CN104888013A - Traditional Chinese medicine preparation for treating conjunctivitis and preparation method of traditional Chinese medicine preparation - Google Patents
Traditional Chinese medicine preparation for treating conjunctivitis and preparation method of traditional Chinese medicine preparation Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating conjunctivitis. The traditional Chinese medicine preparation comprises raw materials in parts by mass as follows: 10-16 parts of cassia seeds, 9-11 parts of Ferula borealis Kuan, 10-15 parts of Chinese St. John'swort roots, 9-16 parts of pale butterflybush flowers, 12-15 parts of akebia stems, 11-15 parts of Chinese usnea, 9-15 parts of lawn pennywort herb, 11-14 parts of white mulberry root-barks, 8-12 parts of herb of shady groundsel, 6-13 parts of great burdock achene, 10-13 parts of frosted mulberry leaves, 12-16 parts of barbary wolfberry leaves, 10-14 parts of reed rhizomes, 7-17 parts of fudzino grass fern and 9-13 parts of all-grass of Java speedwell. The traditional Chinese medicine preparation is prepared from various medicines, has little side effects and is high in safety and wide in applicability; the components completely accord with the principle of the traditional Chinese medicine and have efficacy of heat clearing, detoxicity, eyesight improvement, nebula removal and the like; the medicine source is wide, the cost is low, and clinical verifications show that the traditional Chinese medicine preparation is good in curative effect, can avoid relapse and has a remarkable curative effect on both acute and chronic conjunctivitis.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine preparation for the treatment of conjunctivitis and preparation method thereof.
Background technology
The general designation of the conjunctivitis inflammatory reaction that to be conjunctival tissue occur in the effect of extraneous and body oneself factor.After conjunctiva is subject to various stimulation, there will be the symptoms such as edema, furious, secretions increase, simple eye or eyes can be involved.According to the state of an illness and the course of disease of conjunctivitis, acute, subacute and chronic three classes can be divided into; Bacillary, viral, chlamydial, fungoid and allergy etc. can be divided into again according to the cause of disease; According to the lesion characteristic of conjunctiva, acute follicular conjunctivitis, chronic follicular conjunctivitis, film and pseudomembranous conjunctivitis etc. can be divided into.Classical symptom has inflamed eyes, ocular foreign bodies sense, photophobia are shed tears, conjunctival congestion, ophthalmic secretions increase, these symptoms are coexpress of all types conjunctivitis, generally do not affect one's power of vision.Treatment conjunctivitis, antibacterials or antiviral eye drop can be used to carry out topical therapeutic, and serious conjunctivitis then needs systemic administration to treat.
Publication No. CN 104189620 A(application number 201410358371.7) Chinese patent literature disclose a kind of Chinese medicine being used for the treatment of conjunctivitis, be prepared from by the Radix Rehmanniae, Artemisia anethoicles Mattf, Radix Stephaniae Tetrandrae, Semen Coicis, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, the Fructus Kochiae, Flos Lonicerae, Fructus Forsythiae, Herba Houttuyniae, peninjau gardenia, Cortex Moutan, Herba Schizonepetae.Publication No. CN 104306521 A(application number 201410624468.8) Chinese patent literature disclose a kind of Chinese medicine for the treatment of conjunctivitis, component has Flos Buddlejae, Radix Notoginseng, Herba Houttuyniae, Herba Taraxaci, Concha Haliotidis, the Radix Astragali and Radix Glycyrrhizae.Publication No. CN 104524339 A(application number 201510006542.4) Chinese patent literature disclose the Chinese medicine formula for the treatment of conjunctivitis, crude drug consist of Poria 8-12 gram, Herba Artemisiae Scopariae 10-13 gram, Semen Coicis 28-32 gram, Herba Houttuyniae 28-35 gram, 5-8 gram, Jiaoshan Hill mast, Radix Saposhnikoviae 8-12 gram, Radix Angelicae Dahuricae 5-6 gram, Zaocys 12-15 gram, Fructus Forsythiae 10-15 gram, Rhizoma Coptidis 5-6 gram, Bulbus Allii Fistulosi 3-5 gram, Fructus Jujubae 10-12 piece, Semen Cassiae 18-22 gram.
Local application, takes effect slow, DeGrain, and western medicine, mainly based on anti-bacteria and anti-virus antiinflammatory, can only eliminate symptom, can not eradicate focus completely, easily occurs recurrence.And Chinese traditional treatment is comparatively safe, and can treat to the ill, treating both the principal and the secondary aspects of a disease at the same time, good effect, therefore, the Chinese medicine formula that a kind of curative effect treats conjunctivitis preferably can be developed.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide Chinese medicine preparation of a kind for the treatment of conjunctivitis of evident in efficacy, taking convenience and preparation method thereof.
Technical scheme of the present invention is:
The Chinese medicine preparation for the treatment of conjunctivitis, is prepared from primarily of following bulk drugs, is mass parts: Semen Cassiae 10-16, sand Fructus Foeniculi 9-11, Radix Hyperici Monogyni (Herba Hyperici Monogyni) 10-15, Flos Buddlejae 9-16, Caulis Akebiae 12-15, Usnea 11-16, Herba Hydrocotyles 9-15, Cortex Mori 11-14, Herba senecionis nemorensis 8-12, Fructus Arctii 6-13, Cortex Lycii 10-13, Folium Lycii 12-16, Rhizoma Phragmitis 10-14, Vittaria fudzinoi Mak. 7-17, Herba Eragrostidis Poaeoidis 9-13.
In preferred scheme, Semen Cassiae 12-14, sand Fructus Foeniculi 9.5-10.5, Radix Hyperici Monogyni (Herba Hyperici Monogyni) 11-14, Flos Buddlejae 11-14, Caulis Akebiae 13-14, Usnea 13-14, Herba Hydrocotyles 11-13, Cortex Mori 12-13, Herba senecionis nemorensis 9-11, Fructus Arctii 8-11, Cortex Lycii 11-12, Folium Lycii 13-15, Rhizoma Phragmitis 11-13, Vittaria fudzinoi Mak. 9-15, Herba Eragrostidis Poaeoidis 10-12.
