CN105709106A - 一种金栀咽喉袋泡茶及其制备方法 - Google Patents

一种金栀咽喉袋泡茶及其制备方法 Download PDF

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CN105709106A
CN105709106A CN201610227314.4A CN201610227314A CN105709106A CN 105709106 A CN105709106 A CN 105709106A CN 201610227314 A CN201610227314 A CN 201610227314A CN 105709106 A CN105709106 A CN 105709106A
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宋洁
祁东风
于婷
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Shenyang Feilong Weiye Pharmaceutical Co Ltd
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Abstract

一种金栀咽喉袋泡茶及其制备方法，其技术要点是：其各成分的重量份数比如下：金银花1416份、诃子肉(制)1416份、元参911份、麦冬1416份、北豆根911份、薄荷叶911份、胖大海911份、金果榄810份、硼砂911份、黄连911份、射干810份、黄芩46份、栀子46份、芦根46份、锦灯笼46份、浙贝母46份、牡蛎46份、甘草46份。制备方法包括粗粉制备；硼砂溶液制备；煎煮滤过，合并滤液，减压浓缩成清膏。加入粗粉，混匀，低温干燥，分装即得。本发明的有益特点是：本发明是在传统中医理论下，精选出各原料及其配比，具有清热解毒、生津利咽的功能。用于上焦风热所致的喉痹，症见咽喉疼痛，咽干喉痒，声音嘶哑；急性咽炎、急性喉炎(轻型)见上述证候者。本发明见效快、可根治且无副作用。

