CN105727018A - External preparation used for treating epistaxis and preparation method - Google Patents
External preparation used for treating epistaxis and preparation method Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention discloses an external preparation used for treating epistaxis. The preparation method is mainly prepared from, by mass, 5-12 parts of alligator weed, 2-6 parts of Asplenium incisum Thunb., 4-9 parts of anoectochilus roxburghii, 7-15 parts of pellionia repens, 10-18 parts of pear roots, 8-14 parts of japanese spicebush bark, 6-10 parts of rubia cordifolia, 3-9 parts of symplocos chinensis, 5-11 parts of Penthorum Chinese Pursh, 9-17 parts of isodon amethystoides, 4-8 parts of broad bean flowers, 5-13 parts of lysimachia fortunei maxim, 9-15 parts of micromelum integerrimum roem and 7-14 parts of aneurolepidium roots. The external preparation is a traditional Chinese medicine preparation, is safe to use and wide in applicability, and can be easily accepted by patients. The formula is obtained according to practical experience of many years, the external preparation has the effects of clearing away heat and relieving exterior syndromes, stopping bleeding and nourishing qi and the like, and the external preparation is good in treatment effect, takes effect quickly, prevents relapse and is worthy of popularization.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of external preparation for treating epistaxis and preparation method.
Background technology
Epistaxis is one of clinical common symptom, is commonly called as epistaxis.Can be caused by nasal disease, it is possible to caused by general disease.Epistaxis is different due to reason its performance different, and most epistaxiss are unilateral, also can be bilateral；Can interval Repeated Hemorrhage, also can be in continued hemorrhage.How many amounts of bleeding differs, band blood, few drops or several milliliters in the lighter's tears, severe one up to tens milliliters of milliliters the most hundreds of more than, cause hemorrhagic shock.Repeated Hemorrhage can cause anemia.Minority is the most hemorrhage can be stopped after only or oppressing voluntarily.Bleeding part majority betides easy the to be hemorrhage district of nasal septum front lower portion, and visible ejection or pulsation small artery are hemorrhage sometimes, and children, adolescence's epistaxis is multiple is born in this district.The epistaxis of middle-aged and elderly people, usually relevant with hypertension and arteriosclerosis, nasal cavity rear portion is more common in bleeding part, is positioned at the woodruff's naso-nasopharyngeal venous plexus-woodruff's plexus near concha nasalis inferior rear end and the tremulous pulse at nasal septum rear portion.This position is hemorrhage the most violent, is difficult to hemostasis, and hemorrhage inflow the most rapidly is pharyngeal, spues from mouth.The multiple side nasal cavity of being born in of epistaxis that topical disorders causes, and general disease causer, possible both sides nasal cavity is the most hemorrhage.Epistaxis belongs to emergency case, and first should sustain life during treatment sign, stops blooding the most rapidly, and etiological treatment.
Publication No. CN 104491382 A(application number 201410680741.9) Chinese patent literature disclose treatment epistaxis Chinese medicine formula, including Radix Rehmanniae 18-23g, Fructus Gardeniae 12-15g, 10-12g Radix Ophiopogonis, Cortex Moutan 12-15g, Herba Cirsii 8-10g, Radix Scutellariae 12-15g, Semen Ziziphi Spinosae 8-10g, Radix Et Rhizoma Rhei 6-8g, Radix Cirsii Japonici 8-10g.Publication No. CN 103800714 A(application number 201210547400.5) Chinese patent literature disclose a kind of Chinese herbal medicine treating epistaxis, be made up of the medicine of following weight proportion: Radix Rehmanniae Preparata 30～45 parts；Radix Ophiopogonis 25～35 parts；Gypsum Fibrosum 30～35 parts；The Rhizoma Anemarrhenae 25～35 parts；Radix Achyranthis Bidentatae 25～35 parts；Rhizoma Imperatae 30～50 parts；Cacumen Platycladi 25～35 parts.Publication No. CN 103656119 A(application number 201210356172.3) Chinese patent literature disclose a kind of Chinese medicine preparation curing mainly epistaxis, it is made up of the raw material of Chinese medicine of following weight: Radix Rehmanniae 10-18 gram, Radix Paeoniae Rubra 11-17 gram, Cortex Moutan 10-20 gram, Rhizoma Anemarrhenae 12-16 gram, Gypsum Fibrosum 27-32 gram, Cornu Bubali 50-63 gram, 3-8 gram of Radix Glycyrrhizae.
Conventional Chinese medicine formula treatment epistaxis effect is not notable, and easily recurs, and therefore needs to improve further the curative effect of Chinese traditional treatment epistaxis, needs to develop a kind of instant effect, the Chinese medicine preparation of anti-recurrence.
Summary of the invention
For the deficiencies in the prior art, it is an object of the invention to provide external preparation and the preparation method for treating epistaxis of a kind of good effect, instant effect.
The technical scheme is that
For treating the external preparation of epistaxis, mainly it is prepared from by following bulk drugs, is mass parts: Radix Alternantherae philoxeroidis 5-12, rock spring grass 2-6, gold line 4-9, Herba Pellioniae repentis 7-15, Radix pyri 10-18, Cortex Linderae Obtusilobae 8-14, Radix Rubiae 6-10, Ramulus et Folium Symplocoris Chinensis 3-9, Herba Penthori chinensis 5-11, Herba Rabdosiae glaucocalycis 9-17, Flos Viciae fabae 4-8, big Herba Hyperici Japonici 5-13, Radix Micromeli Integerrimi 9-15, Radix Aneurolepidii 7-14.
