CN104288319B - A kind of Tibetan medicine of hair growth - Google Patents
A kind of Tibetan medicine of hair growth Download PDFInfo
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Abstract
The invention discloses the Tibetan medicine of a kind of hair growth, it is made up of active component or is made up of active component and pharmaceutically acceptable adjuvant, and wherein said active component is to be prepared from according to a certain weight ratio by Herba Trigonellae Ruthenicae, Ligularia achyrotricha (Diels) Ling., Borax, calabash, Herba veronicae, blue or green spar, Semen Persicae.It can be prepared to any conventional exterior-applied formulation.Tibetan medicine of the present invention has the function of blood circulation promoting and blood stasis dispelling, blood nourishing and hair., desquamation, pruritus greasy for scalp, hypotrichosis, withered and yellow, bifurcated, jewelry, expensive clothing and other valuables, hair easily snaps off, alopecia, alopecia, early whitening of beard and hair etc..
Description
Technical field
The present invention relates to the Tibetan medicine of a kind of hair growth, belong to Tibetan medicine field.
Background technology
Alopecia refers to the abnormal phenomenon come off of hair, and its reason is a lot, common are seborrheica (i.e. male type) alopecia；Nervous alopecia and pathologic alopecia.Seborrheic alopecia (SeobrrheicAlopecia, SA) is called for short seborrheic alopecia, has another name called male pattern alopecia, androgenetic alopecia, and clinic shows as the gradual alopecia that hair is greasy, consider more, have obvious scratchiness, E Nie district and top to be worth doing more, then forms great number.
This disease is the commonly encountered diseases of department of dermatologry, frequently-occurring disease, is also one of refractory disease.Under normal circumstances, a healthy adult every day can alopecia 50～75.If alopecia every day more than 100, and continue more than 30 days, can be diagnosed and suffer from alopecia.
World Health Organization (WHO) delivers report: alopecia and poliosis are becoming a global problem.Investigate according to national authority health organ: domestic alopecia, alopecia, withered and yellow, bifurcated, jewelry, expensive clothing and other valuables, poliosis number more than 1.5 hundred million people；25～35 years old man of China suffers from the ratio of male pattern alopecia up to 40%, and 84.8% is diagnosed as seborrheic alopecia.Cause alopecia due to atmospheric pollution, social pressure increasing and dietary structure imbalance etc., the people of poliosis gets more and more, and the crowd of alopecia is tending to rejuvenation.
The growth of hair and regeneration depend on the enough nutrition blood supplies to hair follicle.Microcirculatory perfusion obstacle causes flow velocity and the flow reduction of hemoperfusion in microcirculation, and the normal nutrition and the oxygen supply that affect scalp hair follicles reduce, thus causing the generation of alopecia.Medicine by raise skin temperature, can skin expansion blood vessel, improve skin microcirculation, increase hair papilla blood supply, improve hair follicle nutrition, promote tissue new life, and then promote hair growth.
Although the medicine of current hair growth is a lot, but curative effect is still unsatisfactory.Therefore, be there is tight demand by people in the Tibetan medicine of the better hair growth of curative effect.
Up to now, but without finding any report about Tibetan medicinal composition of the present invention and preparation method thereof.The present inventor is through repeatedly studying, and by the checking repeatedly of animal and clinical trial, finally have found the Tibetan medicine of safe, to have better curative effect hair growth and takes medicine thing and preparation method thereof, thus completing the present invention.
Summary of the invention
The object of the invention is just to provide the Tibetan medicine of a kind of more effectively hair growth.
The present invention is a kind of Tibetan medicine, being made up of active component or be made up of active component and pharmaceutically acceptable adjuvant, wherein said active component is made up of following bulk drugs: Cornu Bubali, walnut shell, Radix rumicis acetosae, Semen Sesami Nigrum, Caulis et Folium Lini, Radix pedicularis muscicolae.
