CN105727028A - Chinese herbal medicine composition for treating acnes - Google Patents

Chinese herbal medicine composition for treating acnes Download PDF

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CN105727028A
CN105727028A CN201610158596.7A CN201610158596A CN105727028A CN 105727028 A CN105727028 A CN 105727028A CN 201610158596 A CN201610158596 A CN 201610158596A CN 105727028 A CN105727028 A CN 105727028A
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herba
radix
chinese medicine
medicine composition
ethanol
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孙桂芝
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Abstract

The invention discloses Chinese herbal medicine composition for treating acnes.The Chinese herbal medicine composition comprises, raw almonds, red-rooted salvia and radix ampelopsis, 60-80 g respectively, flos chrysanthemi indici, folium ilicis chinensis, caulis trachelospermi, golden cypress, mung bean, and desmodium, 40-60 g respectively, purslane, burdock, gypsum, borax, bamboo leaves, cutch, commelina communis and pangolin, 20-40 g respectively, 10-20 g of liquorice, 10-30 g of sulphur, 5-15 tubes of 0.25 g chloramphenicol injection in 2 mL, and 2000-3000 g of 75% alcohol.The Chinese herbal medicine composition is simple in preparation, convenient to use, good in bacterial effect, capable of suppressing sebum secretion, fast in acne treatment, and not easy to recur.

Description

The Chinese medicine composition for the treatment of acne
Technical field
The present invention relates to technical field of Chinese medicines, particularly to a kind of Chinese medicine composition treating acne and preparation method thereof.
Background technology
Acne is common dermatosis, and feature is that skin area has seborrhea: such as squamous Folium Styracis Suberifoliae skin, acne: such as blackhead and hoary hair, pimple, pustule, tuberosity, cicatrix etc..The acne origin cause of formation is multifactorial, and the exfoliative cyte extremely adhered to such as hair follicle block, and antibacterial (Propionibacterium) breeds and surely grows and causes local inflammation, and hair follicle keratinization and sebum generate abnormal.Western medicine method: antibiotic, as erythromycin, clindamycin and tetracycline treat acne by local or oral administration.For another example market is general chemical bactericide, hormone, astringent, antiinflammatory etc., as, local topical medicine-tretinoin (tretinoin emulsifiable paste, adapalene gel, Tazarotene gel), benzoyl peroxide, antibiotics (clindamycin, erythromycin, chloromycetin etc.), Azelaic Acid, sulfur lotion etc..Oral antibiotic-first-selection Tetracyclines (minocycline, doxycycline etc.); but; although above-mentioned Therapeutic Method can diminish inflammation at short notice; but, owing to there is no fundamentally to solve the paathogenic factor of acne, it is impossible to enough suppress the secretion of sebaceous gland; the basic reason that hair follicle blocks does not releases; curing the symptoms, not the disease, acne usually can recur soon, the phenomenon risen one after another occurs.Additionally, pathogenic bacteria easily produces drug resistance for the antibacterial of chemical, the acne after recurrence are the most more difficult to treat, and form refractory acne, and can concurrent cicatrix and pigmentation, skin is produced catastrophic consequence.
Chinese medicinal skin care product not only can improve skin quality, and can antiinflammatory, increase cutaneous permeability.Therefore, occur in that the multiple Chinese medicine product for acne on the market, such as: Chinese patent application 2014103993887 disclose a kind of Chinese medicine composition for treating acne include according to unit of weight configuration following composition: Radix Astragali 15-25g, Rhizoma Atractylodis Macrocephalae 15-25g, Radix Rehmanniae Preparata 15-25g, Caulis Perillae 15-20g, Radix Curcumae 15-20g, Folium Eriobotryae 15-20g, Herba Artemisiae Scopariae 15-20g, Bombyx Batryticatus 15-20g, Rhizoma Zingiberis Recens 15-20g, Semen Persicae 10-15g, Arisaema Cum Bile 10-15g, Spina Gleditsiae 10-15g, Fructus Schisandrae Chinensis 15-20g, Semen Armeniacae Amarum 10-15g, Thallus Laminariae (Thallus Eckloniae) 10-15g, Rhizoma Chuanxiong 10-15g, Radix Glycyrrhizae 8-12g.For another example: Chinese patent application 2014100851210 discloses one and removes acne gel, composed of the following components: Rhizoma Polygoni Cuspidati extract, wheat malt germ extract, Radix Arnebiae extract, Helianthi extract, hyaluronic acid extract, Indigo Naturalis extract, Flos Lonicerae extract, bamboo salt, nanometer Margarita powder, hyaluronate sodium, gel, polyhydric alcohol, glycyrrhizic acid dipotassium, polysorbas20, β-glucosan, a-bisabolol, allantoin, ethanol, alkali liquor, antiseptic and antibiotic agent and deionized water.It is contemplated that on the basis of prior art, it is provided that a kind of proportioning is simple, and easy to use, bactericidal effect is good, suppresses sebum secretion, treats acne fast onset and is difficult to the Chinese medicine composition of the treatment acne repeatedly recurred.