Preferably in scheme, Radix Alternantherae philoxeroidis 7-10, rock spring grass 3-5, gold line 5-8, Herba Pellioniae repentis 9-13, Radix pyri 12-16, Cortex Linderae Obtusilobae 10-12, Radix Rubiae 7-9, Ramulus et Folium Symplocoris Chinensis 5-7, Herba Penthori chinensis 7-9, Herba Rabdosiae glaucocalycis 11-15, Flos Viciae fabae 5-7, big Herba Hyperici Japonici 8-10, Radix Micromeli Integerrimi 10-14, Radix Aneurolepidii 9-12.
More preferably, Radix Alternantherae philoxeroidis 8.5, rock spring grass 4, gold line 6.5, Herba Pellioniae repentis 11, Radix pyri 14, Cortex Linderae Obtusilobae 11, Radix Rubiae 8, Ramulus et Folium Symplocoris Chinensis 6, Herba Penthori chinensis 8, Herba Rabdosiae glaucocalycis 13, Flos Viciae fabae 6, big Herba Hyperici Japonici 9, Radix Micromeli Integerrimi 12, Radix Aneurolepidii 10.5.
The preparation method of the described external preparation for treating epistaxis, step is:
(1) Radix Alternantherae philoxeroidis, Radix Rubiae, Ramulus et Folium Symplocoris Chinensis and Radix Aneurolepidii roguing are taken, section, to mix thoroughly with sweet wine and Saccharum Sinensis Roxb., then be placed in container, Steam by water bath takes out thoroughly, dries；
(2) Cortex Linderae Obtusilobae and Radix Micromeli Integerrimi are cleaned, boil to being boiling for 7-13 minute (preferably, lasting 8-12 minute with vinegar；More preferably, continue 10 minutes), taking-up drains, and is placed in intense fire heating in frying pan, fries and take out to during surface coke brown, dry in the air cool；
(3) being placed in frying pan by Flos Viciae fabae, intense fire heats, and fries and has focal spot to surface, drenches and mix thoroughly into refined honey, fries and takes out to time tack-free, dries in the air cool；
(4) rock spring grass, gold line, Herba Pellioniae repentis, Radix pyri, Herba Penthori chinensis, Herba Rabdosiae glaucocalycis and big Herba Hyperici Japonici are cleaned, add water boil, turn boiling with soft fire 20-35 minute and (preferably, turn boiling with soft fire 25-30 minute；More preferably, turn boiling with soft fire 27 minutes), filter, filtering residue adds water and boils, and after big fire is boiled, little fire is decocted 15-20 minute (preferably, little fire is decocted 16-19 minute；More preferably, little fire decocts 17 minutes), filter, merge twice gained filtrate；
(5) step (1) (2) (3) made crude drug being pulverized 80 mesh sieves, the heated and boiled that adds water, after 15 minutes, is added a cover vexed 2-6 hour and (preferably, is added a cover vexed 3-5 hour；More preferably, add a cover vexed 4 hours), to filter, gained filtrate merges mixing with step (4) made filtrate, concentrates, and adds concentrated liquid and amasss the tween 80 vibration mixing of 2%, stands 4-8 hour and (preferably, stand 5-7 hour；More preferably, stand 6 hours), filter, embedding, prepare spray, obtain external preparation.
The preparation method of the described external preparation for treating epistaxis, (preferably, the amount of sweet wine is 2.5-3.5 times of crude drug quality to 2-4 times that amount is crude drug quality of step (1) sweet wine；More preferably, the amount of sweet wine is 3 times of crude drug quality).
The preparation method of the described external preparation for treating epistaxis, (preferably, the amount of Saccharum Sinensis Roxb. is 0.6-0.7 times of crude drug quality to 0.5-0.8 times that amount is crude drug quality of step (1) Saccharum Sinensis Roxb.；More preferably, the amount of Saccharum Sinensis Roxb. is 0.65 times of crude drug quality).
The preparation method of the described external preparation for treating epistaxis, 0.1-0.3 times (preferably, the amount of refined honey is 0.2 times of crude drug quality) that amount is crude drug quality of step (3) refined honey.
The preparation method of the described external preparation for treating epistaxis, (preferably, amount of water is 5-6 times of boiled crude drug quality to 4-7 times that step (4) amount of water is boiled crude drug quality；More preferably, amount of water is 5.5 times of boiled crude drug quality).
The preparation method of the described external preparation for treating epistaxis, (preferably, amount of water is 6-7 times of boiled crude drug quality to 5-8 times that step (5) amount of water is boiled crude drug quality；More preferably, amount of water is 6.5 times of boiled crude drug quality).
The preparation method of the described external preparation for treating epistaxis, the mass ratio of volume and crude drug that step (5) is concentrated into filtrate is 3-5:1(g/ml) (preferably, the mass ratio of the volume and crude drug that are concentrated into filtrate is 4:1).
It is simple for treating the external preparation preparation of epistaxis that the present invention provides, and methodological science is easy to use.In addition, the excellent results of the present invention is also manifested by:
1, the present invention is Chinese medicine preparation, uses safety, and the suitability is wide, and patient is easily accepted by；
2, this prescription is summed up according to years'experiences and is obtained, and has the effect such as clearing away heat and expelling pathogen in the exterior, hemostasis QI invigorating；
3, good effect of the present invention, instant effect, anti-recurrence, it is worthy to be popularized.
Detailed description of the invention
Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.
Used by the present invention, the pharmacology of main raw material of Chinese medicine is as follows:
Radix Alternantherae philoxeroidis: base: for root or the stem and leaf of amaranthaceous plant Alternanthera philoxeroides.Nature and flavor: bitter, sweet, cold in nature.Gui Jing: lung, the heart, liver, bladder warp.Function cures mainly: clearing away heat and cooling blood, removing toxic substances, diuresis.Main hemoptysis, hematuria, cold, fever, measles, encephalitis B, jaundice, stranguria with turbid discharge, mumps, eczema, carbuncle furuncle, venom.
Rock spring grass: base: for the herb of Aspleniaceae plant tiger tail Asplenium trchomanes L..Nature and flavor: bitter, sweet, cool.Function cures mainly: heat-clearing and toxic substances removing, checking hyperfunction of the liver for relieving convulsion, diuresis of stopping blooding.Main acute icteric infectious hepatitis, cough due to lung-heat, infantile convulsion, dysuria, dactylitis, venom
Gold line: base: for the herb of gentianaceae plant Hong Kong Tripterospermum affine.Nature and flavor: sweet, pungent, cold in nature.Function cures mainly: heat-clearing and toxic substances removing, cough-relieving, hemostasis.Main cough due to lung-heat, spitting of blood, lung abscess, urine leaching is puckery, acute mastitis, furuncle furuncle and phyma, traumatic hemorrhage.
Herba Pellioniae repentis: base: for the herb of contrayerva Herba Pellioniae repentis.Nature and flavor: sweet, micro-puckery are cool.Function cures mainly: clearing away heat-damp and promoting diuresis.Treating acute and chronic hepatitis, neurasthenia.Allergic dermatitis, ulcer of the lower limb and furuncle and phyma are controlled in external.
Radix pyri: base: for the root of rosaceous plant Pyrus bretschneideri, Nashi Pear or Pyrus ussuriensis Maxim etc..Nature and flavor: sweet light, flat, nontoxic.Gui Jing: lung, large intestine channel.Function cures mainly: clearing away lung-heat to relieve cough, regulating QI to relieve pain.Main cough due to deficiency of the lung, hernia is suffered from abdominal pain.
Cortex Linderae Obtusilobae: base: for the bark of canella Cortex Linderae Obtusilobae.Nature and flavor: pungent, temperature.Gui Jing: stomach, Liver Channel.Function cures mainly: warming middle-JIAO to promote flow of QI, promoting blood circulation to remove blood stasis.Main trusted subordinate's pain, traumatic injury, swelling and pain due to blood stasis, sore.
Radix Rubiae: base: for root and the rhizome of Maguireothamnus speciosus Radix Rubiae.Nature and flavor: bitter, cold.Gui Jing: return Liver Channel.Function cures mainly: removing heat from blood and promoting blood circulation, and blood stasis dispelling stimulates the menstrual flow.For spitting blood, epistaxis, metrostaxis, traumatic hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling.Cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling: this product is stopped blooding and do not stayed the stasis of blood, amenorrhea stomachache, traumatic injury hemorrhage for heat syndrome.Join Os Sepiae hemostasis power higher.
Ramulus et Folium Symplocoris Chinensis: base: for the branch and leaf of Symplocaceae plant Ramulus et Folium Symplocoris Chinensis.Nature and flavor: bitter, cool in nature, mild toxicity.Gui Jing: stomach, large intestine channel.Function cures mainly: clearing away heat-damp and promoting diuresis, removing toxic substances, hemostasia and promoting granulation.Main dysentery, sore swollen toxin, wound hemorrhage, burn and scald, ulcer.
Herba Penthori chinensis: base: for the herb of saxifragaceae plant Herba Lysimachiae Clethroids.Nature and flavor: sweet, temperature.Function cures mainly: invigorate blood circulation, row water.Control amenorrhea, edema, metrorrhagia, leukorrhagia, traumatic injury.
Herba Rabdosiae glaucocalycis: base: for the herb of labiate Rabdosia japonica.Nature and flavor: pungent, bitter are cool.Function cures mainly: heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.For venom, treating swelling and pain by traumatic injury, muscles and bones aches, skin infection.
Flos Viciae fabae: base: for the flower of leguminous plant Semen Viciae fabae.Nature and flavor: sweet are flat.Function cures mainly: removing heat from blood, hemostasis.Control hemoptysis, epistaxis, dysentery, leukorrhagia, hypertension.
Big Herba Hyperici Japonici: base: for herb or the root of Ofthe Primulaceae Arisaema balansae Engl. grass.Nature and flavor: bitter, pungent, cool in nature.Function cures mainly: clearing away heat-damp and promoting diuresis, removing heat from blood and promoting blood circulation, removing toxic substances and promoting subsidence of swelling.Main jaundice, dysentery, conjunctival congestion, spit blood, stranguria with blood, leucorrhea, metrorrhagia, dysmenorrhea, amenorrhea, laryngopharynx swelling and pain, carbuncle sore tumefacting virus, erysipelas, scrofula, traumatic injury, snake bite and insect sting.
