CN105816693A - Preparation process of dendrobium superfine powder - Google Patents
Preparation process of dendrobium superfine powder Download PDFInfo
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- CN105816693A CN105816693A CN201610305100.4A CN201610305100A CN105816693A CN 105816693 A CN105816693 A CN 105816693A CN 201610305100 A CN201610305100 A CN 201610305100A CN 105816693 A CN105816693 A CN 105816693A
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- herba dendrobii
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- antistaling agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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Abstract
The invention discloses a preparation process of dendrobium superfine powder, which comprises the following steps: (1) pre-treating; (2) grinding and pulping: adding water and grinding into slurry; (3) freeze drying; (4) pulverizing into micropowder by using an ultrafine pulverizer; (5) mixing the micropowder with antistaling agent. The health-care wine can regulate the immunologic function, resist fatigue, invigorate qi and nourish yin, is suitable for people with weak constitution and easy fatigue, particularly has good effects on patients with rehabilitation after illness, overwork and deficiency of lung-stomach yin, eliminates mental fatigue and hypodynamia caused by busy work and study of people, and can effectively improve the work and study efficiency.
Description
Technical field
The present invention relates to Study on Supermicro-pulverization of Traditional Chinese Drugs processing technique field, be specifically related to a kind of dendrobe ultrafine powder preparation technology.
Background technology
Herba Dendrobii (formal name used at school: DendrobiumofficinaleKimuraetMigo) is the orchid family Herba Dendrobii; belong to herbaceos perennial; it it is China's rare Chinese medicine; it it is Chinese Second Class Key Protected Plant; have " China's Herba mesonae chinensis ", the laudatory title of " gold in medicine "; first of row " China's nine big Herba mesonae chinensis ", it is referred to as " medicine circle giant panda " by international medicinal plants circle.Herba Dendrobii is the famous and precious tonic Chinese medicine material of dietotherapeutic." Taoist Scriptures " of the Tang Dynasty was once classified as Herba Dendrobii as China's nine big Herba mesonae chinensis with Herba Saussureae Involueratae, three liang of Radix Ginsengs, 120 years Radix Polygoni Multiflori, cycle of sixty years Poria, Herba Cistanches, remote mountains Ganoderma, Haiti Margarita, Cordyceps, Herba Dendrobii ranks the first, and directly demonstrates effect of Herba Dendrobii on them.The main component of Herba Dendrobii has the trace element such as the materials such as polysaccharide, alkaloid, aminoacid, and calcic, potassium, sodium, magnesium, zinc, ferrum, manganese, selenium, copper, chromium, nickel.Because its effect is peculiar, market is rare, have " a thousand pieces of gold grass ", the title of " a soft gold ".In Shennong's Herbal, Herba Dendrobii has the effects such as nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid, nourishing the lung to arrest cough.Modern pharmacological research shows, Herba Dendrobii also has the regulation effect such as anticancer immune, anti-ageing.
Have more than 1500 kind of Herba Dendrobii in the world, in state-owned 76 kinds of Herba Dendrobiis, the Herba Dendrobii on Huoshan 60,000 stockaded village grows the best Herba Dendrobii of China, 60,000 stockaded village's height above sea level 644 meters, hills and mountains cincture, and vegetation is luxuriant, and long-term cloud and mist curls up, and weather is unique.Temperature on average is at 14.2-16.1 degree Celsius throughout the year, and warmer climate moistens, and beneficially growth and dendrobium polysaccharide, the effective of alkaloid component of Herba Dendrobii accumulates；Precipitation is between 1100-1600mm throughout the year, and rainfall is abundant, is suitable for the growth characteristics that Herba Dendrobii happiness the moon happiness is wet.Secondly, 60,000 stockaded villages have an area of tens inner hills and mountains cinctures, include more than 2500 kind of wild plant, and these plants all discharge oxygen and substantial amounts of trace element every day in air so that the air on 60,000 stockaded villages has reached the standard of natural oxygen-bar.And Herba Dendrobii grows by the moisture in root absorption air and oxygen, therefore, after absorbing the air of 60,000 stockaded villages so high-quality so that in Herba Dendrobii, the composition of dendrobium polysaccharide and alkaloid is the most ecological and naturalization；In addition, spring water ph value here between 6.6 to 7.0, the beneficially growth of Herba Dendrobii.