It has selected Cornu Bubali, walnut shell, Radix rumicis acetosae, Semen Sesami Nigrum, Caulis et Folium Lini, Radix pedicularis muscicolae are combined as crude drug, and wherein (1) Cornu Bubali is the angle of bovid Babalus bubalis L. BubalusbubalisLinnaeus.There is inducing diuresis to remove edema, effect that repiece is sent out.For trembling with fear, heat two kinds of edema caused and alopecia disease.(2) walnut shell is the outer peel of juglandaceae plant Semen Juglandis JuglansregiaL..There is black hair, effect of hair growth promoting.For poliosis, alopecia disease.(3) Radix rumicis acetosae is the dry root of polygonaceae plant Nepal Radix rumicis acetosae RumexnepalensisSpreng.There is heat clearing away, damp eliminating, detumescence, more effect of skin ulcer.For furuncle, eczema.(4) Semen Sesami Nigrum is the dry mature seed of Pedaliaceae plant sesame SesamumindicumL..There is invigorating the liver and kidney, benefiting essence-blood, effect that intestine moistening is dry.For dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.(5) Caulis et Folium Lini is the dry mature seed of flax family (Linaceae) plant Caulis et Folium Lini LinumusitatissimumL..Have and moisturize, the effect dispeled the wind.For dryness of the intestine constipation, xerosis cutis pruritus, hair is withered to come off.(6) Radix pedicularis muscicolae is the dried floral of goatweed Radix pedicularis muscicolae PedicularismuscicolaMaxim..Have and hold back poison, heat clearing away, effect of growing and blacking hair.For meat poison, Baconic's wood brucellosis, hot diarrhoea, painful abdominal mass tumor, pneumonopathy, disorders of meridian.These crude drug combine use makes each crude drug effect produce synergism such that it is able to effectively hair growth.
The consumption of Tibetan medicine active component of the present invention also is groped to sum up to draw through inventor in a large number, and each crude drug consumption for all to have good therapeutic effect within the scope of following concrete weight proportion:
Cornu Bubali 10～30g, walnut shell 15～45g, Radix rumicis acetosae 7.5～22.5g, Semen Sesami Nigrum 7.5～22.5g, Caulis et Folium Lini 10～30g, Radix pedicularis muscicolae 15～45g.
It is preferably: Cornu Bubali 16～24g, walnut shell 24～36g, Radix rumicis acetosae 12～18g, Semen Sesami Nigrum 12～18g, Caulis et Folium Lini 16～24g, Radix pedicularis muscicolae 24～36g.
More preferably: Cornu Bubali 20g, walnut shell 30g, Radix rumicis acetosae 15g, Semen Sesami Nigrum 15g, Caulis et Folium Lini 20g, Radix pedicularis muscicolae 30g.
The preparation of Tibetan medicine active component of the present invention can be pulverize the crude drug convection drying of above-mentioned consumption to make；Conventional method such as decoction and alcohol sedimentation technique or ethanol extract from water precipitation (referring to " pharmaceutics of Chinese drugs " the 73rd～74 page of Cao Chunlin chief editor, Science and Technology of Shanghai publishing house publishes in November, 1986) that the crude drug of above-mentioned consumption can also adopt Chinese medicine preparation prepare.
The active component of Tibetan medicine of the present invention can add various customary adjuvant required when preparing different dosage form, if suitable substrate, suitable solvent, suitable propellant etc. are with conventional method of Chinese medicinal (" pharmaceutics of Chinese drugs " referring to Cao Chunlin chief editor, Science and Technology of Shanghai publishing house publishes in November, 1986) prepare into any common formulations, such as tincture, fluid extract, extractum, ointment, liniment, lotion, aerosol, spray etc..
Tibetan medicine of the present invention has the function of blood circulation promoting and blood stasis dispelling, blood nourishing and hair., desquamation, pruritus greasy for scalp, hypotrichosis, withered and yellow, bifurcated, jewelry, expensive clothing and other valuables, hair easily snaps off, alopecia, alopecia, early whitening of beard and hair etc..
