CN105816692A - Herba dendrobii granule preparation and preparation method thereof - Google Patents
Herba dendrobii granule preparation and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a herba dendrobii granule preparation and a preparation method thereof. The herba dendrobii granule preparation is characterized by being prepared from, by weight, 35-45 parts of herba dendrobii, 10-20 parts of ginseng, 20-30 parts of barbary wolfberry fruit and 15-25 parts of milkvetch roots. The herba dendrobii granule preparation can regulate the immune function, resist fatigue and invigorate qi to replenish yin, is suitable for people who are weak in constitution and prone to fatigue, especially has the good effect on rehabilitation after illness, excessive fatigue and people who suffer from lung and stomach yin deficiency, eliminates people mental fatigue and debilitation caused by busy work and study and can effectively improve the working and studying efficiency.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of dendrobium officinale granula and
Its preparation method.
Background technology
Herba Dendrobii (formal name used at school: Dendrobium officinale Kimura et Migo) is the orchid family
Herba Dendrobii, belongs to herbaceos perennial, is China's rare Chinese medicine, is Chinese Second Class Key Protected Plant,
Have " China's Herba mesonae chinensis ", the laudatory title of " gold in medicine ", first of row " China's nine big Herba mesonae chinensis ", by state
Border medicinal plants circle is referred to as " medicine circle giant panda ".Herba Dendrobii is the famous and precious nourishing of dietotherapeutic
Chinese crude drug." Taoist Scriptures " of the Tang Dynasty once Herba Dendrobii and Herba Saussureae Involueratae, three liang of Radix Ginsengs, 102
Within 10 years, Radix Polygoni Multiflori, cycle of sixty years Poria, Herba Cistanches, remote mountains Ganoderma, Haiti Margarita, Cordyceps are classified as
China's nine big Herba mesonae chinensis, Herba Dendrobii ranks the first, directly demonstrate effect of Herba Dendrobii far away from
On them.The main component of Herba Dendrobii has the materials such as polysaccharide, alkaloid, aminoacid, and
The trace element such as calcic, potassium, sodium, magnesium, zinc, ferrum, manganese, selenium, copper, chromium, nickel.Because of it
Effect is peculiar, and market is rare, have " a thousand pieces of gold grass ", the title of " a soft gold ".In " legendary god of farming's basis
Grass warp " in, Herba Dendrobii has the effects such as nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid, nourishing the lung to arrest cough.Existing
Showing for pharmacological research, Herba Dendrobii also has the regulation effect such as anticancer immune, anti-ageing.
Have more than 1500 kind of Herba Dendrobii in the world, in state-owned 76 kinds of Herba Dendrobiis, the Herba Dendrobii on Huoshan 60,000 stockaded village
Growing the Herba Dendrobii that China is best, 60,000 stockaded village's height above sea level 644 meters, hills and mountains cincture, vegetation is luxuriant,
Cloud and mist curls up throughout the year, and weather is unique.Temperature on average is at 14.2-16.1 degree Celsius throughout the year, weather
The growth of warm and moist, beneficially Herba Dendrobii and dendrobium polysaccharide, the effective of alkaloid component amass
Tired；Precipitation is between 1100-1600mm throughout the year, and rainfall is abundant, is suitable for Herba Dendrobii happiness the moon happiness wet
Growth characteristics.Secondly, 60,000 stockaded villages have an area of tens inner hills and mountains cinctures, include kind more than 2500
Wild plant, these plants are all discharged oxygen and substantial amounts of trace element in air, make every days
The air obtaining 60,000 stockaded villages has reached the standard of natural oxygen-bar.And Herba Dendrobii is exactly by root absorption
Moisture in air and oxygen grow, and therefore, absorb the air of 60,000 stockaded villages so high-quality
After so that in Herba Dendrobii, the composition of dendrobium polysaccharide and alkaloid is the most ecological and naturalization；Except this
Outside, spring water ph value here between 6.6 to 7.0, the beneficially growth of Herba Dendrobii.
Chinese medicine granules refers to that the extract of Chinese crude drug mixes with proper auxiliary materials or part fine medicinal material powder
Dry graininess dosage form that is even, that make.The extraction of Chinese medicinal granule, concentrate, be dried, adjuvant choosing
Select, method of granulating and granularity selection etc. all should carry out preferably with detailed research.Due to Chinese medicine
Complicated component, the self-character of guidance of traditional Chinese medicine theory should be embodied, Chinese medicine to be retained tradition
Preparation reasonably essence, attention composition and the Close relation etc. of curative effect, so Chinese medicine granules
The crucial problem of preparation be the technique of extracting to crude drug and dry technology research.
