CN105816546B - A kind of rose flower composition, compound emulsion agent and its application for improving skin temperature - Google Patents
A kind of rose flower composition, compound emulsion agent and its application for improving skin temperature Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The present invention relates to a kind of rose flower composition, compound emulsion agent and its application for improving skin temperature, belong to biomedicine field.The rose flower composition mainly includes rose, vitamin E, vitamin C, Radix Angelicae Sinensis, Ligusticum wallichii and reticulate millettia.A kind of rose flower composition for improving skin temperature disclosed by the invention can be prepared to a variety of formulations, such as emulsion agent, tablet, dripping pill, sustained release preparation, controlled release preparation etc..At present, many people usually feel cold limbs, especially women.The common method for improving cold limbs has high caloric diet, spicy food stimulation, water-bath or cold/hot dressing alternately stimulation, physical training etc., also there is electronics heat treatment unit of physical means etc., though these methods can improve skin temperature, all more or less exist in-convenience in use, heating it is slow the problems such as.A kind of rose flower composition for improving skin temperature disclosed by the invention have it is easy to use, practical, can rapidly promote blood circulation, the effect of raising skin temperature.
Description
Technical field：
The present invention relates to a kind of rose flower composition, compound emulsion agent and its application for improving skin temperature, belong to biology
Field of medicaments.
Background technology：
Many people often feel cold limbs, for climacteric women, even more common.As soon as weather is cold, whole body hair is felt
Cold, trick is especially ice-cold, such case, is exactly " deficiency of yang " described in the traditional Chinese medical science, that is, is typically commonly called as " cold bottom " or " cold
Bottom ".For the situation of this cold limbs, treatment method common at present has high caloric diet, spicy food to stimulate, water-bath or
Cold/hot dressing alternately stimulation, physical training etc., also there is electronics heat treatment unit of physical means etc., though these methods can lift skin temperature
Degree, but all more or less exist in-convenience in use, heating it is slow the problems such as.Therefore, it is necessary to develop a kind of convenient, practical, energy quickly
Raise the product of skin temperature.
For problems of the prior art, the present invention provides a kind of rose flower composition for improving skin temperature, should
Composition can quickly and efficiently improve skin temperature and have pleasant fragrance.
The content of the invention：
To achieve the above object, technical scheme is implemented as follows：
The invention discloses a kind of rose flower composition, compound emulsion agent and its application for improving skin temperature, the combination
Thing mainly contains rose, vitamin E, vitamin C, Radix Angelicae Sinensis, Ligusticum wallichii, reticulate millettia.Said composition has pleasant fragrance.
The invention discloses a kind of rose flower composition for improving skin temperature, mainly including rose, vitamin E, dimension
Raw plain C, Radix Angelicae Sinensis, Ligusticum wallichii and reticulate millettia.
The invention discloses a kind of rose flower composition for improving skin temperature, include by weight：
10~20 parts of rose
0.5~1.0 part of vitamin E
0.5~2.5 part of vitamin C
10~25 parts of Radix Angelicae Sinensis
15~35 parts of Ligusticum wallichii
10~25 parts of reticulate millettia.
The invention discloses a kind of preparation method for the rose flower composition for improving skin temperature：By rose 10~20
10~25 parts of part, 10~25 parts of Radix Angelicae Sinensis, 15~35 parts of Ligusticum wallichii, reticulate millettia mixings, add water 1000ml, 80 degrees Celsius of warm water every time
Half an hour is decocted, is filtered to remove sediment, in triplicate, merges filtered fluid, concentration is settled to 200ml, prepares mixed aqueous solution.
Add 0.5~1.0 part of vitamin E, 0.5~2.5 part of vitamin C mixes and produces a kind of rose combination for improving skin temperature
Thing.
The invention discloses a kind of rose flower composition for improving skin temperature, said composition adds customary adjuvant, according to
Common process, is made the formulation of clinical receiving, the formulation be emulsion agent, tablet, capsule, powder, soft capsule, dripping pill,
Honeyed bolus, pill, granule, paste, sustained release preparation, quick releasing formulation, controlled release preparation, oral liquid, freeze drying powder injection or note
Penetrate preparation.
The invention also discloses a kind of rose compound medicine emulsion agent for improving skin temperature, described emulsion agent are main
Including rose, vitamin E, vitamin C, Radix Angelicae Sinensis, Ligusticum wallichii, reticulate millettia, castor oil and triethanolamine.
A kind of preparation method of rose compound medicine emulsion agent for improving skin temperature disclosed by the invention is as follows：By rose
It is rare spend 10~20 parts, 10~25 parts of Radix Angelicae Sinensis, 15~35 parts of Ligusticum wallichii, 10~25 parts of reticulate millettia proportionally, mix, add water
1000ml, 80 degrees Celsius of warm water decoct half an hour, in triplicate, are filtered to remove sediment repeatedly, obtain filtrate, concentration is settled to
200ml, prepare mixed aqueous solution.0.5~2.5 part of 0.5~1.0 part of vitamin E, vitamin C mixing, add 5 parts of castor oil, 5
Part triethanolamine, stirs while adding mixing, prepares emulsus oil mixture, is slowly added to above-mentioned mixed aqueous solution afterwards, slowly
Quick stirring is added, prepares the Chinese medicine emulsion formulations containing rose.The invention is not restricted to emulsion preparation, emulsification can also be added
Agent, excipient and prepare paste making agent, liniment.
The invention also discloses a kind of rose flower composition for improving skin temperature to prepare the medicine of raising skin temperature
In application.
Embodiment：
Embodiment 1：A kind of preparation for the rose flower composition for improving skin temperature：By 10 grams of rose, 10 grams of Radix Angelicae Sinensis, river
10 grams of 15 grams of rhizome of chuanxiong, reticulate millettia mixings, every time plus water 1000ml, 80 degrees Celsius of warm water decoct half an hour, are filtered to remove sediment, weight
Multiple to merge filtered fluid three times, concentration is settled to 200ml, prepares mixed aqueous solution.Add 0.5 gram of vitamin E, vitamin C 0.5
Gram mix and to produce rose flower composition.
Embodiment 2：A kind of preparation for the rose compound medicine emulsion agent for improving skin temperature：By 10 grams of rose, when
Return 10 grams, 15 grams of Ligusticum wallichii, the mixing of 10 grams of reticulate millettia, every time plus water 1000ml, 80 degrees Celsius of warm water decoct half an hour, are filtered to remove
Sediment, in triplicate, merge filtered fluid, concentration is settled to 200ml, prepares mixed aqueous solution.Add 0.5 gram of vitamin E, dimension
Raw plain C0.5 grams of mixing, adds 5 grams of castor oil, 5 grams of triethanolamines, stirs while adding mixing, prepare emulsus oil mixture,
Above-mentioned mixed aqueous solution is slowly added to afterwards, is slowly added to quickly stir, and prepares rose combined pharmaceutical composition emulsion agent.
Embodiment 3：A kind of preparation for the rose flower composition for improving skin temperature：By 20 grams of rose, 25 grams of Radix Angelicae Sinensis, river
25 grams of 35 grams of rhizome of chuanxiong, reticulate millettia mixings, every time plus water 1000ml, 80 degrees Celsius of warm water decoct half an hour, are filtered to remove sediment, weight
Multiple to merge filtered fluid three times, concentration is settled to 200ml, prepares mixed aqueous solution.Add .0 grams of vitamin e1, Catergen .5
Gram mix and to produce rose flower composition.
Embodiment 4：A kind of preparation for the rose compound medicine emulsion agent for improving skin temperature：A kind of rose combination drug
The preparation of composition：By 25 grams of 20 grams of rose, 25 grams of Radix Angelicae Sinensis, 35 grams of Ligusticum wallichii, reticulate millettia mixings, add water 1000ml, 80 every time
Degree Celsius warm water decoct half an hour, be filtered to remove sediment, in triplicate, merge filtered fluid, concentration be settled to 200ml, prepare
Mixed aqueous solution..0 grams of vitamin e1 .5 grams of Catergen are added, adds 5 grams of castor oil, 5 grams of triethanolamines, when adding
Stir and evenly mix, prepare emulsus oil mixture, be slowly added to above-mentioned mixed aqueous solution afterwards, be slowly added to quickly stir, prepare rose
Rare colored compound medicine emulsion agent.