Be more preferably, Semen Cassiae 13, sand Fructus Foeniculi 10, Radix Hyperici Monogyni (Herba Hyperici Monogyni) 12.5, Flos Buddlejae 12.5, Caulis Akebiae 13.5, Usnea 13.5, Herba Hydrocotyles 12, Cortex Mori 12.5, Herba senecionis nemorensis 10, Fructus Arctii 9.5, Cortex Lycii 11.5, Folium Lycii 14, Rhizoma Phragmitis 11, Vittaria fudzinoi Mak. 12, Herba Eragrostidis Poaeoidis 11.
The Chinese medicine preparation of described treatment conjunctivitis, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Fagopyrum esculentum Moench and put into pot, moderate heat is heated to smolder, and puts into clean Semen Cassiae and Fructus Arctii, when heating stir-fries to micro-savory effusion, takes out, cools;
(2) get Cortex Mori and Cortex Lycii, adding water infiltration, to be placed on steaming tray Steam by water bath saturating, and take out, shredding, mixes thoroughly with hydromel and vinegar, then is placed in frying pan, fry to tack-free be degree, take out, dry;
(3) get Flos Buddlejae and pick clean impurity, after soaking into, pull out, put into frying pan with yellow wine, slow fire heats, and fries to micro-dry, takes out dry;
(4) by sand Fructus Foeniculi, Radix Hyperici Monogyni (Herba Hyperici Monogyni), Caulis Akebiae, Usnea, sky recklessly appropriate, Herba senecionis nemorensis, Folium Lycii, Rhizoma Phragmitis, Vittaria fudzinoi Mak. and Herba Eragrostidis Poaeoidis decontamination, clean, dry, pulverize and sieve together with step (1) (2) (3) made crude drug, obtain powder.
The preparation method of the Chinese medicine preparation powder of described treatment conjunctivitis, step (4) was pulverized 140-200 mesh sieve and (preferably, was pulverized 160-180 mesh sieve; Be more preferably, pulverized 170 mesh sieves).
The Chinese medicine preparation of described treatment conjunctivitis, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) get Fagopyrum esculentum Moench and put into pot, moderate heat is heated to smolder, and puts into clean Semen Cassiae and Fructus Arctii, when heating stir-fries to micro-savory effusion, takes out, cools;
(2) get Cortex Mori and Cortex Lycii, adding water infiltration, to be placed on steaming tray Steam by water bath saturating, and take out, shredding, mixes thoroughly with hydromel and vinegar, then is placed in frying pan, fry to tack-free be degree, take out, dry;
(3) get Flos Buddlejae and pick clean impurity, after soaking into, pull out, put into frying pan with yellow wine, slow fire heats, and fries to micro-dry, takes out dry;
(4) by sand Fructus Foeniculi, Radix Hyperici Monogyni (Herba Hyperici Monogyni), Caulis Akebiae, Usnea, sky recklessly appropriate, Herba senecionis nemorensis, Folium Lycii, Rhizoma Phragmitis, Vittaria fudzinoi Mak. and Herba Eragrostidis Poaeoidis decontamination, clean, decoct with water together with step (1) (2) made crude drug, big fire is boiled rear little fire and is decocted 20-30 minute (preferred, 22-28 minute decocted by little fire; Be more preferably, little fire decocts 25 minutes), filter, medicinal residues add water and again decoct, and merge twice gained filtrate, concentrated, dry;
(5) step (3) and (4) made crude drug are pulverized together with dry thing 80-140 mesh sieve and (preferably, pulverize 90-130 mesh sieve; Be more preferably, pulverized 110 mesh sieves), obtained medicated powder, suppresses conglobate tablet dosage form by made medicated powder according to the preparation for processing of tablet.
The preparation method of the Chinese medicine preparation tablet of described treatment conjunctivitis, step (4) decocts with water the 7-9 of middle amount of water total raw material medicine quality, and doubly (preferred, amount of water is 7.5-8.5 times of total raw material medicine quality; Be more preferably, amount of water is 8 times of total raw material medicine quality).
The Chinese medicine preparation of described treatment conjunctivitis, be made into pharmaceutically acceptable granule, its preparation method is:
(1) get Fagopyrum esculentum Moench and put into pot, moderate heat is heated to smolder, and puts into clean Semen Cassiae and Fructus Arctii, when heating stir-fries to micro-savory effusion, takes out, cools;
(2) get Cortex Mori and Cortex Lycii, adding water infiltration, to be placed on steaming tray Steam by water bath saturating, and take out, shredding, mixes thoroughly with hydromel and vinegar, then is placed in frying pan, fry to tack-free be degree, take out, dry;
(3) get Flos Buddlejae and pick clean impurity, after soaking into, pull out, put into frying pan with yellow wine, slow fire heats, and fries to micro-dry, takes out dry;
(4) by sand Fructus Foeniculi, Radix Hyperici Monogyni (Herba Hyperici Monogyni), Caulis Akebiae, Usnea, sky recklessly appropriate, Herba senecionis nemorensis, Folium Lycii, Rhizoma Phragmitis, Vittaria fudzinoi Mak. and Herba Eragrostidis Poaeoidis decontamination, clean, add the soak by water of boiled crude drug quality 9 times, big fire is boiled rear little fire and is decocted 20-36 minute (preferred, 24-32 minute decocted by little fire; Be more preferably, little fire decocts 28 minutes), filter, medicinal residues add water and again decoct, and merge twice gained filtrate, are condensed into clear paste;
(5) step (1) (2) (3) made crude drug was pulverized 60 mesh sieves together, made medicated powder, with alcohol reflux 3-6 hour (preferably, the reflux, extract, 4-5 hour of 75% of made medicated powder quality 6 times; Be more preferably, reflux, extract, 4.5 hours), extract twice, merge extractive liquid, is evaporated to gained extracting solution without alcohol taste, mixes, dry, pulverize, add adjuvant soft material with step (4) made clear paste, granulates, and dry, granulate, obtains granule.
The preparation method of the Chinese medicine preparation granule of described treatment conjunctivitis, step (5) was pulverized 100-140 mesh sieve and (preferably, was pulverized 110-130 mesh sieve; Be more preferably, pulverized 120 mesh sieves).
The Chinese medicine preparation of described treatment conjunctivitis, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Fagopyrum esculentum Moench and put into pot, moderate heat is heated to smolder, and puts into clean Semen Cassiae and Fructus Arctii, when heating stir-fries to micro-savory effusion, takes out, cools;
(2) get Cortex Mori and Cortex Lycii, adding water infiltration, to be placed on steaming tray Steam by water bath saturating, and take out, shredding, mixes thoroughly with hydromel and vinegar, then is placed in frying pan, fry to tack-free be degree, take out, dry;
(3) get Flos Buddlejae and pick clean impurity, after soaking into, pull out, put into frying pan with yellow wine, slow fire heats, and fries to micro-dry, takes out dry;
(4) by sand Fructus Foeniculi, Radix Hyperici Monogyni (Herba Hyperici Monogyni), Caulis Akebiae, Usnea, sky recklessly appropriate, Herba senecionis nemorensis, Folium Lycii, Rhizoma Phragmitis, Vittaria fudzinoi Mak. and Herba Eragrostidis Poaeoidis decontamination, clean, dry, decoct with water together with step (1) (2) (3) made crude drug three times (decocting 8 times that amount of water is total raw material medicine quality) at every turn, during decoction, big fire is boiled rear little fire and is decocted, and filters, and merges three decoction gained medicinal liquids, be concentrated into 1/3rd of original volume, obtain decoction.
The preparation method of the Chinese medicine preparation decoction of described treatment conjunctivitis, when step (4) decocts, big fire is boiled rear little fire and is decocted 30-40 minute (preferred, 32-38 minute decocted by little fire; Be more preferably, little fire decocts 35 minutes).
The Chinese medicine preparation scientific formula for the treatment of conjunctivitis provided by the invention, prepares simple and easy, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1, the present invention is made up of several kinds of Chinese medicinal materials, and side effect is little, and safety is high, and the suitability is wide;
2, this prescription meets Chinese medicine principle completely, has the effect such as heat-clearing and toxic substances removing, improving acuity of vision and removing nebula;
3, medicine source of the present invention is wide, and cost is low, and through clinical verification, good effect, anti-recurrence, all has significant curative effect to acute and chronic conjunctivitis.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the Chinese medicine preparation for the treatment of conjunctivitis, is prepared from (every part of 10g) primarily of following bulk drugs: Semen Cassiae 10 parts, 9 parts, sand Fructus Foeniculi, Radix Hyperici Monogyni (Herba Hyperici Monogyni) 10 parts, Flos Buddlejae 9 parts, Caulis Akebiae 12 parts, Usnea 11 parts, Herba Hydrocotyles 9 parts, Cortex Mori 11 parts, Herba senecionis nemorensis 8 parts, Fructus Arctii 6 parts, Cortex Lycii 10 parts, Folium Lycii 12 parts, Rhizoma Phragmitis 10 parts, Vittaria fudzinoi Mak. 7 parts, Herba Eragrostidis Poaeoidis 9 parts.
The preparation method of the Chinese medicine preparation powder of above-mentioned treatment conjunctivitis is:
(1) get Fagopyrum esculentum Moench and put into pot, moderate heat is heated to smolder, and puts into clean Semen Cassiae and Fructus Arctii, when heating stir-fries to micro-savory effusion, takes out, cools;
(2) get Cortex Mori and Cortex Lycii, adding water infiltration, to be placed on steaming tray Steam by water bath saturating, and take out, shredding, mixes thoroughly with hydromel and vinegar, then is placed in frying pan, fry to tack-free be degree, take out, dry;
(3) get Flos Buddlejae and pick clean impurity, after soaking into, pull out, put into frying pan with yellow wine, slow fire heats, and fries to micro-dry, takes out dry;
(4) by sand Fructus Foeniculi, Radix Hyperici Monogyni (Herba Hyperici Monogyni), Caulis Akebiae, Usnea, sky recklessly appropriate, Herba senecionis nemorensis, Folium Lycii, Rhizoma Phragmitis, Vittaria fudzinoi Mak. and Herba Eragrostidis Poaeoidis decontamination, clean, dry, pulverized 170 mesh sieves together with step (1) (2) (3) made crude drug, obtain powder.
embodiment 2the Chinese medicine preparation for the treatment of conjunctivitis, is prepared from (every part of 10g) primarily of following bulk drugs: Semen Cassiae 16 parts, 11 parts, sand Fructus Foeniculi, Radix Hyperici Monogyni (Herba Hyperici Monogyni) 15 parts, Flos Buddlejae 16 parts, Caulis Akebiae 15 parts, Usnea 16 parts, Herba Hydrocotyles 15 parts, Cortex Mori 14 parts, Herba senecionis nemorensis 12 parts, Fructus Arctii 13 parts, Cortex Lycii 13 parts, Folium Lycii 16 parts, Rhizoma Phragmitis 14 parts, Vittaria fudzinoi Mak. 17 parts, Herba Eragrostidis Poaeoidis 13 parts.
The preparation method of the Chinese medicine preparation tablet for the treatment of conjunctivitis is:
(1) get Fagopyrum esculentum Moench and put into pot, moderate heat is heated to smolder, and puts into clean Semen Cassiae and Fructus Arctii, when heating stir-fries to micro-savory effusion, takes out, cools;
(2) get Cortex Mori and Cortex Lycii, adding water infiltration, to be placed on steaming tray Steam by water bath saturating, and take out, shredding, mixes thoroughly with hydromel and vinegar, then is placed in frying pan, fry to tack-free be degree, take out, dry;
(3) get Flos Buddlejae and pick clean impurity, after soaking into, pull out, put into frying pan with yellow wine, slow fire heats, and fries to micro-dry, takes out dry;
(4) by sand Fructus Foeniculi, Radix Hyperici Monogyni (Herba Hyperici Monogyni), Caulis Akebiae, Usnea, sky recklessly appropriate, Herba senecionis nemorensis, Folium Lycii, Rhizoma Phragmitis, Vittaria fudzinoi Mak. and Herba Eragrostidis Poaeoidis decontamination, clean, decoct with water together with step (1) (2) made crude drug (amount of water is 8 times of total raw material medicine quality), big fire is boiled rear little fire and is decocted 25 minutes, filter, medicinal residues add water and again decoct, and merge twice gained filtrate, concentrated, dry;
(5) step (3) was pulverized 110 mesh sieves with (4) made crude drug together with dry thing, obtained medicated powder, suppresses conglobate tablet dosage form by made medicated powder according to the preparation for processing of tablet.
Model case: xxx, female, 46 years old.Main suit: occurred ophthalmalgia without obvious inducement before 3 days, itch, with foreign body sensation, photophobia, easily to shed tears and ophthalmic has sticky pus to secrete, the treatment of bright eye drip is valued in use, DeGrain, examination in hospital, conjunctival congestion, edema, palpebral conjunctiva has pseudomembrane to be formed, and conjunctival sac secretions Bacteria Detection is positive, is diagnosed as acute conjunctivitis.
Take the Chinese medicine preparation tablet of the present embodiment gained treatment conjunctivitis, every day 3 times, each 3-4 sheet, warm water delivery service, 7 days courses for the treatment of.After taking 2 days, ophthalmalgia, itching obviously alleviates, and foreign body sensation also alleviates, but still have and shed tears and secretions, after taking a course for the treatment of, ophthalmalgia is itched transference cure, to shed tears elimination, have a small amount of secretions, after taking 10 days, secretions is eliminated, check, conjunctival congestion, edema extinction, patient fully recovers, and follows up a case by regular visits to and do not recur in half a year.
embodiment 3the Chinese medicine preparation for the treatment of conjunctivitis, is prepared from (every part of 10g) primarily of following bulk drugs: Semen Cassiae 12 parts, 9.5 parts, sand Fructus Foeniculi, Radix Hyperici Monogyni (Herba Hyperici Monogyni) 11 parts, Flos Buddlejae 11 parts, Caulis Akebiae 13 parts, Usnea 13 parts, Herba Hydrocotyles 11 parts, Cortex Mori 12 parts, Herba senecionis nemorensis 9 parts, Fructus Arctii 8 parts, Cortex Lycii 11 parts, Folium Lycii 13 parts, Rhizoma Phragmitis 11 parts, Vittaria fudzinoi Mak. 9 parts, Herba Eragrostidis Poaeoidis 10 parts.
The preparation method of the Chinese medicine preparation granule for the treatment of conjunctivitis is:
(1) get Fagopyrum esculentum Moench and put into pot, moderate heat is heated to smolder, and puts into clean Semen Cassiae and Fructus Arctii, when heating stir-fries to micro-savory effusion, takes out, cools;
(2) get Cortex Mori and Cortex Lycii, adding water infiltration, to be placed on steaming tray Steam by water bath saturating, and take out, shredding, mixes thoroughly with hydromel and vinegar, then is placed in frying pan, fry to tack-free be degree, take out, dry;
(3) get Flos Buddlejae and pick clean impurity, after soaking into, pull out, put into frying pan with yellow wine, slow fire heats, and fries to micro-dry, takes out dry;
(4) by sand Fructus Foeniculi, Radix Hyperici Monogyni (Herba Hyperici Monogyni), Caulis Akebiae, Usnea, sky recklessly appropriate, Herba senecionis nemorensis, Folium Lycii, Rhizoma Phragmitis, Vittaria fudzinoi Mak. and Herba Eragrostidis Poaeoidis decontamination, clean, add the soak by water of boiled crude drug quality 9 times, big fire is boiled rear little fire and is decocted 28 minutes, filter, medicinal residues add water and again decoct, and merge twice gained filtrate, are condensed into clear paste;
(5) step (1) (2) (3) made crude drug was pulverized 60 mesh sieves together, made medicated powder, the alcohol reflux with 75% of made medicated powder quality 6 times 4.5 hours, extract twice, merge extractive liquid, is evaporated to gained extracting solution without alcohol taste, mix with step (4) made clear paste, dry, pulverize 120 mesh sieves, add adjuvant soft material, granulate, drying, granulate, obtains granule.
Model case: xxx, man, 26 years old.Overtime work of often staying up late in nearly one week, diet is also irregular, and before 2 days, self-induction eyes are itched puckery causalgia sense, and with foreign body sensation, happiness rubbing eyes, photophobia, eye discharge increases, and more sticky, yellowish or reddish urine, large dry stool, examination in hospital, conjunctival congestion, red tongue, yellow and greasy fur, thready and rapid pulse, is diagnosed as acute conjunctivitis.
Take the Chinese medicine preparation granule of the present embodiment gained treatment conjunctivitis, adopt every day 3 times, each 4-6g, with warm boiled water, 7 days courses for the treatment of.After taking 2 days, eyes puckery causalgia of itching alleviates, and photophobia is alleviated, and after taking 5 days, puckery causalgia of itching disappears substantially, and foreign body sensation is eliminated substantially, still has a small amount of secretions, and after taking 11 days, all diseases disappear entirely, and conjunctival congestion is eliminated, and patient fully recovers, and follows up a case by regular visits to and do not recur in half a year.
embodiment 4the Chinese medicine preparation for the treatment of conjunctivitis, is prepared from (every part of 10g) primarily of following bulk drugs: Semen Cassiae 14 parts, 10.5 parts, sand Fructus Foeniculi, Radix Hyperici Monogyni (Herba Hyperici Monogyni) 14 parts, Flos Buddlejae 14 parts, Caulis Akebiae 14 parts, Usnea 14 parts, Herba Hydrocotyles 13 parts, Cortex Mori 13 parts, Herba senecionis nemorensis 11 parts, Fructus Arctii 11 parts, Cortex Lycii 12 parts, Folium Lycii 15 parts, Rhizoma Phragmitis 13 parts, Vittaria fudzinoi Mak. 15 parts, Herba Eragrostidis Poaeoidis 12 parts.
The preparation method of the Chinese medicine preparation decoction for the treatment of conjunctivitis is:
(1) get Fagopyrum esculentum Moench and put into pot, moderate heat is heated to smolder, and puts into clean Semen Cassiae and Fructus Arctii, when heating stir-fries to micro-savory effusion, takes out, cools;
(2) get Cortex Mori and Cortex Lycii, adding water infiltration, to be placed on steaming tray Steam by water bath saturating, and take out, shredding, mixes thoroughly with hydromel and vinegar, then is placed in frying pan, fry to tack-free be degree, take out, dry;
(3) get Flos Buddlejae and pick clean impurity, after soaking into, pull out, put into frying pan with yellow wine, slow fire heats, and fries to micro-dry, takes out dry;
(4) by sand Fructus Foeniculi, Radix Hyperici Monogyni (Herba Hyperici Monogyni), Caulis Akebiae, Usnea, sky recklessly appropriate, Herba senecionis nemorensis, Folium Lycii, Rhizoma Phragmitis, Vittaria fudzinoi Mak. and Herba Eragrostidis Poaeoidis decontamination, clean, dry, decoct with water together with step (1) (2) (3) made crude drug three times (decocting 8 times that amount of water is total raw material medicine quality) at every turn, during decoction, big fire is boiled rear little fire and is decocted 35 minutes, filters, and merges three times and decocts gained medicinal liquid, be concentrated into 1/3rd of original volume, obtain decoction.
Model case: xxx, man, 33 years old.Main suit: suffer from conjunctivitis 4 years, recurrent exerbation, eye is dry and astringent, fatiguability, and self-induction ophthalmic has foreign body, order a lot of secretion in the eye, and eyelid is heavy, palpebral conjunctiva is congested, and nipple follicle hypertrophy, once used multiple eye drops in treatment, and after symptom controls, drug withdrawal, soon just has recurrence.
Take the Chinese medicine preparation decoction of the present embodiment gained treatment conjunctivitis, adopt every day 3 times, each 100-200ml(is warm), 7 days courses for the treatment of.After taking 3 days, patient's eye is dry and astringent to be alleviated, and secretions does not increase again, after taking a course for the treatment of, the dry and astringent basic elimination of eye, secretions reduces, foreign body sensation obviously alleviates, the heavy elimination of eyelid, after taking two courses for the treatment of, all diseases disappear entirely, palpebral conjunctiva still has mild hyperaemia, and take to three courses for the treatment of, palpebral conjunctiva hyperemia is disappeared, patient fully recovers, and follows up a case by regular visits to and do not recur in half a year.
embodiment 5the Chinese medicine preparation for the treatment of conjunctivitis, is prepared from (every part of 10g) primarily of following bulk drugs: Semen Cassiae 13 parts, 10 parts, sand Fructus Foeniculi, Radix Hyperici Monogyni (Herba Hyperici Monogyni) 12.5 parts, Flos Buddlejae 12.5 parts, Caulis Akebiae 13.5 parts, Usnea 13.5 parts, Herba Hydrocotyles 12 parts, Cortex Mori 12.5 parts, Herba senecionis nemorensis 10 parts, Fructus Arctii 9.5 parts, Cortex Lycii 11.5 parts, Folium Lycii 14 parts, Rhizoma Phragmitis 11 parts, Vittaria fudzinoi Mak. 12 parts, Herba Eragrostidis Poaeoidis 11 parts.
The preparation method of the Chinese medicine preparation powder for the treatment of conjunctivitis is:
(1) get Fagopyrum esculentum Moench and put into pot, moderate heat is heated to smolder, and puts into clean Semen Cassiae and Fructus Arctii, when heating stir-fries to micro-savory effusion, takes out, cools;
(2) get Cortex Mori and Cortex Lycii, adding water infiltration, to be placed on steaming tray Steam by water bath saturating, and take out, shredding, mixes thoroughly with hydromel and vinegar, then is placed in frying pan, fry to tack-free be degree, take out, dry;
(3) get Flos Buddlejae and pick clean impurity, after soaking into, pull out, put into frying pan with yellow wine, slow fire heats, and fries to micro-dry, takes out dry;
(4) by sand Fructus Foeniculi, Radix Hyperici Monogyni (Herba Hyperici Monogyni), Caulis Akebiae, Usnea, sky recklessly appropriate, Herba senecionis nemorensis, Folium Lycii, Rhizoma Phragmitis, Vittaria fudzinoi Mak. and Herba Eragrostidis Poaeoidis decontamination, clean, dry, pulverized 170 mesh sieves together with step (1) (2) (3) made crude drug, obtain powder.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Semen Cassiae: base is former: be the mature seed of leguminous plant Semen Cassiae.Nature and flavor: sweet, bitter, salty, are slightly cold.Gui Jing: return liver, large intestine channel.Function cures mainly: clearing away heat to improve acuity of vision, loosening bowel to relieve constipation.For the puckery pain of conjunctival congestion, the many tear of photophobia, has a headache dizzy, poor vision, constipation.
Sand Fructus Foeniculi: base is former: be the whole herb with root of the hard Resina Ferulae of samphire.Nature and flavor: sweet in the mouth, micro-hardship, cool in nature.Gui Jing: return lung meridian.Function cures mainly: reducing heat and dispersing lung-QI, expectorant powder junction, reducing swelling and alleviating pain.Chef generates heat, laryngopharynx swelling and pain, cough with asthma, bone tuberculosis, scrofula, skin infection, lumbar sprain.
Radix Hyperici Monogyni (Herba Hyperici Monogyni): base is former: be the herb of Garcinia maingayii Radix Hyperici Monogyni (Herba Hyperici Monogyni).Nature and flavor: bitter, cool.Function cures mainly: heat-clearing and toxic substances removing, detumescence of dispeling the wind.For acute pharyngolaryngitis, eye conjunctivitis, hepatitis, venom.
Flos Buddlejae: base is former: be dried floral or the alabastrum of loganiaceae plant Flos Buddlejae.Nature and flavor: sweet, are slightly cold.Gui Jing: return Liver Channel.Function cures mainly: heat clearing away nourishing the liver, improving acuity of vision and removing nebula.For conjunctival congestion and swelling pain, many tear photophobia, nebula of looking unfamiliar film, hepatasthenia dim eyesight, blurring of vision.
Caulis Akebiae: base is former: be the woody stems of plants of Lardizabalaceae Caulis Akebiae or threeleaf akebia, Caulis Akebiae.Nature and flavor: bitter, cool.Gui Jing: enter the heart, small intestinal, urinary bladder channel.Function cures mainly: pathogenic fire purging row water, promoting blood circulation.Control hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis.
Usnea: base is former: be the filamentous of Usneaceae plant Usnea Longissima, broken stem Usnea.Nature and flavor: bitter, sweet, flat.Function cures mainly: liver heat removing, reduces phlegm, hemostasis, removing toxic substances.Control headache, conjunctival congestion, cough with copious phlegm, malaria, scrofula, leucorrhea, metrorrhagia, traumatic hemorrhage, carbuncle, venom.
It is recklessly appropriate: base is former: be the herb of samphire Herba Hydrocotyles.Nature and flavor: sweet, light, micro-pungent, cool.Function cures mainly: expelling wind and clearing away heat, preventing phlegm from forming and stopping coughing.For icteric infectious hepatitis, cirrhotic ascites, cholelithiasis, urinary system infection, urinary system calculus, Common Cold, cough, pertussis, pharyngolaryngitis, tonsillitis, corneal nebula; Eczema is controlled in external, herpes zoster, epistaxis.
Cortex Mori: base is former: be the root bark of moraceae plants Mulberry removing cork.Nature and flavor: sweet, cold.Gui Jing: return lung meridian.Function cures mainly: eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For dyspnea and cough due to lung-heat, edema distension oliguria, appearance skin edema.
Herba senecionis nemorensis: base is former: be the herb of chrysanthemum kind of plant wood groundsel.Nature and flavor: bitter, acrid, cold.Gui Jing: enter liver, spleen channel.Function cures mainly: heat-clearing and toxic substances removing.Control hematodiarrhoea, swelling around the eyes, carbuncle furuncle furunculosis.
Fructus Arctii: base is former: be the fruit of feverfew Fructus Arctii.Nature and flavor: pungent, bitter, cold.Gui Jing: attach to the lung and stomach meridians.Function cures mainly: dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat.For anemopyretic cold, cough with copious phlegm, measles, rubella, laryngopharynx swelling and pain, mumps erysipelas, carbuncle sore tumefacting virus.
Cortex Lycii: base is former: be the root bark of eggplant kind of plant Fructus Lycii etc.Nature and flavor: sweet, cold.Gui Jing: return lung, liver, kidney channel.Function cures mainly: removing heat from blood removes and steams, lung heat clearing pathogenic fire reducing.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat, spitting of blood, epistaxis, interior-heat is quenched one's thirst.
Folium Lycii: base is former: be the young stem and leaf of matrimony vine of solanaceae plant or lycium barbarum.Nature and flavor: bitter, sweet, cool.Gui Jing: enter the heart, lung, spleen, kidney channel.Function cures mainly: tonify deficiency benefit essence, heat clearing away, quenches the thirst, dispelling pathogenic wind for improving eyesight.Control deficient fever, excessive thirst, the confused pain of conjunctival congestion, nyctalopia of hiding from view, bleeding not during menses, hot carbuncle toxin.
Rhizoma Phragmitis: base is former: be the rhizome of grass phragmites communis.Nature and flavor: sweet, cold.Gui Jing: attach to the lung and stomach meridians.Function cures mainly: clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.For calentura excessive thirst, gastric heat is vomitted the sound of vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.
Vittaria fudzinoi Mak.: base is former: be the herb of the flat rib Herba Vittariae Flexuosae of Vittariaceae plant.Nature and flavor: tepor, micro-hardship, nontoxic.Gui Jing: liver, stomach warp.Function cures mainly: regulate the flow of vital energy, and invigorates blood circulation, pain relieving.Main traumatic injury, bones and muscles pain, impairment caused by overstrain pain, peratodynia, infantile convulsion, infantile malnutrition, corneal nebula, an emaciation due to blood disorder.
Herba Eragrostidis Poaeoidis: base is former: be the herb of grass Herba Eragrostidis Poaeoidis.Nature and flavor: light are cool.Function cures mainly: wind and heat dispersing, removing heat from blood, diuresis.The red nebula of argument, metrorrhagia, pyretic stranguria, dysuria.
test example 1the clinical practice of the Chinese medicine preparation (embodiment 5) of gained treatment conjunctivitis of the present invention:
In April ,-2014 in October, 2012, in the conjunctivitis patient of 4 hospitals treatment, filter out 332 routine patients, wherein women 153 example, male 179 example, age 8-60 year, the mean age (40.7 ± 4.2) year, course of disease 4-16 days, average course of disease (7.8 ± 0.4) sky.Diagnostic criteria: 1, morbidity is anxious or slowly, has or without acute conjunctivitis medical history, eye has photophobia, sheds tears, pain, foreign body sensation, the malaise symptoms such as dry and astringent, scorching hot; 2, eye portion secretions and in coctum; 3, the tortuous increasing of conjunctival congestion, edema or blood vessel is thick, or has nipple follicle hypertrophy; 4, Bacteria Detection is positive.
Patient is divided into two groups at random, experimental group 185 example and matched group 147 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (
p> 0.05), there is comparability.Experimental group takes products obtained therefrom of the present invention, every day takes twice, each 5-8g(adjusts to some extent depending on concrete condition), 7 days courses for the treatment of, matched group uses other medicine (conventional medication such as chlortetracycline hydrochloride eye ointment, aspartic vitamin eye drops, oxymetazoline hydrochloride eye drop).Treatments period carries out Continuous Observation to two groups of patients conjunctival, palpebral conjunctiva nipple and folliculus, eyes malaise symptoms, record symptom and change.
Curative effect situation criterion: cure: all diseases of eye disappear entirely, conjunctival congestion, edema extinction, secretions disappears, and the symptoms such as nipple follicle hypertrophy disappear completely, and antibacterial culturing is negative; Effective: all diseases of eye are obviously improved, and conjunctival congestion, edema are disappeared substantially, secretions reduces, and the symptoms such as nipple follicle hypertrophy obviously alleviate, and antibacterial culturing is negative; Effective: all diseases of eye are improved, and conjunctival congestion, edema are disappeared to some extent, and secretions is without increase, and the symptoms such as nipple follicle hypertrophy alleviate, and antibacterial culturing is negative; Invalid: ophthalmic uncomfortable symptom is unchanged or increase the weight of.Result is as shown in table 1.