The traditional diamond-making technique of Herba Dendrobii, generally use baking, crimp, the method such as drying is processed into Herba Dendrobii extract.A part of effective ingredient is destroyed in the course of processing.And after being processed into Herba Dendrobii extract, owing to containing substantial amounts of phlegmatic temperament and polysaccharide in Herba Dendrobii, during decocting, effective ingredient is difficult to fried, and the most more effective ingredient is stayed in medicinal residues, causes waste.For promoting active ingredient absorption in vivo, improving utilization rate and the extraction efficiency of drug resource, the research broken to dendrobium candidum ultrafine powder is highly desirable to.
Summary of the invention
For above-mentioned deficiency present in prior art, the technical problem to be solved is to provide a kind of dendrobe ultrafine powder preparation technology.
The present invention seeks to be achieved through the following technical solutions:
A kind of dendrobe ultrafine powder preparation technology, comprises the following steps:
(1) pretreatment: take Herba Dendrobii, removes impurity, washes, be cut into the section of 1-3mm；
(2) grinding making beating: grind to form serosity after adding water, water be (0.5-1.5) with the mass ratio of Herba Dendrobii: 1, then serosity is placed in-10～-20 DEG C at, freezing 10-15 hour；
(3) lyophilization: cryodesiccated control condition is-45～-50 DEG C, and lyophilization to moisture is 1-10wt%；
(4) micropowder is broken: use super micron mill to be ground into micropowder；
(5) by micropowder and antistaling agent in mass ratio for (95-105): (0.05-0.5) mixs homogeneously and get final product.
Preferably, described antistaling agent is the mixture of one or more in procyanidin, resveratrol, Quercetin.
It is highly preferred that described antistaling agent is made up of the raw material of following weight parts: procyanidin 20-40 part, resveratrol 20-40 part, Quercetin 20-40 part.
Concrete, in the present invention:
Procyanidin, No. CAS: 4852-22-6.
Resveratrol, No. CAS: 501-36-0.
Quercetin, No. CAS: 117-39-5.
The present invention can regulate immunologic function, resisting fatigue, boosting qi and nourishing yin, it is applicable to have a delicate constitution and fatiguability person, especially to rehabilitation after being ill, overwork, lung-stomach yin deficiency shower has good effect, people are by the spiritlessness and weakness caused by busy working and learning in elimination, can be effectively improved working and learning efficiency.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further, the following stated, it is only to presently preferred embodiments of the present invention, the present invention not does the restriction of other forms, and any those skilled in the art are changed to the Equivalent embodiments changed on an equal basis possibly also with the technology contents of the disclosure above.Every without departing from the present invention program content, any simple modification following example done according to the technical spirit of the present invention or equivalent variations, all fall within protection scope of the present invention.
Herba Dendrobii is for plucking from Bao Xin garden, Huoshan Herba Dendrobii development corporation, Ltd., the Herba Dendrobii of the planting base of Huoshan 60,000 stockaded village height above sea level 644 meters.
Embodiment 1
Dendrobe ultrafine powder preparation technology, comprises the following steps:
(1) pretreatment: take Herba Dendrobii, removes impurity, washes, be cut into the section of 2mm；
(2) making beating is ground: after the Herba Dendrobii of cutting is added distilled water, grind to form serosity, distilled water is 0.8:1 (i.e. every gram Herba Dendrobii adds 0.8 gram of distilled water) with the mass ratio of Herba Dendrobii, then at serosity being placed in-18 DEG C, within freezing 12 hours, become solid state, obtain solid content；
(3) lyophilization: solid content carries out lyophilization, at cryodesiccated control condition is-47 DEG C, the moisture of lyophilization to solid content is 5wt%；
(4) micropowder is broken: use super micron mill (use Sanqing Stainless Steel Apparatus Co., Ltd., Shandong provide SQW-6A super micron mill) to carry out micronizing to 5 microns after lyophilization, obtain micropowder；
(5) micropowder is mixed homogeneously for 100:0.18 in mass ratio with antistaling agent, obtain the dendrobe ultrafine powder of embodiment 1.
