CN105816546A - Rose flower composition for improving skin temperature, compound emulsion and applications thereof - Google Patents
Rose flower composition for improving skin temperature, compound emulsion and applications thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention relates to a rose flower composition for improving the skin temperature, compound emulsion and applications thereof. The rose flower composition mainly comprises rose flowers, vitamin E, vitamin C, Chinese angelica, ligusticum wallichii, and spatholobus stem. The rose flower composition can be made into a plurality of dosage forms such as emulsion, tablets, dripping pills, sustained-release preparation, controlled-release preparation, and the like. Many people feel cold in limbs, especially females. Through high calorie diet, spicy food, water bath, cold-hot compress, exercise, and physical method such as electronic thermal therapy instrument, the symptom of coldness in limbs can be relieved, but the method mentioned above has the disadvantages of inconvenience and slow effect. The provided rose composition has the advantages of user-friendliness and practicality, and is capable of promoting blood circulation and increasing the skin temperature.
Description
Technical field:
The present invention relates to a kind of improve the Flos Rosae Rugosae compositions of skin temperature, compound recipe emulsion agent and application thereof, belong to biomedicine field.
Background technology:
Many people often feel cold limbs, for climacteric women, the most common.Weather one is cold, just feels to go cold all over, and trick is the most ice-cold, this situation, it is simply that " yang deficiency " described in the traditional Chinese medical science, " the cold end " or " the cold end " being the most typically commonly called as.Situation for this cold limbs, the most common Therapeutic Method has the stimulation of high caloric diet, spicy food, water-bath or cold/hot dressing alternately stimulation, physical training etc., also there is the electronics heat treatment unit etc. of physical means, though these methods can promote skin temperature, but the most more or less exist in-convenience in use, heat up the problem such as slow.Accordingly, it would be desirable to develop a kind of convenience, practicality, can quickly raise the product of skin temperature.
For problems of the prior art, the present invention provides a kind of Flos Rosae Rugosae compositions improving skin temperature, and said composition can improve skin temperature quickly and efficiently and have pleasant fragrance.
Summary of the invention:
For achieving the above object, technical scheme is implemented as follows:
The invention discloses and a kind of improve the Flos Rosae Rugosae compositions of skin temperature, compound recipe emulsion agent and application thereof, said composition mainly contains Flos Rosae Rugosae, vitamin E, vitamin C, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Caulis Spatholobi.Said composition has pleasant fragrance.
The invention discloses a kind of Flos Rosae Rugosae compositions improving skin temperature, mainly include Flos Rosae Rugosae, vitamin E, vitamin C, Radix Angelicae Sinensis, Rhizoma Chuanxiong and Caulis Spatholobi.
The invention discloses a kind of Flos Rosae Rugosae compositions improving skin temperature, include by weight:
Flos Rosae Rugosae 10～20 parts
Vitamin E 0.5～1.0 parts
Vitamin C 0.5～2.5 parts
Radix Angelicae Sinensis 10～25 parts
Rhizoma Chuanxiong 15～35 parts
Caulis Spatholobi 10～25 parts.
The invention discloses the preparation method of a kind of Flos Rosae Rugosae compositions improving skin temperature: by Flos Rosae Rugosae 10～20 parts, Radix Angelicae Sinensis 10～25 parts, Rhizoma Chuanxiong 15～35 parts, Caulis Spatholobi 10～25 parts of mixings, every time add water 1000ml, the warm water of 80 degrees Celsius decocts half an hour, it is filtered to remove precipitate, in triplicate, merge filtrate, concentration is settled to 200ml, prepares mixed aqueous solution.Add vitamin E 0.5～1.0 parts, vitamin C 0.5～2.5 parts to mix and i.e. obtain a kind of Flos Rosae Rugosae compositions improving skin temperature.
The invention discloses a kind of Flos Rosae Rugosae compositions improving skin temperature, said composition adds customary adjuvant, according to common process, making the dosage form of clinical acceptance, described dosage form is emulsion agent, tablet, capsule, powder, soft capsule, drop pill, honeyed pill, pill, granule, unguentum, slow releasing preparation, quick releasing formulation, controlled release preparation, oral liquid, lyophilized injectable powder or ejection preparation.
The invention also discloses a kind of Flos Rosae Rugosae compound medicine emulsion agent improving skin temperature, described emulsion agent mainly includes Flos Rosae Rugosae, vitamin E, vitamin C, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Caulis Spatholobi, Oleum Ricini and triethanolamine.
