CN105395947A - 一种治疗前列腺炎的药物及其制备方法 - Google Patents
一种治疗前列腺炎的药物及其制备方法 Download PDFInfo
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- CN105395947A CN105395947A CN201510945727.1A CN201510945727A CN105395947A CN 105395947 A CN105395947 A CN 105395947A CN 201510945727 A CN201510945727 A CN 201510945727A CN 105395947 A CN105395947 A CN 105395947A
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Abstract
本发明公开了一种治疗前列腺炎的药物及其制备方法,其主要是由败酱、王不留行、萆薢、金樱子、益母草、通草、瞿麦、紫菀、海金沙、萹蓄、滑石、知母、马鞭草、白花蛇舌草、车前子、白茅根、菟丝子、猪苓、延胡索、肉苁蓉、淫羊藿、牛膝、玉米须、牡丹皮、芡实、覆盆子、鹿角霜、金银花。按一定重量配比制备而成。本发明药物具有活血散瘀,祛风除湿,健脾和胃,散瘀理气,平肝利胆的功能,用于治疗前列腺炎见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗前列腺炎的药物及其制备方法,属中药领域。
背景技术
前列腺炎是一种病原体感染,以逆行感染为主,病原体主要为葡萄球菌属,常有反复的尿路感染发作病史或前列腺按摩液中持续有致病菌存在。中医则认为前列腺炎与湿热瘀阻,脾肾亏虚,肝气郁结有关。由于西药治疗副作用大,因此人们对有效治疗前列腺炎的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗前列腺炎的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗前列腺炎的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择败酱、王不留行、萆薢、金樱子、益母草、通草、瞿麦、紫菀、海金沙、萹蓄、滑石、知母、马鞭草、白花蛇舌草、车前子、白茅根、菟丝子、猪苓、延胡索、肉苁蓉、淫羊藿、牛膝、玉米须、牡丹皮、芡实、覆盆子、鹿角霜、金银花、玄参、神曲、川楝子药物进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗前列腺炎。其中,选用败酱是因为其性味苦,平,入肝、胃、大肠经,有清热解毒,排脓破瘀的功能,治肠痈,下痢,赤白带下,产后瘀滞腹痛,目赤肿痛,痈肿疥癣。选用王不留行是因为其性味苦平,入肝、胃经,有行血通经,催生下乳,消肿敛疮的功能,治妇女经闭,乳汁不通,难产,血淋,痈肿,金疮出血。选用萆薢是因为其性味苦,平,入肝、胃、膀胱经,有祛风,利湿的功能,治风湿顽痹,腰膝疼痛,小便不利,淋浊,遗精,湿热疮毒。选用金樱子是因为其性味酸涩,平,有固精涩肠,缩尿止泻的功能,治滑精,遗尿,小便频数,脾虚泻痢。选用益母草是因为其性味辛苦,凉,入心包、肝经,有活血,祛瘀,调经,消水的功能,治月经不调,治漏难产,胞衣不下,产后血晕,瘀血腹痛,崩中漏下,尿血,泻血,痈肿疮疡。选用通草是因为其性味甘淡,凉,入肺、胃经,有泻肺,利小便,下乳汁的功能,治小便不利,淋病,水肿,产妇乳汁不通,目昏,鼻塞。选用瞿麦是因为其性味苦,寒,入心、肾、小肠、膀胱经,有清热利水,破血通经的功能,治小便不通,淋病,水肿,经闭,痈肿,目赤障翳,浸淫疮毒。选用紫菀是因为其性味苦,温,入肺经,有温肺,下气,水痰,止咳的功能,治风寒,咳嗽,止喘,虚劳咳吐脓血。选用海金沙是因为其性味甘淡,寒,入小肠、膀胱经,有清热解毒,利水通淋的功能,治尿路感染,尿路结石,白浊,白带,肝炎,肾炎水肿,咽喉肿痛,痄腮,肠炎,痢疾,皮肤湿疹,带状疱疹。选用萹蓄是因为其性味苦,寒,入膀胱经,有利尿,清热,杀虫的功能,治热淋、癃闭,黄疸,阴蚀,白带,蛔虫,疳积,痔肿,湿疮。选用滑石是因为其性味甘、淡,寒,归膀胱、肺、胃经,有利尿通淋,清热解毒,祛湿解暑的功能,治热淋、石淋,尿热涩痛,暑湿烦渴,湿热水泻,外治湿疹,湿疮,痱子。选用知母是因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。选用马鞭草是因为其性味苦,凉,入肝、脾经,有清热解毒,活血散瘀,利水消肿的功能,治外感发热,湿热黄疸,水肿,痢疾,疟疾,白喉,喉痹,淋病,经闭,癥瘕,痈肿疮毒牙疳。选用白花蛇舌草是因为其性味苦甘,寒,入心、肝、脾三经,有清热,利湿,解毒的功能,治肺热喘咳,扁桃体炎,咽喉炎,阑尾炎,痢疾,黄疸,盆腔炎,附件炎,痈肿疔疮,毒蛇咬伤。选用车前子是因为其性味甘,寒,入肾、膀胱经,有利水,清热,明目,祛痰的功能,治小便不通,淋浊,带下,尿血,暑湿泻痢,咳嗽多痰,湿痹,目赤障翳。选用白茅根是因为其性味甘、寒,入肺、胃、小肠经,有凉血,止血,清热,利尿的功能,治热病烦渴,吐血,衄血,肺热喘急,胃热哕逆,淋病,小便不利,水肿,黄疸。选用菟丝子是因为其性味辛甘,平,入肝、肾经,有补肝肾,益精髓,明目的功能,治腰膝酸痛,遗精,消渴,尿有余沥,目暗。选用猪苓是因为其性味甘淡,平,入脾、肾、膀胱经,有利尿渗湿的功能,治小便不利,水肿胀满,脚气,泄泻,淋、浊,带下。选用延胡索是因为其性味辛苦,温,入肝、胃经,有活血,散瘀,理气,止痛的功能,治心腹腰膝诸痛,月经不调,癥瘕,崩中,产后血晕,恶露不尽,跌打损伤。选用肉苁蓉是因为其性味甘酸咸,温,入肾、大肠经,有补肾,益精,润燥,清肠的功能,治男子阳痿,女子不孕,带下,血崩,腰膝冷痛,血枯便秘。选用淫羊藿是因为其性味辛甘,温,入肝、肾经,有补肾壮阳,祛风除湿的功能,治阳痿不举,小便淋沥,筋骨挛急,半身不遂,腰膝无力,风湿痹痛,四脚不仁。选用牛膝是因为其性味甘苦酸,平,入肝、肾经,生用散瘀血,消痈肿的功能,治淋病,尿血,经闭,癥瘕,难产,胞衣不下,产后瘀血腹痛,喉痹,痈肿,跌打损伤,熟用补肝肾,强筋骨,治腰膝骨痛,四肢拘挛,痿痹。选用玉米须是因为其性味甘,平,有利尿,泄热,平肝,利胆的功能,治肾炎水肿,脚气,黄疸肝炎,高血压,胆囊炎,胆结石,糖尿病,吐血衄血,鼻渊,乳痈。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。选用芡实是因为其性味甘涩,平,入脾、肾经,有固肾涩精,补脾止泄,治遗精,淋浊,带下,小便不禁,大便泄泻。选用覆盆子是因为其性味甘,酸,平,入肝、肾二经,有补肝肾,缩小便,助阳,固精,明目的功能,治阳痿,遗精,溲数,遗溺,虚劳,目暗。选用鹿角霜是因为其性味咸,温,入肝、肾经,有补虚,助阳的功能,治肾阳不足,腰脊酸痛,脾胃虚寒,呕吐,食少便溏,子宫虚冷,崩漏带下。选用金银花是因为其性味甘,寒,入肺、胃经,有清热,解毒的功能,治温病发热,热毒血痢,痈疡,肿毒,瘰疬,痔漏。选用玄参是因为其性味苦,咸,凉,入肺、肾经,有滋阴,降火,除烦,解毒的功能,治热病烦渴,发斑,骨蒸劳热,夜寐不宁,自汗盗汗,津伤便秘,吐血衄血,咽喉肿痛,痈肿,瘰疬。选用神曲是因为其性味甘辛,温,入碑、胃经,有健脾和胃,消食调中的功能,治饮食停滞,胸痞腹胀,呕吐泻痢,产后瘀血腹痛,小儿腹大坚积。选用川楝子是因为其性味苦,寒,有毒,入肝、胃、小肠经,有降湿热,清肝火,止痛,杀虫的功能,治热厥心痛,胁痛,疝痛,虫积腹痛。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
败酱15-25克,王不留行10-20克,萆薢10-20克,金樱子10-20克,益母草10-20克,通草5-15克,瞿麦10-20克,紫菀10-20克,海金沙10-20克,萹蓄10-20克,滑石10-15克,知母10-20克,马鞭草10-20克,白花蛇舌草10-15克,车前子5-15克,白茅根15-20克,菟丝子10-20克,猪苓5-15克,延胡索5-15克,肉苁蓉5-15克,淫羊藿5-15克,牛膝7-12克,玉米须10-20克,牡丹皮5-15克,芡实10-20克,覆盆子5-15克,鹿角霜10-15克,金银花10-20克,玄参10-15克,神曲10-15克,川楝子5-10克。
优选为:
败酱20克,王不留行15克,萆薢15克,金樱子15克,益母草15克,通草10克,瞿麦15克,紫菀15克,海金沙15克,萹蓄15克,滑石12克,知母15克,马鞭草15克,白花蛇舌草12克,车前子10克,白茅根18克,菟丝子15克,猪苓10克,延胡索10克,肉苁蓉10克,淫羊藿10克,牛膝9克,玉米须15克,牡丹皮10克,芡实15克,覆盆子10克,鹿角霜12克,金银花15克,玄参12克,神曲12克,川楝子8克。
本发明药物的制备方法如下
一、备料
1、败酱:取原药材,除去杂质,用水喷淋,稍晾,切段,干燥;
2、王不留行:簸净杂质,置锅内,用文火炒至爆开白花六、七成时取出,放凉;
3、萆薢:除去杂质,切片,洗净,浸泡,润透,干燥,筛去碎屑;
4、金樱子:拣去杂质,切两瓣,用水稍浸泡,捞出,闷润后除去残留毛刺,挖净毛、核,干燥;
5、益母草:拣去杂质,洗净,润透,切段,晒干;
6、通草:拣去杂质,切片;
7、瞿麦:拣净杂质,除去残根,洗净,闷润,切段,晒干;
8、紫菀:拣去杂质,除去残茎,洗净,稍闷润,切成小段,晒干;
9、海金沙:取原药材,过细筛,筛取孢子,除去杂质;
10、萹蓄:去净杂质及根,洗净,润软,切段晒干;
11、滑石:取原药材,除去杂质,洗净,干燥;
12、知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
13、马鞭草:拣净杂质,洗净,润软切段,晒干;
14、白花蛇舌草:取原药材,除去杂质,抢水洗净,稍晾,切段,干燥,筛去灰屑;
15、车前子:拣去杂质,筛去泥屑,空粒;
16、白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎屑;
17、菟丝子:过箩去净杂质,洗净,晒干;
18、猪苓:洗净泥砂,润软切片,晾干;
19、延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
20、肉苁蓉:拣净杂质,清水浸泡,每天换水1—2次如系咸苁蓉,泡尽盐分,润透,纵向切片,晒干;
21、淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
22、牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
23、玉米须:取原药材,除去杂质,筛去灰屑;
24、牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
25、芡实:先将麸皮放热锅内炒至烟起,再将净芡实倒入,拌炒至微黄色,取出,筛净麸皮,放凉;
26、覆盆子:筛去灰屑,拣净杂质,去柄;
27、鹿角霜:拣去杂质,斫成小块;
28、金银花:筛去泥沙,拣净杂质;
29、玄参:拣净杂质,除去芦头,洗净润透,切片,晾干;
30、神曲:取麸皮撒匀于热锅内,俟起烟,将神曲倒入,炒至黄色,取出,筛去麸皮,放凉;
31、川楝子:拣去杂质,洗净,烘干,轧碎或劈成两半;
二、制备
1、将炮制好的败酱、王不留行、萆薢、金樱子、益母草、通草、瞿麦、紫菀、海金沙、萹蓄、滑石、知母、马鞭草、白花蛇舌草、车前子、白茅根、菟丝子、猪苓、延胡索、肉苁蓉、淫羊藿、牛膝、玉米须、牡丹皮、芡实、覆盆子、鹿角霜、金银花、玄参、神曲、川楝子放入煎药容器内,其中滑石装入布袋,第一次加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内。
2、将过滤的药渣加6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液。
3、将两次煎煮液混合搅拌均匀即得,分为4剂服用。
组方中马鞭草有清热解毒,活血散瘀,利水的功能为君药;神曲健脾和胃,消食调中;淫羊藿有补肾壮阳,祛风除湿的的功能,二者为臣药,三味药共同发挥清热解毒,活血散瘀,利水,健脾和胃,补肾壮阳,祛风除湿的作用,治疗前列腺炎效力全面,且以清热解毒,利水,健脾和胃,祛风除湿,补肾壮阳为主可治本,玉米须有利尿,泄热,平肝,利胆的功能为佐药,延胡索有活血,散瘀理气的功能为使药,与余下诸药是治标。
本发明药物具有活血散瘀,祛风除湿,健脾和胃,散瘀理气,平肝利胆的功能,用于治疗前列腺炎,疗程短、见效快、治愈后不复发。
具体实施方式:
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。服用药液超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治前列腺炎门诊患者共26例。
2、诊断标准
典型症状为寒战,发热,疲乏无力,会阴部和耻骨上疼痛,甚至急性尿潴留;疼痛和排尿异常;性功能障碍,夜尿次数增多等症状。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:前列腺炎症状消失,体质恢复正常,痊愈;
好转:患者寒战发热,全身乏力,阴部疼痛和排尿异常的症状减轻,前列腺炎症状明显好转,体质逐步恢复;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗前列腺炎患者26例,结果显效19例,显效率为73.08%,好转5例,好转率为19.23%,无效2例,总有效率为92.31%。
Claims (3)
1.一种治疗前列腺炎的药物,其特征在于:它是由下列重量范围内的原料药制成:
败酱15-25克,王不留行10-20克,萆薢10-20克,金樱子10-20克,益母草10-20克,通草5-15克,瞿麦10-20克,紫菀10-20克,海金沙10-20克,萹蓄10-20克,滑石10-15克,知母10-20克,马鞭草10-20克,白花蛇舌草10-15克,车前子5-15克,白茅根15-20克,菟丝子10-20克,猪苓5-15克,延胡索5-15克,肉苁蓉5-15克,淫羊藿5-15克,牛膝7-12克,玉米须10-20克,牡丹皮5-15克,芡实10-20克,覆盆子5-15克,鹿角霜10-15克,金银花10-20克,玄参10-15克,神曲10-15克,川楝子5-10克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
败酱20克,王不留行15克,萆薢15克,金樱子15克,益母草15克,通草10克,瞿麦15克,紫菀15克,海金沙15克,萹蓄15克,滑石12克,知母15克,马鞭草15克,白花蛇舌草12克,车前子10克,白茅根18克,菟丝子15克,猪苓10克,延胡索10克,肉苁蓉10克,淫羊藿10克,牛膝9克,玉米须15克,牡丹皮10克,芡实15克,覆盆子10克,鹿角霜12克,金银花15克,玄参12克,神曲12克,川楝子8克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)败酱:取原药材,除去杂质,用水喷淋,稍晾,切段,干燥;
(2)王不留行:簸净杂质,置锅内,用文火炒至爆开白花六、七成时取出,放凉;
(3)萆薢:除去杂质,切片,洗净,浸泡,润透,干燥,筛去碎屑;
(4)金樱子:拣去杂质,切两瓣,用水稍浸泡,捞出,闷润后除去残留毛刺,挖净毛、核,干燥;
(5)益母草:拣去杂质,洗净,润透,切段,晒干;
(6)通草:拣去杂质,切片;
(7)瞿麦:拣净杂质,除去残根,洗净,闷润,切段,晒干;
(8)紫菀:拣去杂质,除去残茎,洗净,稍闷润,切成小段,晒干;
(9)海金沙:取原药材,过细筛,筛取孢子,除去杂质;
(10)萹蓄:去净杂质及根,洗净,润软,切段晒干;
(11)滑石:取原药材,除去杂质,洗净,干燥;
(12)知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
(13)马鞭草:拣净杂质,洗净,润软切段,晒干;
(14)白花蛇舌草:取原药材,除去杂质,抢水洗净,稍晾,切段,干燥,筛去灰屑;
(15)车前子:拣去杂质,筛去泥屑,空粒;
(16)白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎屑;
(17)菟丝子:过箩去净杂质,洗净,晒干;
(18)猪苓:洗净泥砂,润软切片,晾干;
(19)延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
(20)肉苁蓉:拣净杂质,清水浸泡,每天换水1—2次如系咸苁蓉,泡尽盐分,润透,纵向切片,晒干;
(21)淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
(22)牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
(23)玉米须:取原药材,除去杂质,筛去灰屑;
(24)牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
(25)芡实:先将麸皮放热锅内炒至烟起,再将净芡实倒入,拌炒至微黄色,取出,筛净麸皮,放凉;
(26)覆盆子:筛去灰屑,拣净杂质,去柄;
(27)鹿角霜:拣去杂质,斫成小块;
(28)金银花:筛去泥沙,拣净杂质;
(29)玄参:拣净杂质,除去芦头,洗净润透,切片,晾干;
(30)神曲:取麸皮撒匀于热锅内,俟起烟,将神曲倒入,炒至黄色,取出,筛去麸皮,放凉;
(31)川楝子:拣去杂质,洗净,烘干,轧碎或劈成两半;
(二)制备
(1)将炮制好的败酱、王不留行、萆薢、金樱子、益母草、通草、瞿麦、紫菀、海金沙、萹蓄、滑石、知母、马鞭草、白花蛇舌草、车前子、白茅根、菟丝子、猪苓、延胡索、肉苁蓉、淫羊藿、牛膝、玉米须、牡丹皮、芡实、覆盆子、鹿角霜、金银花、玄参、神曲、川楝子放入煎药容器内,其中滑石装入布袋,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀即得,分为4剂服用。
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