CN105796818A - 一种用于治疗功能失调性子宫出血的药物 - Google Patents

一种用于治疗功能失调性子宫出血的药物 Download PDF

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CN105796818A
CN105796818A CN201610289904.XA CN201610289904A CN105796818A CN 105796818 A CN105796818 A CN 105796818A CN 201610289904 A CN201610289904 A CN 201610289904A CN 105796818 A CN105796818 A CN 105796818A
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宋云飞
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Abstract

本发明涉及一种用于治疗功能失调性子宫出血的药物，它是由以下重量配比的原料药材制备而成：毛狗苕15份、松藻6份、凌羊角草9份、血余炭12份、凤眼草6份、钮子七9份、茜草12份、胜红蓟15份、养心草6份、血水草15份、叶下红15份。本发明运用：毛狗苕补脾益肾，利湿消肿；松藻性凉，味淡收涩止血；凌羊角草郐盘通络，活血止痛；血余炭、凤眼草收涩止血化瘀，助血止而无留瘀之弊；钮子七、茜草、胜红蓟祛瘀生新，止痛止血；养心草活血止血，宁心；血水草清热解毒，活血止痛止血；叶下红凉血止血，活血消肿，清热利湿。诸药合用，共奏健脾补肾，益气养血，固冲摄血之功。临床实验证明，本发明能够安全有效治疗功能失调性子宫出血。

Description

一种用于治疗功能失调性子宫出血的药物
技术领域
本发明涉及一种中药，具体涉及一种用于治疗功能失调性子宫出血的药物。
背景技术
功能失调性子宫出血是由于生殖内分泌轴功能紊乱造成的异常子宫出血，分为无排卵性功血和有排卵性功血。临床上常见的典型症状有月经持续时间延长或月经增多＞80ml，但月经周期规律；月经变频，月经期间隔少于21天；月经周期不准，间隔时间增长，有时次数过频且伴有月经量增多及持续时间增长；月经中期出血。
中医：崩漏。崩漏即是阴道不规则流血，来势急骤，忽然暴下，称之经崩；来势缓者，淋漓不断，谓之曰漏。二者常交替出现，互相转化。本病的发生主要是由于冲任损伤所致。各种原因引起的血热、肾虚、脾虚、血瘀等均可伤及冲任二脉，冲任损伤，不能约制其经血，故血从胞中非时而下。
临床表现
①月经持续时间延长或月经增多，一次经期总量可达500～600ml，多伴有较大血块。或经期延长，约10～20天，血色陈旧，多见于30～40岁年龄的妇女。
②月经变频，多见于有排卵型功血中黄体发育不健全者，月经周期缩短，少于21天，往往伴有不孕或早期流产。
③不规则子宫出血：多发生于青春期及更年期妇女。流血时间、血量和间隔都不规律，有时流血可持续月余，一般不发生腹痛。
④月经中期出血。
此症诊断主要依靠实验室检查
①激素测定：为确定有无排卵或黄体健全与否，可测孕二醇。如疑有卵巢功能失调者，可测定雌激素、睾酮、孕二醇、17-羟酮或hCG等水平。
②诊断性刮宫：诊刮时必须注意宫腔大小、形态、宫壁是否光滑，刮出物的性质和量。必须搔刮整个宫腔。为了解有无排卵或黄体功能是否健全，应在经前期或月经来潮6h以内行刮宫；如疑有子宫内膜脱落不全，则应在月经第5日刮宫。至于不规则流血患者，任何时候都可刮取内膜。诊刮具有明确诊断和刮净内膜达到止血目的双重意义。
③基础体温测定：基础体温单相提示无排卵。黄体功能不全时显示双相型，但体温升高时间短，仅9—11d。子宫内膜脱落不全时呈双相型但下降缓慢。
④宫颈粘液结晶检查：经前出现羊齿状结晶提示无排卵。阴道脱落细胞涂片检查：无排卵型功血时反映仅有雌激素作用，黄体功能不全时反映孕激素作用不足，缺乏典型的细胞堆集和皱褶。
药物治疗①性激素止血法，炔诺酮（妇康片)：止血效果较好，但对肝脏功能影响较大；②抗纤溶治疗，止血芳酸、6-氨基已酸、止血环酸、安络血等；③广谱抗生素或抑制大肠杆菌，控制感染长期流血可引起贫血，因此抵抗力低下，易致感染；另外，流血容易导致生殖道逆行感染。所以控制感染非常必要。④促进排卵疗法，一般用于功血患者月经周期基本形成之后，目的在于促使排卵，并能减少或防止该病复发，如氯菧酚胺。⑤中药治疗功能失调性子宫出血可用中医中药治疗，效果比较理想。同时应注意饮食以及生活习惯。
本发明所涉及药材均可见记载于《中华本草》。
发明内容
本发明旨在提供一种用于治疗功能失调性子宫出血的药物，通过选择合适的药材及其配比，达到安全有效治愈功能失调性子宫出血的目的。
为了达到上述目的，本发明采用以下技术方案：
一种用于治疗功能失调性子宫出血的药物，其特征在于，它是由以下重量配比的原料药材制备而成：毛狗苕15份、松藻6份、凌羊角草9份、血余炭12份、凤眼草6份、钮子七9份、茜草12份、胜红蓟15份、养心草6份、血水草15份、叶下红15份。
下面结合中药学理论说明本发明有益效果：
发明人认为，功能失调性子宫出血的基本病机是由于冲任损伤所致。各种原因引起的血热、肾虚、脾虚、血瘀等均可伤及冲任二脉，冲任损伤，不能约制其经血，故血从胞中非时而下。治疗宜健脾补肾，益气养血，固冲摄血。
本发明运用：毛狗苕补脾益肾，利湿消肿；松藻性凉，味淡收涩止血；凌羊角草郐盘通络，活血止痛；血余炭、凤眼草收涩止血化瘀，助血止而无留瘀之弊；钮子七、茜草、胜红蓟祛瘀生新，止痛止血；养心草活血止血，宁心；血水草清热解毒，活血止痛止血；叶下红凉血止血，活血消肿，清热利湿。诸药合用，共奏健脾补肾，益气养血，固冲摄血之功。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2012年08月-2014年08月间共收集130例功能失调性子宫出血患者。随机分为：治疗组66例，对照组64例。治疗组66例患者中，年龄21~53岁，平均年龄37岁；对照组64例患者中年龄22~50岁，平均年龄33.5岁。两组性别、年龄、病程等资料无显著性差异，具有可比性。
纳入标准①经期无周期可循。②经量或暴下如注，或漏下不止，或两者交替出现。③自愿参加试验的成年患者。
排除标准①子宫肌瘤、子宫内膜异位症、子宫内膜息肉、生殖道恶性肿瘤等器质性病变患者；②血液系统疾病、凝血功能障碍及自身免疫性疾病患者；③有心、脑、肝、肾等疾病者；④有试验药物服用禁忌症者；⑤用药前3个月内接受过其他激素治疗者。
2、治疗方法
治疗组口服本发明按照具体实施例3制得的胶囊，每日3次。月经出血停止后第3日开始服用至下一次月经来临日。连续治疗3个周期。
对照组口服诀诺酮片，月经出血停止后第3日开始服用至下一次月经来临日。连续治疗3个周期。
3、疗效标准与治疗结果
3.1疗效标准
①痊愈：经量、经期、周期恢复正常，青春期、育龄期有连续2次排卵，黄体期12～14天，停药后仍维持3个月经周期以上者；更年期患者经期、经量维持3次以上正常者，或稀发至闭经、子宫切除或其它治疗后，症状消失者；
②有效：经量减少1/3～1/2，经期10天以内，有1～2个月经周期正常。育龄期排卵1次，黄体不足者有改善；无排卵者，出现黄体期变化；更年期经期缩短，经量有所减少；
③无效：经量、经期、周期均无好转。
3.2治疗统计结果见表1。
表1两组疗效比较
组别 n 痊愈 有效 无效 总有效率(%) 明显不良反应例
治疗组 66 49 14 3 95.45% 0
对照组 64 41 13 10 84.38% 0
可见，本发明制得的药物能够安全有效治疗功能失调性子宫出血，治愈率高。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
实施例1
称取：毛狗苕15克、松藻6克、凌羊角草9克、血余炭12克、凤眼草6克、钮子七9克、茜草12克、胜红蓟15克、养心草6克、血水草15克、叶下红15克；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120克，即得符合正常成人一天用量的煎剂。
用于治疗功能失调性子宫出血。口服，每日服用一次。
实施例2
称取：毛狗苕15克、松藻6克、凌羊角草9克、血余炭12克、凤眼草6克、钮子七9克、茜草12克、胜红蓟15克、养心草6克、血水草15克、叶下红15克；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗功能失调性子宫出血。口服，每日分早晚两次服用。
实施例3
称取：毛狗苕15克、松藻6克、凌羊角草9克、血余炭12克、凤眼草6克、钮子七9克、茜草12克、胜红蓟15克、养心草6克、血水草15克、叶下红15克；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗功能失调性子宫出血。口服，每日分早中晚三次服用。

