CN105816692B - dendrobium officinale granules and preparation method thereof - Google Patents
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Abstract
The invention discloses a dendrobium officinale granule and a preparation method thereof, and the dendrobium officinale granule is characterized by being prepared from the following raw materials in parts by weight: 35-45 parts of dendrobium officinale, 10-20 parts of ginseng, 20-30 parts of medlar and 15-25 parts of astragalus membranaceus. The health-care wine can regulate the immunologic function, resist fatigue, invigorate qi and nourish yin, is suitable for people with weak constitution and easy fatigue, particularly has good effects on patients with rehabilitation after illness, overwork and deficiency of lung-stomach yin, eliminates mental fatigue and hypodynamia caused by busy work and study of people, and can effectively improve the work and study efficiency.
Description
Technical Field
the invention relates to the technical field of traditional Chinese medicine preparations, and particularly relates to dendrobium officinale granules and a preparation method thereof.
Background
Dendrobium officinale (the scientific name: Dendrobium officinale Kimura et Migo) is Dendrobium nobile of Orchidaceae, belongs to perennial herb, is a famous and precious Chinese traditional medicine, is a national secondary protection plant, is the first name of "Chinese immortal grass" and "gold in medicine", listed as "nine big immortal grass" in China, and is called "panda in medicine world" by the international medicinal plant community. The dendrobium huoshanense is a rare nourishing traditional Chinese medicine used as both medicine and food. In Tang dynasty, the efficacy of dendrobium huoshanense is directly proved to be far above the traditional Chinese medicine by listing dendrobium huoshanense, saussurea involucrate, three or two ginseng, fleece-flower root of twenty years old, Indian buead, desertliving cistanche, ganoderma lucidum, sea pearl and Chinese caterpillar fungus as nine immortal grass of China. The main components of dendrobium huoshanense comprise polysaccharide, alkaloid, amino acid and other substances, and calcium, potassium, sodium, magnesium, zinc, iron, manganese, selenium, copper, chromium, nickel and other trace elements. Because of its peculiar efficacy and scarce market, it is called as "Qianjin grass" or "Soft-golden". In Shen nong Ben Cao Jing, Dendrobium officinale Kimura et Migo has the effects of nourishing yin and moisturizing lung, nourishing stomach and promoting fluid production, moistening lung and relieving cough. Modern pharmacological research shows that the dendrobium officinale also has the effects of regulating immunity, resisting aging, resisting cancer and the like.
there are more than 1500 kinds of dendrobe in the world, 76 kinds of dendrobe in China, the best dendrobe in China grows from the dendrobe in six thousand villages in Hooshan, the altitude of the six thousand villages is 644 meters, the mountains surround, the vegetation is flourishing, cloud and fog are lingering all the year round, and the climate is unique. The annual average temperature is 14.2-16.1 ℃, the climate is warm and humid, and the growth of dendrobium huoshanense and the effective accumulation of dendrobium polysaccharide and alkaloid components are facilitated; the perennial rainfall is between 1100 and 1600mm, the rainfall is abundant, and the dendrobium nobile is suitable for the growth characteristics of preferring yin and moisture. And secondly, the county mountains in the square circle of the six-ten-thousand-village surround the world and contain more than 2500 wild plants, and the plants discharge oxygen and a large amount of trace elements into the air every day, so that the air of the six-ten-thousand-village reaches the standard of a natural oxygen bar. The dendrobium huoshanense grows by absorbing moisture and oxygen in the air by roots, so that the components of dendrobium polysaccharide and alkaloid in the dendrobium huoshanense are more ecological and natural after the high-quality air like six-ten-thousand village is absorbed; in addition, the pH value of the mountain spring water is between 6.6 and 7.0, which is beneficial to the growth of dendrobium.
the Chinese medicinal granule is dry granular preparation prepared by mixing the extract of Chinese medicinal materials with appropriate adjuvants or part of the fine powder of the Chinese medicinal materials. The extraction, concentration, drying, selection of auxiliary materials, granulation method and particle size selection of the traditional Chinese medicine particles should be preferably and specifically studied. The preparation of the traditional Chinese medicine granules is key to the extraction technical research and the drying technical research of raw medicinal materials because the traditional Chinese medicine components are complex, the characteristics of the theoretical guidance of the traditional Chinese medicine are reflected, the reasonable essence of the traditional Chinese medicine preparation is kept, the close correlation of the components and the curative effect is noticed, and the like.
