CN105816690A - 一种治疗垂体前叶激素分泌不足的中药 - Google Patents

一种治疗垂体前叶激素分泌不足的中药 Download PDF

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CN105816690A
CN105816690A CN201610276610.3A CN201610276610A CN105816690A CN 105816690 A CN105816690 A CN 105816690A CN 201610276610 A CN201610276610 A CN 201610276610A CN 105816690 A CN105816690 A CN 105816690A
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刘瑞英
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Abstract

本发明公开了一种治疗垂体前叶激素分泌不足的中药，包括以下原料：生地、淮山药、覆盆子、山萸肉、枸杞子、菟丝子、紫菀、川附子、泽泻、杜仲、玉竹、青蒿、白薇、西洋参、淮山药、龙眼、石斛、女贞子、旱莲草、白扁豆、黑豆、山楂、木瓜、仙灵脾、肉苁蓉、凤尾参、蚌兰叶、木贼草、密蒙花、鸡血藤。本发明以多味中药为原料，科学配伍，各原料药之间协同作用，具有补肾壮阳，益气养血，健脾温肾，补虚调冲，调整阴阳的功效，疗程短，见效快、治疗率高。

Description

一种治疗垂体前叶激素分泌不足的中药
（一）技术领域
本发明属于中药领域，具体涉及一种治疗垂体前叶激素分泌不足的中药。
（二）背景技术
垂体前叶激素分泌不足分为原发性和继发性两类，前者是由于垂体分泌细胞破坏所致，后者是由于下丘脑病变导致垂体缺乏刺激所致，临床上以前者多见。垂体前叶激素分泌不足的治疗方法包括激素替代治疗，中医中药，病因治疗。目前临床上以激素替代治疗为主，该方法见效较快，但一般副作用大，对身体健康不利。
（三）发明内容
为弥补现有技术的不足，本发明提供一种安全无副作用的治疗垂体前叶激素分泌不足的中药。
本发明是通过如下技术方案实现的：
一种治疗垂体前叶激素分泌不足的中药，其特殊之处在于：其特征在于：包括以下重量份数的原料：生地6-10份、淮山药8-15份、覆盆子5-8份、山萸肉6-9份、枸杞子8-10份、菟丝子6-10份、紫菀2-8份、川附子6-12份、泽泻4-8份、杜仲6-12份、玉竹3-6份、青蒿4-8份、白薇6-10份、西洋参4-8份、淮山药6-12份、龙眼5-10份、石斛5-9份、女贞子5-8份、旱莲草4-8份、白扁豆8-12份、黑豆6-10份、山楂6-10份、木瓜3-6份、仙灵脾3-6份、肉苁蓉4-8份、凤尾参4-6份、蚌兰叶4-6份、木贼草6-9份、密蒙花7-10份、鸡血藤3-7份。
本发明的优选配方是：由以下重量份数的原料制成：
生地7份、淮山药13份、覆盆子7份、山萸肉9份、枸杞子9份、菟丝子9份、紫菀6份、川附子9份、泽泻5份、杜仲7份、玉竹4份、青蒿6份、白薇8份、西洋参7份、淮山药9份、龙眼7份、石斛6份、女贞子7份、旱莲草6份、白扁豆10份、黑豆7份、山楂8份、木瓜5份、仙灵脾5份、肉苁蓉7份、凤尾参5份、蚌兰叶5份、木贼草7份、密蒙花9份、鸡血藤5份。
本发明中各原料药的作用如下：
生地：甘，寒。归心，肝，肾经。既能凉血，又能滋阴，具清热滋阴、凉血止血、生津止渴的功效。
淮山药：味甘，性平。归脾，肺，肾经。补脾养胃，生津益肺，补肾涩精，清热解毒。主治脾虚食少、久泻不止、肺虚喘咳、肾虚遗精、带下、尿频、虚热消渴。
覆盆子：味甘、酸，性温。归肝、肾、膀胱经。益肾固精缩尿，养肝明目。主治：用于遗精滑精，遗尿尿频，阳痿早泄，目暗昏花。