Described antistaling agent is made up of the raw material of following weight parts: procyanidin 30 parts, resveratrol 30 parts, Quercetin 30 parts.
Embodiment 2
Substantially the same manner as Example 1, differ only in: described antistaling agent is made up of the raw material of following weight parts: procyanidin 45 parts, resveratrol 45 parts.Obtain the dendrobium candidum ultrafine powder of embodiment 2.
Embodiment 3
Substantially the same manner as Example 1, differ only in: described antistaling agent is made up of the raw material of following weight parts: procyanidin 45 parts, Quercetin 45 parts.Obtain the dendrobium candidum ultrafine powder of embodiment 3.
Embodiment 4
Substantially the same manner as Example 1, differ only in: described antistaling agent is made up of the raw material of following weight parts: resveratrol 45 parts, Quercetin 45 parts.Obtain the dendrobium candidum ultrafine powder of embodiment 4.
Test case 1
Dendrobium candidum ultrafine powder to embodiment 1-6, is placed in 25 DEG C, preservation half a year under relative humidity 85% environment, uses " GB/T4789.2-2010 microbiological test of food hygiene total plate count mensuration " to carry out total plate count test.Concrete test result is shown in Table 1.
Table 1: total plate count test table
After adding antistaling agent, total plate count is decreased obviously, and shelf life of products is significantly extended.Comparing embodiment 1 and embodiment 2-4, embodiment 1 (procyanidin, resveratrol, Quercetin are compounding) fresh-keeping effect is substantially better than embodiment 2-4 (in procyanidin, resveratrol, Quercetin, arbitrarily the two is compounding).
Test case 2
The dendrobium officinale granula preparing embodiment 1-6 carries out resisting fatigue test.
Totally 4 groups, often 100 mices of group.Every mice every morning 9 point, 6 pm feeding dendrobium candidum ultrafine powder, feeding 10 grams every time, after continuous 30 days, the walking weight load of test mice, serum urea, hepatic glycogen are detected by the method for inspection tested with reference to function of physical fatigue alleviation in Ministry of Public Health " health food inspection with assessment technique specification-2003 ", average.After Bi compare, carry out statistical analysis P < 0.05.Test data is shown in Table 2.
Table 2: resisting fatigue test result table
Comparing embodiment 1 and embodiment 2-4, embodiment 1 (procyanidin, resveratrol, Quercetin are compounding) resisting fatigue effect is substantially better than embodiment 2-4 (in procyanidin, resveratrol, Quercetin, arbitrarily the two is compounding).
Claims (3)
1. a dendrobe ultrafine powder preparation technology, it is characterised in that comprise the following steps:
(1) pretreatment: take Herba Dendrobii, removes impurity, washes, be cut into the section of 1-3mm；
(2) grinding making beating: grind to form serosity after adding water, water be (0.5-1.5) with the mass ratio of Herba Dendrobii: 1, then serosity is placed in-10～-20 DEG C at, freezing 10-15 hour；
(3) lyophilization: cryodesiccated control condition be-45～-50 DEG C at, lyophilization to moisture is 1-10wt%；
(4) micropowder is broken: use super micron mill to be ground into micropowder；
(5) by micropowder and antistaling agent in mass ratio for (95-105): (0.05-0.5) mixs homogeneously and get final product.
2. dendrobe ultrafine powder preparation technology as claimed in claim 1, it is characterised in that: described antistaling agent is the mixture of one or more in procyanidin, resveratrol, Quercetin.
