CN105287302A - Acne removing facial cleanser - Google Patents
Acne removing facial cleanser Download PDFInfo
- Publication number
- CN105287302A CN105287302A CN201510830338.4A CN201510830338A CN105287302A CN 105287302 A CN105287302 A CN 105287302A CN 201510830338 A CN201510830338 A CN 201510830338A CN 105287302 A CN105287302 A CN 105287302A
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- Prior art keywords
- parts
- acid
- glycol
- lauric acid
- acne
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- 230000001815 facial effect Effects 0.000 title claims abstract description 20
- 208000002874 Acne Vulgaris Diseases 0.000 title abstract description 7
- 206010000496 acne Diseases 0.000 title abstract description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 33
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims abstract description 33
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 33
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical class NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 22
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000002502 liposome Substances 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims abstract description 12
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims abstract description 12
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims abstract description 12
- DWANEFRJKWXRSG-UHFFFAOYSA-N 1,2-tetradecanediol Chemical compound CCCCCCCCCCCCC(O)CO DWANEFRJKWXRSG-UHFFFAOYSA-N 0.000 claims abstract description 11
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Chemical class NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 11
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims abstract description 11
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims abstract description 11
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 11
- FPVVYTCTZKCSOJ-UHFFFAOYSA-N Ethylene glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC(=O)CCCCCCCCCCCCCCCCC FPVVYTCTZKCSOJ-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000005639 Lauric acid Substances 0.000 claims abstract description 11
- 229930195725 Mannitol Natural products 0.000 claims abstract description 11
- 229920000168 Microcrystalline cellulose Chemical class 0.000 claims abstract description 11
- 229920000881 Modified starch Polymers 0.000 claims abstract description 11
- 235000021355 Stearic acid Nutrition 0.000 claims abstract description 11
- 229960000458 allantoin Drugs 0.000 claims abstract description 11
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims abstract description 11
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims abstract description 11
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical class CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims abstract description 11
- NDORGWUNFGHGKU-UHFFFAOYSA-N dodecanoic acid;sodium Chemical compound [Na].CCCCCCCCCCCC(O)=O NDORGWUNFGHGKU-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000000594 mannitol Substances 0.000 claims abstract description 11
- 235000010355 mannitol Nutrition 0.000 claims abstract description 11
- 239000008108 microcrystalline cellulose Chemical class 0.000 claims abstract description 11
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 11
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 11
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 11
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229960003415 propylparaben Drugs 0.000 claims abstract description 11
- 229940065859 sodium cocoyl glycinate Drugs 0.000 claims abstract description 11
- IKGKWKGYFJBGQJ-UHFFFAOYSA-M sodium;2-(dodecanoylamino)acetate Chemical class [Na+].CCCCCCCCCCCC(=O)NCC([O-])=O IKGKWKGYFJBGQJ-UHFFFAOYSA-M 0.000 claims abstract description 11
- 239000008117 stearic acid Substances 0.000 claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 8
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 claims abstract description 4
- 230000003255 anti-acne Effects 0.000 claims description 18
- 229940116707 mentha piperita extract Drugs 0.000 claims description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 10
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical class [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 10
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 10
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 10
- SOROIESOUPGGFO-UHFFFAOYSA-N diazolidinylurea Chemical compound OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O SOROIESOUPGGFO-UHFFFAOYSA-N 0.000 claims description 10
- 229960001083 diazolidinylurea Drugs 0.000 claims description 10
- 229940100608 glycol distearate Drugs 0.000 claims description 10
- -1 hydroxypropyl Chemical group 0.000 claims description 10
- 229910052740 iodine Inorganic materials 0.000 claims description 10
- 239000011630 iodine Substances 0.000 claims description 10
- KRPAJLYSLFNDOA-UHFFFAOYSA-N mephenesin carbamate Chemical compound CC1=CC=CC=C1OCC(O)COC(N)=O KRPAJLYSLFNDOA-UHFFFAOYSA-N 0.000 claims description 10
- 229950006838 mephenesin carbamate Drugs 0.000 claims description 10
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims description 10
- 235000010384 tocopherol Nutrition 0.000 claims description 10
- 229960001295 tocopherol Drugs 0.000 claims description 10
- 229930003799 tocopherol Natural products 0.000 claims description 10
- 239000011732 tocopherol Substances 0.000 claims description 10
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 9
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 claims description 7
- 235000021360 Myristic acid Nutrition 0.000 claims description 7
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 6
- 238000010792 warming Methods 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 3
- 239000008367 deionised water Substances 0.000 claims description 3
- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 5
- 235000004357 Mentha x piperita Nutrition 0.000 abstract description 4
- 241001479543 Mentha x piperita Species 0.000 abstract description 4
- 239000001771 mentha piperita Substances 0.000 abstract description 4
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 2
- 229940099451 3-iodo-2-propynylbutylcarbamate Drugs 0.000 abstract 1
- WYVVKGNFXHOCQV-UHFFFAOYSA-N 3-iodoprop-2-yn-1-yl butylcarbamate Chemical compound CCCCNC(=O)OCC#CI WYVVKGNFXHOCQV-UHFFFAOYSA-N 0.000 abstract 1
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical class CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 abstract 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 abstract 1
- BVTHRGZMQHOCOL-UHFFFAOYSA-N OCC(O)(C1(NC(=O)NCNC(=O)NC2(CO)NC(=O)NC2=O)NC(=O)NC1=O)CO Chemical compound OCC(O)(C1(NC(=O)NCNC(=O)NC2(CO)NC(=O)NC2=O)NC(=O)NC1=O)CO BVTHRGZMQHOCOL-UHFFFAOYSA-N 0.000 abstract 1
- 235000021314 Palmitic acid Nutrition 0.000 abstract 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 abstract 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 abstract 1
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 abstract 1
- 229960005150 glycerol Drugs 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 239000001866 hydroxypropyl methyl cellulose Chemical class 0.000 abstract 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 1
- 229920003088 hydroxypropyl methyl cellulose Chemical class 0.000 abstract 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical class OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 1
- LIKBJVNGSGBSGK-UHFFFAOYSA-N iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[Fe+3].[Fe+3] LIKBJVNGSGBSGK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 abstract 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 abstract 1
- 229960002216 methylparaben Drugs 0.000 abstract 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 abstract 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 abstract 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 abstract 1
- 229960004063 propylene glycol Drugs 0.000 abstract 1
- 235000013772 propylene glycol Nutrition 0.000 abstract 1
- 125000001453 quaternary ammonium group Chemical class 0.000 abstract 1
- 229940104256 sodium taurate Drugs 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 235000013336 milk Nutrition 0.000 description 8
- 239000008267 milk Substances 0.000 description 8
- 210000004080 milk Anatomy 0.000 description 8
- 230000000694 effects Effects 0.000 description 6
- 239000003921 oil Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 241000700647 Variola virus Species 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 235000007421 Mentha citrata Nutrition 0.000 description 1
- 244000007703 Mentha citrata Species 0.000 description 1
- 235000008660 Mentha x piperita subsp citrata Nutrition 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000002144 chemical decomposition reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 239000003845 household chemical Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229940105902 mint extract Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 230000037204 skin physiology Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
Abstract
The present invention discloses an acne removing facial cleanser, and belongs to the technical field of daily chemicals, wherein the acne removing facial cleanser is prepared from the following raw materials: stearic acid, lauric acid, myristic acid, palmitic acid, ethylene glycol distearate, tocopheryl acetate, ceteareth-60 myristyl glycol, butylated hydroxytoluene, methylparaben, propylparaben, glycerol, propylene glycol, modified corn starch, lauric acid sodium taurate, sodium cocoyl glycinate, cocoamido propyl betaine, microcrystalline cellulose, hydroxypropyl methyl cellulose, EDTA disodium, allantoin, poly quaternary ammonium salt-7, mannitol, potassium hydroxide, CI 77891, CI 77491, mentha piperita leaf extract nanometer liposome, bis(hydroxymethyl) imidazolidinyl urea, iodopropynyl butylcarbamate, essence and water. According to the present invention, the mentha piperita leaf extract nanometer liposome is added so as to provide better antibacterial and anti-inflammatory effect compared with the common mentha piperita leaf extract, the acne on the face can be effectively removed with the prepared acne removing facial cleanser, the face acne removal rate can be up to 80%, and no pockmark is left after the removing.
Description
Technical field
The present invention relates to household chemicals field, be specifically related to a kind of anti-acne facial cleanser.
Background technology
Cleansing milk is the emulsion-formulated products adopting the mode of washing to clean human facial skin.It can remove skin surface attachment the skin physiology metabolite such as sebum, horny layer chip, perspiration and dust, microorganism, use cosmetics residue etc.On domestic market, cleansing milk product category is various, by increasing consumer is accepted in city.General cleansing milk only has clean effect, if add the composition with acne-removing wherein, then cleansing milk is while cleaning, and can also reach the effect of anti-acne, uses easily.
Summary of the invention
The present invention aims to provide a kind of anti-acne facial cleanser, and it, by adding leaf of Mentha piperita extract nano-liposome, has effect of good bactericidal antiphlogistic, Bergamot Mint Extract.
For achieving the above object, the technical scheme that the present invention takes is:
A kind of anti-acne facial cleanser, is made up of following raw material: stearic acid 15-20 part, lauric acid 5 ~ 10 parts, myristic acid 4 ~ 8 parts, Palmic acid 3 ~ 6 parts, glycol distearate 1 ~ 2 part, tocopherol acetas 0.1 ~ 0.5 part, ceteareth-60 myristyl glycol 0.1 ~ 0.5 part, butylated hydroxytoluene 0.1 ~ 0.2 part, methyl hydroxybenzoate 0.1 ~ 0.2 part, propyl hydroxybenzoate 0.05 ~ 0.15 part, glycerol 15 ~ 25 parts, propylene glycol 0.1 ~ 0.5 part, modified corn starch 2 ~ 5 parts, lauric acid sodium taurocholate 2 ~ 4 parts, sodium cocoyl glycinate 2 ~ 4 parts, lauroylamidopropyl betaine 2 ~ 4 parts, microcrystalline Cellulose 0.1 ~ 0.5 part, hydroxypropyl emthylcellulose 0.1 ~ 0.5 part, EDETATE SODIUM 0.05 ~ 0.2 part, allantoin 0.05 ~ 0.2 part, polyquaternary ammonium salt-70.5 ~ 1 part, mannitol 0.5 ~ 1 part, potassium hydroxide 4.5 ~ 6.5 parts, CI778910.1 ~ 0.5 part, CI774910.1 ~ 0.5 part, leaf of Mentha piperita extract nano-liposome 0.5 ~ 5 part, diazolidinyl urea 0.1 ~ 0.5 part, iodine propilolic alcohol butyl mephenesin Carbamate 0.002 ~ 0.0075 part, 0.1 ~ 0.5 part, essence, water To100.
A kind of anti-acne facial cleanser, its preparation method comprises the steps: first to add in oil tank by stearic acid, lauric acid, myristic acid, Palmic acid, glycol distearate, tocopherol acetas, ceteareth-60 myristyl glycol, butylated hydroxytoluene, methyl hydroxybenzoate, propyl hydroxybenzoate, stir, be warming up to 80 DEG C; Deionized water is added water pot, be heated to 65 DEG C, add glycerol, propylene glycol, modified corn starch, lauric acid sodium taurocholate, sodium cocoyl glycinate, lauroylamidopropyl betaine, microcrystalline Cellulose, hydroxypropyl emthylcellulose, EDETATE SODIUM, allantoin, polyquaternary ammonium salt-7, mannitol successively, be warming up to 80 DEG C; Main tank is preheating to 45 DEG C, be evacuated down to-0.8mpa, material body ready in oil tank and water pot is all drawn into main tank, drove homogenizer with 2500r/ minute, homogenizing is after 10 minutes, and constant temperature starts cooling for 20 minutes, when being cooled to 50 DEG C, add potassium hydroxide successively, leaf of Mentha piperita extract nano-liposome, CI77891, CI77491 stir, be cooled to 45 DEG C, add diazolidinyl urea, iodine propilolic alcohol butyl mephenesin Carbamate, essence successively; Be cooled to 40 DEG C, discharging when detection pH value is 5-7.
In anti-acne facial cleanser of the present invention, described leaf of Mentha piperita extract nano-liposome has antibacterial and antiinflammation, and making an addition in cleansing milk can the growing of anti-bacteria, the generation of prevention, easing whelk.
Nanometer liposome is ultra micro spheroid carrier preparation drug encapsulation formed in lipoids bilayer.Liposome is as a kind of novel pharmaceutical carrier in recent years, obtains and develop rapidly in preparation for external application to skin research and apply.The feature that nanometer liposome is used as percutaneous drug delivery carrier is: compatible, can strengthen the transdermal effect of medicine; Skin histology targeting; Slow-releasing; Liposomal encapsulatedly improve medicine ` thing dissolubility and stability.Nanometer liposome external preparation has the advantages such as efficient, long-acting, safety, skin targeting are strong.Exploitation external preparation for skin nano liposome preparations improves enepidermic trend, become the direction of external used medicine and cosmetics research and development.
Described leaf of Mentha piperita extract is by Chemical Decomposition method, and obtain from the extract of the leaf site of Mentha piperita, Extraction solvent can be the organic solvents such as ethanol, water, ether, petroleum ether; Described leaf of Mentha piperita extract nano-liposome, by adopting thin-film ultrasonic-high pressure homogenization method preparation.
Compared with prior art, its beneficial effect is in the present invention:
First: rationally composite by each component of the present invention; gained cleansing milk has excellent clean-up performance, can also remove the oils and fats that skin overflows, life-time service in clean process simultaneously; effect of control oil, moisturizing, nourishes rough skin can be reached, improve and protection skin.
Second: the present invention adds leaf of Mentha piperita extract nano-liposome and has better antibacterial, anti-inflammatory effects than common leaf of Mentha piperita extract.Obtained cleansing milk can effectively remove facial small pox, can up to 80%, and not stay pox to print after removing to facial small pox clearance.
Detailed description of the invention
Below in conjunction with embodiment, embodiments of the present invention are described
Embodiment 1
A kind of anti-acne facial cleanser, be made up of following raw material: stearic acid 15 parts, lauric acid 5 parts, myristic acid 4 parts, Palmic acid 3 parts, glycol distearate 1 part, tocopherol acetas 0.1 part, ceteareth-60 myristyl glycol 0.1 part, butylated hydroxytoluene 0.1 part, methyl hydroxybenzoate 0.1 part, propyl hydroxybenzoate 0.05 part, glycerol 15 parts, propylene glycol 0.1 part, modified corn starch 2 parts, lauric acid sodium taurocholate 2 parts, sodium cocoyl glycinate 2 parts, lauroylamidopropyl betaine 2 parts, microcrystalline Cellulose 0.1 part, hydroxypropyl emthylcellulose 0.1 part, EDETATE SODIUM 0.05 part, allantoin 0.05 part, polyquaternary ammonium salt-70.5 parts, mannitol 0.5 part, potassium hydroxide 4.5 parts, CI778910.1 part, CI774910.1 part, leaf of Mentha piperita extract nano-liposome 0.5 part, diazolidinyl urea 0.1 part, iodine propilolic alcohol butyl mephenesin Carbamate 0.002 part, 0.1 part, essence, water To100.