The preparation method of a kind of Flos Rosae Rugosae compound medicine emulsion agent improving skin temperature disclosed by the invention is as follows: by Flos Rosae Rugosae 10～20 parts, Radix Angelicae Sinensis 10～25 parts, Rhizoma Chuanxiong 15～35 parts, Caulis Spatholobi 10～25 parts proportionally, mixing, add water 1000ml, the warm water of 80 degrees Celsius decocts half an hour, in triplicate, repeatedly it is filtered to remove precipitate, obtain filtrate, concentration is settled to 200ml, prepares mixed aqueous solution.Vitamin E 0.5～1.0 parts, vitamin C 0.5～2.5 parts of mixing, add 5 parts of Oleum Ricini, 5 parts of triethanolamine, stir while adding mixing, preparation emulsus oil mixture, it is slowly added to above-mentioned mixed aqueous solution afterwards, is slowly added to quickly stir, the preparation Chinese medicine emulsion formulations containing Flos Rosae Rugosae.The invention is not restricted to emulsion prepare, it is also possible to add emulsifying agent, excipient and be prepared as unguentum, liniment.
The invention also discloses the application in preparation improves the medicine of skin temperature of a kind of Flos Rosae Rugosae compositions improving skin temperature.
Detailed description of the invention:
Embodiment 1: the preparation of a kind of Flos Rosae Rugosae compositions improving skin temperature: by Flos Rosae Rugosae 10 grams, Radix Angelicae Sinensis 10 grams, Rhizoma Chuanxiong 15 grams, Caulis Spatholobi 10 grams mixing, every time add water 1000ml, the warm water of 80 degrees Celsius decocts half an hour, it is filtered to remove precipitate, in triplicate, merge filtrate, concentration is settled to 200ml, prepares mixed aqueous solution.Add vitamin E 0.5 gram, vitamin C 0.5 gram to mix and i.e. obtain Flos Rosae Rugosae compositions.
Embodiment 2: the preparation of a kind of Flos Rosae Rugosae compound medicine emulsion agent improving skin temperature: by Flos Rosae Rugosae 10 grams, Radix Angelicae Sinensis 10 grams, Rhizoma Chuanxiong 15 grams, Caulis Spatholobi 10 grams mixing, every time add water 1000ml, the warm water of 80 degrees Celsius decocts half an hour, it is filtered to remove precipitate, in triplicate, merge filtrate, concentration is settled to 200ml, prepares mixed aqueous solution.Add vitamin E 0.5 gram, vitamin C 0.5 gram mixing, add 5 grams of Oleum Ricini, 5 grams of triethanolamine, stir while adding mixing, preparation emulsus oil mixture, it is slowly added to above-mentioned mixed aqueous solution afterwards, is slowly added to quickly stir, prepare Flos Rosae Rugosae combined pharmaceutical composition emulsion agent.
Embodiment 3: the preparation of a kind of Flos Rosae Rugosae compositions improving skin temperature: by Flos Rosae Rugosae 20 grams, Radix Angelicae Sinensis 25 grams, Rhizoma Chuanxiong 35 grams, Caulis Spatholobi 25 grams mixing, every time add water 1000ml, the warm water of 80 degrees Celsius decocts half an hour, it is filtered to remove precipitate, in triplicate, merge filtrate, concentration is settled to 200ml, prepares mixed aqueous solution.Add vitamin e1 .0 gram, Catergen .5 gram to mix and i.e. obtain Flos Rosae Rugosae compositions.
Embodiment 4: the preparation of a kind of Flos Rosae Rugosae compound medicine emulsion agent improving skin temperature: the preparation of a kind of Flos Rosae Rugosae combined pharmaceutical composition: by Flos Rosae Rugosae 20 grams, Radix Angelicae Sinensis 25 grams, Rhizoma Chuanxiong 35 grams, Caulis Spatholobi 25 grams mixing, every time add water 1000ml, the warm water of 80 degrees Celsius decocts half an hour, it is filtered to remove precipitate, in triplicate, merge filtrate, concentration is settled to 200ml, prepares mixed aqueous solution.Add vitamin e1 .0 gram, Catergen .5 gram, add 5 grams of Oleum Ricini, 5 grams of triethanolamine, stir while adding mixing, preparation emulsus oil mixture, it is slowly added to above-mentioned mixed aqueous solution afterwards, is slowly added to quickly stir, prepare Flos Rosae Rugosae compound medicine emulsion agent.
Embodiment 5: promote skin temperature experiment
Women ice-cold for trick is taken one's test as experimenter.After the Flos Rosae Rugosae compositions that they use raising skin temperature disclosed by the invention, their watch face temperature is measured.
