药保健组合物,其特征在于:还包括辅料,所述辅料淀粉或糊精中的一种或两种;所述辅料重量占保健组合物总量的10%-30%。
3.根据权利要求1-2任一项所述的补气健脑的中药保健组合物,其特征在于:该组合物可加入医学或食品学或保健品学上能够接受的载体制成制剂。
4.根据权利要求1所述的补气健脑的中药保健组合物的制备方法,其特征在于:包括以下步骤:
a.将党参按设定重量份的1/2粉碎成粉末;
b.将剩余的党参与原料中的其他组分混合加水煎煮3次,其中第1次加水量是保健组合物总量的12-16倍,煎煮0.8-1.2小时,过滤收集滤液;第2次加水量是保健组合物总量的8-12倍,煎煮0.8-1.2小时,过滤收集滤液;第3次加水量是保健组合物总量的6-10倍,煎煮0.8-1.2小时,过滤收集滤液;合并三次收集的滤液浓缩至相对密度1.1-1.3的浸膏;
c.将党参粉末与浸膏混合。
5.根据权利要求4所述的补气健脑的中药保健组合物的制备方法,其特征在于:步骤b中,第1次加水量是保健组合物总量的15倍,煎煮1小时,过滤收集滤液;第2次加水量是保健组合物总量的10倍,煎煮1小时,过滤收集滤液;第3次加水量是保健组合物总量的8倍,煎煮1小时。
6.根据权利要求1所述的补气健脑的中药保健组合物的使用方法,其特征在于:将保健组合物的原料的提取液与党参粉末和辅料混合制成保健食品。
7.根据权利要求6所述的补气健脑的中药保健组合物的使用方法,其特征在于:将提取液与党参粉和面粉混合做成面条。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610240827.9A CN105831751B (zh) | 2016-04-18 | 2016-04-18 | 补气健脑的中药保健组合物、制备方法及其使用方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610240827.9A CN105831751B (zh) | 2016-04-18 | 2016-04-18 | 补气健脑的中药保健组合物、制备方法及其使用方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105831751A CN105831751A (zh) | 2016-08-10 |
CN105831751B true CN105831751B (zh) | 2020-01-03 |
Family
ID=56588508
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610240827.9A Active CN105831751B (zh) | 2016-04-18 | 2016-04-18 | 补气健脑的中药保健组合物、制备方法及其使用方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105831751B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108991497A (zh) * | 2018-06-20 | 2018-12-14 | 罗国球 | 一种具有预防记忆力衰退功能的营养含片的制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101549124A (zh) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | 一种补心安神、健脾益气的药物组合及其制备方法 |
CN104012971A (zh) * | 2014-06-17 | 2014-09-03 | 史克勇 | 改善记忆力的保健食品 |
CN104474251A (zh) * | 2014-11-28 | 2015-04-01 | 西南大学 | 具有健脑固本功能的组合物及其制剂和应用 |
-
2016
- 2016-04-18 CN CN201610240827.9A patent/CN105831751B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101549124A (zh) * | 2008-04-03 | 2009-10-07 | 北京中科仁和科技有限公司 | 一种补心安神、健脾益气的药物组合及其制备方法 |
CN104012971A (zh) * | 2014-06-17 | 2014-09-03 | 史克勇 | 改善记忆力的保健食品 |
CN104474251A (zh) * | 2014-11-28 | 2015-04-01 | 西南大学 | 具有健脑固本功能的组合物及其制剂和应用 |
Non-Patent Citations (1)
Title |
---|
健脑益智汤治疗脑萎缩25例临床体会;刘信奇;《实用中医杂志》;19951231(第6期);第41页 * |
Also Published As
Publication number | Publication date |
---|---|
CN105831751A (zh) | 2016-08-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104491759B (zh) | 一种治疗偏头痛的中药组合物及其制备方法 | |
CN105496917A (zh) | 一种积雪草抗皱面霜及其制备方法 | |
CN103599403B (zh) | 一种治疗偏头痛的中药组合物及其制备方法 | |
CN104491236A (zh) | 一种治疗原发性高血压的中药制剂及其制备方法 | |
CN104398980A (zh) | 一种治疗中风后偏瘫的中药制剂及其制备方法 | |
CN106215118A (zh) | 抗肿瘤的保健制剂及其制备方法 | |
CN105831751B (zh) | 补气健脑的中药保健组合物、制备方法及其使用方法 | |
CN105497789A (zh) | 一种治疗脑卒中后抑郁症的中药制剂及其制备方法 | |
CN104800771A (zh) | 一种用于儿童夜惊症的中药制剂及其制备方法 | |
CN101129576A (zh) | 八珍益母丸 | |
CN103495103B (zh) | 消食健脾的药物 | |
CN104840773A (zh) | 治疗椎动脉型颈椎病的中药组合物及制法 | |
CN104958677A (zh) | 一种治疗膜性肾病的中药制剂及其制备方法 | |
CN105232677A (zh) | 一种治疗心肌梗死的中药组合物及其制备方法 | |
CN104998158A (zh) | 一种治疗肝硬化的药物组合物及其应用 | |
CN104857370A (zh) | 一种治疗乳腺癌症的中药组合物 | |
CN104623532A (zh) | 一种治疗脑胶质瘤的中药组合物及其制备方法 | |
CN105709060A (zh) | 一种中药制剂在制备治疗病毒性心肌炎的药物中的用途 | |
CN104706961A (zh) | 失眠多梦患者润肺清心中药药剂及制备方法 | |
CN106039075A (zh) | 一种治疗肺胃蕴热型慢性咽炎的中药组合物及方法 | |
CN105055658A (zh) | 用于治疗肝经湿热型小儿遗尿的药物及其制备方法 | |
CN105395710A (zh) | 含有艾叶的治疗眼底出血的中药制剂及其制备方法 | |
CN105288086A (zh) | 一种治疗脑血栓的中药组合物及其制备方法 | |
CN104906313A (zh) | 治疗气滞血瘀型职业性慢性铅中毒的药物及制备方法 | |
CN104352872A (zh) | 一种治疗虚热型肺痿病的中药 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |