CN103604936A - Automatic control and analysis detector for micro-fluidic chip - Google Patents
Automatic control and analysis detector for micro-fluidic chip Download PDFInfo
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- CN103604936A CN103604936A CN201310550501.2A CN201310550501A CN103604936A CN 103604936 A CN103604936 A CN 103604936A CN 201310550501 A CN201310550501 A CN 201310550501A CN 103604936 A CN103604936 A CN 103604936A
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Abstract
The invention relates to an automatic control and analysis detector for a micro-fluidic chip. The automatic control and analysis detector is used for the analysis fields of bioanalysis, chemical analysis, environment detection, food safety and medical diagnosis. The automatic control and analysis detector for the micro-fluidic chip mainly comprises two parts, namely an automatic control device and an analysis detection chip device. The input pressure or flow velocity is automatically controlled, so that complex operation of micro fluid is realized, and automatic analysis detection based on a micro-fluidic chip technology is realized. The automatic control and analysis detector has the advantages of automation, portability, miniaturization and simplicity and convenience in operation.
Description
Technical field
The present invention relates to a kind of micro-fluidic chip automatic Control detector, this instrument is controlled the complex operations that realizes micro fluid by the robotization to input pressure or flow velocity, and then realize the automated analysis detection based on micro-fluidic chip technology, belong to micro-total system robotization control analysis detection field.
Background technology
Micro-total analysis system (miniaturized total analysis system, μ TAS) is the multifunction micro determination and analysis system that integrated sample introduction, sample preparation, biochemical reaction, separation, detection are integrated.Micro-fluidic chip (Micro-fluidic chip) is its main building block, there is microminiaturization, robotization, the advantage such as integrated, convenient and quick, in a lot of fields, obtain a wide range of applications fields such as cell biology, analytical chemistry, materialogy, organizational project, environment measuring, food security and medical diagnosis.It is basis that micro-fluidic chip be take analytical chemistry and biological chemistry, utilize the technology (MEMS) of micro electronmechanical processing, at silicon, glass, quartz, frosting, process the microchannel network of 1-500 micron, by complicated design, realize steps such as the sampling of target analytes, dilution, reagent adding, enrichment, extraction, mixing, reaction, separation, detections.
Current analysis and detecting instrument adopts following several large class methods mostly: atom fluorescent luminosity method, inductive coupling plasma mass analytic approach, high performance liquid chromatography, ultraviolet-visible method and electrochemical methods etc., these analyzing detecting methods have that instrument is expensive, bulky, detection time is long, operation inconvenience etc. determine, the micro-fluidic chip technology therefore with advantages such as microminiaturization, portability, robotization, efficient fast detecting is the inevitable development trend of analysis and detecting instrument of future generation.
But at present the fluid type of drive on micro-fluidic chip mainly contains two kinds of internal drive and external drives, it is driving force that internal drive mainly be take electroosmotic flow, electrophoresis stream and surface tension, by changing driving voltage and material character, controls flow direction and the flow velocity of fluid in the network of microchannel; External drive is mainly syringe pump, peristaltic pump and constant pressure pump.The former cost is high, and design is complicated, needs expensive external main equipment to realize, and the latter only can provide the flow control of pressure source and simple break-make, cannot realize and meet the needs that micro-fluidic chip is processed complex fluid.
Because microfluidic chip analysis technology is in the wide application prospect in analyzing and testing field, setting up a kind of performance micro-fluidic chip automatic Control detector efficient, with low cost, full-automatic, multi-functional, easy and simple to handle, is a technical matters in the urgent need to address.
Summary of the invention
In order to solve the problems of the technologies described above, the object of this invention is to provide micro-fluidic chip automatic Control detector efficiently cheap, full-automatic, multi-functional and easy and simple to handle.
The technical solution adopted in the present invention is: a kind of micro-fluidic chip automatic Control detector, its structure mainly comprises automatic control device and two ingredients of analyzing and testing chip, and wherein automatic control device partly mainly includes pressure source, presetting apparatus, pressure-display device, control program input media, control program display device, pressure adjustment assembly, hyperchannel output port, hyperchannel output indicating device, standby pressure source interface, multi-path conversion and control device.Analyzing and testing chip apparatus mainly includes micro-fluidic chip, interface card slot, conduit and detecting device.Pressure source is distributed to hyperchannel output port by presetting apparatus, and at the pre-booking process output pressure of setting according to control program input media, thereby the complex operations of fluid on micro-fluidic chip is controlled in robotization, and then the automated analysis of realizing based on micro-fluidic chip technology detects.
Further, described automatic control device working method is: control program input media is inputted instruction to presetting apparatus, the Output pressure mode in the latter's controlled pressure source, and input process and final instruction can be visual by control program display device; Described pressure source, can also be by accessing with pressure source interface the quantity that external pressure source comes propagation pressure source except the pressure source of this multi-channel fluid automaton self assembling; By described multi-path conversion and control device, pressure source can be distributed to hyperchannel output port artificially, and can pass through the artificial setup control way of output of presetting apparatus; Described pressure adjustment assembly can regulate size and the flow velocity of the input of input pressure source, and can show by pressure-display device size and the flow velocity of pressure source; The way of output of described hyperchannel output port can be passed through hyperchannel output indicating device synchronously visual.
Further, described analyzing and testing chip apparatus working method is: by interface card slot and conduit linking automation control device and analyzing and testing chip apparatus, by the operation of reagent in the reagent injection port robotization control analysis detection chip of integrating on micro-fluidic chip; By detecting device, gather the hybrid reaction signal in micro-fluidic chip reaction microchamber on micro-fluidic chip, thereby realize the automated analysis detection of testing sample; Reagent after final reaction is reclaimed or is discharged by reagent outlet.
Further, the installation site of described pressure source, presetting apparatus, pressure-display device, control program input media, control program display device, pressure adjustment assembly, hyperchannel output port, hyperchannel output indicating device, standby pressure source interface and multi-path conversion and control device and other servicing units and mode can be all around, upper and lower and internal freedom combination.
Further, described pressure source can be gas, can be also liquid, or while air inclusion and two kinds of pressure sources of liquid.
Further, what described pressure source provided can be both constant pressure, can be also constant flow velocity, or variable pressure or flow velocity.
Further, what described pressure source provided both can malleation, can be also negative pressure.
Further, described pressure source output or the pressure range of input can be 0-1Mpa, and the flow rates of output or input can be 0-1000mL/s.
Further, described presetting apparatus can be both single-chip microcomputer autonomous control system, can be also to control by host computer or computer.
Further, described control program input media both can be inputted the control program of robotization, can be also manual control mode.
Further, described control program input media can be both push button panel, can be also touch panel.
Further, described control program display device can be both non-touch display screen, can be also touch display screen.
Further, described pressure adjustment assembly can be both knob regulative mode, can be also button regulative mode, or touch-screen regulative mode.
Further, described hyperchannel output port can be both push-in, can be also other interface modes such as knob, or buckle-type.
Further, described hyperchannel output port can be the port of independence or one, the port of electronic control element that can be also comprising of independence or one.
Further, described hyperchannel output port can be output gas or liquid, can be also extracting gases or liquid, or has comprised output simultaneously and extracted two kinds of functions.
Further, the quantity of described hyperchannel output port, can be both 1, can be also 2, or a plurality of.
Further, described hyperchannel output indicating device both can synchronously have been indicated the pressure of each port of hyperchannel output port or output or the input state of flow velocity, pressure or the output of flow velocity or the value of input that also can each port of simultaneous display hyperchannel output port.
Further, described multi-path conversion and control device can be both fluid conversion and control element, can be also electric conversion and control element, or had comprised these two kinds conversions and control element simultaneously.
Further, described multi-path conversion and control device can be 1, can be also 2, or a plurality of.
Further, the mode that interconnects of described multi-path conversion and control device can independent assortment.
Further, described analyzing and testing chip apparatus, is characterized in that described interface card slot and conduit can be metal, plastics, quartz or glass.
Further, described analyzing and testing chip apparatus, is characterized in that the material of described micro-fluidic chip can be metal, PMMA, PC, PDMS, quartz, glass or other macromolecule organic polymers.
Further, described analyzing and testing chip apparatus, is characterized in that described reagent injection port and reagent outlet can be the reservoirs of belt lacing not, can be also the joint with connecting duct.
Further, described analyzing and testing chip apparatus, is characterized in that described micro-fluidic chip reaction microchamber can be closed environment, can be also open environment.
Further, described analyzing and testing chip apparatus, is characterized in that the detection principle of described detecting device can be optics, galvanochemistry, acoustics and Biological Principles.
Further, described analyzing and testing chip apparatus, is characterized in that described reagent outlet can collect reacted potpourri automatically, also can automatically discharge outside micro-fluidic chip.
The invention has the beneficial effects as follows: the present invention is by controlling the robotization of input pressure or flow velocity, can realize the complex operations of micro fluid, and then realize the automated analysis detection based on micro-fluidic chip technology, and instrument performance of the present invention is efficient, with low cost, full-automatic, multi-functional and easy and simple to handle.
Accompanying drawing explanation
Below in conjunction with accompanying drawing, the specific embodiment of the present invention is described further:
Fig. 1 is the structural front view of a kind of micro-fluidic chip automatic Control of the present invention detector;
Fig. 2 is the automatic control device part of a kind of micro-fluidic chip automatic Control of the present invention detector;
Fig. 3 is the analyzing and testing chip apparatus part of a kind of micro-fluidic chip automatic Control of the present invention detector;
1 pressure source; 2 force control devices; 3 pressure-display devices; 4 control program input medias; 5 control program display device; 6 pressure adjustment assemblys; 7 hyperchannel output ports; 8 hyperchannel output indicating devices; 9 standby pressure source interfaces; 10 multi-path conversion and control device; 11 micro-fluidic chips; 12 interface card slots; 13 conduits; 14 detecting devices; 15-18 micro-fluidic chip reagent injection port; 19 micro-fluidic chip reagent outlets; 20 micro-fluidic chip reaction microchambers.
Embodiment
Below in conjunction with 1 ~ 3 pair of the specific embodiment of the present invention of accompanying drawing, make a detailed explanation.
Embodiment: a kind of micro-fluidic chip automatic Control detector, its structure mainly comprises automatic control device and two ingredients of analyzing and testing chip; Its automatic control device mainly comprises: pressure source 1, presetting apparatus 2, pressure-display device 3, control program input media 4, control program display device 5, pressure adjustment assembly 6, hyperchannel output port 7, hyperchannel output indicating device 8, standby pressure source interface 9, multi-path conversion and control device 10.
Described device pressure source 1 is input as 0-1Mpa high-pressure air source, and control program input media 4 is inputted instructions to presetting apparatus 2, the Output pressure in the latter's controlled pressure source 1, and input process and final instruction show by control program display device 5; According to the demonstration of pressure-display device 3, by pressure adjustment assembly 6, regulate suitable pressure to input; Multi-path conversion and control device 10, by default control program in presetting apparatus 2, are controlledly distributed to high-pressure air source hyperchannel output port 7; Hyperchannel output port 7 according to the control mode of pre-set programs to conveying high-pressure source of the gas in micro-fluidic chip 11.
Whole operating process is done once to detailed step explanation below: on micro-fluidic chip 11, in micro-fluidic chip reagent injection port 15-18, add different reaction reagents in advance; Hyperchannel output port 7 is connected to micro-fluidic chip reagent injection port 15-18 by pre-set programs control mode, open micro-fluidic chip automatic Control detector operation of the present invention, different reaction reagents is by micro-fluidic chip reagent injection port 15-18, according to pre-set programs, enter micro-fluidic chip reaction microchamber 20, reacted potpourri enters micro-fluidic chip and goes out reagent sample mouth 19, so far completes robotization control and the analyzing and testing of reagent and determinand in micro-fluidic chip.
Claims (15)
1. a micro-fluidic chip automatic Control detector, its structure mainly comprises automatic control device and two ingredients of analyzing and testing chip apparatus, by the robotization to input pressure or flow velocity, control the complex operations that realizes micro fluid, and then the automated analysis of realizing based on micro-fluidic chip technology detects.
2. by a kind of micro-fluidic chip automatic Control detector claimed in claim 1, it is characterized in that described automatic control device working method is: control program input media is after presetting apparatus input instruction, Output pressure mode by presetting apparatus controlled pressure source, by multi-path, change with control device pressure source is distributed to hyperchannel output port, pressure adjustment assembly regulates size and the flow velocity of the input of input pressure source, and by pressure-display device, shows size and the flow velocity of pressure source.
3. the analyzing and testing chip apparatus working method described in is: by interface card slot and conduit linking automation control device and analyzing and testing chip apparatus, by the operation of reagent in the reagent injection port robotization control analysis detection chip of integrating on micro-fluidic chip; By detecting device, gather the hybrid reaction signal in micro-fluidic chip reaction small chamber on micro-fluidic chip, thereby realize the automated analysis detection of testing sample; Reagent after final reaction is reclaimed or is discharged by reagent outlet.
4. by a kind of micro-fluidic chip automatic Control detector claimed in claim 2, described automatic control device can be both push button panel, can be also touch panel.
5. the automatic control device described in can driving gas, can be also liquid.
6. what the automatic control device described in provided can be both constant pressure, can be also constant flow velocity, or variable pressure or flow velocity.
7. what the automatic control device described in provided both can malleation, can be also negative pressure.
8. the quantity of the hyperchannel output port that the automatic control device described in provides, can be both 1, can be also 2, or a plurality of.