The invention provides a kind of dendrobium officinale granula, there is good health-care effect.
Summary of the invention
For above-mentioned deficiency present in prior art, the technical problem to be solved is
A kind of dendrobium officinale granula and preparation method thereof is provided.
The present invention seeks to be achieved through the following technical solutions:
A kind of dendrobium officinale granula, the raw material including following weight parts is prepared from: iron sheet stone
Dry measure used in former times 35-45 part, Radix Ginseng 10-20 part, Fructus Lycii 20-30 part, Radix Astragali 15-25 part.
A kind of dendrobium officinale granula, is prepared from by the raw material of following weight parts: Herba Dendrobii
35-45 part, Radix Ginseng 10-20 part, Fructus Lycii 20-30 part, Radix Astragali 15-25 part, adjuvant 80-150
Part.
Preferably, described adjuvant is in maltotriose, maltotetraose, hydroxyl isomaltulose
The mixture of one or more.
It is highly preferred that described adjuvant is mixed by maltotriose, maltotetraose, hydroxyl isomaltulose
Conjunction forms, and described maltotriose, maltotetraose, the mass ratio of hydroxyl isomaltulose are (1-3):
(1-3): (1-3).
The preparation method of a kind of dendrobium officinale granula, comprises the following steps:
(1) mix homogeneously after Herba Dendrobii, Radix Ginseng, Fructus Lycii, the Radix Astragali being pulverized, in obtaining
Medicinal material mixture, is then (10-30) by water with Chinese crude drug mixture quality ratio: 1 is mixed into
Row extracts for the first time, filters to obtain first-time filtrate and a filtering residue；
(2) add water to a filtering residue is carried out second time extract, filter secondary filtrate and
Secondary filtering residue；
(3) merging first-time filtrate and secondary filtrate, after filtering with flame filter press, filtrate is put
In concentrating under reduced pressure tank；55-65 DEG C, be evaporated under vacuum 0.07-0.09MPa relatively
Density is 1.01-1.10 (60 DEG C of measurements), obtains concentrated extract；
(4) concentrated extract carried out boiling granulating with adjuvant and get final product.
Preferably, the extraction of described first time is divided into 3 stages, and first stage temperature is
95-100 DEG C, time first stage is 10-20 minute；Second stage temperature is 75-85 DEG C,
The second stage time is 30-40 minute；Phase III temperature is 95-100 DEG C, during the phase III
Between be 5-15 minute.
Preferably, in the extraction of described second time, the addition of water is identical with first time, and second time carries
Taking temperature and be 75-85 DEG C, the time is 20-40 minute.
Preferably, in described step (3), flame filter press filters the filter using 160-200 mesh
Cloth, control pressure is 0.2-0.4Mpa.
Concrete, in the present invention:
Herba Dendrobii is orchid Herba Dendrobii Dendrobium officinale Kimuraet
The dry stem of Migo, sweet in the mouth, cold nature, return stomach, kidney channel.There is reinforcing stomach reg fluid, YIN nourishing
The function of heat clearing away.Modern medicine and pharmacology research shows, Herba Dendrobii mainly contains polysaccharide, amino
The chemical compositions such as acid and trace element, luxuriant and rich with fragrance class and a small amount of alkaloid, have enhancing immunity, anti-
Fatigue, antitumor, blood sugar lowering, hepatoprotective protect the pharmacological actions such as stomach.
Radix Ginseng is the dry root and rhizome of Araliaceae Radix Ginseng Panax ginseng C.A.Mey.,
Sweet in the mouth, micro-hardship, property is put down, is returned spleen, lung, heart channel.Having strongly invigorating primordial QI, multiple arteries and veins takes off admittedly,
Invigorating the spleen to benefit the lung, promotes the production of body fluid, the function calmed the nerves.Modern medicine and pharmacology research shows, Radix Ginseng is mainly containing many
Plant ginsenoside, saccharide, volatile oil, aminoacid, trace element and organic acid, the life of multiple dimension
The compositions such as element, choline and enzyme.There is resisting fatigue, enhancing immunity, antitumor, blood sugar lowering and
The anti-ageing effect of waiting for a long time.