The usage and dosage of Tibetan medicine of the present invention is: external；Embrocate affected part, massage 3～5 minutes and generate heat to affected part, 2～3 times on the one.
[detailed description of the invention]
The preparation method that of the present invention Tibetan medicine is expanded on further by the following examples.
The preparation of [embodiment 1] Tibetan medicine tincture of the present invention:
Weigh Cornu Bubali 20g, walnut shell 30g, Radix rumicis acetosae 15g, Semen Sesami Nigrum 15g, Caulis et Folium Lini 20g, Radix pedicularis muscicolae 30g, be ground into coarse powder, make solvent with 75% ethanol, Mi Gai, time add stirring, impregnate seven, take supernatant, filter, squeeze medicinal residues, press liquor merges with filtrate, stir evenly, stand 24 hours, filter, subpackage, obtains tincture.
The preparation of [embodiment 2] Tibetan medicine fluid extract of the present invention:
Weigh Cornu Bubali 10g, walnut shell 15g, Radix rumicis acetosae 7.5g, Semen Sesami Nigrum 7.5g, Caulis et Folium Lini 10g, Radix pedicularis muscicolae 15g, it is ground into coarse powder, solvent is made with 70% ethanol, slowly percolation after impregnating 48 hours, collects percolate, is concentrated into relative density 1.05～1.10(25 DEG C), stand 24 hours, take supernatant, subpackage, obtain fluid extract.
The preparation of [embodiment 3] Tibetan medicine extractum of the present invention:
Weigh Cornu Bubali 30g, walnut shell 45g, Radix rumicis acetosae 22.5g, Semen Sesami Nigrum 22.5g, Caulis et Folium Lini 30g, Radix pedicularis muscicolae 45g, it is ground into coarse powder, solvent is made with 70% ethanol, slowly percolation after impregnating 48 hours, collect percolate, be concentrated into relative density 1.25～1.30(25 DEG C) thick paste, subpackage, obtain extractum.
The preparation of [embodiment 4] Tibetan medicine ointment of the present invention:
Weigh Cornu Bubali 16g, walnut shell 24g, Radix rumicis acetosae 12g, Semen Sesami Nigrum 12g, Caulis et Folium Lini 16g, Radix pedicularis muscicolae 24g, after mixing, be jointly ground into impalpable powder, mixing, add ointment base, stir evenly to semisolid dress, subpackage, obtain ointment.
The preparation of [embodiment 5] Tibetan medicine liniment of the present invention:
Weigh Cornu Bubali 24g, walnut shell 36g, Radix rumicis acetosae 18g, Semen Sesami Nigrum 18g, Caulis et Folium Lini 24g, Radix pedicularis muscicolae 36g, be ground into coarse powder, make solvent with 75% ethanol, Mi Gai, time add stirring, impregnate seven, take supernatant, filter, squeeze medicinal residues, press liquor merges with filtrate, stir evenly, stand 24 hours, filter, subpackage, obtains liniment.
The preparation of [embodiment 6] Tibetan medicine lotion of the present invention:
Weigh Cornu Bubali 14g, walnut shell 21g, Radix rumicis acetosae 10.5g, Semen Sesami Nigrum 10.5g, Caulis et Folium Lini 14g, Radix pedicularis muscicolae 21g, be ground into coarse powder, by appropriate water boiling and extraction 3 times, each 1 hour, filter, merge 3 filtrates, it is concentrated into relative density 1.10～1.15(25 DEG C), subpackage, obtain lotion.
The preparation of [embodiment 7] Tibetan medicine aerosol of the present invention:
Weigh Cornu Bubali 26g, walnut shell 39g, Radix rumicis acetosae 19.5g, Semen Sesami Nigrum 19.5g, Caulis et Folium Lini 26g, Radix pedicularis muscicolae 39g, it is ground into coarse powder, by appropriate water boiling and extraction 3 times, each 1 hour, filter, merge 3 filtrates, it is concentrated into relative density 1.10～1.15(25 DEG C), add suitable propellant, mixing, it is packaged in suitable container, obtains aerosol.