The dendrobium officinale granules provided by the invention have good health-care effects.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide dendrobium officinale granules and a preparation method thereof.
The purpose of the invention is realized by the following technical scheme:
The dendrobium officinale granules are prepared from the following raw materials in parts by weight: 35-45 parts of dendrobium officinale, 10-20 parts of ginseng, 20-30 parts of medlar and 15-25 parts of astragalus membranaceus.
The dendrobium officinale granules are prepared from the following raw materials in parts by weight: 35-45 parts of dendrobium officinale, 10-20 parts of ginseng, 20-30 parts of medlar, 15-25 parts of astragalus membranaceus and 80-150 parts of auxiliary materials.
Preferably, the auxiliary material is one or a mixture of more of maltotriose, maltotetraose and isomalt.
More preferably, the auxiliary material is formed by mixing maltotriose, maltotetraose and isomaltitol, wherein the mass ratio of the maltotriose to the maltotetraose to the isomaltitol is (1-3): (1-3): (1-3).
A preparation method of dendrobium officinale granules comprises the following steps:
(1) pulverizing herba Dendrobii, Ginseng radix, fructus Lycii, and radix astragali, mixing well to obtain Chinese medicinal material mixture, and then mixing with water at a mass ratio of (10-30): 1, mixing, extracting for the first time, and filtering to obtain a primary filtrate and a primary filter residue;
(2) Adding water into the primary filter residue for secondary extraction, and filtering to obtain secondary filtrate and secondary filter residue;
(3) Mixing the primary filtrate and the secondary filtrate, filtering with a plate-and-frame filter, and placing the filtrate in a reduced pressure concentration tank; concentrating under reduced pressure at 55-65 deg.C and vacuum degree of 0.07-0.09MPa to relative density of 1.01-1.10 (measured at 60 deg.C) to obtain concentrated extract;
(4) Boiling and granulating the concentrated extract and auxiliary materials to obtain the finished product.
Preferably, the first extraction is divided into 3 stages, the temperature of the first stage is 95-100 ℃, and the time of the first stage is 10-20 minutes; the temperature of the second stage is 75-85 ℃, and the time of the second stage is 30-40 minutes; the temperature of the third stage is 95-100 ℃, and the time of the third stage is 5-15 minutes.
Preferably, the amount of water added in the second extraction is the same as that in the first extraction, the temperature of the second extraction is 75-85 ℃, and the time is 20-40 minutes.
Preferably, in the step (3), the plate-frame filter adopts filter cloth with 160-200 meshes for filtration, and the pressure is controlled to be 0.2-0.4 MPa.
specifically, in the present invention:
dendrobium officinale is the dried stem of Dendrobium officinale Kimuraet Migo, a plant of Orchidaceae, is sweet in taste and slightly cold in nature, and enters stomach and kidney meridians. Has effects in invigorating stomach, promoting salivation, nourishing yin, and clearing away heat. Modern medicine and pharmacology researches show that the dendrobium officinale mainly contains chemical components such as polysaccharides, amino acids, trace elements, phenanthrenes, a small amount of alkaloids and the like, and has pharmacological effects of enhancing immunity, resisting fatigue, resisting tumors, reducing blood sugar, protecting liver and stomach and the like.
Ginseng is dried root and rhizome of Panax ginseng C.A.Mey. of Araliaceae, and has sweet, slightly bitter and neutral nature, and can enter spleen, lung and heart channels. Has effects in invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, and tranquilizing mind. Modern medical research shows that ginseng mainly contains various ginsenosides, saccharides, volatile oil, amino acids, trace elements, organic acids, various vitamins, choline, enzyme and other components. Has effects in relieving fatigue, enhancing immunity, resisting tumor, lowering blood sugar, and resisting aging.
