CN105823727B - A kind of micro-fluidic detection device and system - Google Patents
A kind of micro-fluidic detection device and system Download PDFInfo
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- CN105823727B CN105823727B CN201610294161.5A CN201610294161A CN105823727B CN 105823727 B CN105823727 B CN 105823727B CN 201610294161 A CN201610294161 A CN 201610294161A CN 105823727 B CN105823727 B CN 105823727B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
Abstract
The invention discloses a kind of micro-fluidic detection devices, including：Pedestal, sample adding device and negative pressure pump, sample adding device are located above pedestal, wherein have chip slot and waste liquid tank on pedestal；Sample adding device includes rotating circular disk, cylinder and liquid storage pipe, and wherein rotating circular disk is fixedly connected with cylinder；There are multiple fixed bits, liquid storage pipe is positioned in fixed bit when use on rotating circular disk；When detection, micro-fluidic chip to be detected is placed in chip slot, the height of rotating circular disk is adjusted by cylinder, and control rotating circular disk rotation, so that liquid storage pipe is located at the top of the liquid injection port of micro-fluidic chip, the liquid outlet of micro-fluidic chip is connect with negative pressure pump, and negative pressure pump is used to inject waste liquid in waste liquid tank.The invention also discloses a kind of micro-fluidic detection systems.Efficiently quick micro-fluidic detection can be achieved using the present invention.
Description
Technical field
The present invention relates to microfluidic chip technologies, and in particular to a kind of micro-fluidic detection device and system.
Background technology
Microflow control technique is the technology that new development in recent years is got up, and the technology is based on analytical chemistry, in the micron-scale
Manipulate fluid in structure, carry out reaction detection, have small, reagent and amount of samples it is few, can be with Multi-example multi objective simultaneously
The advantages that detection.It is several milliliters of detection to need sample size in the past, after using microfluidic chip technology, it is only necessary to several microlitres
The consumption of sample and reagent is greatly saved in sample size, and performance indicator is better than common detection method, has extensive
Application prospect and important application value.
Micro-fluidic chip is the main platform that microflow control technique is realized, is primarily characterized in that by controlling fluid in miniflow
The various functions of chip system are completed in flowing in channel.Currently, the driving with control of microfluid are in micro-fluidic chip system
By integrating pump (or external pump) in the chips and various forms of valve bodies in a variety of manners with the use of realizing, because
This current microfluidic analysis detecting instrument is in automanual state by hand mostly, and instrument price it is expensive, it is bulky,
It is inconvenient for operation.Micro-fluidic detection field is made a general survey of, existing micro-fluidic detection device certain structures are simple, fluid control function list
One, although some can realize the various forms of controls of microfluid, structure is complex, processing difficulties, expensive, unfavorable
In mass production.Moreover, existing micro-fluidic detection device needs to be equipped with because the valve body function in chip is undesirable mostly
Various bulky microfluidic control facilities, this does not obviously meet the micromation of microfluidic chip technology, portability requirement, nothing
Method meets the needs of micro-fluidic chip processing complex fluid.
Invention content
In view of this, the present invention proposes a kind of micro-fluidic detection device and system, it can be achieved that efficiently quickly micro-fluidic inspection
It surveys.
On the one hand, the present invention provides a kind of micro-fluidic detection device, including：Pedestal, sample adding device and negative pressure pump, sample-adding dress
Setting in above pedestal, wherein have chip slot and waste liquid tank on pedestal；Sample adding device includes rotating circular disk, cylinder and liquid storage
Pipe, wherein rotating circular disk is fixedly connected with cylinder；There are multiple fixed bits, liquid storage pipe is positioned over fixation when use on rotating circular disk
In position；When detection, micro-fluidic chip to be detected is placed in chip slot, and the height of rotating circular disk is adjusted by cylinder, and is controlled
Rotating circular disk processed rotation so that liquid storage pipe is located at the top of the liquid injection port of micro-fluidic chip, the liquid outlet of micro-fluidic chip with bear
Press pump connects, and negative pressure pump is used to inject waste liquid in waste liquid tank.
Preferably, the tip of the liquid storage pipe is placed with piezoelectric ceramics, for controlling liquid storage intraluminal fluid by piezoelectric effect
The flowing of body.
Preferably, the rotating circular disk is connected with Zero-point positioning system, and the rotational circle is controlled by Zero-point positioning system
The rotation and positioning of disk.
Preferably, the size of the chip slot and the size of micro-fluidic chip to be detected are adapted.
Preferably, the micro-fluidic chip to be detected is the micro-fluidic chip in S bend pipe road.
On the other hand, the present invention also provides a kind of micro-fluidic detection systems, including data acquisition module, data analysis module
And micro-fluidic detection device as described above；Wherein,
Data acquisition module is used for the acquisition testing signal in the micro-fluidic detection device detection process；
Data analysis module carries out scheduled analyzing processing for detection signal collected to data acquisition module.