Experimental group is the Flos Rosae Rugosae compositions improving skin temperature of preparation in above-described embodiment 1 and embodiment 3, the Flos Rosae Rugosae compound medicine emulsion agent improving skin temperature of preparation in embodiment 2 and embodiment 4.
Choosing of matched group: set Flos Rosae Rugosae+Radix Angelicae Sinensis+szechuan lovage rhizome composition, Flos Rosae Rugosae, Radix Angelicae Sinensis and four matched groups of Rhizoma Chuanxiong.
Use the distilled water of equivalent as negative control group.
Flos Rosae Rugosae+Radix Angelicae Sinensis+szechuan lovage rhizome composition matched group preparation method: Flos Rosae Rugosae 10 grams, Radix Angelicae Sinensis 10 grams, Rhizoma Chuanxiong 15 grams mixing, every time add water 1000ml, the warm water of 80 degrees Celsius decocts half an hour, it is filtered to remove precipitate, in triplicate, merge filtrate, concentration is settled to 200ml, prepares compositions control drug.
Flos Rosae Rugosae matched group preparation method: add water 500ml by 10 grams of Flos Rosae Rugosaes every time, the warm water of 80 degrees Celsius is decocted half an hour, is filtered to remove precipitate, in triplicate, merges filtrate, concentrates and be settled to 200ml, prepares Flos Rosae Rugosae control drug.
Radix Angelicae Sinensis matched group preparation method: add water 500ml by 10 grams of Radix Angelicae Sinensis every time, the warm water of 80 degrees Celsius is decocted half an hour, is filtered to remove precipitate, in triplicate, merges filtrate, concentrates and be settled to 200ml, prepare Radix Angelicae Sinensis control drug.
Rhizoma Chuanxiong matched group preparation method: add water 500ml by 15 grams of Rhizoma Chuanxiongs every time, the warm water of 80 degrees Celsius is decocted half an hour, is filtered to remove precipitate, in triplicate, merges filtrate, concentrates and be settled to 200ml, prepare Rhizoma Chuanxiong control drug.
The Flos Rosae Rugosae compound medicine emulsion agent improving skin temperature is prepared according to the preparation method in embodiment 2 and embodiment 4
Before testing, every experimenter need to clean hand, is not then having air flowing, can keep having a rest no less than 1 hour at the cool place of constant temperature and humidity.The left hand of every experimenter will be carried on the back enforcement by described test, and forbids that every experimenter shows the posture that can make hand variations in temperature.
Using method: above each experimental group and matched group everyone disposably smear 10ml, disposably smear before checking medication and the change of their hand temperature after medication 1 hour.Each medicine group is all assessed respectively with 15 identical experimenters.
Carrying out thermometric after before medicine and with after medicine 15,30,45 and 60 minutes.Experimenter's arm temperature changes such as table 1.Display uses the Flos Rosae Rugosae compositions improving skin temperature after 15,30,45 and 60 minutes, and the temperature of skin is significantly raised, and the Flos Rosae Rugosae compositions group improving skin temperature compares with each matched group, has significant difference (P ＜ 0.05)
This shows to use the Flos Rosae Rugosae compositions improving skin temperature can significantly make its skin temperature significantly raised, and the prolongation temperature effect with drug treating time is the most notable, and Flos Rosae Rugosae has the effect increasing its pharmaceutical composition effect, and extends its liter of temperature effect.Therefore, it is known that the Flos Rosae Rugosae compositions of raising skin temperature disclosed by the invention can effectively promote skin temperature, trick is alleviated ice-cold.
The result (putting 0 on the basis of the temperature surveyed before medicine) of skin temperature change after table 1 medicine effect
Claims (9)
1. the Flos Rosae Rugosae compositions improving skin temperature, it is characterised in that described a kind of Flos Rosae Rugosae compositions improving skin temperature mainly includes Flos Rosae Rugosae, vitamin E, vitamin C, Radix Angelicae Sinensis, Rhizoma Chuanxiong and Caulis Spatholobi.
A kind of Flos Rosae Rugosae compositions improving skin temperature the most according to claim 1, it is characterised in that described Flos Rosae Rugosae compositions includes by weight:
Flos Rosae Rugosae 10～20 parts
Vitamin E 0.5～1.0 parts
Vitamin C 0.5～2.5 parts
Radix Angelicae Sinensis 10～25 parts
Rhizoma Chuanxiong 15～35 parts
Caulis Spatholobi 10～25 parts.
A kind of Flos Rosae Rugosae compositions improving skin temperature the most according to claim 1, it is characterised in that said composition adds customary adjuvant, according to common process, makes the dosage form of clinical acceptance.