The Radix Astragali is leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge
Var or the root of Radix Astragali.Main product is in the Inner Mongol of China, Shanxi, Heilungkiang and other places.Yellow
Stilbene sweet in the mouth, slightly warm in nature, return liver, spleen, lung, kidney channel.There are benefiting QI for strengthening the superficies, arresting sweating admittedly to take off, hold in the palm
Skin ulcer granulation promoting, effect of inducing diuresis to remove edema.Modern study shows that the Radix Astragali has enhancing human body immunity merit
Can, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and wide antibacterial action.
Fructus Lycii is the drying and ripening fruit of plant of Solanaceae lycium barbarum Lycium barbarum L.
Real, sweet in the mouth, property is put down, is returned liver, kidney channel.There is nourishing the liver and kidney, the function of replenishing vital essence to improve eyesight.Existing
Showing for medicine drug development, Fructus Lycii mainly contains saccharide, aminoacid and trace element etc. and changes
Study point, there is the functions such as enhancing immunity, antitumor, blood fat reducing.
Maltotriose, No. CAS: 1109-28-0.
Maltotetraose, No. CAS: 34612-38-9.
Hydroxyl isomaltulose, No. CAS: 64519-82-0.
The present invention can regulate immunologic function, resisting fatigue, boosting qi and nourishing yin, it is adaptable to has a delicate constitution
And fatiguability person, especially to rehabilitation after being ill, overwork, lung-stomach yin deficiency shower has well
Effect, eliminate people by the spiritlessness and weakness caused by busy working and learning, can effectively carry
High workload and the learning efficiency.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further, the following stated, is only to this
The preferred embodiment of invention, not does the restriction of other forms to the present invention, any familiar
Professional and technical personnel is changed to become on an equal basis possibly also with the technology contents of the disclosure above
The Equivalent embodiments changed.Every without departing from the present invention program content, the technology according to the present invention is real
Any simple modification that confrontation following example are done or equivalent variations, all fall within the guarantor of the present invention
In the range of protecting.
Embodiment 1
The preparation method of dendrobium officinale granula, comprises the following steps:
(1) by 4kg Herba Dendrobii, 1.5kg Radix Ginseng, 2.5kg Fructus Lycii, the 2kg Radix Astragali respectively
It is crushed to 20 mesh, then mix homogeneously, obtains 10kg Chinese crude drug mixture；By in 10kg
Carrying out extracting for the first time in medicinal material mixture addition 200kg water, the extraction of described first time is divided into 3
In the individual stage, temperature is heated to 100 DEG C by the first stage, and time first stage is 15 minutes；
Second stage cools the temperature to 80 DEG C, and the second stage time is 35 minutes；Phase III will again
Temperature is heated to 100 DEG C, and time phase III is 10 minutes；80 mesh filter clothes are used after extraction
Filter, obtain first-time filtrate and a filtering residue；
(2) extracting carrying out second time in a 200kg water filtering residue of addition, second time is extracted
Temperature is 80 DEG C, and the time is 30 minutes, uses 80 mesh filter-cloth filterings, obtain secondary after extraction
Filtrate and secondary filtering residue；
(3) merge first-time filtrate and secondary filtrate, filter with flame filter press, use 180
Purpose filter cloth, control pressure is 0.3Mpa, obtains filtrate；Filtrate is placed in concentrating under reduced pressure tank
In；60 DEG C, to be evaporated to relative density under vacuum 0.08MPa be 1.05 (60 DEG C of measurements),
Obtain concentrated extract；
(4) concentrated extract is sprayed in 9kg adjuvant and carry out boiling granulating, obtain embodiment 1
Dendrobium officinale granula.
Described adjuvant is 1 in mass ratio by maltotriose, maltotetraose, hydroxyl isomaltulose:
1:1 is uniformly mixed and obtains.
Embodiment 2
Substantially the same manner as Example 1, differ only in: described in described step (1)
Once it is extracted as being heated to temperature 100 DEG C, extracts 60 minutes；80 mesh filters are used after extraction
Cloth filters, and obtains first-time filtrate and a filtering residue.Obtain the dendrobium officinale granula of embodiment 2.
Embodiment 3
Substantially the same manner as Example 1, differ only in: described in described step (1)
Once it is extracted as being heated to temperature 80 DEG C, extracts 60 minutes；80 mesh filters are used after extraction
Cloth filters, and obtains first-time filtrate and a filtering residue.Obtain the dendrobium officinale granula of embodiment 3.
Embodiment 4
Substantially the same manner as Example 1, differ only in: described in described step (1)
Once it is extracted as being heated to temperature 90 DEG C, extracts 60 minutes；80 mesh filters are used after extraction
Cloth filters, and obtains first-time filtrate and a filtering residue.Obtain the dendrobium officinale granula of embodiment 4.
