CN105708718A - Acne-removal cosmetic composition containing nano-zinc - Google Patents
Acne-removal cosmetic composition containing nano-zinc Download PDFInfo
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- CN105708718A CN105708718A CN201610232092.5A CN201610232092A CN105708718A CN 105708718 A CN105708718 A CN 105708718A CN 201610232092 A CN201610232092 A CN 201610232092A CN 105708718 A CN105708718 A CN 105708718A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
Abstract
The invention discloses acne-removal cosmetic composition containing nano-zinc. The acne-removal cosmetic composition comprises nano-zinc and other cosmetic matrix components. Through synergistic interaction of nano-zinc and azelaic acid, the acne-removal cosmetic composition can perform the efficacy of pore clearing, balancing of grease secretion, sterilization, inflammation eliminating, acne mark removal, moisturization, sun blocking and the like, comprehensively repairs and improves the barrier function of skin and thoroughly removes acne.
Description
Technical field
The present invention relates to cosmetic field, be specifically related to a kind of acne-eliminating cosmetic composition containing Nano-Zinc.
Background technology
With the quickening pace of modern life, work and the increase of life stress, add environmental pollution and food-safety problem take place frequently, the sickness rate of comedo rises year by year.Comedo is a kind of common chronic pilosebaceous inflammations disease, it is apt to occur in the position that the sebum secretions such as face, shirtfront and upper back are vigorous, course of disease length, easily recurring, often show as Whiteheads, blackhead or inflamed papules, serious has pustule, tuberosity, cyst or cicatrix.If inflammation is obvious, more can cause pain or touch pain, and with seborrhea, Pericarpium Citri Reticulatae face even occurring.Comedo incidence rate in youth of both sexes crowd is high, it not only has a strong impact on the attractive in appearance of face, and affect social activity and the psychology of people, make patient occur not self-confident, awkward, lose, the negative emotions such as anxiety, anxiety, irritability and depression, thus affecting quality of life.
CN201210422637 discloses one and comprises zinc oxide and salicylic cosmetic water and preparation method; comprising zinc oxide 0.1-5%, bentonite 0.001-2%, isopropyl methyl phenol 0.01-0.1%, salicylic acid 0.2-2%, bright protective agent PARSOLGUARD0.01-1%, wherein zinc oxide particle diameter is 0.05-6 micron super fine zinc oxide.But, zinc oxide is used for cosmetic water by this patent, it does not have obtain good anti-acne effect, and salicylic acid consumption is excessive, Diazolidinyl Urea.
Summary of the invention
In order to overcome the defect of prior art, inventors performed further investigation, it has unexpectedly been found that adopt Nano-Zinc and Azelaic Acid can arrive good anti-acne effect, and the effect of wound healing can be promoted.
The invention provides a kind of acne-eliminating cosmetic composition containing Nano-Zinc, including Nano-Zinc and Azelaic Acid.It is preferably based on the gross weight gauge of compositions, including the Azelaic Acid of the Nano-Zinc of 0.3-5.0wt% and 0.005-1wt%.It is preferably based on the gross weight gauge of compositions, including the Azelaic Acid of the Nano-Zinc of 1-4wt% and 0.05-0.5wt%.It is highly preferred that based on the gross weight gauge of compositions, including the Azelaic Acid of the Nano-Zinc of 2-3wt% and 0.1-0.4wt%.
In the present invention, the particle diameter of Nano-Zinc is 80-150nm, it is preferable that the particle diameter of Nano-Zinc is 100-130nm, more preferably 110-120nm.
In the present invention, one or more following components that described compositions can also include: glycerol, Dormant oils, ring five polydimethylsiloxane, isopropyl myristate, propylene glycol, polydimethylsiloxane, the different ceteth-20 of methyl gluceth-20/ isosteareth-20/, glyceryl stearate/PEG-100 stearate, polyvinyl alcohol, carbomer, triethanolamine, methyl hydroxybenzoate, Bis(hydroxymethyl)imidazolidinyl urea/iodine propilolic alcohol butyl mephenesin Carbamate, propyl hydroxybenzoate.Preferably, described compositions includes propylene glycol, it is preferred to 1,3-PD.It is further preferred that the compositions of the present invention also includes cetearyl alcohol, polyvinyl alcohol, lanoline.In the present invention, based on the gross weight gauge of compositions, described compositions can also include following components:
Glycerol 3-10wt%；It is preferably 4-6wt%；
Dormant oils 2-8wt%；It is preferably 5-7wt%；
Ring five polydimethylsiloxane 1-6wt%；It is preferably 2-4wt%；
Isopropyl myristate 0.5-4wt%；It is preferably 2-3wt%；
Propylene glycol 3-8wt%；It is preferably 5-6wt%；
Polydimethylsiloxane 1-6wt%；It is preferably 2-4wt%；
Different ceteth-the 200.5-3wt% of methyl gluceth-20/ isosteareth-20/；
It is preferably 1.5-2wt%；
Glyceryl stearate/PEG-100 stearate 0.5-2.5wt%；It is preferably 0.8-1.5wt%；
Carbomer 0.05-0.3wt%；It is preferably 0.1-0.2wt%；
Triethanolamine 0.5-2Wt%；It is preferably 0.8-1.2wt%；
Methyl hydroxybenzoate 0.01-0.1wt%；It is preferably 0.05-0.08wt%；
Bis(hydroxymethyl)imidazolidinyl urea/iodine propilolic alcohol butyl mephenesin Carbamate 0.2-0.7Wt%；It is preferably 0.3-0.5wt%；
Propyl hydroxybenzoate 0.01-0.1wt%；It is preferably 0.05-0.08wt%.
In the present invention, based on the gross weight gauge of compositions, described compositions also includes following components:
Cetearyl alcohol 0.5-2wt%；It is preferably 0.8-1.2wt%；
Polyvinyl alcohol 0.3-1.5wt%；It is preferably 0.5-1wt%；
Lanoline 0.2-1.5wt%；It is preferably 0.5-0.8wt%.
The product for resolving poxes of the present invention can be obtained by conventional method.For example, after being mixed in proportion by the material of the material of Nano-Zinc and Azelaic Acid, adding other raw materials, heated, stirring, high pressure homogenize etc. are made into.
In this article, term " particle diameter " is technical term well known to those skilled in the art, for instance, " particle diameter " specifically described herein can be measured by laser diffraction analyzer.
Nano-Zinc is a kind of polyfunctional new inorganic material.Due to the granular of crystal grain, its Electronic Structure and crystal structure change, and create skin effect, bulk effect, quantum size effect and macroscopic view tunnel-effect and the feature such as the high grade of transparency, polymolecularity that macro object does not have.Discovered in recent years it in catalysis, optics, magnetics, mechanics etc., show many specific functions, make it have important using value in many fields such as pottery, chemical industry, electronics, optics, biology, medicine, there is particularity and purposes that common zinc oxide cannot compare.The outstanding feature of Nano-class zinc oxide is in that product pellet is nanoscale, has nano material and the double grading of conventional oxidation zinc simultaneously.Compared with conventional oxidation zinc product, its specific surface area is big, chemism is high, and product fineness, chemical purity and shape of particle can be adjusted as required, and has Photochemical effects and cover ultraviolet performance preferably, and its UV-preventing rate is up to 98%；Meanwhile, it also there is antibacterial bacteriostatic, a series of special performances such as the anti-enzyme of taste of dispelling.There is good ultraviolet-shielding type and superior antibacterial, bacteriostasis property, the functions such as sun-proof, antibacterial, deodorization can be given.
Azelaic Acid of the present invention directly suppresses and kills skin surface and intrafollicular antibacterial, eliminates pathogen；Competitive inhibition produces the enzyme process of dihydrotestosterone, and the skin oil and fat that minimizing dihydrotestosterone factor is brought out is too much；The generation of inhibitory activity oxygen-derived free radicals and effect, be conducive to antiinflammatory；Reduce thread keratic synthesis, it is prevented that follicular hyperkeratosis.
The present invention from Bergamot Mint Extract, dissolution angular embolization, suppression bacterial multiplication, repair cicatrix, opposing ultraviolet, antiinflammatory, antiallergic, antioxidation, moisturizing, anti-inflammatory after pigmentation, promote anti-acne composition percutaneous absorbtion, promote the aspect such as comedo wound healing, play comprehensive and significant anti-acne effect, make skin recover normal fine and smooth soft and smooth.After disabling, the symptom such as comedo not easily recurs, acne-removing is notable, quickly, persistently, safety.
The present invention has acne-eliminating cosmetic composition and selects Nano-Zinc, has the good compatibility with skin, can be absorbed by the skin rapidly, safe, gentle, does not cause the reactions such as stimulation, allergy, and skin is also without burden.The acne-eliminating cosmetic composition of the present invention is by the Synergistic of Nano-Zinc with Azelaic Acid, dredging pore, Bergamot Mint Extract, sterilization, antiinflammatory, acne removing print, moisturizing, the effect such as sun-proof can be played simultaneously, to repair and to improve the barrier function of skin comprehensively, thorough removing acne.When Nano-Zinc and Azelaic Acid are composite, it is especially pronounced that inflammatory damage, pustule and Cystic comedo are cured effect by acne-eliminating cosmetic composition of the present invention.