山萸肉：酸、涩、微温。补肝肾，涩精气，固虚脱。治腰膝酸痛，眩晕，耳鸣，阳痿，遗精，小便频数，肝虚寒热，虚汗不止，心摇脉散。
枸杞子：甘，平。归肝、肾经。滋补肝肾，益精明目。用于肝肾阴虚证本品甘平质润，平补肝肾，有滋补强壮作用，凡肝肾阴虚诸证均可应用。
菟丝子：味辛、甘，性平。归肝、肾、脾经。补益肝肾，固精缩尿，安胎，明目，止泻；外用消风祛斑。
紫菀：性味：苦，温。温肺，下气，消痰，止咳。治风寒咳嗽气喘，虚劳咳吐脓血，喉痹，小便不利。
川附子：味辛、甘，性大热。归心、肾、脾经。回阳救逆，补火助阳，散寒止痛。用于亡阳虚脱，肢冷脉微，心阳不足，胸痹心痛，虚寒吐泻，脘腹冷痛，肾阳虚衰，阳痿宫冷，阴寒水肿，阳虚外感，寒湿痹痛。
泽泻：味甘、淡，性寒。归肾、膀胱经。利水渗湿，泄热，化浊降脂。用于小便不利，水肿胀满，泄泻尿少，痰饮眩晕，热淋涩痛，高脂血症。
杜仲：甘，温，无毒。入肾经。杜仲具有补肝肾，治腰脊酸疼，足膝痿弱，小便余沥，阴下湿痒，高血压、安胎的功效。杜仲对免疫系统、内分泌系统、中枢神经系统、循环系统和泌尿系统都有不同程度的调节作用，杜仲能兴奋垂体-肾上腺皮质系统，增强肾上腺皮质功能。
玉竹：养阴润燥，生津止渴。用于肺胃阴伤，燥热咳嗽，咽干口渴，内热消渴。
青蒿：味苦、辛，性寒。归肝、胆经。清虚热，除骨蒸，解暑热，截疟，退黄。用于温邪伤阴，夜热早凉，阴虚发热，骨蒸劳热，暑邪发热，疟疾寒热，湿热黄疸等病症的治疗。
白薇：苦咸，寒。清热凉血，利尿通淋，解毒疗疮。用于温邪伤营发热，阴虚发热，骨蒸劳热，产后血虚发热，热淋，血淋，痈疽肿毒。刀伤。
西洋参：性凉，味甘、微苦。补气养阴，清热生津。用于气虚阴亏，内热，咳喘痰血，虚热烦倦，消渴，口燥喉干。用量3～6g。益肺阴，清虚火，生津止渴。治肺虚久嗽，失血，咽干口渴，虚热烦倦。
淮山药：味甘，性平。归脾，肺，肾经。补脾养胃，生津益肺，补肾涩精，清热解毒。主治脾虚食少、久泻不止、肺虚喘咳、肾虚遗精、带下、尿频、虚热消渴。
龙眼：补心脾，益气血，健脾胃，养肌肉。思虑伤脾，头昏，失眠，心悸怔忡，虚赢，病后或产后体虚，及由于脾虚所致之下血失血症。
石斛：味甘，性微寒。归胃、肾经。益胃生津，滋阴清热。用于热病津伤，口干烦渴，胃阴不足，食少干呕，病后虚热不退，阴虚火旺，骨蒸劳热，目暗不明，筋骨痿软。
女贞子：甘、苦，凉。归肝、肾经。补益肝肾，明目，清虚热。头晕目眩，须发早白，视物昏花，阴虚发热。
旱莲草：味甘酸，性凉，入肝肾二经，无毒。滋补肝肾、凉血止血，可治各种吐血，肠出血等症。捣汁涂眉发，能促进毛发生长，内服有乌发、黑发功效。
白扁豆：味甘，性微温，有健脾化湿，利尿消肿，清肝明目等功效，营养价值较高，矿物质和维生素含量比大部分根茎菜和瓜菜都高，味亦鲜嫩可口。每百克白扁豆含蛋白质2.8克，脂肪O.2克，糖5.4克，热量35千卡，粗纤维1.4克，钙116毫克，铁1.5毫克，胡萝卜素O.32毫克，硫胺酸O.05毫克，核黄酸O.07毫克，尼克酸O.7毫克，抗坏血酸13毫克。白扁豆作为滋补佳品，夏暑又是一种清凉饮料。
黑豆：黑豆营养丰富，含有蛋白质、脂肪、维生素、微量元素等多种营养成分，同时又具有多种生物活性物质，如黑豆色素、黑豆多糖和异黄酮等。
山楂：核果类水果，核质硬，果肉薄，味微酸涩。果可生吃或作果脯果糕，干制后可入药，是中国特有的药果兼用树种，具有降血脂、血压、强心、抗心律不齐等作用，同时也是健脾开胃、消食化滞、活血化痰的良药，对胸膈脾满、疝气、血淤、闭经等症有很好的疗效。山楂内的黄酮类化合物牡荆素，是一种抗癌作用较强的药物，其提取物对抑制体内癌细胞生长、增殖和浸润转移均有一定的作用。
木瓜：果肉厚实、香浓鲜甜，素有“岭南果王”无论是直接食用还是以之入馔都备受众多食客喜爱。木瓜含有多种酶元素、维生素和矿物质元素，有消暑解渴、润肺止咳的食效。