Table 1 liang component patient treatment outcome
As shown in Table 1: experimental group patient, cure 114 examples, effective 45 examples, effective 21 examples, experimental group total effective rate is 97.3%.Matched group patient, cures 48 examples, effective 58 examples, and effective 23 examples, matched group total effective rate is 87.8%, and the therapeutic effect of visible matched group is lower than experimental group.Treatments period, all there is not any untoward reaction in two groups of patients.
Crude drug of the present invention has the Semen Cassiae of clearing away heat to improve acuity of vision, the sand Fructus Foeniculi of reducing heat and dispersing lung-QI, dispel the wind the Radix Hyperici Monogyni (Herba Hyperici Monogyni) of subsiding a swelling, the Flos Buddlejae of improving acuity of vision and removing nebula, the Caulis Akebiae of pathogenic fire purging row water, the Usnea that liver heat removing is reduced phlegm, the sky of expelling wind and clearing away heat is recklessly appropriate, the Cortex Mori of inducing diuresis to remove edema, the Herba senecionis nemorensis of heat-clearing and toxic substances removing, the Fructus Arctii of dispelling wind and heat pathogens, the Cortex Lycii of lung heat clearing pathogenic fire reducing, the Folium Lycii of tonify deficiency benefit essence, the Rhizoma Phragmitis of clearing away heat and promoting production of body fluid, the Vittaria fudzinoi Mak. of vital energy regualting and blood circulation-promoting, the Herba Eragrostidis Poaeoidis of wind and heat dispersing, multiple medical material coupling, can play the effect such as heat-clearing and toxic substances removing, improving acuity of vision and removing nebula.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the Chinese medicine preparation of conjunctivitis, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Semen Cassiae 10-16, sand Fructus Foeniculi 9-11, Radix Hyperici Monogyni (Herba Hyperici Monogyni) 10-15, Flos Buddlejae 9-16, Caulis Akebiae 12-15, Usnea 11-16, Herba Hydrocotyles 9-15, Cortex Mori 11-14, Herba senecionis nemorensis 8-12, Fructus Arctii 6-13, Cortex Lycii 10-13, Folium Lycii 12-16, Rhizoma Phragmitis 10-14, Vittaria fudzinoi Mak. 7-17, Herba Eragrostidis Poaeoidis 9-13.
2. the Chinese medicine preparation for the treatment of conjunctivitis as claimed in claim 1, it is characterized in that, Semen Cassiae 12-14, sand Fructus Foeniculi 9.5-10.5, Radix Hyperici Monogyni (Herba Hyperici Monogyni) 11-14, Flos Buddlejae 11-14, Caulis Akebiae 13-14, Usnea 13-14, Herba Hydrocotyles 11-13, Cortex Mori 12-13, Herba senecionis nemorensis 9-11, Fructus Arctii 8-11, Cortex Lycii 11-12, Folium Lycii 13-15, Rhizoma Phragmitis 11-13, Vittaria fudzinoi Mak. 9-15, Herba Eragrostidis Poaeoidis 10-12 is (preferred, Semen Cassiae 13, sand Fructus Foeniculi 10, Radix Hyperici Monogyni (Herba Hyperici Monogyni) 12.5, Flos Buddlejae 12.5, Caulis Akebiae 13.5, Usnea 13.5, Herba Hydrocotyles 12, Cortex Mori 12.5, Herba senecionis nemorensis 10, Fructus Arctii 9.5, Cortex Lycii 11.5, Folium Lycii 14, Rhizoma Phragmitis 11, Vittaria fudzinoi Mak. 12, Herba Eragrostidis Poaeoidis 11).
3. the Chinese medicine preparation of the treatment conjunctivitis as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Fagopyrum esculentum Moench and put into pot, moderate heat is heated to smolder, and puts into clean Semen Cassiae and Fructus Arctii, when heating stir-fries to micro-savory effusion, takes out, cools;
(2) get Cortex Mori and Cortex Lycii, adding water infiltration, to be placed on steaming tray Steam by water bath saturating, and take out, shredding, mixes thoroughly with hydromel and vinegar, then is placed in frying pan, fry to tack-free be degree, take out, dry;
(3) get Flos Buddlejae and pick clean impurity, after soaking into, pull out, put into frying pan with yellow wine, slow fire heats, and fries to micro-dry, takes out dry;
(4) by sand Fructus Foeniculi, Radix Hyperici Monogyni (Herba Hyperici Monogyni), Caulis Akebiae, Usnea, sky recklessly appropriate, Herba senecionis nemorensis, Folium Lycii, Rhizoma Phragmitis, Vittaria fudzinoi Mak. and Herba Eragrostidis Poaeoidis decontamination, clean, dry, pulverize and sieve together with step (1) (2) (3) made crude drug, obtain powder.
4. the preparation method of the Chinese medicine preparation powder for the treatment of conjunctivitis as claimed in claim 3, it is characterized in that, step (4) was pulverized 140-200 mesh sieve and (preferably, was pulverized 160-180 mesh sieve; Be more preferably, pulverized 170 mesh sieves).