Detailed description of the invention
The following component title occurred in literary composition is the title of INCI (InternationalNomenclatureCosmeticIngredient, the i.e. name of international cosmetic raw material) defined: the different ceteth-20 of methyl gluceth-20/ isosteareth-20/, glyceryl stearate/PEG-100 stearate, Bis(hydroxymethyl)imidazolidinyl urea/iodine propilolic alcohol butyl mephenesin Carbamate.Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited to this.
Table 1 acne eliminating cream/breast formulation Example 1-5
Above-described embodiment, by common process and the adjuvant of preparing cosmetics, prepares into acne eliminating cream/breast.
Adopting the acne eliminating cream prepared of above-described embodiment to carry out clinic trial sight case 100 example respectively, clinical main manifestations is acne in various degree or pox print, pox scar, and the time is 1～15 year, and in pustule state or aubergine pox print, at 20～40 years old age, men and women does not limit.It is simultaneously provided with the matched group of 1 example, adopts commercially available acne eliminating cream.
(1) method
After every day cleansing milk face cleaning, take the amount uniform application of each Margarita size up and down in face, and clap to mastic with have gentle hands and be completely absorbed, sooner or later each once.Within 7 days, 15 days, 1 month, 3 months, observe and add up.
(2) standard
Cure: clinical symptom disappearance；
Effective: clinical symptom relief, acne forms a scab, and pox print is thin out, pox scar shoals；
Invalid: clinical symptoms has no improvement.
(3) result
Table 2
The feature that acne eliminating cream has instant effect, cure rate is big prepared by the experimental result display present composition, within 7 days, effective percentage is up to 80%, and has certain cure rate, and the cure rate of 1 month is up to 80%.Said composition can cut down skin sore acne, control oil, improves sebum secretion, pore refining, stimulates cutaneous circulation, repair cicatrix, promotes wound healing, make pore compact, skin refreshing.Do not have an example reaction that allergy occurs, the phenomenons such as skin is uncomfortable.
Above example is only in order to illustrate that technical scheme is not intended to limit; those of ordinary skill in the field are to be understood that; the specific embodiment of the present invention can being modified with reference to above-described embodiment or equivalent replacement, these are all being applied within the claims awaited the reply without departing from any amendment or equivalent replacement of spirit and scope of the invention.
Claims (8)
1. the acne-eliminating cosmetic composition containing Nano-Zinc, it is characterised in that include Nano-Zinc and Azelaic Acid, based on the gross weight gauge of compositions, Nano-Zinc content is 0.3-5.0wt%, and Azelaic Acid content is 0.005-1wt%；Nano-Zinc particle diameter is 100-150nm.
2. compositions according to claim 1, it is characterised in that the gross weight gauge Nano-Zinc content based on compositions is 2-3wt%, and Azelaic Acid content is 0.1-0.4wt%.
3. compositions according to claim 1 and 2, it is characterised in that the particle diameter of Nano-Zinc is 110-120nm.
4. compositions according to claim 1 and 2, it is characterized in that, described compositions also includes one or more of following components: glycerol, Dormant oils, ring five polydimethylsiloxane, isopropyl myristate, propylene glycol, polydimethylsiloxane, the different ceteth-20 of methyl gluceth-20/ isosteareth-20/, glyceryl stearate/PEG-100 stearate, polyvinyl alcohol, carbomer, triethanolamine, methyl hydroxybenzoate, Bis(hydroxymethyl)imidazolidinyl urea/iodine propilolic alcohol butyl mephenesin Carbamate, propyl hydroxybenzoate.
5. compositions according to claim 4, it is characterised in that described compositions includes propylene glycol.
6. compositions according to claim 5, it is characterised in that described propylene glycol is 1,3-PD；Based on the gross weight gauge of compositions, the consumption of 1,3-PD is 3-8wt%.
7. compositions according to claim 1 and 2, it is characterised in that based on the gross weight gauge of compositions, described compositions also includes: glycerol 3-10wt%；Dormant oils 2-8wt%；Ring five polydimethylsiloxane 1-6wt%；Isopropyl myristate 0.5-4wt%；Propylene glycol 3-8wt%；Polydimethylsiloxane 1-6wt%；Different ceteth-the 200.5-3wt% of methyl gluceth-20/ isosteareth-20/；Glyceryl stearate/PEG-100 stearate 0.5-2.5wt%；Carbomer 0.05-0.3wt%；Triethanolamine 0.5-2Wt%；Methyl hydroxybenzoate 0.01-0.1wt%；Bis(hydroxymethyl)imidazolidinyl urea/iodine propilolic alcohol butyl mephenesin Carbamate 0.2-0.7Wt%；Propyl hydroxybenzoate 0.01-0.1wt%.