仙灵脾：气味辛、温、无毒。李明珍说：“淫羊藿味甘气香，性温不寒，能益精气。主治、阳痿，腰膝冷；偏风不遂、服仙灵脾酒、
咳嗽，气不顺，腹满不思饮食。用淫羊藿、覆盆子、五味子(炒)各一两，共研为末，加熟蜜做成丸子，如梧子大。每服二十丸，姜茶送下。
肉苁蓉：味甘；咸；性温。归肾；大肠经。补肾阳；益精血；润肠道。主肾阳虚衰；精血不足之阳痿；遗精；白浊；尿频余沥；腰痛脚弱；耳鸣目花；月经衍期；宫寒不孕；肠燥便秘。
凤尾参：性温，味甘微苦。补气血，活络。治头晕耳鸣，心慌心跳，筋骨疼痛，虚烧不退。
蚌兰叶：清热，止血，去瘀。治肺热燥咳，吐血，便血，尿血，痢疾，跌打损伤。
木贼草：味甘，苦，平，无毒，微寒。归心经，肝经，胃经，膀胱经。清肝明目，止血，利尿通淋。主风热感冒，咳嗽，目赤肿痛，云翳，鼻衄，尿血，肠风下血，淋证，黄疸，带下，骨折。
密蒙花：味甘，微寒。归肝经。清热泻火，养肝明目，退翳。用于目赤肿痛，多泪羞明，目生翳膜，肝虚目暗，视物昏花。
鸡血藤：活血舒筋，养血调经。主治风湿痹痛，手足麻木，肢体瘫痪，月经不调，经行不畅，痛经，经闭，白细胞减少症。治疗风湿所致的腰膝关节疼痛、风湿痹痛、肢体麻木。
本发明的有益效果是：本发明以多味中药为原料，科学配伍，各原料药之间协同作用，具有补肾壮阳，益气养血，健脾温肾，补虚调冲，调整阴阳的功效，疗程短，见效快、治疗率高，值得推广。
（四）临床观察：
（1）临床资料
本发明人于2013年至今，对350例垂体前叶激素分泌不足患者进行临床观察治疗。
（2）治疗方法
每日一剂，早、晚各服一次，5天一个疗程，轻度患者两个疗程，重度患者四个疗程。
（3）疗效判定标准
疗效标准参照《中医病症判断疗效标准》中有关疗效标准。
治愈：临床症状全部消失，试验室检查正常。
显效：临床症状基本消失，试验室检查各相关指标接近正常水平。
有效：临床症状减轻，试验室检查各相关指标有所改善，体征有改善。
无效：临床症状无明显好转或加重。
（4）临床结果
临床治愈325例，治愈率高达92.9%，有效17人，总有效率高达97.7%。
本发明配制简单，吸收效果好，药效持续时间长，疗效显著，无副作用，安全性高，生产成本低，有利于病患及时减轻病状。
（四）具体实施方式
实施例1
中药组份：生地6g、淮山药8g、覆盆子5g、山萸肉6g、枸杞子8g、菟丝子6g、紫菀2g、川附子6g、泽泻4g、杜仲6g、玉竹3g、青蒿4g、白薇6g、西洋参4g、淮山药6g、龙眼5g、石斛5g、女贞子5g、旱莲草4g、白扁豆8g、黑豆6g、山楂6g、木瓜3g、仙灵脾3g、肉苁蓉4g、凤尾参4g、蚌兰叶4g、木贼草6g、密蒙花7g、鸡血藤3g。
制备工艺：将处方量药材加水煎煮3次，合并煎液。每日一剂，早、晚各服一次，5天一个疗程。
实施例2
中药组份：生地7g、淮山药13g、覆盆子7g、山萸肉9g、枸杞子9g、菟丝子9g、紫菀6g、川附子9g、泽泻5g、杜仲7g、玉竹4g、青蒿6g、白薇8g、西洋参7g、淮山药9g、龙眼7g、石斛6g、女贞子7g、旱莲草6g、白扁豆10g、黑豆7g、山楂8g、木瓜5g、仙灵脾5g、肉苁蓉7g、凤尾参5g、蚌兰叶5g、木贼草7g、密蒙花9g、鸡血藤5g。
制备工艺：将处方量药材加水煎煮3次，合并煎液。每日一剂，早、晚各服一次，5天一个疗程。
实施例3
中药组份：生地10g、淮山药15g、覆盆子8g、山萸肉9g、枸杞子10g、菟丝子10g、紫菀8g、川附子12g、泽泻8g、杜仲12g、玉竹6g、青蒿8g、白薇10g、西洋参8g、淮山药12g、龙眼10g、石斛9g、女贞子8g、旱莲草8g、白扁豆12g、黑豆10g、山楂10g、木瓜6g、仙灵脾6g、肉苁蓉8g、凤尾参6g、蚌兰叶6g、木贼草9g、密蒙花10g、鸡血藤7g。
制备工艺：将处方量药材加水煎煮3次，合并煎液。每日一剂，早、晚各服一次，5天一个疗程。