Embodiment 5
Substantially the same manner as Example 1, differ only in: described adjuvant by maltotetraose,
Hydroxyl isomaltulose is uniformly mixed for 1:1 in mass ratio and obtains.Obtain embodiment 5
Dendrobium officinale granula.
Embodiment 6
Substantially the same manner as Example 1, differ only in: described adjuvant by maltotriose,
Hydroxyl isomaltulose is uniformly mixed for 1:1 in mass ratio and obtains.Obtain embodiment 6
Dendrobium officinale granula.
Embodiment 7
Substantially the same manner as Example 1, differ only in: described adjuvant by maltotriose,
Maltotetraose is uniformly mixed for 1:1 in mass ratio and obtains.Obtain the iron sheet of embodiment 7
Herba Dendrobii granule.
Test case 1
Testing the extraction effect of embodiment 1-4, concrete outcome is shown in Table 1.
Table 1: extraction effect test result list position: %
| Crude polysaccharides | Ginsenoside | |
| Embodiment 1 | 55.4 | 61.6 |
| Embodiment 2 | 50.2 | 49.7 |
| Embodiment 3 | 45.5 | 52.8 |
| Embodiment 4 | 48.7 | 50.4 |
Comparing embodiment 1 and embodiment 2-4, embodiment 1 is divided into 3 stage extraction effects obvious
It is better than embodiment 2-4.
Test case 2
The dendrobium officinale granula preparing embodiment 1 and embodiment 5-7 carries out stability survey
Examination.
The ginsenoside comprised in granule of the present invention is the index composition of Radix Ginseng.By embodiment
1 and the dendrobium officinale granula for preparing of embodiment 5-7 respectively by aluminum-plastic composite membrane bag sealed bundle
Dress, places 3 months at a temperature of they are placed in 38 DEG C, measures people during March in each sample
Ginseng saponin is relative to residual content during this sample 0 month.Concrete outcome is shown in Table 2.
Table 2: stability test result list position: %
| Life saponin residual content | |
| Embodiment 1 | 99.6 |
| Embodiment 5 | 95.2 |
| Embodiment 6 | 92.6 |
| Embodiment 7 | 93.1 |
Comparing embodiment 1 and embodiment 5-7, embodiment 1 (maltotriose, maltotetraose,
Hydroxyl isomaltulose compounds) stability is substantially better than embodiment 5-7 (maltotriose, Fructus Hordei Germinatus four
In sugar, hydroxyl isomaltulose, arbitrarily the two is compounding).
Test case 3
The dendrobium officinale granula preparing embodiment 1-7 carries out resisting fatigue test.
Totally 7 groups, often 50 mices of group.Every mice every morning 9 point, 6 pm feed
Food dendrobium officinale granula, each feeding 10 grams, after continuous 30 days, " protect with reference to Ministry of Public Health
Health food inspection with assessment technique specification-2003 " in function of physical fatigue alleviation experiment inspection
The walking weight load of test mice, serum urea, hepatic glycogen are detected by method, make even
Average.After Bi compare, carry out statistical analysis P < 0.05.Test data is shown in Table 3.
Table 3: resisting fatigue test result table
Comparing embodiment 1 and embodiment 2-4, embodiment 1 was divided into for 3 stages extracted resisting fatigue effect
Fruit is substantially better than embodiment 2-4.Comparing embodiment 1 and embodiment 5-7, embodiment 1 (Fructus Hordei Germinatus
Trisaccharide, maltotetraose, hydroxyl isomaltulose are compounding) resisting fatigue effect is substantially better than embodiment
5-7 (in maltotriose, maltotetraose, hydroxyl isomaltulose, arbitrarily the two is compounding).
Claims (8)
1. a dendrobium officinale granula, it is characterised in that include the raw material of following weight parts
It is prepared from: Herba Dendrobii 35-45 part, Radix Ginseng 10-20 part, Fructus Lycii 20-30 part, the Radix Astragali
15-25 part.
2. a dendrobium officinale granula, it is characterised in that by the raw material system of following weight parts
For forming: Herba Dendrobii 35-45 part, Radix Ginseng 10-20 part, Fructus Lycii 20-30 part, Radix Astragali 15-25
Part, adjuvant 80-150 part.
3. dendrobium officinale granula as claimed in claim 2, it is characterised in that: described
Adjuvant is the mixture of one or more in maltotriose, maltotetraose, hydroxyl isomaltulose.