8. compositions according to claim 7, it is characterised in that based on the gross weight gauge of compositions, described compositions also includes: cetearyl alcohol 0.5-2wt%；Polyvinyl alcohol 0.3-1.5wt%；Lanoline 0.2-1.5wt%.
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106860033A (en) * | 2017-02-17 | 2017-06-20 | 南京凯创协同纳米技术有限公司 | Washing-free antibacterial is washed one's hands gel and preparation method thereof |
| CN106880507A (en) * | 2017-02-17 | 2017-06-23 | 南京凯创协同纳米技术有限公司 | Washing-free antibacterial hand sanitizer and preparation method thereof |
| CN107028797A (en) * | 2017-06-12 | 2017-08-11 | 南京凯创协同纳米技术有限公司 | Anti-acne essence and preparation method thereof |
| CN107028805A (en) * | 2017-06-12 | 2017-08-11 | 南京凯创协同纳米技术有限公司 | Emulsifying anti-acne mildy wash and preparation method thereof |
| CN107137243A (en) * | 2017-06-12 | 2017-09-08 | 南京凯创协同纳米技术有限公司 | Anti-acne facial treatment milk and preparation method thereof |
| CN107213038A (en) * | 2017-06-12 | 2017-09-29 | 南京凯创协同纳米技术有限公司 | Anti-acne face cream and preparation method thereof |
| CN107213033A (en) * | 2017-06-12 | 2017-09-29 | 南京凯创协同纳米技术有限公司 | Transparent gel type anti-acne mildy wash and preparation method thereof |
| CN107260577A (en) * | 2017-06-12 | 2017-10-20 | 南京凯创协同纳米技术有限公司 | Anti-acne toner and preparation method thereof |
| CN110893149A (en) * | 2019-12-30 | 2020-03-20 | 盛芮医疗科技(杭州)有限公司 | Composition added with natural antibacterial repair components, preparation method and application thereof |
| CN111467268A (en) * | 2020-05-09 | 2020-07-31 | 广州丽彦妆生物科技有限公司 | Production process of yeast moisturizing face cream |
| CN112401248A (en) * | 2020-07-01 | 2021-02-26 | 张超 | Nano zinc-selenium powder |
| US11026907B2 (en) * | 2018-07-25 | 2021-06-08 | Chengdu Joy Young Biotechnology Co., Ltd. | Azelaic acid gel, preparation method and application thereof |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106860033A (en) * | 2017-02-17 | 2017-06-20 | 南京凯创协同纳米技术有限公司 | Washing-free antibacterial is washed one's hands gel and preparation method thereof |
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| CN107028797A (en) * | 2017-06-12 | 2017-08-11 | 南京凯创协同纳米技术有限公司 | Anti-acne essence and preparation method thereof |
| CN107028805A (en) * | 2017-06-12 | 2017-08-11 | 南京凯创协同纳米技术有限公司 | Emulsifying anti-acne mildy wash and preparation method thereof |
| CN107137243A (en) * | 2017-06-12 | 2017-09-08 | 南京凯创协同纳米技术有限公司 | Anti-acne facial treatment milk and preparation method thereof |
| CN107213038A (en) * | 2017-06-12 | 2017-09-29 | 南京凯创协同纳米技术有限公司 | Anti-acne face cream and preparation method thereof |
| CN107213033A (en) * | 2017-06-12 | 2017-09-29 | 南京凯创协同纳米技术有限公司 | Transparent gel type anti-acne mildy wash and preparation method thereof |
| CN107260577A (en) * | 2017-06-12 | 2017-10-20 | 南京凯创协同纳米技术有限公司 | Anti-acne toner and preparation method thereof |
| US11026907B2 (en) * | 2018-07-25 | 2021-06-08 | Chengdu Joy Young Biotechnology Co., Ltd. | Azelaic acid gel, preparation method and application thereof |
| CN110893149A (en) * | 2019-12-30 | 2020-03-20 | 盛芮医疗科技(杭州)有限公司 | Composition added with natural antibacterial repair components, preparation method and application thereof |
| CN111467268A (en) * | 2020-05-09 | 2020-07-31 | 广州丽彦妆生物科技有限公司 | Production process of yeast moisturizing face cream |
| CN112401248A (en) * | 2020-07-01 | 2021-02-26 | 张超 | Nano zinc-selenium powder |
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