Radix astragali is root of Astragalus membranaceus Bge var (Fisch.) Bge of Leguminosae or Astragalus membranaceus Bge. Mainly produced in inner Mongolia, Shanxi and Heilongjiang provinces of China. Huang Qi is sweet in flavor and slightly warm in nature, and enters liver, spleen, lung and kidney meridians. Has the effects of invigorating qi, consolidating exterior, arresting sweating, promoting granulation, inducing diuresis, and relieving swelling. Modern researches show that astragalus has the effects of enhancing the immunologic function of organisms, protecting the liver, promoting urination, resisting aging, resisting stress, reducing blood pressure and having wide antibacterial action.
Fructus Lycii is dry mature fruit of Lycium barbarum L. of Solanaceae, has sweet taste and neutral nature, and enters liver and kidney meridians. Has effects in nourishing liver and kidney, replenishing vital essence, and improving eyesight. Modern medical research shows that the wolfberry fruit mainly contains chemical components such as saccharides, amino acids, trace elements and the like, and has the functions of enhancing immunity, resisting tumors, reducing blood fat and the like.
maltotriose, CAS number: 1109-28-0.
Maltotetraose, CAS No.: 34612-38-9.
Isomalt, CAS No.: 64519-82-0.
the health-care wine can regulate the immunologic function, resist fatigue, invigorate qi and nourish yin, is suitable for people with weak constitution and easy fatigue, particularly has good effects on patients with rehabilitation after illness, overwork and deficiency of lung-stomach yin, eliminates mental fatigue and hypodynamia caused by busy work and study of people, and can effectively improve the work and study efficiency.
Detailed Description
The present invention will be further described with reference to the following examples, which are intended to be illustrative only and not to be limiting of the invention in any way, and any person skilled in the art can modify the present invention by applying the teachings disclosed above and applying them to equivalent embodiments with equivalent modifications. Any simple modification or equivalent changes made to the following embodiments according to the technical essence of the present invention, without departing from the technical spirit of the present invention, fall within the scope of the present invention.
Example 1
The preparation method of the dendrobium officinale granules comprises the following steps:
(1) Respectively pulverizing 4kg of Dendrobium officinale, 1.5kg of ginseng, 2.5kg of medlar and 2kg of radix astragali to 20 meshes, and then uniformly mixing to obtain 10kg of a traditional Chinese medicine mixture; adding 10kg of the traditional Chinese medicine mixture into 200kg of water for carrying out first extraction, wherein the first extraction is divided into 3 stages, the temperature is heated to 100 ℃ in the first stage, and the time of the first stage is 15 minutes; in the second stage, the temperature is reduced to 80 ℃, and the time of the second stage is 35 minutes; in the third stage, the temperature is heated to 100 ℃, and the time of the third stage is 10 minutes; filtering with 80 mesh filter cloth to obtain primary filtrate and primary residue;
(2) Adding 200kg of water into the primary filter residue for secondary extraction at 80 ℃ for 30 minutes, and filtering with 80-mesh filter cloth after extraction to obtain secondary filtrate and secondary filter residue;
(3) Mixing the primary filtrate and the secondary filtrate, filtering with a plate-frame filter, and controlling the pressure to 0.3Mpa by using 180-mesh filter cloth to obtain filtrate; putting the filtrate into a reduced pressure concentration tank; concentrating under reduced pressure at 60 deg.C and vacuum degree of 0.08MPa to relative density of 1.05 (measured at 60 deg.C) to obtain concentrated extract;
(4) And spraying the concentrated extract into 9kg of auxiliary materials for boiling granulation to obtain the dendrobium officinale granules in the embodiment 1.
the auxiliary materials comprise maltotriose, maltotetraose and isomaltitol according to the mass ratio of 1: 1: 1 stirring and mixing uniformly.
example 2
Essentially the same as example 1, except that: the first extraction in the step (1) is to heat the temperature to 100 ℃ and extract for 60 minutes; filtering with 80 mesh filter cloth to obtain primary filtrate and primary residue. The dendrobium officinale granules of example 2 are obtained.