4. dendrobium officinale granula as claimed in claim 3, it is characterised in that: described
Adjuvant is mixed by maltotriose, maltotetraose, hydroxyl isomaltulose, described maltotriose,
Maltotetraose, the mass ratio of hydroxyl isomaltulose are (1-3): (1-3): (1-3).
5. the preparation method of the dendrobium officinale granula as according to any one of claim 2-4,
It is characterized in that: comprise the following steps:
(1) mix homogeneously after Herba Dendrobii, Radix Ginseng, Fructus Lycii, the Radix Astragali being pulverized, in obtaining
Medicinal material mixture, is then (10-30) by water with Chinese crude drug mixture quality ratio: 1 is mixed into
Row extracts for the first time, filters to obtain first-time filtrate and a filtering residue；
(2) add water to a filtering residue is carried out second time extract, filter secondary filtrate and
Secondary filtering residue；
(3) merging first-time filtrate and secondary filtrate, after filtering with flame filter press, filtrate is put
In concentrating under reduced pressure tank；55-65 DEG C, be evaporated under vacuum 0.07-0.09MPa relatively
Density is 1.01-1.10 (60 DEG C of measurements), obtains concentrated extract；
(4) concentrated extract carried out boiling granulating with adjuvant and get final product.
6. the preparation method of dendrobium officinale granula as claimed in claim 5, its feature exists
In: the extraction of described first time is divided into 3 stages, and first stage temperature is 95-100 DEG C, and first
Phases-time is 10-20 minute；Second stage temperature is 75-85 DEG C, and the second stage time is
30-40 minute；Phase III temperature is 95-100 DEG C, and time phase III is 5-15 minute.
7. the preparation method of dendrobium officinale granula as claimed in claim 5, its feature exists
In: in the extraction of described second time, the addition of water is identical with first time, and Extracting temperature is for the second time
75-85 DEG C, the time is 20-40 minute.
8. the preparation method of dendrobium officinale granula as claimed in claim 5, its feature exists
In: in described step (3), flame filter press filters the filter cloth of employing 160-200 mesh, controls
Pressure is 0.2-0.4Mpa.
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| CN106579406A (en) * | 2016-11-28 | 2017-04-26 | 安徽牧龙山生态旅游开发股份有限公司 | Medicated diet raw material composition by using dendrobium candidum as main material |
| CN106924549A (en) * | 2017-05-09 | 2017-07-07 | 无限极（中国）有限公司 | A kind of preparation method of composition and extract with benefiting qi and nourishing blood function and application |
| CN109480149A (en) * | 2017-09-12 | 2019-03-19 | 冯军 | Nutrition selenium peptide drinks formula and preparation process |
| CN111298028A (en) * | 2020-04-21 | 2020-06-19 | 重庆成方英汇健康管理有限公司 | Astragalus dendrobium granules and preparation process thereof |
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| CN102988828A (en) * | 2012-11-21 | 2013-03-27 | 光明食品集团云南石斛生物科技开发有限公司 | Preparation method of dendrobium officinale granula |
| CN103740558A (en) * | 2014-01-13 | 2014-04-23 | 江苏海昇药业有限公司 | Dendrobium nobile wine and preparation method thereof |
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| CN102266490A (en) * | 2011-07-15 | 2011-12-07 | 安徽圣农生物科技股份有限公司 | Formula of compound dendrobium huoshanense granules and production method |
| CN102988828A (en) * | 2012-11-21 | 2013-03-27 | 光明食品集团云南石斛生物科技开发有限公司 | Preparation method of dendrobium officinale granula |
| CN103740558A (en) * | 2014-01-13 | 2014-04-23 | 江苏海昇药业有限公司 | Dendrobium nobile wine and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106579406A (en) * | 2016-11-28 | 2017-04-26 | 安徽牧龙山生态旅游开发股份有限公司 | Medicated diet raw material composition by using dendrobium candidum as main material |
| CN106924549A (en) * | 2017-05-09 | 2017-07-07 | 无限极（中国）有限公司 | A kind of preparation method of composition and extract with benefiting qi and nourishing blood function and application |
| CN109480149A (en) * | 2017-09-12 | 2019-03-19 | 冯军 | Nutrition selenium peptide drinks formula and preparation process |
| CN111298028A (en) * | 2020-04-21 | 2020-06-19 | 重庆成方英汇健康管理有限公司 | Astragalus dendrobium granules and preparation process thereof |
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