Summary of the invention:
It is an object of the invention to provide a kind of proportioning simple, easy to use, bactericidal effect is good, suppresses sebum secretion, treats acne fast onset and is difficult to the Chinese medicine composition of the treatment acne repeatedly recurred.
To achieve these goals, the invention provides a kind of Chinese medicine composition treating acne, wherein, the following composition including configuring according to unit of weight:
Raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, each 60-80g of Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, each 40-60g of Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, each 20-40g of Squama Manis, Radix Glycyrrhizae 10-20g；The chloramphenicol injection 5-15 of sulfur 10-30g, 2ml:0.25g props up, the ethanol 2000-3000g of volume fraction 75%.
Or, the following composition including configuring according to unit of weight:
Raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, each 60-70g of Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, each 40-50g of Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, each 20-30g of Squama Manis, Radix Glycyrrhizae 10-15g；The chloramphenicol injection 5-10 of sulfur 10-20g, 2ml:0.25g props up, the ethanol 2000-2500g of volume fraction 75%.
Or, the following composition including configuring according to unit of weight:
Raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, each 70-80g of Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, each 50-60g of Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, each 30-40g of Squama Manis, Radix Glycyrrhizae 15-20g；The chloramphenicol injection 10-15 of sulfur 20-30g, 2ml:0.25g props up, the ethanol 2500-3000g of volume fraction 75%.
Or, the following composition including configuring according to unit of weight:
Raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, each 65-75g of Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, each 45-55g of Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, each 25-35g of Squama Manis, Radix Glycyrrhizae 12-18g；The chloramphenicol injection 8-12 of sulfur 12-22g, 2ml:0.25g props up, the ethanol 2200-2600g of volume fraction 75%.
Purpose to better implement the present invention, the present invention discloses again the preparation method of a kind of Chinese medicine composition treating acne, wherein,
By raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, Squama Manis, Radix Glycyrrhizae；
Soaking after being mixed 30 minutes to 1 hour, heated and boiled 30 minutes, filter, filtrate is standby；Filtering residue adds water, second time heating, boils 30 minutes, refilters, and filtrate is standby；Filtering residue adds water, for the third time heated and boiled 40 minutes, filters；Three filtrates being combined, heating is concentrated into pasty state, puts into baking oven, controls at 80 DEG C, cools down, obtain Chinese medicine powder after drying；
By Chinese medicine powder, sulfur, the chloramphenicol injection of 2ml:0.25g, pour into after the ethanol of volume fraction 75% soaks 48 hours, 3 extracting solution each 2 hours, are merged by heating and refluxing extraction 3 times, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/ml, to obtain final product.
When the present invention uses, dip in above-mentioned gained medicinal liquid by cotton swab or swab stick, smear at acne, three times a day.
Proportioning of the present invention is simple, and easy to use, bactericidal effect is good, suppresses sebum secretion, treats acne fast onset and is difficult to repeatedly recur.
Concrete principle is: the present invention includes the Chinese medicine powder that Chinese medicine composition prepares, sulfur and chloramphenicol injection.The part of Chinese medicine composition is: to give birth to Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, Radix Ampelopsis as monarch drug, with Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, Herba Lysimachiae as ministerial drug, with Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, Squama Manis as adjuvant drug, with Radix Glycyrrhizae for making medicine；The Chinese medicinal components constituted has anti-inflammation detumescence, disinfecting detoxifying, the effect of expelling pus and promoting granulation.
The sulfur added, belongs to multipurpose agent, in addition to having bactericidal action, moreover it is possible to mite killing and parasite killing (acarid is also one of origin cause of formation causing acne), effect is external energy killing parasites for relieving itching.Can be used for scabies, eczema, skin pruritus.Hydrogen sulfide and pentathionic acid, energy acaricide worm, antifungal, moreover it is possible to depilation is produced after it and contact skin.Sulfur and skin and contact tissue, generate sulfide under the effect of its secretions, make dermalaxia and bactericidal action.