Radix Micromeli Integerrimi: base: for root, bark or the leaf of rutaceae Radix Micromeli Integerrimi.Nature and flavor: bitter, pungent, temperature.Function cures mainly: dispelling wind to relieve the exterior syndrome, eliminating stasis to stop pain.Curing mainly cold cough, stomachache, rheumatic ostalgia, external is controlled treating swelling and pain by traumatic injury, is fractured.
Radix Aneurolepidii: base: rely the root of grass for grass.Nature and flavor: sweet, cold.Function cures mainly: heat clearing away, hemostasis, diuresis.Cure cold, epistaxis, asthma.
Embodiment 1 For treating the external preparation of epistaxis, mainly it is prepared from (every part of 10g) by following bulk drugs: Radix Alternantherae philoxeroidis 5 parts, rock spring grass 2 parts, gold line 4 parts, Herba Pellioniae repentis 7 parts, Radix pyri 10 parts, Cortex Linderae Obtusilobae 8 parts, 6 parts of Radix Rubiae, Ramulus et Folium Symplocoris Chinensis 3 parts, Herba Penthori chinensis 5 parts, Herba Rabdosiae glaucocalycis 9 parts, Flos Viciae fabae 4 parts, big Herba Hyperici Japonici 5 parts, Radix Micromeli Integerrimi 9 parts, Radix Aneurolepidii 7 parts.
The preparation method of the above-mentioned external preparation for treating epistaxis is:
(1) Radix Alternantherae philoxeroidis, Radix Rubiae, Ramulus et Folium Symplocoris Chinensis and Radix Aneurolepidii roguing are taken, section, to mix 2 times and 0.5 times of crude drug quality (amount of sweet wine and Saccharum Sinensis Roxb. be respectively) thoroughly with sweet wine and Saccharum Sinensis Roxb., then be placed in container, Steam by water bath takes out thoroughly, dries；
(2) Cortex Linderae Obtusilobae and Radix Micromeli Integerrimi being cleaned, boil to being boiling for 7 minutes with vinegar, taking-up drains, and is placed in intense fire heating in frying pan, fries and take out to during surface coke brown, dry in the air cool；
(3) being placed in frying pan by Flos Viciae fabae, intense fire heats, and fries and has focal spot to surface, drenches and mixes 0.1 times of crude drug quality (amount of refined honey be) thoroughly into refined honey, fries and takes out to time the most tack-free, dries in the air cool；
(4) rock spring grass, gold line, Herba Pellioniae repentis, Radix pyri, Herba Penthori chinensis, Herba Rabdosiae glaucocalycis and big Herba Hyperici Japonici are cleaned, add water boil (amount of water is 4 times of boiled crude drug quality), turn boiling with soft fire 20 minutes, filter, filtering residue adds water and boils, after big fire is boiled, little fire is decocted 15 minutes, filters, merges twice gained filtrate；
(5) step (1) (2) (3) made crude drug being pulverized 80 mesh sieves, the heated and boiled that adds water is (amount of water is 5 times of boiled crude drug quality) after 15 minutes, adds a cover vexed 2 hours, filter, gained filtrate merges mixing with step (4) made filtrate, concentrates, and the mass ratio of the volume and crude drug that are concentrated into filtrate is 3:1(g/ml), add concentrated liquid and amass the tween 80 vibration mixing of 2%, stand 4 hours, filter, embedding, prepare spray, obtain external preparation.
Embodiment 2 For treating the external preparation of epistaxis, mainly it is prepared from (every part of 10g) by following bulk drugs: Radix Alternantherae philoxeroidis 12 parts, rock spring grass 6 parts, gold line 9 parts, Herba Pellioniae repentis 15 parts, Radix pyri 18 parts, Cortex Linderae Obtusilobae 14 parts, 10 parts of Radix Rubiae, Ramulus et Folium Symplocoris Chinensis 9 parts, Herba Penthori chinensis 11 parts, Herba Rabdosiae glaucocalycis 17 parts, Flos Viciae fabae 8 parts, big Herba Hyperici Japonici 13 parts, Radix Micromeli Integerrimi 15 parts, Radix Aneurolepidii 14 parts.
For treating the preparation method of the external preparation of epistaxis it is:
(1) Radix Alternantherae philoxeroidis, Radix Rubiae, Ramulus et Folium Symplocoris Chinensis and Radix Aneurolepidii roguing are taken, section, to mix 4 times and 0.8 times of crude drug quality (amount of sweet wine and Saccharum Sinensis Roxb. be respectively) thoroughly with sweet wine and Saccharum Sinensis Roxb., then be placed in container, Steam by water bath takes out thoroughly, dries；
(2) Cortex Linderae Obtusilobae and Radix Micromeli Integerrimi being cleaned, boil to being boiling for 13 minutes with vinegar, taking-up drains, and is placed in intense fire heating in frying pan, fries and take out to during surface coke brown, dry in the air cool；
(3) being placed in frying pan by Flos Viciae fabae, intense fire heats, and fries and has focal spot to surface, drenches and mixes 0.3 times of crude drug quality (amount of refined honey be) thoroughly into refined honey, fries and takes out to time the most tack-free, dries in the air cool；
(4) rock spring grass, gold line, Herba Pellioniae repentis, Radix pyri, Herba Penthori chinensis, Herba Rabdosiae glaucocalycis and big Herba Hyperici Japonici are cleaned, add water boil (amount of water is 7 times of boiled crude drug quality), turn boiling with soft fire 35 minutes, filter, filtering residue adds water and boils, after big fire is boiled, little fire is decocted 20 minutes, filters, merges twice gained filtrate；
(5) step (1) (2) (3) made crude drug being pulverized 80 mesh sieves, the heated and boiled that adds water is (amount of water is 8 times of boiled crude drug quality) after 15 minutes, adds a cover vexed 6 hours, filter, gained filtrate merges mixing with step (4) made filtrate, concentrates, and the mass ratio of the volume and crude drug that are concentrated into filtrate is 5:1(g/ml), add concentrated liquid and amass the tween 80 vibration mixing of 2%, stand 8 hours, filter, embedding, prepare spray, obtain external preparation.
Model case: xxx, female, 23 years old.Main suit: often there will be epistaxis from little, attempts multiple method therapeutic effect the most undesirable, within nearly 3 years, catches a cold every time or epistaxis must occur in cough, with headache, rhinocnesmus, heating, uses gelfoam to stop blooding or intramuscular injection hemostatic needle during outbreak every time.Nearly one week flu of catching a cold, bleeds more than, uses the present embodiment gained for treating the external preparation of epistaxis, is sprayed on affected part, every day 3-4 time, 7 days courses for the treatment of.After using one day, stopping of bleeding, after using 3 days, bleeding capacity reduces, and uses one course for the treatment of, occurs bleeding the most again, is continuing with drug withdrawal after two courses for the treatment of, after catch a cold to catch a cold and do not bleed occurring, follow up a case by regular visits to after 1 year recur the most again.
Embodiment 3For treating the external preparation of epistaxis, mainly it is prepared from (every part of 10g) by following bulk drugs: Radix Alternantherae philoxeroidis 7 parts, rock spring grass 3 parts, gold line 5 parts, Herba Pellioniae repentis 9 parts, Radix pyri 12 parts, Cortex Linderae Obtusilobae 10 parts, 7 parts of Radix Rubiae, Ramulus et Folium Symplocoris Chinensis 5 parts, Herba Penthori chinensis 7 parts, Herba Rabdosiae glaucocalycis 11 parts, Flos Viciae fabae 5 parts, big Herba Hyperici Japonici 8 parts, Radix Micromeli Integerrimi 10 parts, Radix Aneurolepidii 9 parts.
For treating the preparation method of the external preparation of epistaxis it is:
(1) Radix Alternantherae philoxeroidis, Radix Rubiae, Ramulus et Folium Symplocoris Chinensis and Radix Aneurolepidii roguing are taken, section, to mix 2.5 times and 0.6 times of crude drug quality (amount of sweet wine and Saccharum Sinensis Roxb. be respectively) thoroughly with sweet wine and Saccharum Sinensis Roxb., then be placed in container, Steam by water bath takes out thoroughly, dries；
(2) Cortex Linderae Obtusilobae and Radix Micromeli Integerrimi being cleaned, boil to being boiling for 8 minutes with vinegar, taking-up drains, and is placed in intense fire heating in frying pan, fries and take out to during surface coke brown, dry in the air cool；
(3) being placed in frying pan by Flos Viciae fabae, intense fire heats, and fries and has focal spot to surface, drenches and mixes 0.1 times of crude drug quality (amount of refined honey be) thoroughly into refined honey, fries and takes out to time the most tack-free, dries in the air cool；
(4) rock spring grass, gold line, Herba Pellioniae repentis, Radix pyri, Herba Penthori chinensis, Herba Rabdosiae glaucocalycis and big Herba Hyperici Japonici are cleaned, add water boil (amount of water is 5 times of boiled crude drug quality), turn boiling with soft fire 25 minutes, filter, filtering residue adds water and boils, after big fire is boiled, little fire is decocted 16 minutes, filters, merges twice gained filtrate；
(5) step (1) (2) (3) made crude drug being pulverized 80 mesh sieves, the heated and boiled that adds water is (amount of water is 6 times of boiled crude drug quality) after 15 minutes, adds a cover vexed 3 hours, filter, gained filtrate merges mixing with step (4) made filtrate, concentrates, and the mass ratio of the volume and crude drug that are concentrated into filtrate is 3:1(g/ml), add concentrated liquid and amass the tween 80 vibration mixing of 2%, stand 5 hours, filter, embedding, prepare spray, obtain external preparation.
Embodiment 4For treating the external preparation of epistaxis, mainly it is prepared from (every part of 10g) by following bulk drugs: Radix Alternantherae philoxeroidis 10 parts, rock spring grass 5 parts, gold line 8 parts, Herba Pellioniae repentis 13 parts, Radix pyri 16 parts, Cortex Linderae Obtusilobae 12 parts, 9 parts of Radix Rubiae, Ramulus et Folium Symplocoris Chinensis 7 parts, Herba Penthori chinensis 9 parts, Herba Rabdosiae glaucocalycis 15 parts, Flos Viciae fabae 7 parts, big Herba Hyperici Japonici 10 parts, Radix Micromeli Integerrimi 14 parts, Radix Aneurolepidii 12 parts.
For treating the preparation method of the external preparation of epistaxis it is:
(1) Radix Alternantherae philoxeroidis, Radix Rubiae, Ramulus et Folium Symplocoris Chinensis and Radix Aneurolepidii roguing are taken, section, to mix 3.5 times and 0.7 times of crude drug quality (amount of sweet wine and Saccharum Sinensis Roxb. be respectively) thoroughly with sweet wine and Saccharum Sinensis Roxb., then be placed in container, Steam by water bath takes out thoroughly, dries；
(2) Cortex Linderae Obtusilobae and Radix Micromeli Integerrimi being cleaned, boil to being boiling for 12 minutes with vinegar, taking-up drains, and is placed in intense fire heating in frying pan, fries and take out to during surface coke brown, dry in the air cool；
(3) being placed in frying pan by Flos Viciae fabae, intense fire heats, and fries and has focal spot to surface, drenches and mixes 0.3 times of crude drug quality (amount of refined honey be) thoroughly into refined honey, fries and takes out to time the most tack-free, dries in the air cool；
(4) rock spring grass, gold line, Herba Pellioniae repentis, Radix pyri, Herba Penthori chinensis, Herba Rabdosiae glaucocalycis and big Herba Hyperici Japonici are cleaned, add water boil (amount of water is 6 times of boiled crude drug quality), turn boiling with soft fire 30 minutes, filter, filtering residue adds water and boils, after big fire is boiled, little fire is decocted 19 minutes, filters, merges twice gained filtrate；
(5) step (1) (2) (3) made crude drug being pulverized 80 mesh sieves, the heated and boiled that adds water is (amount of water is 7 times of boiled crude drug quality) after 15 minutes, adds a cover vexed 5 hours, filter, gained filtrate merges mixing with step (4) made filtrate, concentrates, and the mass ratio of the volume and crude drug that are concentrated into filtrate is 5:1(g/ml), add concentrated liquid and amass the tween 80 vibration mixing of 2%, stand 7 hours, filter, embedding, prepare spray, obtain external preparation.
Model case: xxx, man, 45 years old.Without the appearance nosebleed of obvious inducement before one month, amount is few, time continuous when stopping, originally do not do and pay attention to, within nearly one week, amount of bleeding increases, and every day is for several times, and community office diagnostics is epistaxis, and carries out the filling of nasal cavity yarn block, transfusion antiinflammatory, stopped bleeding, nasal cavity is bled profusely again two days later.Use the present embodiment gained for treating the external preparation of epistaxis upon somebody's introduction, be sprayed on affected part, every day 3-4 time, 7 days courses for the treatment of.Use after half a day, stopping of bleeding, after using one day, bleed number of times and bleeding capacity all significantly reduces, within one day, bleed once or two days once, each few drops, after using a course for the treatment of, stopping of bleeding, adhere to using drug withdrawal after two courses for the treatment of, follow up a case by regular visits to after half a year recur the most again.
Embodiment 5 For treating the external preparation of epistaxis, mainly it is prepared from (every part of 10g) by following bulk drugs: Radix Alternantherae philoxeroidis 8.5 parts, rock spring grass 4 parts, gold line 6.5 parts, Herba Pellioniae repentis 11 parts, Radix pyri 14 parts, Cortex Linderae Obtusilobae 11 parts, 8 parts of Radix Rubiae, Ramulus et Folium Symplocoris Chinensis 6 parts, Herba Penthori chinensis 8 parts, Herba Rabdosiae glaucocalycis 13 parts, Flos Viciae fabae 6 parts, big Herba Hyperici Japonici 9 parts, Radix Micromeli Integerrimi 12 parts, Radix Aneurolepidii 10.5 parts.
For treating the preparation method of the external preparation of epistaxis it is:
(1) Radix Alternantherae philoxeroidis, Radix Rubiae, Ramulus et Folium Symplocoris Chinensis and Radix Aneurolepidii roguing are taken, section, to mix 3 times and 0.65 times of crude drug quality (amount of sweet wine and Saccharum Sinensis Roxb. be respectively) thoroughly with sweet wine and Saccharum Sinensis Roxb., then be placed in container, Steam by water bath takes out thoroughly, dries；
(2) Cortex Linderae Obtusilobae and Radix Micromeli Integerrimi being cleaned, boil to being boiling for 10 minutes with vinegar, taking-up drains, and is placed in intense fire heating in frying pan, fries and take out to during surface coke brown, dry in the air cool；
(3) being placed in frying pan by Flos Viciae fabae, intense fire heats, and fries and has focal spot to surface, drenches and mixes 0.2 times of crude drug quality (amount of refined honey be) thoroughly into refined honey, fries and takes out to time the most tack-free, dries in the air cool；
(4) rock spring grass, gold line, Herba Pellioniae repentis, Radix pyri, Herba Penthori chinensis, Herba Rabdosiae glaucocalycis and big Herba Hyperici Japonici are cleaned, add water boil (amount of water is 5.5 times of boiled crude drug quality), turn boiling with soft fire 27 minutes, filter, filtering residue adds water and boils, after big fire is boiled, little fire is decocted 17 minutes, filters, merges twice gained filtrate；
(5) step (1) (2) (3) made crude drug being pulverized 80 mesh sieves, the heated and boiled that adds water is (amount of water is 6.5 times of boiled crude drug quality) after 15 minutes, adds a cover vexed 4 hours, filter, gained filtrate merges mixing with step (4) made filtrate, concentrates, and the mass ratio of the volume and crude drug that are concentrated into filtrate is 4:1(g/ml), add concentrated liquid and amass the tween 80 vibration mixing of 2%, stand 6 hours, filter, embedding, prepare spray, obtain external preparation.