Embodiment 5：Lift skin temperature experiment
The ice-cold women of trick is taken one's test as subject.Treat that they use raising skin temperature disclosed by the invention
Rose flower composition after, their watch face temperature is measured.
Experimental group is the rose flower composition of the raising skin temperature prepared in above-described embodiment 1 and embodiment 3, embodiment
2 and embodiment 4 in the rose compound medicine emulsion agent of raising skin temperature for preparing.
The selection of control group：If four rose+Radix Angelicae Sinensis+szechuan lovage rhizome composition, rose, Radix Angelicae Sinensis and Ligusticum wallichii control groups.
Using the distilled water of equivalent as negative control group.
Rose+Radix Angelicae Sinensis+szechuan lovage rhizome composition control group preparation method：10 grams of rose, 10 grams of Radix Angelicae Sinensis, 15 grams of Ligusticum wallichii are mixed
Even, every time plus water 1000ml, 80 degrees Celsius of warm water decoct half an hour, are filtered to remove sediment, in triplicate, merge filtered fluid,
Concentration is settled to 200ml, prepares composition control drug.
Rose control group preparation method：10 grams of roses are added into water 500ml every time, it is small that 80 degrees Celsius of warm water decocts half
When, sediment is filtered to remove, in triplicate, merges filtered fluid, concentration is settled to 200ml, prepares rose control drug.
Radix Angelicae Sinensis control group preparation method：10 grams of Radix Angelicae Sinensis are added into water 500ml every time, 80 degrees Celsius of warm water decocts half an hour, mistake
Sediment is filtered out, in triplicate, merges filtered fluid, concentration is settled to 200ml, prepares Radix Angelicae Sinensis control drug.
Ligusticum wallichii control group preparation method：15 grams of Ligusticum wallichiis are added into water 500ml every time, 80 degrees Celsius of warm water decocts half an hour, mistake
Sediment is filtered out, in triplicate, merges filtered fluid, concentration is settled to 200ml, prepares Ligusticum wallichii control drug.
The rose compound medicine emulsion agent of skin temperature is improved according to the preparation method system in embodiment 2 and embodiment 4
It is standby
Before testing, every subject need to clean hand, then in no air flow, the cool place of constant temperature and humidity can be kept
Place's rest is no less than 1 hour.The test will carry on the back to the left hand of every subject to be implemented, and forbids every subject to show energy
Make the posture of hand temperature change.
Application method：More than each experimental group and control group everyone disposably smear 10ml, it is disposable smear check medication before
With the change of their hand temperature after medication 1 hour.Each medicine group is assessed respectively with 15 subjects of identical.
Thermometric is carried out before with medicine and with 15 after medicine, after 30,45 and 60 minutes.Subject's arm temperature change such as table
1.Using the rose flower composition 15 of skin temperature is improved, after 30,45 and 60 minutes, the temperature of skin is significantly raised, carries for display
The rose flower composition group of high skin temperature has significant difference (P ＜ 0.05) compared with each control group
This show using improve skin temperature rose flower composition can significantly make its skin temperature significantly raised, Er Qiesui
The extension temperature effect of drug treating time is more notable, and rose has the function that to increase its pharmaceutical composition effect, and extends it
Heat up effect.Therefore, it is known that the rose flower composition disclosed by the invention for improving skin temperature can effectively lift skin temperature, delay
It is ice-cold to solve trick.
The result (putting 0 on the basis of the temperature surveyed before medicine) that skin temperature changes after the effect of the medicine of table 1
Claims (7)
1. a kind of external application improves the rose flower composition of skin temperature, it is characterised in that a kind of described external application improves skin temperature
The rose flower composition of degree by weight by 10~20 parts of rose, 0.5~1.0 part of vitamin E, 0.5~2.5 part of vitamin C,
10~25 parts of 10~25 parts of Radix Angelicae Sinensis, 15~35 parts of Ligusticum wallichii, reticulate millettia compositions.
2. a kind of external application according to claim 1 improves the rose flower composition of skin temperature, it is characterised in that the combination
Thing adds customary adjuvant, and according to common process, the clinical formulation received is made.
3. a kind of external application according to claim 2 improves the rose flower composition of skin temperature, it is characterised in that described dose
Type is emulsion agent, paste.
4. a kind of a kind of external application as claimed in claim 1 improves the rose flower composition of skin temperature, it is characterised in that described
A kind of external application improve skin temperature rose flower composition preparation method it is as follows：By 10~20 parts of rose, Radix Angelicae Sinensis 10~
25 parts, 15~35 parts of Ligusticum wallichii, the mixing of 10~25 parts of reticulate millettia, every time plus water 1000ml, 80 degrees Celsius of warm water decoct half an hour, mistake
Sediment is filtered out, in triplicate, merges filtered fluid, concentration is settled to 200ml, prepares mixed aqueous solution, adds vitamin
E0.5~1.0 part, 0.5~2.5 part of vitamin C, which mix, produces the rose flower composition that a kind of external application improves skin temperature.
5. a kind of external application improves the rose compound medicine emulsion agent of skin temperature, it is characterised in that described emulsion agent is by weight
Part is measured by 10~20 parts of rose, 0.5~1.0 part of vitamin E, 0.5~2.5 part of vitamin C, 10~25 parts of Radix Angelicae Sinensis, Ligusticum wallichii 15
~35 parts, 10~25 parts of reticulate millettia, 5 parts of castor oil, 5 parts of triethanolamine composition.
6. a kind of external application according to claim 5 improves the rose compound medicine emulsion agent of skin temperature, its feature exists
In the preparation method for the rose compound medicine emulsion agent that a kind of external application improves skin temperature is as follows：By 10 parts of rose,
10 parts of Radix Angelicae Sinensis, 15 parts of Ligusticum wallichii, 10 parts of reticulate millettia proportionally, mix, add water 1000ml, 80 degrees Celsius of warm water decoct half an hour,
In triplicate, sediment is filtered to remove repeatedly, obtains filtrate, and concentration is settled to 200ml, prepares mixed aqueous solution, vitamin
0.5 part of E0.5 parts, vitamin C mixing, add 5 parts of castor oil, 5 parts of triethanolamines, stir while adding mixing, prepare emulsus oil
Mixture, above-mentioned mixed aqueous solution is slowly added to afterwards, be slowly added to quickly to stir and produce a kind of external application and improve skin temperature
Rose compound medicine emulsion agent.
7. prepared by the rose flower composition that a kind of a kind of external application as described in any one of claims 1 to 3 improves skin temperature
External application improves the application in the medicine of skin temperature.
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| CN201610154032.6A CN105816546B (en) | 2016-03-17 | 2016-03-17 | A kind of rose flower composition, compound emulsion agent and its application for improving skin temperature |
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| CN201610154032.6A CN105816546B (en) | 2016-03-17 | 2016-03-17 | A kind of rose flower composition, compound emulsion agent and its application for improving skin temperature |
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| CN105816546B true CN105816546B (en) | 2018-02-13 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101715960A (en) * | 2008-12-02 | 2010-06-02 | 天津天狮生物发展有限公司 | Beauty capsule and production and manufacturing process thereof |
| CN102861148A (en) * | 2012-10-19 | 2013-01-09 | 天津中医药大学 | Chinese medicine preparation for treating primary dysmenorrheal and preparation method and application |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6485990A (en) * | 1987-09-28 | 1989-03-30 | Tsumura & Co | Antihypertestoeronemia agent |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101715960A (en) * | 2008-12-02 | 2010-06-02 | 天津天狮生物发展有限公司 | Beauty capsule and production and manufacturing process thereof |
| CN102861148A (en) * | 2012-10-19 | 2013-01-09 | 天津中医药大学 | Chinese medicine preparation for treating primary dysmenorrheal and preparation method and application |
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