The chloromycetin added: be the antibacterial of suppression bacterioprotein synthesis, and propionibacterium acnes (Propionibacterium acnes), also referred to as Propiobacterium, Propionibacterium, be the main bacteria causing comedo.This antibacterial can manufacture some enzyme decomposing skin histology and immunogenic protein, and chloromycetin suppresses this bacterial decomposition to manufacture protein.It is to be noted that chloromycetin is relatively big to the toxicity of blood system due to it, the most less using it to is injected or for oral administration, but, the present invention, by its external, ignores its impact on blood system.
The ethanol of the present invention, uses as solvent, and how many consumptions adjusts depending on practical situation.
Detailed description of the invention
The present invention treats the Chinese medicine composition of acne, wherein, the following composition including configuring according to unit of weight:
Raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, each 60-80g of Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, each 40-60g of Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, each 20-40g of Squama Manis, Radix Glycyrrhizae 10-20g；The chloramphenicol injection 5-15 of sulfur 10-30g, 2ml:0.25g props up, the ethanol 2000-3000g of volume fraction 75%.
Or, the following composition including configuring according to unit of weight:
Raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, each 60-70g of Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, each 40-50g of Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, each 20-30g of Squama Manis, Radix Glycyrrhizae 10-15g；The chloramphenicol injection 5-10 of sulfur 10-20g, 2ml:0.25g props up, the ethanol 2000-2500g of volume fraction 75%.
Or, the following composition including configuring according to unit of weight:
Raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, each 70-80g of Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, each 50-60g of Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, each 30-40g of Squama Manis, Radix Glycyrrhizae 15-20g；The chloramphenicol injection 10-15 of sulfur 20-30g, 2ml:0.25g props up, the ethanol 2500-3000g of volume fraction 75%.
Or, the following composition including configuring according to unit of weight:
Raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, each 65-75g of Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, each 45-55g of Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, each 25-35g of Squama Manis, Radix Glycyrrhizae 12-18g；The chloramphenicol injection 8-12 of sulfur 12-22g, 2ml:0.25g props up, the ethanol 2200-2600g of volume fraction 75%.
Preparation method:
By raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, Squama Manis, Radix Glycyrrhizae；
Soaking after being mixed 30 minutes to 1 hour, heated and boiled 30 minutes, filter, filtrate is standby；Filtering residue adds water, second time heating, boils 30 minutes, refilters, and filtrate is standby；Filtering residue adds water, for the third time heated and boiled 40 minutes, filters；Three filtrates being combined, heating is concentrated into pasty state, puts into baking oven, controls at 80 DEG C, cools down, obtain Chinese medicine powder after drying；
By Chinese medicine powder, sulfur, the chloramphenicol injection of 2ml:0.25g, pour into after the ethanol of volume fraction 75% soaks 48 hours, 3 extracting solution each 2 hours, are merged by heating and refluxing extraction 3 times, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/ml, to obtain final product.
When the present invention uses, dip in above-mentioned gained medicinal liquid by cotton swab or swab stick, smear at acne, three times a day.
Concrete example is as follows
Embodiment 1:
Miss Jin, 22 years old, forms hoary hair and acne at pore.Cortex is thickening, the tissue inflammation near pore, causes the skin sore of redness, especially more at chin.Local topical medicine adapalene gel is invalid, and doxycycline poor effect is administered orally afterwards, and acne recurs after calming down the most repeatedly.The use present invention:
Raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, each 60g of Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, each 40g of Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, each 20g of Squama Manis, Radix Glycyrrhizae 10g；The chloramphenicol injection of sulfur 10g, 2ml:0.25g 5, the ethanol 2000g of volume fraction 75%.
Preparation method: by raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, Squama Manis, Radix Glycyrrhizae；Soaking after being mixed 30 minutes to 1 hour, heated and boiled 30 minutes, filter, filtrate is standby；Filtering residue adds water, second time heating, boils 30 minutes, refilters, and filtrate is standby；Filtering residue adds water, for the third time heated and boiled 40 minutes, filters；Three filtrates being combined, heating is concentrated into pasty state, puts into baking oven, controls at 80 DEG C, cools down, obtain Chinese medicine powder after drying；
By Chinese medicine powder, sulfur, the chloramphenicol injection of 2ml:0.25g, pour into after the ethanol of volume fraction 75% soaks 48 hours, 3 extracting solution each 2 hours, are merged by heating and refluxing extraction 3 times, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/ml, to obtain final product.