Prepared by the spray of [embodiment 8] Tibetan medicine of the present invention:
Weigh Cornu Bubali 28g, walnut shell 42g, Radix rumicis acetosae 21g, Semen Sesami Nigrum 21g, Caulis et Folium Lini 28g, Radix pedicularis muscicolae 42g, it is ground into coarse powder, by appropriate water boiling and extraction 3 times, each 1 hour, filter, merge 3 filtrates, be concentrated into relative density 1.05～1.15(25 DEG C), it is packaged in suitable container, obtains spray.
The beneficial effect of of the present invention Tibetan medicine is expanded on further below by way of test example, these test examples include pharmacodynamics test and the clinical observation on the therapeutic effect test of Tibetan medicine embodiment 1 tincture of the present invention.
[test example 1] the Tibetan medicine embodiment 1 tincture of the present invention pharmacodynamics test to mouse skin temperature and auricle Microcirculation Effect:
Test material: anthology invention Tibetan medicine embodiment 1 tincture；101 HAIR BREEDING AGENT (Beijing Zhangguang 101 Technology Co., Ltd., product batch number: 20101001)；95% ethanol (Tianjin Fu Yu Fine Chemical Co., Ltd, product batch number: 100312)；Pentobarbital (chemical experimental factory of Foshan City, product batch number: 20100406)；Sodium chloride injection (Shandong Lukang Cisen Pharmaceutical Co., Ltd, product batch number: 1004234202)；Picric acid (Guangzhou Chemical Reagent Factory, product batch number: 20090411)；Sodium sulfide (Fanyu, Guangzhou power strengthens factory, product batch number: 20100706)；NIH mice is provided by Qinghai Province's Experimental Animal Center.
Experimental technique and result: 1, take mice 50, male and female half and half.Back wool is cut short, by depilatory (6%Na2S) being applied to mouse back, depilation area is with warm water cleaning (smooth with mouse back, to be clean without hindering without residual hair) after 3cm × 4cm, 3min.Mice is randomly divided into 5 groups by next day, each 10, respectively blank group (75% ethanol group), positive controls (101 HAIR BREEDING AGENT group), the basic, normal, high dosage group of Tibetan medicine embodiment 1 tincture of the present invention, smears relative medicine in each group of mice depilation district, and dosage is in Table 1.Smear 1 time, with infrared radiation thermometer measure each group of mice different time points (15,30,60,120min) be administered forward and backward skin temperature.Laboratory temperature is 19～21 DEG C, and result is in Table 1, table 2, table 3, table 4.
After table 1 is administered 15min, separate groups of mice skin temperature changes (x ± s, n=10)
Group Animals number dosage (ml/ is only) temperature gap
Blank group 100.2-2.93 ± 3.21
Positive controls 100.2-0.49 ± 2.26
Low dose group 100.11.23 ± 2.53**
Middle dosage group 100.2-0.39 ± 3.56
High dose group 100.4-1.32 ± 3.47
Illustrate: compare with blank group:**P<0.01。
Table 1 result shows, after administration 15min, owing to all containing a certain amount of ethanol in medicinal liquid, the heat of skin, therefore each equal decrease to some degree of treated animal skin temperature are taken away in ethanol volatilization.Comparing with blank group matched group, Tibetan medicine embodiment 1 tincture low dose group dosage of the present invention is few, and therefore mouse skin temperature reduces inconspicuous, and shows the situation (P < 0.01) that temperature significantly raises；Positive controls, Tibetan medicine embodiment 1 tincture of the present invention dosage high, middle group mouse skin temperature all decreases, but reduction amplitude is respectively less than blank group, prompting medicine can resist the skin temperature reduction that ethanol volatilization causes to a certain extent, but there was no significant difference (P > 0.05).Compare with positive controls, the high, medium and low dosage group of Tibetan medicine embodiment 1 tincture of the present invention there are no significant difference (P > 0.05).
