CN105777610A - 一种制备4-氯-2-(三氟乙酰基)苯胺盐酸盐水合物的方法 - Google Patents
一种制备4-氯-2-(三氟乙酰基)苯胺盐酸盐水合物的方法 Download PDFInfo
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- CN105777610A CN105777610A CN201610218044.0A CN201610218044A CN105777610A CN 105777610 A CN105777610 A CN 105777610A CN 201610218044 A CN201610218044 A CN 201610218044A CN 105777610 A CN105777610 A CN 105777610A
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- chloro
- hydrate
- trifluoroacetyl group
- anilinechloride
- phthalic
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
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- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (10)
Applications Claiming Priority (2)
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CN201510673321 | 2015-10-16 | ||
CN2015106733212 | 2015-10-16 |
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CN105777610A true CN105777610A (zh) | 2016-07-20 |
CN105777610B CN105777610B (zh) | 2018-10-09 |
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CN201610218044.0A Active CN105777610B (zh) | 2015-10-16 | 2016-04-09 | 一种制备4-氯-2-(三氟乙酰基)苯胺盐酸盐水合物的方法 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108997150A (zh) * | 2018-08-31 | 2018-12-14 | 江苏沙星化工有限公司 | 一种依法韦仑中间体的制备方法 |
CN110204450A (zh) * | 2019-05-24 | 2019-09-06 | 浙江江北药业有限公司 | 一种4-氯-2-三氟乙酰基苯胺盐酸盐水合物的合成方法 |
CN112194558A (zh) * | 2020-11-26 | 2021-01-08 | 阿里生物新材料(常州)有限公司 | 一种2-氟-3-甲基-4-(三氟甲基)苯甲胺盐酸盐的合成方法 |
Citations (6)
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US6028237A (en) * | 1996-12-16 | 2000-02-22 | Dupont Pharmaceuticals Company | Synthesis of cyclopropylacetylene |
WO2006077367A1 (en) * | 2005-01-19 | 2006-07-27 | Biolipox Ab | Indoles useful in the treatment of inflamation |
WO2009121033A2 (en) * | 2008-03-27 | 2009-10-01 | University Of Southern California | Substituted nitrogen heterocycles and synthesis and uses thereof |
CN101844990A (zh) * | 2010-05-27 | 2010-09-29 | 浙江沙星医药化工有限公司 | 中间体4-氯-2-(三氟乙酰基)苯胺盐酸盐水合物的合成方法 |
CN102675125A (zh) * | 2011-03-15 | 2012-09-19 | 中国科学院上海有机化学研究所 | 一种4-氯-2-三氟乙酰基苯胺及其类似物的简便高效合成方法 |
WO2015111004A2 (en) * | 2014-01-24 | 2015-07-30 | Discovery Intermediates Private Limited | Improved process for the preparation of chlorophenyl trifluoroethanone |
-
2016
- 2016-04-09 CN CN201610218044.0A patent/CN105777610B/zh active Active
Patent Citations (6)
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US6028237A (en) * | 1996-12-16 | 2000-02-22 | Dupont Pharmaceuticals Company | Synthesis of cyclopropylacetylene |
WO2006077367A1 (en) * | 2005-01-19 | 2006-07-27 | Biolipox Ab | Indoles useful in the treatment of inflamation |
WO2009121033A2 (en) * | 2008-03-27 | 2009-10-01 | University Of Southern California | Substituted nitrogen heterocycles and synthesis and uses thereof |
CN101844990A (zh) * | 2010-05-27 | 2010-09-29 | 浙江沙星医药化工有限公司 | 中间体4-氯-2-(三氟乙酰基)苯胺盐酸盐水合物的合成方法 |
CN102675125A (zh) * | 2011-03-15 | 2012-09-19 | 中国科学院上海有机化学研究所 | 一种4-氯-2-三氟乙酰基苯胺及其类似物的简便高效合成方法 |
WO2015111004A2 (en) * | 2014-01-24 | 2015-07-30 | Discovery Intermediates Private Limited | Improved process for the preparation of chlorophenyl trifluoroethanone |
Non-Patent Citations (5)
Title |
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LINGJIAN ZHU,等: "An alternative route for synthesis of o-trifluoroacetylanilines as useful fluorine-containing intermediates", 《JOURNAL OF FLUORINE CHEMISTRY》 * |
MICHAEL E. PIERCE等: "Practical Asymmetric Synthesis of Efavirenz (DMP 266), an HIV-1 Reverse Transcriptase Inhibitor", 《J. ORG. CHEM.》 * |
三、氨基的保护: "《基础有机化学(第三版)》", 30 June 2005 * |
孙春霞: "选择性锂化法合成吡啶及其它杂芳基三氟甲基酮化合物", 《郑州大学硕士学位论文》 * |
闻韧,等: "《药物合成反应(第二版)》", 31 January 2003 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108997150A (zh) * | 2018-08-31 | 2018-12-14 | 江苏沙星化工有限公司 | 一种依法韦仑中间体的制备方法 |
CN108997150B (zh) * | 2018-08-31 | 2021-01-12 | 江苏沙星化工有限公司 | 一种依法韦仑中间体的制备方法 |
CN110204450A (zh) * | 2019-05-24 | 2019-09-06 | 浙江江北药业有限公司 | 一种4-氯-2-三氟乙酰基苯胺盐酸盐水合物的合成方法 |
CN110204450B (zh) * | 2019-05-24 | 2022-05-03 | 浙江江北药业有限公司 | 一种4-氯-2-三氟乙酰基苯胺盐酸盐水合物的合成方法 |
CN112194558A (zh) * | 2020-11-26 | 2021-01-08 | 阿里生物新材料(常州)有限公司 | 一种2-氟-3-甲基-4-(三氟甲基)苯甲胺盐酸盐的合成方法 |
CN112194558B (zh) * | 2020-11-26 | 2022-05-10 | 阿里生物新材料(常州)有限公司 | 一种2-氟-3-甲基-4-(三氟甲基)苯甲胺盐酸盐的合成方法 |
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Address after: Huangjiao Yantou, Yongquan Town, Linhai City, Taizhou City, Zhejiang Province Patentee after: Zhejiang Shaxing Technology Co.,Ltd. Address before: Huangjiao Yantou, Yongquan Town, Linhai City, Taizhou City, Zhejiang Province Patentee before: ZHEJIANG SHAXING TECHNOLOGY Co.,Ltd. |
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Application publication date: 20160720 Assignee: Zhejiang Shaxing Bohai Technology Co.,Ltd. Assignor: Zhejiang Shaxing Technology Co.,Ltd. Contract record no.: X2023330000338 Denomination of invention: A method for preparing 4-chloro-2- (trifluoro Acetyl group) aniline hydrochloride salt complex Granted publication date: 20181009 License type: Common License Record date: 20230613 |
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