When the present invention uses, dip in above-mentioned gained medicinal liquid by cotton swab or swab stick, smear at acne, three times a day.After 3 days, redness disappears, and after 6 days, hoary hair disappears, and after 10 days, acne is calmed down, and after 14 days, skin recovers smooth.Period keeps flat diet, visits, do not recur after 3 months.
Embodiment 2
Mrs Gong, 29 years old, skin rubefaction around acne and somewhat projection, there is pain.A large amount of sebums deposit in hair follicle, block hair follicle, have thickness pus after festering.Oral antibiotic minocycline, external used medicine tretinoin emulsifiable paste is the most invalid, the use present invention:
Raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, each 80g of Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, each 60g of Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, each 40g of Squama Manis, Radix Glycyrrhizae 20g；The chloramphenicol injection of sulfur 30g, 2ml:0.25g 15, the ethanol 3000g of volume fraction 75%.
Preparation method: by raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, Squama Manis, Radix Glycyrrhizae；Soaking after being mixed 30 minutes to 1 hour, heated and boiled 30 minutes, filter, filtrate is standby；Filtering residue adds water, second time heating, boils 30 minutes, refilters, and filtrate is standby；Filtering residue adds water, for the third time heated and boiled 40 minutes, filters；Three filtrates being combined, heating is concentrated into pasty state, puts into baking oven, controls at 80 DEG C, cools down, obtain Chinese medicine powder after drying；
By Chinese medicine powder, sulfur, the chloramphenicol injection of 2ml:0.25g, pour into after the ethanol of volume fraction 75% soaks 48 hours, 3 extracting solution each 2 hours, are merged by heating and refluxing extraction 3 times, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/ml, to obtain final product.
When the present invention uses, dip in above-mentioned gained medicinal liquid by cotton swab or swab stick, smear at acne, three times a day.Swelling and ache after 5 days and disappear, after 9 days, pus disappears, and after 14 days, acne is calmed down, and after 18 days, skin recovers smooth.Period keeps flat diet, visits, do not recur after 3 months.
Embodiment 3
Mr. Lu, 23 years old, face foxtail millet grain to pea-sized lesser tubercle, the bronzing that is translucent or brown, the softness touched, there are necrosis in central authorities, and external medication effect is small, repeatedly recurs, the use present invention:
Raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, each 70g of Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, each 50g of Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, each 30g of Squama Manis, Radix Glycyrrhizae 15g；The chloramphenicol injection of sulfur 20g, 2ml:0.25g 10, the ethanol 2500g of volume fraction 75%.
Preparation method: by raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, Squama Manis, Radix Glycyrrhizae；Soaking after being mixed 30 minutes to 1 hour, heated and boiled 30 minutes, filter, filtrate is standby；Filtering residue adds water, second time heating, boils 30 minutes, refilters, and filtrate is standby；Filtering residue adds water, for the third time heated and boiled 40 minutes, filters；Three filtrates being combined, heating is concentrated into pasty state, puts into baking oven, controls at 80 DEG C, cools down, obtain Chinese medicine powder after drying；
By Chinese medicine powder, sulfur, the chloramphenicol injection of 2ml:0.25g, pour into after the ethanol of volume fraction 75% soaks 48 hours, 3 extracting solution each 2 hours, are merged by heating and refluxing extraction 3 times, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/ml, to obtain final product.
When the present invention uses, dip in above-mentioned gained medicinal liquid by cotton swab or swab stick, smear at acne, three times a day.After 8 days, mottle alleviates, and after 15 days, lesser tubercle reduces, and within one month, posterior tubercle disappears, and skin recovers smooth.Period keeps flat diet, visits, do not recur after 3 months.
Embodiment 4
Mr. Hou, 20 years old, pore outlet obstruction, neighbouring tissue inflammation, cause the skin sore of redness.There is pus head on top, has thickness pus after festering.After oral antibiotic minocycline, recurrent exerbation, the use present invention:
Raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, each 65g of Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, each 45g of Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, each 25g of Squama Manis, Radix Glycyrrhizae 12g；The chloramphenicol injection of sulfur 12g, 2ml:0.25g 8, the ethanol 2200g of volume fraction 75%.