After table 2 is administered 30min, separate groups of mice skin temperature changes (x ± s, n=10)
Group Animals number dosage (ml/ is only) temperature gap
Blank group 100.2-2.23 ± 3.12
Positive controls 100.20.43 ± 4.86
Low dose group 100.11.37 ± 1.26*
Middle dosage group 100.2-1.11 ± 3.58
High dose group 100.40.39 ± 3.19
Illustrate: compare with blank group:*P<0.05。
Table 2 result shows, after administration 30min, the skin temperature of blank group still is below being administered front level, compare with blank group, positive controls and Tibetan medicine embodiment 1 tincture high dose group mouse skin temperature of the present invention return to the front level of administration, but still there was no significant difference (P > 0.05) with blank group；In Tibetan medicine embodiment 1 tincture of the present invention, dosage group mouse skin temperature slightly reduces, and reduces Amplitude Ratio blank group little, but there was no significant difference (P > 0.05)；Tibetan medicine embodiment 1 tincture low dose group mouse skin temperature of the present invention is significantly higher than blank group (P < 0.05), and it is relevant that and medicine less than normal to dosage resists factor；Compare with positive controls, the high, medium and low dosage group of Tibetan medicine embodiment 1 tincture of the present invention there are no significant difference (P > 0.05).
After table 3 is administered 60min, separate groups of mice skin temperature changes (x ± s, n=10)
Group Animals number dosage (ml/ is only) temperature gap
Blank group 100.2-3.23 ± 3.46
Positive controls 100.2-0.98 ± 4.26
Low dose group 100.10.89 ± 2.42*
Middle dosage group 100.2-0.27 ± 2.63
High dose group 100.40.59 ± 3.76*
Illustrate: compare with blank group:*P<0.05。
Table 3 result shows, after administration 60min, the skin temperature of blank group still is below being administered front level, compare with blank group, positive controls and dosage group mouse skin temperature in Tibetan medicine embodiment 1 tincture of the present invention are slightly below before administration, but the amplitude of reduction is less than blank group, and both there was no significant difference (P > 0.05)；Tibetan medicine embodiment 1 tincture high and low dose group mouse skin temperature of the present invention is raised significantly to be higher than the front level (P < 0.05) of administration；Compare with positive controls, the high, medium and low dosage group of Tibetan medicine embodiment 1 tincture of the present invention there are no significant difference (P > 0.05).
After table 4 is administered 120min, separate groups of mice skin temperature changes (x ± s, n=10)
Group Animals number dosage (ml/ is only) temperature gap
Blank group 100.2-2.32 ± 1.21
Positive controls 100.21.34 ± 3.43**
Low dose group 100.11.21 ± 0.52**
Middle dosage group 100.20.83 ± 2.63**
High dose group 100.43.89 ± 2.16**#
Illustrate: compare with blank group:**P<0.01；Compare by positive controls:#P<0.05。
Table 4 result shows, after administration 120min, the skin temperature of blank group still is below being administered front level, and positive controls can significantly raise mouse skin temperature (P < 0.01), prompting modeling success；And Tibetan medicine embodiment 1 tincture of the present invention high, medium and low dosage group mouse skin temperature significantly raises (P < 0.01).Compare with positive controls, Tibetan medicine embodiment 1 tincture high dose group skin temperature of the present invention significantly raises, there is significant difference (P < 0.05), point out Tibetan medicine embodiment 1 tincture high dose group of the present invention can significantly improve the microcirculation of local skin, improve skin temperature, and drug effect is significantly stronger than positive controls.