Description

一种金栀咽喉袋泡茶及其制备方法
技术领域
本发明涉及一种清热解毒、生津利咽的药品，具体说是一种金栀咽喉袋泡茶及其制备方法。
背景技术
众所周知，咽喉炎是由细菌引起的一种疾病，可分为急性咽喉炎和慢性咽喉炎。
急性咽炎：常为病毒引起，其次为细菌所致。冬春季最为多见。多继发于急性鼻炎、急性鼻窦炎、急性扁桃体炎，且常是麻疹，流感，猩红热等传染病的并发症。受凉、疲劳、长期受化学气体或粉尘的刺激、吸烟过度等，降低人体抗力，容易促其发病。成年人以咽部症状为主，病初咽部有干痒，灼热，渐有疼痛，吞咽时加重，唾液增多，咽侧索受累则有明显的耳痛。体弱成人或小儿，则全身症状显著，有发烧怕冷，头痛，食欲不振，四肢酸痛等。
慢性咽炎：主要是由于急性咽炎治疗不彻底而反复发作，转为慢性，或是因为患各种鼻病，鼻窍阻塞，长期张口呼吸，以及物理、化学因素、颈部放射治疗等经常刺激咽部所致。全身各种慢性疾病，如贫血、便秘、下呼吸道慢性炎症、心血管疾病等也可继发本病。自觉咽部不适，干、痒、胀，分泌物多而灼痛，易恶心，有异物感，咯之不出，吞之不下，以上症状在说话稍多，过食刺激性食物后、疲劳或天气变化时加重。呼吸及吞烟均畅通无阻。
咽部、喉部作为人体的重要器官，如果咽喉炎不能及时正确的治疗，不但可引起全身性的病理改变，它又可能是全身病的反应，所以检查和治疗咽喉疾病，其意义尤为重要。
目前，治疗咽喉炎的药品很多，西药见效快，但大多无法根治且副作用大；而中药却见效缓慢。所以研制一种见效快、可根治且无副作用的新型药品势在必行。
发明内容
本发明的目的是提供一种金栀咽喉袋泡茶及其制备方法。
本发明的目的是这样实现的：
一种金栀咽喉袋泡茶，其各成分的重量份数比如下：金银花14-16份、诃子肉(制)14-16份、元参9-11份、麦冬14-16份、北豆根9-11份、薄荷叶9-11份、胖大海9-11份、金果榄8-10份、硼砂9-11份、黄连9-11份、射干8-10份、黄芩4-6份、栀子4-6份、芦根4-6份、锦灯笼4-6份、浙贝母4-6份、牡蛎4-6份、甘草4-6份。
一种金栀咽喉袋泡茶的制备方法，它的工艺步骤如下：
(1)将金银花、诃子肉、麦冬、薄荷叶、胖大海、栀子、芦根、锦灯笼、牡蛎、甘草粉碎成粗粉，混匀，备用；
(2)硼砂加热水使溶解，制成硼砂溶液，备用；
(3)其余元参、北豆根、金果榄、黄连、射干、黄芩、浙贝母等七味加水浸泡2小时后煎煮二次；
(4)滤过步骤3内产生的溶液，合并滤液，加入硼砂溶液，在65℃的条件下，减压浓缩成相对密度为1.10～1.12的清膏；
(5)加入步骤1的粗粉，混匀，制粒，在40～50℃的条件下低温干燥，分装即得成品。
进一步的技术方案，上述步骤3中煎煮二次，第一次2小时，第二次1.5小时。
本发明与现有技术相比具有的有益特点是：本发明是在传统中医理论下，精选出各原料及其配比，具有清热解毒、生津利咽的功能。可用于上焦风热所致的喉痹，症见咽喉疼痛，咽干喉痒，声音嘶哑；急性咽炎、急性喉炎(轻型)见上述证候者。本发明见效快、可根治且无副作用。
具体实施方式
实例1
一种金栀咽喉袋泡茶的各成分如下：金银花150g，诃子肉(制)150g，元参100g，麦冬150g，北豆根100g，薄荷叶100g，胖大海100g，金果榄90g，硼砂100g，黄连100g，射干90g，黄芩50g，栀子50g，芦根50g，锦灯笼50g，浙贝母50g，牡蛎50g，甘草50g。
本品为袋泡茶，内容物为黄棕色至棕褐色的颗粒或粗粉；气香、味淡、微苦。
制备方法：(1)将金银花、诃子肉、麦冬、薄荷叶、胖大海、栀子、芦根、锦灯笼、牡蛎、甘草粉碎成粗粉，混匀，备用；
(2)硼砂加热水使溶解，制成硼砂溶液，备用；
(3)其余元参、北豆根、金果榄、黄连、射干、黄芩、浙贝母等七味加水浸泡2小时后煎煮二次，第一次2小时，第二次1.5小时；
(4)滤过步骤3内产生的溶液，合并滤液，加入硼砂溶液，在65℃的条件下，减压浓缩成相对密度为1.10～1.12的清膏；
(5)加入步骤1的粗粉，混匀，制粒，在40～50℃的条件下低温干燥，分装即得成品。
实例2
一种金栀咽喉袋泡茶的各成分如下：金银花140g，诃子肉(制)160g，元参90g，麦冬140g，北豆根90g，薄荷叶100g，胖大海100g，金果榄100g，硼砂90g，黄连110g，射干100g，黄芩40g，栀子60g，芦根50g，锦灯笼50g，浙贝母60g，牡蛎50g，甘草50g。
制备方法与实例1相同，故省略。
实例3
一种金栀咽喉袋泡茶的各成分如下：金银花160g，诃子肉(制)160g，元参110g，麦冬150g，北豆根90g，薄荷叶100g，胖大海90g，金果榄90g，硼砂110g，黄连100g，射干110g，黄芩60g，栀子50g，芦根50g，锦灯笼40g，浙贝母60g，牡蛎50g，甘草50g。
制备方法与实例1相同，故省略。
【鉴别】(1)取本品置显微镜下观察：花粉粒类圆形或类三角形，黄色，直径62～98μm，外壁表面有细密短刺及圆形颗粒状雕纹，具3萌发孔，腺毛头部6～33细胞，排成2～4层，有的细胞含淡黄色分泌物，柄部2～5细胞。腺鳞头部8细胞，直径65～100μm，柄极短；叶片碎片细胞中含有淡黄色橙皮苷结晶。种皮厚壁细胞成片，细胞类多角形、类方形或不规则形，直径4～31μm，壁厚1.4～1.5μm，孔沟清晰，胞腔充满红棕色物，纤维束周围薄壁细胞含草酸钙方晶，形成晶纤维。果皮纤维层淡黄色，斜向交错排列，壁较薄。
(2)取本品5g，研细，加石油醚(30-60℃)50ml，密塞，振摇数分钟，放置1小时，滤过，弃去滤液，药渣加盐酸-甲醇(1∶100)50ml，置水浴上加热回流提取30分钟，放冷，滤过，滤液蒸干，残渣加甲醇2ml使溶解，作为供试品溶液。另取盐酸小檗碱对照品，加甲醇制成每1ml含0.5mg的溶液，作为对照品溶液。照薄层色谱法(中国药典2000年版一部附录VI B)试验，吸取上述两种溶液各2μl，分别点于同一含0.2％羧甲基纤维素钠为黏合剂的硅胶G薄层板上，以正丁醇-冰醋酸-水(7∶1∶2)为展开剂，展开，取出，晾干，置紫外光灯(365nm)下检视。供视品色谱中，在与对照品色谱相应的位置上，显相同颜色的荧光斑点。
(3)取本品10g，研细，加甲醇50ml，超声处理30分钟，滤过，滤液蒸干，残渣加水30ml使溶解，加醋酸乙酯振摇提取3次(25ml，25ml，20ml)，弃去醋酸乙酯液，水层加水饱和正丁醇振摇提取2次(20ml，10ml)，合并正丁醇液，加1％氢氧化钠溶液洗涤2次，每次25ml，再加水30ml洗涤一次，取正丁醇层，水浴蒸干，残渣加甲醇1ml使溶解，作为供试品溶液。另取栀子苷对照品，加甲醇制成每1ml含1mg的溶液，作为对照品溶液。照薄层色谱法(中国药典2000年版一部附录VI B)试验，吸取上述两种溶液各5μl，分别点于同一以羧甲基纤维素钠为黏合剂的硅胶G薄层板上，以氯仿-甲醇-水(65∶35∶10)10℃以下放置的下层溶液为展开剂，展开，取出，晾干，喷以10％硫酸乙醇溶液，于110℃加热至斑点显色清晰，供试品色谱中，在与对照品色谱相应的位置上，显相同颜色的斑点。
(4)取本品10g，加甲醇50ml，超声处理30分钟，滤过，滤液蒸干，残渣加1％氢氧化钠溶液25ml使溶解，加氯仿振摇提取2次(30ml，20ml)，合并氯仿液，蒸干，残渣加氯仿1ml使溶解，作为供试品溶液。另取北豆根对照药材1g，同法制成对照药材溶液。照薄层色谱法(中国药典2000年版一部附录VI B)试验，吸取供试品溶液5μl，对照药材溶液1μl，分别点于同一用2％氢氧化钠溶液制备的以羧甲基纤维素钠为黏合剂的硅胶G薄层板上，以甲苯-丙酮-甲醇(8∶3∶0.5)为展开剂，置氨蒸气预饱和的展开缸中展开，取出，晾干，喷以稀碘化铋钾试液。供试品色谱中，在与对照药材色谱相应的位置上，显相同颜色的斑点。
【检查】应符合茶剂项下有关的各项规定(中国药典2000年版一部附录IT)
【含量测定】照高效液相色谱法(中国药典2000年版一部附录VID)测定。
色谱条件与系统适用性试验用十八烷基硅烷健合硅胶为填充剂；以甲醇-0.0025mol/L磷酸溶液(取85％磷酸0.14ml用水稀释至1000ml，用三乙胺调节pH值至3.0±0.1)(30∶70)为流动相，检测波长330nm。理论板数按绿原酸峰计算不得低于1500。
对照品溶液的制备：精密称取经110℃干燥至恒重的绿原酸对照品适量，用50％甲醇制成每1ml中含6μg的溶液，即得。
供试品溶液的制备：取本品装量差异项下的内容物，研细，取约1g，精密称定，置索氏提取器中，加甲醇100ml，置水浴中回流提取至提取液无色。回收甲醇至干，残渣加50％甲醇溶液适量使溶解，用干燥滤器滤过，用50％甲醇溶液分次洗涤滤器，洗液与滤液合并，置250ml量瓶中，加50％甲醇溶液至刻度，摇匀，即得。
测定法：分别精密量取对照品溶液与供试品溶液各10μl，注入高效液相色谱仪，测定，即得。
本品每袋含金银花以绿原酸(C16H18O9)计，不得低于1.56mg。