Preparation method: by raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, Squama Manis, Radix Glycyrrhizae；Soaking after being mixed 30 minutes to 1 hour, heated and boiled 30 minutes, filter, filtrate is standby；Filtering residue adds water, second time heating, boils 30 minutes, refilters, and filtrate is standby；Filtering residue adds water, for the third time heated and boiled 40 minutes, filters；Three filtrates being combined, heating is concentrated into pasty state, puts into baking oven, controls at 80 DEG C, cools down, obtain Chinese medicine powder after drying；
By Chinese medicine powder, sulfur, the chloramphenicol injection of 2ml:0.25g, pour into after the ethanol of volume fraction 75% soaks 48 hours, 3 extracting solution each 2 hours, are merged by heating and refluxing extraction 3 times, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/ml, to obtain final product.
When the present invention uses, dip in above-mentioned gained medicinal liquid by cotton swab or swab stick, smear at acne, three times a day.After 3 days, redness disappears, and after 6 days, pus head disappears, disappearance of festering after 12 days, and after 18 days, skin recovers smooth.Period keeps flat diet, visits, do not recur after 3 months.
One, comparative experiments:
Packet:
Example 1-4 gained medicinal liquid of the present invention is group 1-group 4,
Example 1 gained Chinese medicine powder of the present invention, adding water and being adjusted to paste is group 5,
Sulfur adds water and regulates mass percent 10% is group 6,
2ml:0.25g chloramphenicol injection be group 7,
Background technology 2014103993887 gains are group 8,
Background technology 2014100851210 gains are group 9,
Two, bacteriostatic experiment: propionibacterium acnes, use growth rate method, the strain that 6mm colony edge is vigorous is taken with card punch, it is placed on the PDA plate of dosing cultivation, the sterilized water adding equivalent with culture medium compares, it is repeated 3 times every time, it is placed in 25 degrees Celsius of cultivations, each colony diameter is surveyed by decussation method, the diameter of bacterium colony is represented with meansigma methods, in the culture dish of the propionibacterium acnes being respectively dropped into correspondence with group 1-9, 25 degrees Celsius of incubators are cultivated 48 hours, observe and sprout quantity, often process and set 5 repetitions, average, calculate germination rate and suppression ratio.
Germination rate %=has sprouted number/microscopy sum × 100%
Suppression ratio %=(compares germination rate-process germination rate)/comparison germination rate × 100%
Colony diameter (mm) and suppression ratio (100%), such as following table
To sum up, it appeared that: the Chinese medicine powder (group 5) of the present invention, sulfur (group 6), chloromycetin (group 7) all have inhibition to propionibacterium acnes, example 1-4(group 1-4 of the present invention) three is organically combined, the fungistatic effect obtained is substantially better than prior art (group 7 and group 8).
Three therapeutic effect compare:
Screen 270 example patients, before test 1 week, this crowd is carried out Continuous Observation, record symptom and change, is randomly divided into 9 groups, often organizes 30 people.
The medicine of 9 groups of 1-9 of use group respectively, external curing is after one month, comparison therapy effect:
Curative effect situation criterion: cure: after using this product, indices is replied normal；Effective: after taking and using this product, malaise symptoms makes moderate progress；Invalid: after using this product, malaise symptoms is unchanged.
Result is as shown in the table.
By upper table it is found that the therapeutic effect of the group 1-4 of the present invention is substantially better than prior art (group 7 and group 8), the most simple Chinese medicine powder (group 5), sulfur (group 6), chloromycetin (group 7) therapeutic effect good.
To sum up, proportioning of the present invention is simple, and easy to use, bactericidal effect is good, suppresses sebum secretion, treats acne fast onset and is difficult to repeatedly recur.
Concrete principle is: the present invention includes the Chinese medicine powder that Chinese medicine composition prepares, sulfur and chloramphenicol injection.The part of Chinese medicine composition is: to give birth to Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, Radix Ampelopsis as monarch drug, with Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, Herba Lysimachiae as ministerial drug, with Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, Squama Manis as adjuvant drug, with Radix Glycyrrhizae for making medicine；The Chinese medicinal components constituted has anti-inflammation detumescence, disinfecting detoxifying, the effect of expelling pus and promoting granulation.
The sulfur added, belongs to multipurpose agent, in addition to having bactericidal action, moreover it is possible to mite killing and parasite killing (acarid is also one of origin cause of formation causing acne), effect is external energy killing parasites for relieving itching.Can be used for scabies, eczema, skin pruritus.Hydrogen sulfide and pentathionic acid, energy acaricide worm, antifungal, moreover it is possible to depilation is produced after it and contact skin.Sulfur and skin and contact tissue, generate sulfide under the effect of its secretions, make dermalaxia and bactericidal action.