2, Tibetan medicine embodiment 1 tincture of the present invention is to Mice Auricle Microcirculation Effect:
Take mice 50, male and female half and half.It is randomly divided into blank group (75% ethanol), positive controls, the basic, normal, high dosage group of Tibetan medicine embodiment 1 tincture of the present invention.By measuring Mice Auricle microcirculatory blood flow (PU) with laser-Doppler microcirculation instrument after mouse anesthesia, smearing relative medicine in each group of Mice Auricle, dosage is in Table 5.Again measuring the blood flow (PU) observing each group of mice after 20min, the PU difference of each group compared, result is in Table 5.
Table 5 Tibetan medicine of the present invention embodiment 1 tincture is on the microcirculatory impact of Mice Auricle (x ± s, n=10)
Group Animals number dosage (μ l/ is only) PU difference
Blank group 1080-1.37 ± 4.16
Positive controls 108025.98 ± 9.76**
Low dose group 104028.72 ± 15.36**
Middle dosage group 108028.93 ± 11.24**
High dose group 1016023.15 ± 12.64**
Illustrate: compare with blank group:**P<0.01。
Table 5 result shows, compares before administration and after administration, and blank group Mice Auricle microcirculation PU value is substantially without changing；Comparing with blank group, positive controls is remarkably improved blood capillary PU value, improves Mice Auricle microcirculation, accelerates blood flow rate (P < 0.01), prompting modeling success.Compare with blank group, the high, medium and low dosage group of Tibetan medicine embodiment 1 tincture of the present invention all can significantly improve Mice Auricle microcirculation (P < 0.01), point out the high, medium and low dosage group of Tibetan medicine embodiment 1 tincture of the present invention all can dramatically increase Mice Auricle microcirculation, expansion blood capillary, accelerates blood flow rate；Compare with positive controls, in Tibetan medicine embodiment 1 tincture of the present invention, low dose group PU value increase level is higher than positive controls, but there was no significant difference (P > 0.05), point out Tibetan medicine embodiment 1 tincture of the present invention to improve microcirculation level and be slightly better than positive controls, but there was no significant difference；There was no significant difference (P > 0.05) between the high, medium and low dosage group of Tibetan medicine embodiment 1 tincture of the present invention, point out Tibetan medicine embodiment 1 tincture of the present invention that the microcirculatory drug effect of Mice Auricle is absent from obvious dose dependent.
There is dependency in the change of androgenetic alopecia and hemorheology, blood viscosity increases, one of the syndrome of blood stasis pathogenesis being probably primary disease.Research finds, androgenetic alopecia patient whole blood's viscosity (being cut to master with height), packed cell volume, whole blood height cut relative indices apparently higher than Normal group." hair is the sign of blood condition ", alopecia is in close relations with " blood ".Blood viscosity is higher, and blood fluidity is less, otherwise bigger.Blood viscosity increase can cause blood circulation and microcirculation disturbance, causes tissue to fill a series of consequences such as insufficiency of blood, hypoxic-ischemic, metabolic function imbalance.From modern medicine angle, microcirculation disturbance makes perifollicolar vasoconstriction, stimulates vascular smooth muscle cell proliferation, finally makes ischemic hypoxia, cause that hair follicle Progressive symmetric erythrokeratodermia reduces.Originally experimental studies have found that, Tibetan medicine embodiment 1 tincture of the present invention has rising mouse skin temperature, expands blood vessel, improves microcirculatory effect.Pointing out Tibetan medicine embodiment 1 tincture energy skin expansion blood vessel of the present invention, improving skin microcirculation, increase hair papilla blood supply, improving hair follicle nutrition, thus promoting hair growth.
[test example 2] Tibetan medicine embodiment 1 tincture hair growth clinical observation on the therapeutic effect of the present invention:
1, physical data: 120 example patients are all from Dermatology Outpatient Department, is randomly divided into two groups by SAS statistical analysis system by patient, treatment group 60 example, male 49 examples, female 11 example, 20～49 years old age, the course of disease 3 months～2 years, average 8.5 months；Matched group 60 example, male 47 examples, female 13 example, 18～47 years old age, the course of disease 3 months～2 years, average 9.3 months.Two groups, at age, the course of disease statistically no significant difference (P > 0.05), have comparability.