Claims (4)

1.一种用于治疗功能失调性子宫出血的药物，其特征在于，它是由以下重量配比的原料药材制备而成：毛狗苕15份、松藻6份、凌羊角草9份、血余炭12份、凤眼草6份、钮子七9份、茜草12份、胜红蓟15份、养心草6份、血水草15份、叶下红15份。
2.如权利要求1所述的用于治疗功能失调性子宫出血的药物，其特征在于，其制备方法为：称取：毛狗苕15份、松藻6份、凌羊角草9份、血余炭12份、凤眼草6份、钮子七9份、茜草12份、胜红蓟15份、养心草6份、血水草15份、叶下红15份；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120份，即得煎剂；上述份均是指重量份。
3.如权利要求1所述的用于治疗功能失调性子宫出血的药物，其特征在于，其制备方法为：称取：毛狗苕15份、松藻6份、凌羊角草9份、血余炭12份、凤眼草6份、钮子七9份、茜草12份、胜红蓟15份、养心草6份、血水草15份、叶下红15份；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得散剂；上述份均是指重量份。
4.如权利要求1所述的用于治疗功能失调性子宫出血的药物，其特征在于，其制备方法为：称取：毛狗苕15份、松藻6份、凌羊角草9份、血余炭12份、凤眼草6份、钮子七9份、茜草12份、胜红蓟15份、养心草6份、血水草15份、叶下红15份；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得胶囊剂；上述份均是指重量份。
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1814196A (zh) * 2005-12-05 2006-08-09 杨雄志 一种治疗功能性子宫出血的中药组合物及其应用
CN104027468A (zh) * 2014-06-24 2014-09-10 俞天阳 一种用于治疗头皮脂溢性皮炎的中药

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1814196A (zh) * 2005-12-05 2006-08-09 杨雄志 一种治疗功能性子宫出血的中药组合物及其应用
CN104027468A (zh) * 2014-06-24 2014-09-10 俞天阳 一种用于治疗头皮脂溢性皮炎的中药

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