A kind of Flos Rosae Rugosae compositions improving skin temperature the most according to claim 3, it is characterised in that described dosage form is emulsion agent, tablet, capsule, powder, soft capsule, drop pill, honeyed pill, pill, granule, unguentum, slow releasing preparation, quick releasing formulation, controlled release preparation, oral liquid, lyophilized injectable powder or ejection preparation.
5. a kind of Flos Rosae Rugosae compositions improving skin temperature as claimed in claim 2, it is characterized in that, the preparation method of described a kind of Flos Rosae Rugosae compositions improving skin temperature is as follows: by Flos Rosae Rugosae 10～20 parts, Radix Angelicae Sinensis 10～25 parts, Rhizoma Chuanxiong 15～35 parts, Caulis Spatholobi 10～25 parts of mixings, add water 1000ml every time, the warm water of 80 degrees Celsius decocts half an hour, it is filtered to remove precipitate, in triplicate, merge filtrate, concentration is settled to 200ml, prepare mixed aqueous solution, add vitamin E 0.5～1.0 parts, vitamin C 0.5～2.5 parts mix and i.e. obtain a kind of Flos Rosae Rugosae compositions improving skin temperature.
6. the Flos Rosae Rugosae compound medicine emulsion agent improving skin temperature, it is characterised in that described emulsion agent mainly includes Flos Rosae Rugosae, vitamin E, vitamin C, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Caulis Spatholobi, Oleum Ricini and triethanolamine.
A kind of Flos Rosae Rugosae compound medicine emulsion agent improving skin temperature the most according to claim 6, it is characterised in that described emulsion agent includes by weight:
Flos Rosae Rugosae 10～20 parts
Vitamin E 0.5～1.0 parts
Vitamin C 0.5～2.5 parts
Radix Angelicae Sinensis 10～25 parts
Rhizoma Chuanxiong 15～35 parts
Caulis Spatholobi 10～25 parts
Oleum Ricini 5 parts
Triethanolamine 5 parts.
nullA kind of Flos Rosae Rugosae compound medicine emulsion agent improving skin temperature the most according to claim 7，It is characterized in that，The preparation method of described a kind of Flos Rosae Rugosae combination drug emulsion agent improving skin temperature is as follows: by Flos Rosae Rugosae 10 parts、Radix Angelicae Sinensis 10 parts、Rhizoma Chuanxiong 15 parts、Caulis Spatholobi 10 parts is proportionally、Mixing，Add water 1000ml、The warm water of 80 degrees Celsius decocts half an hour，In triplicate，Repeatedly it is filtered to remove precipitate，Obtain filtrate，Concentration is settled to 200ml，Prepare mixed aqueous solution，Vitamin E 0.5 part、Vitamin C 0.5 part mixing，Add 5 parts of Oleum Ricini、5 parts of triethanolamine，Stir while adding mixing，Preparation emulsus oil mixture，It is slowly added to above-mentioned mixed aqueous solution afterwards，It is slowly added to quickly stir and i.e. obtains a kind of Flos Rosae Rugosae compound medicine emulsion agent improving skin temperature.
9. a kind of as described in any one of Claims 1-4 improves the application in preparation improves the medicine of skin temperature of the Flos Rosae Rugosae compositions of skin temperature.
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| CN201610154032.6A CN105816546B (en) | 2016-03-17 | 2016-03-17 | A kind of rose flower composition, compound emulsion agent and its application for improving skin temperature |
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| CN201610154032.6A CN105816546B (en) | 2016-03-17 | 2016-03-17 | A kind of rose flower composition, compound emulsion agent and its application for improving skin temperature |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6485990A (en) * | 1987-09-28 | 1989-03-30 | Tsumura & Co | Antihypertestoeronemia agent |
| CN101715960A (en) * | 2008-12-02 | 2010-06-02 | 天津天狮生物发展有限公司 | Beauty capsule and production and manufacturing process thereof |
| CN102861148A (en) * | 2012-10-19 | 2013-01-09 | 天津中医药大学 | Chinese medicine preparation for treating primary dysmenorrheal and preparation method and application |
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- 2016-03-17 CN CN201610154032.6A patent/CN105816546B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6485990A (en) * | 1987-09-28 | 1989-03-30 | Tsumura & Co | Antihypertestoeronemia agent |
| CN101715960A (en) * | 2008-12-02 | 2010-06-02 | 天津天狮生物发展有限公司 | Beauty capsule and production and manufacturing process thereof |
| CN102861148A (en) * | 2012-10-19 | 2013-01-09 | 天津中医药大学 | Chinese medicine preparation for treating primary dysmenorrheal and preparation method and application |
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