2, diagnosis and exclusion standard:
(1) diagnostic criteria: 1. fat secretion is vigorous, hair is greasy, or the dandruff is obvious, and hair dries, with pruritus；2. volume anterior hair line line constantly raises；3. alopecia is continuously more than 3 months, and alopecia every day number is more than 100；4. hair is tapered deliquescing, in rarefaction state.All meet above two standard persons, namely diagnosable for androgenetic alopecia.
(2) exclusion standard: 1. the age is at under-18s；2. other endocrine alopecias (such as hypothyroidism or hyperfunction, parathyroid gland or primary pituitary hypofunction, hypogonadism, diabetes etc.)；3. alopecia medicamentosa person, symptomatic alopecia person, women puerperal alopecia；4. do not meet inclusive criteria or data not umbra rings statistical analysis person.
3, Therapeutic Method: treatment group adopts Tibetan medicine embodiment 1 tincture of the present invention, embrocates affected part, massages 3～5 minutes and generates heat to affected part, 2～3 times on the one；Percussopunctator head buckles thorn, 3 days/time, each 15min；It within 60 days, it is 1 course for the treatment of.
Matched group selects climing enlightening, every day 2 times, each 1ml, outer spray, and starts to smear from center, affected part, massages 3～5min with hands；Percussopunctator head buckles thorn, 3 days/time, each 15min；It within 60 days, it is 1 course for the treatment of.
All treat 3 courses for the treatment of, after 6 months, judge curative effect for two groups.1 skin lesion place hair growth situation of every two weeks record, observes with or without systemic adverse reactions (include heating, headache, weak etc.).
4, clinical efficacy evaluation criteria: the therapeutic effect of hair is with reference to the criterion of therapeutical effect proposed such as WEISS.
(1) recovery from illness: new sending out all grows, distribution density, hair thickness, the same normal hair of color and luster gently draw negative；
(2) effective: kainogenesis length more than 50%, there is more fine hair on birds or animals hair to become terminal hair, gently draw negative；
(3) effective: kainogenesis length more than 10% (including fine hair on birds or animals hair), but poor growth, gently draw negative or the positive；
(4) invalid: without kainogenesis length or kainogenesis length lower than 10% or growth while continuing to come off.
(5) simultaneous phenomenon standards of grading, select three main simultaneous phenomenons of primary disease (scalp greasy, scalp itch, dandruff) to observe.The point system of the greasy degree of scalp, scalp itch degree and dandruff quantitative degree uses for reference the visual analogue scales (VisualAnalogueScale in pain therapy, VAS): draw a scale, 11 numerals 0～10 are uniformly marked on chi as scale, by patient according to the autoscopia corresponding mark of labelling on scale.0 point=nothing, 1～3 point=slight, 4～7 points=moderate, 8～10 points=severe.
Recovery from illness adds and effective adds up to total effective rate.
Clinical observation result is in Table 6, table 7, table 8.
6 liang of table group distinct methods treatment androgenetic alopecia comparitive study (example, %)
The group number of cases effective enabledisable cure rate total effective rate of recovery from illness
Treatment group 6024199840.0071.67
Matched group 601914151231.6755.00
Table 6 result shows, cure rate compares significant difference (P < 0.05), and total effective rate comparing difference has significance (P < 0.05), it was shown that treatment group curative effect is better than matched group.Two groups of researchs all find the prolongation with androgenetic alopecia patient's course of disease, and its cure rate and effective percentage are gradually reduced.
7 liang of table group distinct methods treatment androgenetic alopecia onset time compares (example)
Group number of cases less than 60 days 60～120 days more than 120 days
Treatment group 60171825
Matched group 6091338
Table 7 result shows: there are significant difference (P < 0.05) two groups of onset times, it was shown that treatment group onset time is early than matched group.