5. the Chinese medicine preparation of the treatment conjunctivitis as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable tablet, its preparation method is:
(1) get Fagopyrum esculentum Moench and put into pot, moderate heat is heated to smolder, and puts into clean Semen Cassiae and Fructus Arctii, when heating stir-fries to micro-savory effusion, takes out, cools;
(2) get Cortex Mori and Cortex Lycii, adding water infiltration, to be placed on steaming tray Steam by water bath saturating, and take out, shredding, mixes thoroughly with hydromel and vinegar, then is placed in frying pan, fry to tack-free be degree, take out, dry;
(3) get Flos Buddlejae and pick clean impurity, after soaking into, pull out, put into frying pan with yellow wine, slow fire heats, and fries to micro-dry, takes out dry;
(4) by sand Fructus Foeniculi, Radix Hyperici Monogyni (Herba Hyperici Monogyni), Caulis Akebiae, Usnea, sky recklessly appropriate, Herba senecionis nemorensis, Folium Lycii, Rhizoma Phragmitis, Vittaria fudzinoi Mak. and Herba Eragrostidis Poaeoidis decontamination, clean, decoct with water together with step (1) (2) made crude drug, big fire is boiled rear little fire and is decocted 20-30 minute (preferred, 22-28 minute decocted by little fire; Be more preferably, little fire decocts 25 minutes), filter, medicinal residues add water and again decoct, and merge twice gained filtrate, concentrated, dry;
(5) step (3) and (4) made crude drug are pulverized together with dry thing 80-140 mesh sieve and (preferably, pulverize 90-130 mesh sieve; Be more preferably, pulverized 110 mesh sieves), obtained medicated powder, suppresses conglobate tablet dosage form by made medicated powder according to the preparation for processing of tablet.
6. the preparation method of the Chinese medicine preparation tablet for the treatment of conjunctivitis as claimed in claim 5, is characterized in that, step (4) decocts with water the 7-9 of middle amount of water total raw material medicine quality, and doubly (preferred, amount of water is 7.5-8.5 times of total raw material medicine quality; Be more preferably, amount of water is 8 times of total raw material medicine quality).
7. the Chinese medicine preparation of the treatment conjunctivitis as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable granule, its preparation method is:
(1) get Fagopyrum esculentum Moench and put into pot, moderate heat is heated to smolder, and puts into clean Semen Cassiae and Fructus Arctii, when heating stir-fries to micro-savory effusion, takes out, cools;
(2) get Cortex Mori and Cortex Lycii, adding water infiltration, to be placed on steaming tray Steam by water bath saturating, and take out, shredding, mixes thoroughly with hydromel and vinegar, then is placed in frying pan, fry to tack-free be degree, take out, dry;
(3) get Flos Buddlejae and pick clean impurity, after soaking into, pull out, put into frying pan with yellow wine, slow fire heats, and fries to micro-dry, takes out dry;
(4) by sand Fructus Foeniculi, Radix Hyperici Monogyni (Herba Hyperici Monogyni), Caulis Akebiae, Usnea, sky recklessly appropriate, Herba senecionis nemorensis, Folium Lycii, Rhizoma Phragmitis, Vittaria fudzinoi Mak. and Herba Eragrostidis Poaeoidis decontamination, clean, add the soak by water of boiled crude drug quality 9 times, big fire is boiled rear little fire and is decocted 20-36 minute (preferred, 24-32 minute decocted by little fire; Be more preferably, little fire decocts 28 minutes), filter, medicinal residues add water and again decoct, and merge twice gained filtrate, are condensed into clear paste;
(5) step (1) (2) (3) made crude drug was pulverized 60 mesh sieves together, made medicated powder, with alcohol reflux 3-6 hour (preferably, the reflux, extract, 4-5 hour of 75% of made medicated powder quality 6 times; Be more preferably, reflux, extract, 4.5 hours), extract twice, merge extractive liquid, is evaporated to gained extracting solution without alcohol taste, mixes, dry, pulverize, add adjuvant soft material with step (4) made clear paste, granulates, and dry, granulate, obtains granule.
8. the preparation method of the Chinese medicine preparation granule for the treatment of conjunctivitis as claimed in claim 7, it is characterized in that, step (5) was pulverized 100-140 mesh sieve and (preferably, was pulverized 110-130 mesh sieve; Be more preferably, pulverized 120 mesh sieves).
9. the Chinese medicine preparation of the treatment conjunctivitis as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Fagopyrum esculentum Moench and put into pot, moderate heat is heated to smolder, and puts into clean Semen Cassiae and Fructus Arctii, when heating stir-fries to micro-savory effusion, takes out, cools;
(2) get Cortex Mori and Cortex Lycii, adding water infiltration, to be placed on steaming tray Steam by water bath saturating, and take out, shredding, mixes thoroughly with hydromel and vinegar, then is placed in frying pan, fry to tack-free be degree, take out, dry;
(3) get Flos Buddlejae and pick clean impurity, after soaking into, pull out, put into frying pan with yellow wine, slow fire heats, and fries to micro-dry, takes out dry;
(4) by sand Fructus Foeniculi, Radix Hyperici Monogyni (Herba Hyperici Monogyni), Caulis Akebiae, Usnea, sky recklessly appropriate, Herba senecionis nemorensis, Folium Lycii, Rhizoma Phragmitis, Vittaria fudzinoi Mak. and Herba Eragrostidis Poaeoidis decontamination, clean, dry, decoct with water together with step (1) (2) (3) made crude drug three times (decocting 8 times that amount of water is total raw material medicine quality) at every turn, during decoction, big fire is boiled rear little fire and is decocted, and filters, and merges three decoction gained medicinal liquids, be concentrated into 1/3rd of original volume, obtain decoction.
10. the preparation method of the Chinese medicine preparation decoction for the treatment of conjunctivitis as claimed in claim 9, is characterized in that, when step (4) decocts, big fire is boiled rear little fire and decocted 30-40 minute (preferred, 32-38 minute decocted by little fire; Be more preferably, little fire decocts 35 minutes).
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| CN103623353A (en) * | 2013-12-09 | 2014-03-12 | 孙凤梅 | Medicine for treating catarrhal conjunctivitis and preparation method thereof |
| CN103655979A (en) * | 2013-12-19 | 2014-03-26 | 青岛友铭辰生物技术有限公司 | Traditional Chinese medicine composition for treating conjunctivitis |
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| CN103623353A (en) * | 2013-12-09 | 2014-03-12 | 孙凤梅 | Medicine for treating catarrhal conjunctivitis and preparation method thereof |
| CN103655979A (en) * | 2013-12-19 | 2014-03-26 | 青岛友铭辰生物技术有限公司 | Traditional Chinese medicine composition for treating conjunctivitis |
| CN104524068A (en) * | 2014-12-19 | 2015-04-22 | 马京平 | Traditional Chinese medicine eye drops for treating pinkeye and preparation method |
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