9. the hyperchannel output indicating device of the automatic control device described in both can synchronously have been indicated the pressure of each port or the output of flow velocity or the input state of hyperchannel output port, also can the pressure of each port of simultaneous display hyperchannel output port or the value of the output of flow velocity or input.
10. by a kind of micro-fluidic chip automatic Control detector claimed in claim 2, it is characterized in that interface card slot and the conduit of described analyzing and testing chip apparatus can be metal, plastics, quartz or glass.
The material of the micro-fluidic chip of the analyzing and testing chip apparatus described in 11. can be metal, PMMA, PC, PDMS, quartz, glass or other macromolecule organic polymers.
12. by a kind of micro-fluidic chip automatic Control detector claimed in claim 2, it is characterized in that the reagent injection port of described analyzing and testing chip apparatus and reagent outlet can be the reservoirs of belt lacing not, can be also the joint with connecting duct.
13. by a kind of micro-fluidic chip automatic Control detector claimed in claim 2, it is characterized in that the micro-fluidic chip reaction small chamber of described analyzing and testing chip apparatus can be closed environment, can be also open environment.
14. by a kind of micro-fluidic chip automatic Control detector claimed in claim 2, it is characterized in that the detection principle of the detecting device of described analyzing and testing chip apparatus can be optics, galvanochemistry, acoustics and Biological Principles.
15. by a kind of micro-fluidic chip automatic Control detector claimed in claim 2, it is characterized in that the reagent outlet of described analyzing and testing chip apparatus can be collected reacted potpourri automatically, also can automatically discharge outside micro-fluidic chip.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103616910A (en) * | 2013-12-17 | 2014-03-05 | 苏州汶颢芯片科技有限公司 | Multi-channel fluid automatic control device |
| CN105021586A (en) * | 2015-08-07 | 2015-11-04 | 湖北民族学院 | Minitype DBD-AFS integrated analyzing system |
| CN111190022A (en) * | 2020-01-07 | 2020-05-22 | 中国科学院半导体研究所 | Biochemical detection system and detection method based on resonant sensor |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1588088A (en) * | 2004-09-23 | 2005-03-02 | 清华大学 | Micro flow control chip detecting system for flowing cell detection |
| CN1727888A (en) * | 2005-07-20 | 2006-02-01 | 中国科学院上海微系统与信息技术研究所 | A kind of mini type electrophoresis detection system of microflow control chip and detection autocontrol method |
| CN101187669A (en) * | 2006-11-22 | 2008-05-28 | 柯尼卡美能达医疗印刷器材株式会社 | Microchip inspection system and method used in microchip inspection system |
| CN101206227A (en) * | 2006-12-22 | 2008-06-25 | 中国科学院大连化学物理研究所 | Large volume sample injection method and special chip in micro-current-control chip |
| US20090325276A1 (en) * | 2006-09-27 | 2009-12-31 | Micronics, Inc. | Integrated microfluidic assay devices and methods |
-
2013
- 2013-11-08 CN CN201310550501.2A patent/CN103604936A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1588088A (en) * | 2004-09-23 | 2005-03-02 | 清华大学 | Micro flow control chip detecting system for flowing cell detection |
| CN1727888A (en) * | 2005-07-20 | 2006-02-01 | 中国科学院上海微系统与信息技术研究所 | A kind of mini type electrophoresis detection system of microflow control chip and detection autocontrol method |
| US20090325276A1 (en) * | 2006-09-27 | 2009-12-31 | Micronics, Inc. | Integrated microfluidic assay devices and methods |
| CN101187669A (en) * | 2006-11-22 | 2008-05-28 | 柯尼卡美能达医疗印刷器材株式会社 | Microchip inspection system and method used in microchip inspection system |
| CN101206227A (en) * | 2006-12-22 | 2008-06-25 | 中国科学院大连化学物理研究所 | Large volume sample injection method and special chip in micro-current-control chip |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103616910A (en) * | 2013-12-17 | 2014-03-05 | 苏州汶颢芯片科技有限公司 | Multi-channel fluid automatic control device |
| CN105021586A (en) * | 2015-08-07 | 2015-11-04 | 湖北民族学院 | Minitype DBD-AFS integrated analyzing system |
| CN105021586B (en) * | 2015-08-07 | 2017-10-24 | 湖北民族学院 | Miniature DBD AFS integrated analysis systems |
| CN111190022A (en) * | 2020-01-07 | 2020-05-22 | 中国科学院半导体研究所 | Biochemical detection system and detection method based on resonant sensor |
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Application publication date: 20140226 |