The group distinct methods treatment androgenetic simultaneous phenomenon scoring of 8 liang of table is compared
The greasy scalp desquamation scalp itch of group number of cases scalp
Treatment group treatment front 606.63 ± 1.475.89 ± 1.025.85 ± 0.14
602.28 ± 0.562.62 ± 0.362.68 ± 0.54 after treatment
606.68 ± 1.525.74 ± 1.534.97 ± 0.69 before treatment of control group
603.46 ± 0.173.87 ± 0.153.23 ± 1.16 after treatment
Table 8 result shows: two groups of simultaneous phenomenons are greasy at scalp, scalp desquamation, scalp itch comparing difference have highly significant (P < 0.05).
5, untoward reaction: treatment group no side effects；Matched group has 5 examples to show as scalp itch burning sensation over the course for the treatment of, but does not affect local hair growth, does not also affect treatment, can recover gradually after stopping treatment.
With the massage of Tibetan medicine embodiment 1 of the present invention tincture local application, by the effect of physics and chemistry aspect, improving scalp microcirculation, increase blood flow, promote hair metabolism, hairy root nourishing, thus reaching the effect of hair growth accelerating.Thorn is buckled in percussopunctator local, can promote neural excitation, cause vasodilation, make hair follicle vascular plexus and the hair papilla congestion of blood vessel, blood supply is abundant, is beneficial to hair growth, and button thorn is hemorrhage, poison can be rushed down eliminating evil, promoting blood circulation to remove obstruction in the collateral, makes the hair follicle vasodilation of local skin, improves local blood circulation, help medicine to absorb better, give full play to property of medicine effect.All methods phase 5, energy dredging the meridian, nourishing blood to tranquillize the mind, improves natural on-off cycles of hair growth environment, accelerates the growth of hair.
This result of study shows: the cure rate for the treatment of group is 40.00%, and obvious effective rate is 31.67%, and total effective rate is 71.67%, and the cure rate of matched group is 31.67%, and obvious effective rate is 23.33%, and total effective rate is 55.00%.All there is not any untoward reaction in two groups of patients.Therefore, the clinical efficacy of Tibetan medicine embodiment 1 tincture hair growth of the present invention is definite, and safety is high.
The test example of Tibetan medicine embodiment 1 tincture of the present invention demonstrates has good effect in hair growth, also just describes the above-mentioned embodiment 18 enumerated and has same effect.Illustrate that Tibetan medicine of the present invention has good effect in hair growth.
Claims (5)
1. the Tibetan medicine of a hair growth, it is characterized in that it is made up of active component or is made up of active component and pharmaceutically acceptable adjuvant, wherein said active component is made up of the crude drug of following concrete weight proportion: Cornu Bubali 10～30g, walnut shell 15～45g, Radix rumicis acetosae 7.5～22.5g, Semen Sesami Nigrum 7.5～22.5g, Caulis et Folium Lini 10～30g, Radix pedicularis muscicolae 15～45g.
2. Tibetan medicine according to claim 1, wherein said active component is made up of the crude drug of following concrete weight proportion: Cornu Bubali 16～24g, walnut shell 24～36g, Radix rumicis acetosae 12～18g, Semen Sesami Nigrum 12～18g, Caulis et Folium Lini 16～24g, Radix pedicularis muscicolae 24～36g.
3. Tibetan medicine according to claim 2, wherein said active component is made up of the crude drug of following concrete weight: Cornu Bubali 20g, walnut shell 30g, Radix rumicis acetosae 15g, Semen Sesami Nigrum 15g, Caulis et Folium Lini 20g, Radix pedicularis muscicolae 30g.
4. the Tibetan medicine according to any one of claim 13, it is exterior-applied formulation.
5. Tibetan medicine according to claim 4, it is tincture, fluid extract, extractum, ointment, liniment, lotion, aerosol or spray.
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