The chloromycetin added: be the antibacterial of suppression bacterioprotein synthesis, and propionibacterium acnes (Propionibacterium acnes), also referred to as Propiobacterium, Propionibacterium, be the main bacteria causing comedo.This antibacterial can manufacture some enzyme decomposing skin histology and immunogenic protein, and chloromycetin suppresses this bacterial decomposition to manufacture protein.It is to be noted that chloromycetin is relatively big to the toxicity of blood system due to it, the most less using it to is injected or for oral administration, but, the present invention, by its external, ignores its impact on blood system.

Claims (5)

1. the Chinese medicine composition treating acne, it is characterised in that include according to unit of weight configuration following composition:
Raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, each 60-80g of Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, each 40-60g of Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, each 20-40g of Squama Manis, Radix Glycyrrhizae 10-20g；The chloramphenicol injection 5-15 of sulfur 10-30g, 2ml:0.25g props up, the ethanol 2000-3000g of volume fraction 75%.
Treat the Chinese medicine composition of acne the most according to claim 1, it is characterised in that include according to unit of weight configuration following composition:
Raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, each 60-70g of Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, each 40-50g of Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, each 20-30g of Squama Manis, Radix Glycyrrhizae 10-15g；The chloramphenicol injection 5-10 of sulfur 10-20g, 2ml:0.25g props up, the ethanol 2000-2500g of volume fraction 75%.
Treat the Chinese medicine composition of acne the most according to claim 1, it is characterised in that include according to unit of weight configuration following composition:
Raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, each 70-80g of Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, each 50-60g of Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, each 30-40g of Squama Manis, Radix Glycyrrhizae 15-20g；The chloramphenicol injection 10-15 of sulfur 20-30g, 2ml:0.25g props up, the ethanol 2500-3000g of volume fraction 75%.
Treat the Chinese medicine composition of acne the most according to claim 1, it is characterised in that include according to unit of weight configuration following composition:
Raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, each 65-75g of Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, each 45-55g of Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, each 25-35g of Squama Manis, Radix Glycyrrhizae 12-18g；The chloramphenicol injection 8-12 of sulfur 12-22g, 2ml:0.25g props up, the ethanol 2200-2600g of volume fraction 75%.
5. the preparation method of the Chinese medicine composition treating acne as described in claim 1-4 is arbitrary, it is characterised in that
By raw Semen Armeniacae Amarum, Radix Salviae Miltiorrhizae, Radix Ampelopsis, Flos Chrysanthemi Indici, Ilex purpurea Hassk.[I.chinensis Sims, Caulis Trachelospermi, Cortex Phellodendri, Semen phaseoli radiati, Herba Lysimachiae, Herba Portulacae, Fructus Arctii, Gypsum Fibrosum, Borax, Folium Bambusae, catechu, Herba Commelinae, Squama Manis, Radix Glycyrrhizae；
Soaking after being mixed 30 minutes to 1 hour, heated and boiled 30 minutes, filter, filtrate is standby；Filtering residue adds water, second time heating, boils 30 minutes, refilters, and filtrate is standby；Filtering residue adds water, for the third time heated and boiled 40 minutes, filters；Three filtrates being combined, heating is concentrated into pasty state, puts into baking oven, controls at 80 DEG C, cools down, obtain Chinese medicine powder after drying；
By Chinese medicine powder, sulfur, the chloramphenicol injection of 2ml:0.25g, pour into after the ethanol of volume fraction 75% soaks 48 hours, 3 extracting solution each 2 hours, are merged by heating and refluxing extraction 3 times, decompression recycling ethanol, and to be concentrated into liquor strength be 0.5g crude drug/ml, to obtain final product.
CN201610158596.7A 2016-03-21 2016-03-21 Chinese herbal medicine composition for treating acnes Withdrawn CN105727028A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106236942A (en) * 2016-08-11 2016-12-21 邢献林 Chinese medicine composition for the treatment of oral ulcer and other disease of cari oris mucosa and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106236942A (en) * 2016-08-11 2016-12-21 邢献林 Chinese medicine composition for the treatment of oral ulcer and other disease of cari oris mucosa and preparation method thereof

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Application publication date: 20160706