Preferably, the data acquisition module is CCD camera.
Preferably, the data analysis module is computer.
The micro-fluidic detection apparatus structure that the embodiment of the present invention is provided is simple, easy to process, of low cost, easy to implement
Industrialization production.Relative to previous detection technique, the micro-fluidic detection device and system simple operation of the embodiment of the present invention, tool
Standby micromation, automation, portability, efficiently quick many advantages, such as detecting.
Description of the drawings
Fig. 1 is the structural schematic diagram of the micro-fluidic detection device of the preferred embodiment of the present invention.
Fig. 2 is the structural schematic diagram of the pedestal of the embodiment of the present invention.
Fig. 3 is the structural schematic diagram of the sample adding device of the embodiment of the present invention.
Fig. 4 is the structural schematic diagram of the micro-fluidic chip to be detected of the embodiment of the present invention.
Specific implementation mode
Below in conjunction with attached drawing and specific embodiment, technical scheme of the present invention is described in detail.
The micro-fluidic detection device of the embodiment of the present invention includes：Pedestal, sample adding device and negative pressure pump, sample adding device are located at bottom
Seat top, wherein there is chip slot and waste liquid tank on pedestal；Sample adding device includes rotating circular disk, cylinder and liquid storage pipe, wherein revolving
Turn disk to be fixedly connected with cylinder；There are multiple fixed bits, liquid storage pipe is positioned in fixed bit when use on rotating circular disk.Detection
When, micro-fluidic chip to be detected is placed in chip slot, and the height of rotating circular disk is adjusted by cylinder, and controls rotating circular disk
Rotation, so that liquid storage pipe is located at the top of the liquid injection port of micro-fluidic chip, the liquid outlet of micro-fluidic chip is connect with negative pressure pump, is born
Press pump is used to inject waste liquid in waste liquid tank.
In practical operation, micro-fluidic chip to be detected is placed in the chip slot of pedestal, connects negative pressure pump, root
According to detection program it needs to be determined that the quantity of liquid storage pipe, corresponding test solution is added in liquid storage pipe, liquid storage pipe is fixed
On a rotary disc, it is moved up and down using cylinder control rotating circular disk, and fixed hand or with motor control rotating circular disk rotation
Position, to which by the liquid injection port of the outlet alignment micro-fluidic chip of liquid storage pipe, micro-fluidic core is injected in then control test solution outflow
It in piece, waits reacting startup negative pressure pump later, waste liquid is injected in waste liquid tank；Then rotating circular disk is rotated, by next liquid storage pipe
In liquid injection micro-fluidic chip in, so carry out successively, until all reaction process finish.
Fig. 1 shows the structural schematic diagram of the micro-fluidic detection device of the preferred embodiment of the present invention, the wherein chip of pedestal 1
The top of micro-fluidic chip there are one being placed in slot 1-1, pedestal 1 is sample adding device 2, and rotating circular disk 2-1 is connected to cylinder 2-2's
Top has multiple fixed bits, liquid storage pipe 2-3 to be placed in fixed bit along rotating circular disk 2-1 circumferencial directions.
Fig. 2 shows the structures of the pedestal of the embodiment of the present invention, and the wherein size of chip slot 1-1 should be with miniflow to be detected
The size for controlling chip is adapted.For different Detection tasks, micro-fluidic chip to be detected can be arbitrary micro-fluidic chip,
Such as the micro-fluidic chip in S bend pipe road, micro-fluidic chip to be detected should have liquid injection port and liquid outlet.
Fig. 3 shows that the structure of the sample adding device of the embodiment of the present invention, wherein rotating circular disk 2-1 are connected to cylinder 2-2's
Top has multiple fixed bits, dismountable liquid storage pipe 2-3 to be placed in fixed bit along rotating circular disk 2-1 circumferencial directions.Liquid storage
The material selection high molecular material of pipe 2-3, such as polypropylene PP.
In an embodiment of the present invention, the tip of liquid storage pipe 2-3 is placed with piezoelectric ceramics (not shown), and when detection is logical
Cross the flowing of piezoelectric effect control liquid storage liquid in pipe.
In an embodiment of the present invention, rotating circular disk 2-1 is connect with Zero-point positioning system (not shown), logical when detection
Zero passage point positioning system controls the rotation and positioning of rotating circular disk.
Fig. 4 shows the structure of the micro-fluidic chip to be detected of the embodiment of the present invention, with liquid injection port 3 and liquid outlet
4。
When being detected using the micro-fluidic detection device of the embodiment of the present invention, micro-fluidic chip is placed in chip slot 1-1,
For the liquid injection port 3 of chip below rotating circular disk 2-1, cylinder 2-2 can drive rotating circular disk 2-1 to move up and down；On rotating circular disk 2-1
Fixed dismountable liquid storage pipe 2-3, can be according to the quantity of detection program adjustment liquid storage pipe 2-3；It is controlled using Zero-point positioning system
The rotation of rotating circular disk 2-1 processed, it is corresponding with detecting step to control liquid storage pipe 2-3；The tip of liquid storage pipe 2-3 is placed with pressure
Electroceramics completes all processes of reaction by piezoelectric effect to control the flowing of liquid in liquid storage pipe 2-3.At liquid outlet 4
Hydraulic pump is accessed, the waste liquid after reaction is pumped into waste liquid tank 1-2.