Claims (3)

1.一种金栀咽喉袋泡茶，其特征是：其各成分的重量份数比如下：金银花14-16份、诃子肉(制)14-16份、元参9-11份、麦冬14-16份、北豆根9-11份、薄荷叶9-11份、胖大海9-11份、金果榄8-10份、硼砂9-11份、黄连9-11份、射干8-10份、黄芩4-6份、栀子4-6份、芦根4-6份、锦灯笼4-6份、浙贝母4-6份、牡蛎4-6份、甘草4-6份。
2.一种金栀咽喉袋泡茶的制备方法，其特征是：它的工艺步骤如下：
(1)将金银花、诃子肉、麦冬、薄荷叶、胖大海、栀子、芦根、锦灯笼、牡蛎、甘草粉碎成粗粉，混匀，备用；
(2)硼砂加热水使溶解，制成硼砂溶液，备用；
(3)其余元参、北豆根、金果榄、黄连、射干、黄芩、浙贝母等七味加水浸泡2小时后煎煮二次；
(4)滤过步骤3内产生的溶液，合并滤液，加入硼砂溶液，在65℃的条件下，减压浓缩成相对密度为1.10～1.12的清膏；
(5)加入步骤1的粗粉，混匀，制粒，在40～50℃的条件下低温干燥，分装即得成品。
3.根据权利要求2所述的一种金栀咽喉袋泡茶制备方法，其特征是：上述步骤3中煎煮二次，第一次2小时，第二次1.5小时。
CN201610227314.4A 2016-04-13 2016-04-13 一种金栀咽喉袋泡茶及其制备方法 Pending CN105709106A (zh)

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CN107319068A (zh) * 2017-07-27 2017-11-07 宾阳县华信种植专业合作社 一种提高免疫力的养生茶
CN114097911A (zh) * 2021-12-28 2022-03-01 西南民族大学 一种预防和治疗咽炎的袋泡茶及其检测方法
CN114097911B (zh) * 2021-12-28 2023-10-03 西南民族大学 一种预防和治疗咽炎的袋泡茶及其检测方法

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