Example 3
Essentially the same as example 1, except that: the first extraction in the step (1) is to heat the temperature to 80 ℃ and extract for 60 minutes; filtering with 80 mesh filter cloth to obtain primary filtrate and primary residue. The dendrobium officinale granules of example 3 are obtained.
Example 4
Essentially the same as example 1, except that: the first extraction in the step (1) is to heat the temperature to 90 ℃ and extract for 60 minutes; filtering with 80 mesh filter cloth to obtain primary filtrate and primary residue. The dendrobium officinale granules of example 4 are obtained.
Example 5
Essentially the same as example 1, except that: the auxiliary materials comprise maltotetraose and isomaltitol in a mass ratio of 1: 1 stirring and mixing uniformly. The dendrobium officinale granules of example 5 are obtained.
Example 6
Essentially the same as example 1, except that: the auxiliary materials comprise maltotriose and isomaltitol in a mass ratio of 1: 1 stirring and mixing uniformly. The dendrobium officinale granules of example 6 are obtained.
Example 7
Essentially the same as example 1, except that: the auxiliary materials comprise maltotriose and maltotetraose according to the mass ratio of 1: 1 stirring and mixing uniformly. The dendrobium officinale granules of example 7 are obtained.
Test example 1
The extraction results of examples 1-4 were tested and are shown in Table 1.
Table 1: extraction effect test result table unit: is based on
| Crude polysaccharide | Ginsenoside | |
| Example 1 | 55.4 | 61.6 |
| Example 2 | 50.2 | 49.7 |
| Example 3 | 45.5 | 52.8 |
| Example 4 | 48.7 | 50.4 |
Comparing example 1 with examples 2-4, the effect of the 3-stage extraction of example 1 is significantly better than that of examples 2-4.
test example 2
The dendrobium officinale granules prepared in example 1 and examples 5-7 were subjected to stability test.
The ginsenoside contained in the granules of the invention is an index component of ginseng. The dendrobium officinale granules prepared in example 1 and examples 5-7 are respectively sealed and packaged by an aluminum-plastic composite film bag, the dendrobium officinale granules are placed at a temperature of 38 ℃ for 3 months, and the residual content of the ginsenoside in each sample at the time of 3 months relative to the residual content of the ginsenoside in each sample at the time of 0 month is measured. The specific results are shown in Table 2.
table 2: stability test results table unit: is based on
| Residual content of ginsenoside | |
| Example 1 | 99.6 |
| Example 5 | 95.2 |
| Example 6 | 92.6 |
| Example 7 | 93.1 |
Comparing example 1 with examples 5-7, example 1 (formulation of maltotriose, maltotetraose, isomalt) is significantly more stable than examples 5-7 (formulation of any two of maltotriose, maltotetraose, isomalt).
Test example 3
The dendrobium officinale granules prepared in examples 1-7 were subjected to an anti-fatigue test.
There were 7 groups of 50 mice each. Each mouse is fed with the dendrobium officinale granules at 9 am and 6 pm every day, 10 g of the dendrobium officinale granules is fed every time, after 30 consecutive days, the heavy burden swimming time, serum urea and liver glycogen of the tested mouse are detected according to a test method of physical fatigue relieving function tests in health food test and evaluation technical Specification-2003 of Ministry of health, and the average value is taken. After comparison, statistical analysis was performed with P < 0.05. The test data are shown in Table 3.
Table 3: anti-fatigue test result table
comparing example 1 with examples 2 to 4, the anti-fatigue effect of the extraction of example 1 divided into 3 stages is significantly better than that of examples 2 to 4. Comparing example 1 with examples 5-7, example 1 (compounding of maltotriose, maltotetraose, isomalt) is significantly superior in fatigue resistance to examples 5-7 (compounding of any two of maltotriose, maltotetraose, isomalt).