Test example 1Gained of the present invention is for treating the clinical practice of the external preparation (embodiment 5) of epistaxis:
In October ,-2014 in April, 2011, filter out 378 example patients, wherein women 188 example, male 190 example, age 4-60 year, the course of disease 20 days-7 years in 4 hospitals.Wherein hemorrhage 213 examples of unilateral nasal, bilateral nasal bleeding 165 example.Clinical symptoms shows as nasal bleeding, blood drop and lower or more than in a large number, scarlet or light red, with symptoms such as dry nasal cavity, weak, dizzy, vexed, thirsty, tinnitus.
Patient is randomly divided into two groups, experimental group 200 example and matched group 178 example, two groups the aspects such as sex, age, the course of disease, the state of an illness without significant difference (P＞ 0.05), there is comparability.Experimental group uses products obtained therefrom of the present invention, wipes dry by nasal cavity blood, finds petechia, is sprayed on affected part, one day 3-4 time, 7 days courses for the treatment of, and matched group uses other medicine must the conventional medication such as physiological seawater nasal sprayer only as sprayed.During treatment, two groups of patients are carried out Continuous Observation, record symptom and change.
Curative effect situation criterion: cure: stopped bleeding, without recurrence in half a year；Effective: stopped bleeding, in half a year, recurrence is less than 3 times；Invalid: before and after treatment, bleeding is the most unchanged.
In experimental group, cure patient 157 example (78.5%), treat effective patient 39 example (19.5%), refractory patient 4 example (2.0%), experimental group total effective rate 98.0%；In matched group, curing patient's example 99 example (55.6%), treat effective patient 55 example (30.9%), matched group total effective rate is 86.5%.Two groups of results are compared, exist significant difference (P＜ 0.05).
Having Radix Alternantherae philoxeroidis clearing away heat and cooling blood, rock spring grass heat-clearing and toxic substances removing in prescription of the present invention, gold line cough-relieving is stopped blooding, Herba Pellioniae repentis clearing away heat-damp and promoting diuresis, Radix pyri regulating QI to relieve pain, Cortex Linderae Obtusilobae warming middle-JIAO to promote flow of QI, Radix Rubiae and Flos Viciae fabae cooling blood for hemostasis, Ramulus et Folium Symplocoris Chinensis hemostasia and promoting granulation, Herba Penthori chinensis invigorates blood circulation row water, Herba Rabdosiae glaucocalycis dissipating blood stasis for subsidence of swelling, big Herba Hyperici Japonici removing toxic substances and promoting subsidence of swelling, Radix Micromeli Integerrimi dispelling wind to relieve the exterior syndrome, Radix Aneurolepidii clearing away heat to stop bleeding, multiple medical material share and can play the effect such as clearing away heat and expelling pathogen in the exterior, hemostasis QI invigorating.
It should be pointed out that, the detailed description of the invention more representational example that is the present invention, it is clear that technical scheme is not limited to above-described embodiment, it is also possible to have many variations.Those of ordinary skill in the art, with the present invention undoubted the obtaining of clearly disclosed or according to file written description, be all considered as this patent scope of the claimed.
Claims (10)
1. for treating the external preparation of epistaxis, it is characterised in that be mainly prepared from by following bulk drugs, it is mass parts: Radix Alternantherae philoxeroidis 5-12, rock spring grass 2-6, gold line 4-9, Herba Pellioniae repentis 7-15, Radix pyri 10-18, Cortex Linderae Obtusilobae 8-14, Radix Rubiae 6-10, Ramulus et Folium Symplocoris Chinensis 3-9, Herba Penthori chinensis 5-11, Herba Rabdosiae glaucocalycis 9-17, Flos Viciae fabae 4-8, big Herba Hyperici Japonici 5-13, Radix Micromeli Integerrimi 9-15, Radix Aneurolepidii 7-14.
2. the external preparation for treating epistaxis as claimed in claim 1, it is characterised in that Radix Alternantherae philoxeroidis 7-10, rock spring grass 3-5, gold line 5-8, Herba Pellioniae repentis 9-13, Radix pyri 12-16, Cortex Linderae Obtusilobae 10-12, Radix Rubiae 7-9, Ramulus et Folium Symplocoris Chinensis 5-7, Herba Penthori chinensis 7-9, Herba Rabdosiae glaucocalycis 11-15, Flos Viciae fabae 5-7, big Herba Hyperici Japonici 8-10, Radix Micromeli Integerrimi 10-14, Radix Aneurolepidii 9-12.
3. the external preparation for treating epistaxis as claimed in claim 1, it is characterised in that Radix Alternantherae philoxeroidis 8.5, rock spring grass 4, gold line 6.5, Herba Pellioniae repentis 11, Radix pyri 14, Cortex Linderae Obtusilobae 11, Radix Rubiae 8, Ramulus et Folium Symplocoris Chinensis 6, Herba Penthori chinensis 8, Herba Rabdosiae glaucocalycis 13, Flos Viciae fabae 6, big Herba Hyperici Japonici 9, Radix Micromeli Integerrimi 12, Radix Aneurolepidii 10.5.