Claims (2)

1.一种治疗垂体前叶激素分泌不足的中药，其特征在于：包括以下重量份数的原料：生地6-10、淮山药8-15、覆盆子5-8、山萸肉6-9、枸杞子8-10、菟丝子6-10、紫菀2-8、川附子6-12、泽泻4-8、杜仲6-12、玉竹3-6、青蒿4-8、白薇6-10、西洋参4-8、淮山药6-12、龙眼5-10、石斛5-9、女贞子5-8、旱莲草4-8、白扁豆8-12、黑豆6-10、山楂6-10、木瓜3-6、仙灵脾3-6、肉苁蓉4-8、凤尾参4-6、蚌兰叶4-6、木贼草6-9、密蒙花7-10、鸡血藤3-7。
2.根据权利要求1所述的一种治疗垂体前叶激素分泌不足的中药，其特征在于：包括以下重量份数的原料：生地7、淮山药13、覆盆子7、山萸肉9、枸杞子9、菟丝子9、紫菀6、川附子9、泽泻5、杜仲7、玉竹4、青蒿6、白薇8、西洋参7、淮山药9、龙眼7、石斛6、女贞子7、旱莲草6、白扁豆10、黑豆7、山楂8、木瓜5、仙灵脾5、肉苁蓉7、凤尾参5、蚌兰叶5、木贼草7、密蒙花9、鸡血藤5。
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