Claims (5)
1. The dendrobium officinale granules are characterized by being prepared from the following raw materials in parts by weight: 35-45 parts of dendrobium officinale, 10-20 parts of ginseng, 20-30 parts of medlar, 15-25 parts of astragalus membranaceus and 80-150 parts of auxiliary materials;
The auxiliary material is formed by mixing maltotriose, maltotetraose and isomaltitol, wherein the mass ratio of the maltotriose to the maltotetraose to the isomaltitol is (1-3): (1-3): (1-3).
2. The preparation method of the dendrobium officinale granules of claim 1, which is characterized in that: the method comprises the following steps:
(1) Pulverizing herba Dendrobii, Ginseng radix, fructus Lycii, and radix astragali, mixing well to obtain Chinese medicinal material mixture, and then mixing with water at a mass ratio of (10-30): 1, mixing, extracting for the first time, and filtering to obtain a primary filtrate and a primary filter residue;
(2) Adding water into the primary filter residue for secondary extraction, and filtering to obtain secondary filtrate and secondary filter residue;
(3) Mixing the primary filtrate and the secondary filtrate, filtering with a plate-and-frame filter, and placing the filtrate in a reduced pressure concentration tank; concentrating under reduced pressure at 55-65 deg.C and vacuum degree of 0.07-0.09MPa to relative density of 1.01-1.10 at 60 deg.C to obtain concentrated extract;
(4) Boiling and granulating the concentrated extract and auxiliary materials to obtain the finished product.
3. The preparation method of the dendrobium officinale granules of claim 2, which is characterized in that: the first extraction is divided into 3 stages, the temperature of the first stage is 95-100 ℃, and the time of the first stage is 10-20 minutes; the temperature of the second stage is 75-85 ℃, and the time of the second stage is 30-40 minutes; the temperature of the third stage is 95-100 ℃, and the time of the third stage is 5-15 minutes.
4. The preparation method of the dendrobium officinale granules of claim 2, which is characterized in that: the amount of water added in the second extraction is the same as that in the first extraction, the temperature of the second extraction is 75-85 ℃, and the time is 20-40 minutes.
5. the preparation method of the dendrobium officinale granules of claim 2, which is characterized in that: in the step (3), the plate-frame filter adopts filter cloth with the size of 160 and 200 meshes for filtration, and the pressure is controlled to be 0.2-0.4 MPa.
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| CN106579406A (en) * | 2016-11-28 | 2017-04-26 | 安徽牧龙山生态旅游开发股份有限公司 | Medicated diet raw material composition by using dendrobium candidum as main material |
| CN106924549A (en) * | 2017-05-09 | 2017-07-07 | 无限极（中国）有限公司 | A kind of preparation method of composition and extract with benefiting qi and nourishing blood function and application |
| CN109480149A (en) * | 2017-09-12 | 2019-03-19 | 冯军 | Nutrition selenium peptide drinks formula and preparation process |
| CN111298028A (en) * | 2020-04-21 | 2020-06-19 | 重庆成方英汇健康管理有限公司 | Astragalus dendrobium granules and preparation process thereof |
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| CN102266490A (en) * | 2011-07-15 | 2011-12-07 | 安徽圣农生物科技股份有限公司 | Formula of compound dendrobium huoshanense granules and production method |
| CN102988828A (en) * | 2012-11-21 | 2013-03-27 | 光明食品集团云南石斛生物科技开发有限公司 | Preparation method of dendrobium officinale granula |
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| CN102266490A (en) * | 2011-07-15 | 2011-12-07 | 安徽圣农生物科技股份有限公司 | Formula of compound dendrobium huoshanense granules and production method |
| CN102988828A (en) * | 2012-11-21 | 2013-03-27 | 光明食品集团云南石斛生物科技开发有限公司 | Preparation method of dendrobium officinale granula |
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