4. the preparation method of the external preparation for treating epistaxis as described in claim 1-3 is arbitrary, it is characterised in that step is:
(1) Radix Alternantherae philoxeroidis, Radix Rubiae, Ramulus et Folium Symplocoris Chinensis and Radix Aneurolepidii roguing are taken, section, to mix thoroughly with sweet wine and Saccharum Sinensis Roxb., then be placed in container, Steam by water bath takes out thoroughly, dries；
(2) Cortex Linderae Obtusilobae and Radix Micromeli Integerrimi are cleaned, boil to being boiling for 7-13 minute (preferably, lasting 8-12 minute with vinegar；More preferably, continue 10 minutes), taking-up drains, and is placed in intense fire heating in frying pan, fries and take out to during surface coke brown, dry in the air cool；
(3) being placed in frying pan by Flos Viciae fabae, intense fire heats, and fries and has focal spot to surface, drenches and mix thoroughly into refined honey, fries and takes out to time tack-free, dries in the air cool；
(4) rock spring grass, gold line, Herba Pellioniae repentis, Radix pyri, Herba Penthori chinensis, Herba Rabdosiae glaucocalycis and big Herba Hyperici Japonici are cleaned, add water boil, turn boiling with soft fire 20-35 minute and (preferably, turn boiling with soft fire 25-30 minute；More preferably, turn boiling with soft fire 27 minutes), filter, filtering residue adds water and boils, and after big fire is boiled, little fire is decocted 15-20 minute (preferably, little fire is decocted 16-19 minute；More preferably, little fire decocts 17 minutes), filter, merge twice gained filtrate；
(5) step (1) (2) (3) made crude drug being pulverized 80 mesh sieves, the heated and boiled that adds water, after 15 minutes, is added a cover vexed 2-6 hour and (preferably, is added a cover vexed 3-5 hour；More preferably, add a cover vexed 4 hours), to filter, gained filtrate merges mixing with step (4) made filtrate, concentrates, and adds concentrated liquid and amasss the tween 80 vibration mixing of 2%, stands 4-8 hour and (preferably, stand 5-7 hour；More preferably, stand 6 hours), filter, embedding, prepare spray, obtain external preparation.
5. the preparation method of the external preparation for treating epistaxis as claimed in claim 4, it is characterised in that (preferably, the amount of sweet wine is 2.5-3.5 times of crude drug quality to 2-4 times that amount is crude drug quality of step (1) sweet wine；More preferably, the amount of sweet wine is 3 times of crude drug quality).
6. the preparation method of the external preparation for treating epistaxis as claimed in claim 4, it is characterised in that (preferably, the amount of Saccharum Sinensis Roxb. is 0.6-0.7 times of crude drug quality to 0.5-0.8 times that amount is crude drug quality of step (1) Saccharum Sinensis Roxb.；More preferably, the amount of Saccharum Sinensis Roxb. is 0.65 times of crude drug quality).
7. the preparation method of the external preparation for treating epistaxis as claimed in claim 4, it is characterised in that 0.1-0.3 times (preferably, the amount of refined honey is 0.2 times of crude drug quality) that amount is crude drug quality of step (3) refined honey.
8. the preparation method of the external preparation for treating epistaxis as claimed in claim 4, it is characterised in that (preferably, amount of water is 5-6 times of boiled crude drug quality to 4-7 times that step (4) amount of water is boiled crude drug quality；More preferably, amount of water is 5.5 times of boiled crude drug quality).
9. the preparation method of the external preparation for treating epistaxis as claimed in claim 4, it is characterised in that (preferably, amount of water is 6-7 times of boiled crude drug quality to 5-8 times that step (5) amount of water is boiled crude drug quality；More preferably, amount of water is 6.5 times of boiled crude drug quality).
10. the preparation method of the external preparation for treating epistaxis as claimed in claim 4, it is characterized in that, the mass ratio of volume and crude drug that step (5) is concentrated into filtrate is 3-5:1(g/ml) (preferably, the mass ratio of the volume and crude drug that are concentrated into filtrate is 4:1).
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103191319A (en) * | 2013-03-31 | 2013-07-10 | 张秀兰 | Medicine for treating epistaxis and preparation method thereof |
| CN103656119A (en) * | 2012-09-24 | 2014-03-26 | 张献奎 | Traditional Chinese medicinal preparation for specifically treating epistaxis |
| CN103800714A (en) * | 2012-12-17 | 2014-05-21 | 唐焱华 | Chinese herbal medicine for treating epistaxis |
| CN104491382A (en) * | 2014-11-25 | 2015-04-08 | 陈善财 | Traditional Chinese medicine preparation used for treating epistaxis |
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2016
- 2016-02-26 CN CN201610104884.4A patent/CN105727018A/en not_active Withdrawn
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656119A (en) * | 2012-09-24 | 2014-03-26 | 张献奎 | Traditional Chinese medicinal preparation for specifically treating epistaxis |
| CN103800714A (en) * | 2012-12-17 | 2014-05-21 | 唐焱华 | Chinese herbal medicine for treating epistaxis |
| CN103191319A (en) * | 2013-03-31 | 2013-07-10 | 张秀兰 | Medicine for treating epistaxis and preparation method thereof |
| CN104491382A (en) * | 2014-11-25 | 2015-04-08 | 陈善财 | Traditional Chinese medicine preparation used for treating epistaxis |
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