Further, the micro-fluidic detection device based on above example, can be the device configuration data acquisition module and
Data analysis module for the acquisition testing signal in micro-fluidic detection device detection process and carries out interpretation of result.Specifically,
The reaction signal of micro-fluidic chip in CCD camera shooting chip slot 1-1, such as chemiluminescence signal, then by CCD camera can be used
The photo taken sends computer to, and analyzing processing is carried out using related software, obtains detection and analysis result.
More than, technical scheme of the present invention is described in detail in conjunction with specific embodiments, described specific implementation
Example is used to help understand the thought of the present invention.The derivation that those skilled in the art make on the basis of the specific embodiment of the invention
It is also belonged within the scope of the present invention with modification.
Claims (6)
1. a kind of micro-fluidic detection device, which is characterized in that including：Pedestal, sample adding device and negative pressure pump, sample adding device are located at bottom
Seat top, wherein
There is chip slot and waste liquid tank on pedestal；
Sample adding device includes rotating circular disk, cylinder and liquid storage pipe, and wherein rotating circular disk is fixedly connected with cylinder；Have on rotating circular disk
There are multiple fixed bits, liquid storage pipe is positioned in fixed bit when use；
When detection, micro-fluidic chip to be detected is placed in chip slot, the height of rotating circular disk is adjusted by cylinder, and manually
Or rotated using motor control rotating circular disk, so that liquid storage pipe is located at the top of the liquid injection port of micro-fluidic chip, micro-fluidic chip
Liquid outlet connect with negative pressure pump, negative pressure pump for will waste liquid inject waste liquid tank in；
Wherein, the rotating circular disk is connected with Zero-point positioning system, and the rotation of the rotating circular disk is controlled by Zero-point positioning system
Turn and positions；
Wherein, the size of the chip slot and the size of micro-fluidic chip to be detected are adapted.
2. micro-fluidic detection device as described in claim 1, which is characterized in that wherein, the tip of the liquid storage pipe is placed with
Piezoelectric ceramics, the flowing for controlling liquid storage liquid in pipe by piezoelectric effect.
3. micro-fluidic detection device as claimed in claim 1 or 2, which is characterized in that wherein, the micro-fluidic core to be detected
Piece is the micro-fluidic chip in S bend pipe road.
4. a kind of micro-fluidic detection system, which is characterized in that including data acquisition module, data analysis module and as right is wanted
Seek the micro-fluidic detection device described in any one of 1-3；Wherein,
Data acquisition module is used for the acquisition testing signal in the micro-fluidic detection device detection process；
Data analysis module carries out scheduled analyzing processing for detection signal collected to data acquisition module.
5. micro-fluidic detection system as claimed in claim 4, which is characterized in that wherein, the data acquisition module is CCD phases
Machine.
6. micro-fluidic detection system as described in claim 4 or 5, which is characterized in that wherein, the data analysis module is meter
Calculation machine.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610294161.5A CN105823727B (en) | 2016-05-05 | 2016-05-05 | A kind of micro-fluidic detection device and system |
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| CN201610294161.5A CN105823727B (en) | 2016-05-05 | 2016-05-05 | A kind of micro-fluidic detection device and system |
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| CN105823727A CN105823727A (en) | 2016-08-03 |
| CN105823727B true CN105823727B (en) | 2018-10-23 |
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| CN113637580A (en) * | 2020-04-27 | 2021-11-12 | 复旦大学 | Multi-force field coupled cell tissue culture chip |
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| WO2002101360A1 (en) * | 2001-06-13 | 2002-12-19 | Kna Technology Inc | Automated fluid handling system and method |
| US20030230488A1 (en) * | 2002-06-13 | 2003-12-18 | Lawrence Lee | Microfluidic device preparation system |
| TWI457561B (en) * | 2011-12-07 | 2014-10-21 | 私立中原大學 | Liquid testing system and liquid testing method |
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| WO2003011462A1 (en) * | 2001-07-24 | 2003-02-13 | Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V. | Device for pipetting a liquid |
| CN203133096U (en) * | 2013-03-21 | 2013-08-14 | 浙江大学 | Full-automatic liquid sample collecting and feeding system without mixing and dead volume |
| CN104280559A (en) * | 2013-07-07 | 2015-01-14 | 上海浦北信息科技有限公司 | Labonchip detector |
| CN204679514U (en) * | 2015-05-12 | 2015-09-30 | 天津微纳芯科技有限公司 | A kind of locking device for flexible biological probe |
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