3. dendrobe ultrafine powder preparation technology as claimed in claim 2, it is characterised in that: described antistaling agent is made up of the raw material of following weight parts: procyanidin 20-40 part, resveratrol 20-40 part, Quercetin 20-40 part.
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| CN201610305100.4A CN105816693B (en) | 2016-05-06 | 2016-05-06 | Preparation process of dendrobium superfine powder |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106262139A (en) * | 2016-08-10 | 2017-01-04 | 自然味（重庆）农业科技股份有限公司 | Health care non-transgenic sweet potato powder and preparation method thereof |
| CN106562424A (en) * | 2016-11-10 | 2017-04-19 | 福建永耕农业开发有限公司 | Preparation method of dendrobium officinale flower instant powder and instant powder prepared thereby |
| CN107569606A (en) * | 2016-11-21 | 2018-01-12 | 广西大学 | A kind of fine grain processing method of dendrobium candidum |
| CN108902975A (en) * | 2018-07-24 | 2018-11-30 | 浙江兰溪锦荣生物科技股份有限公司 | A kind of production technology of dendrobium candidum dried frozen aquatic products |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1732916A (en) * | 2004-08-09 | 2006-02-15 | 李川明 | Compound medical health-caring preparation containing procyanidins and other functional ingredients |
| CN102669657A (en) * | 2012-04-20 | 2012-09-19 | 苏州爱斯欧蒂生物科技有限公司 | Immunity-improving health product |
| CN103028048A (en) * | 2012-12-25 | 2013-04-10 | 浙江百草中药饮片有限公司 | Preparation process for dendrobe ultrafine powder |
| CN104068014A (en) * | 2014-06-10 | 2014-10-01 | 浙江欧银农业发展有限公司 | Dendrobium officinale preservative and preservation method |
-
2016
- 2016-05-06 CN CN201610305100.4A patent/CN105816693B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1732916A (en) * | 2004-08-09 | 2006-02-15 | 李川明 | Compound medical health-caring preparation containing procyanidins and other functional ingredients |
| CN102669657A (en) * | 2012-04-20 | 2012-09-19 | 苏州爱斯欧蒂生物科技有限公司 | Immunity-improving health product |
| CN103028048A (en) * | 2012-12-25 | 2013-04-10 | 浙江百草中药饮片有限公司 | Preparation process for dendrobe ultrafine powder |
| CN104068014A (en) * | 2014-06-10 | 2014-10-01 | 浙江欧银农业发展有限公司 | Dendrobium officinale preservative and preservation method |
Non-Patent Citations (1)
| Title |
|---|
| 何丽: "《防癌抗癌食物掌中查》", 30 April 2013, 中国人口出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106262139A (en) * | 2016-08-10 | 2017-01-04 | 自然味（重庆）农业科技股份有限公司 | Health care non-transgenic sweet potato powder and preparation method thereof |
| CN106562424A (en) * | 2016-11-10 | 2017-04-19 | 福建永耕农业开发有限公司 | Preparation method of dendrobium officinale flower instant powder and instant powder prepared thereby |
| CN107569606A (en) * | 2016-11-21 | 2018-01-12 | 广西大学 | A kind of fine grain processing method of dendrobium candidum |
| CN108902975A (en) * | 2018-07-24 | 2018-11-30 | 浙江兰溪锦荣生物科技股份有限公司 | A kind of production technology of dendrobium candidum dried frozen aquatic products |
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Effective date of registration: 20220518 Address after: 214000 2-18-206, 211 Longshan Road, Xinwu District, Wuxi City, Jiangsu Province Patentee after: Zhonghuan Health Technology (Wuxi) Co.,Ltd. Address before: 237200 Hengshan Town Zhongxing North Road, Huoshan County, Lu'an City, Anhui Province Patentee before: ANHUI SHANZHENCANG ECOLOGICAL AGRICULTURE Co.,Ltd. |