Embodiment 2
A kind of anti-acne facial cleanser, be made up of following raw material: stearic acid 20 parts, lauric acid 10 parts, myristic acid 8 parts, Palmic acid 6 parts, glycol distearate 2 parts, tocopherol acetas 0.5 part, ceteareth-60 myristyl glycol 0.5 part, butylated hydroxytoluene 0.2 part, methyl hydroxybenzoate 0.2 part, propyl hydroxybenzoate 0.15 part, glycerol 25 parts, propylene glycol 0.5 part, modified corn starch 5 parts, lauric acid sodium taurocholate 4 parts, sodium cocoyl glycinate 4 parts, lauroylamidopropyl betaine 4 parts, microcrystalline Cellulose 0.5 part, hydroxypropyl emthylcellulose 0.5 part, EDETATE SODIUM 0.2 part, allantoin 0.2 part, polyquaternary ammonium salt-71 parts, mannitol 1 part, potassium hydroxide 6.5 parts, CI778910.5 part, CI774910.5 part, leaf of Mentha piperita extract nano-liposome 5 parts, diazolidinyl urea 0.5 part, iodine propilolic alcohol butyl mephenesin Carbamate 0.0075 part, 0.5 part, essence, water To100.
Embodiment 3
A kind of anti-acne facial cleanser, be made up of following raw material: stearic acid 18 parts, lauric acid 7 parts, myristic acid 4 parts, Palmic acid 5 parts, glycol distearate 1.5 parts, tocopherol acetas 0.2 part, ceteareth-60 myristyl glycol 0.3 part, butylated hydroxytoluene 0.1 part, methyl hydroxybenzoate 0.2 part, propyl hydroxybenzoate 0.1 part, glycerol 20 parts, propylene glycol 0.2 part, modified corn starch 4 parts, lauric acid sodium taurocholate 3 parts, sodium cocoyl glycinate 3 parts, lauroylamidopropyl betaine 2.5 parts, microcrystalline Cellulose 0.3 part, hydroxypropyl emthylcellulose 0.3 part, EDETATE SODIUM 0.1 part, allantoin 0.12 part, polyquaternary ammonium salt-70.6 parts, mannitol 0.8 part, potassium hydroxide 5 parts, CI778910.2 part, CI774910.2 part, leaf of Mentha piperita extract nano-liposome 4 parts, diazolidinyl urea 0.2 part, iodine propilolic alcohol butyl mephenesin Carbamate 0.002 part, 0.15 part, essence, water To100.
The preparation method of above-described embodiment 1-3 is as follows: first add in oil tank by stearic acid, lauric acid, myristic acid, Palmic acid, glycol distearate, tocopherol acetas, ceteareth-60 myristyl glycol, butylated hydroxytoluene, methyl hydroxybenzoate, propyl hydroxybenzoate, stir, be warming up to 80 DEG C; Deionized water is added water pot, be heated to 65 DEG C, add glycerol, propylene glycol, modified corn starch, lauric acid sodium taurocholate, sodium cocoyl glycinate, lauroylamidopropyl betaine, microcrystalline Cellulose, hydroxypropyl emthylcellulose, EDETATE SODIUM, allantoin, polyquaternary ammonium salt-7, mannitol successively, be warming up to 80 DEG C; Main tank is preheating to 45 DEG C, be evacuated down to-0.8mpa, material body ready in oil tank and water pot is all drawn into main tank, drove homogenizer with 2500r/ minute, homogenizing is after 10 minutes, and constant temperature starts cooling for 20 minutes, when being cooled to 50 DEG C, add potassium hydroxide successively, leaf of Mentha piperita extract nano-liposome, CI77891, CI77491 stir, be cooled to 45 DEG C, add diazolidinyl urea, iodine propilolic alcohol butyl mephenesin Carbamate, essence successively; Be cooled to 40 DEG C, discharging when detection pH value is 5-7.
Comparative example 1
A kind of anti-acne facial cleanser, be made up of following raw material: stearic acid 18 parts, lauric acid 7 parts, myristic acid 4 parts, Palmic acid 5 parts, glycol distearate 1.5 parts, tocopherol acetas 0.2 part, ceteareth-60 myristyl glycol 0.3 part, butylated hydroxytoluene 0.1 part, methyl hydroxybenzoate 0.2 part, propyl hydroxybenzoate 0.1 part, glycerol 20 parts, propylene glycol 0.2 part, modified corn starch 4 parts, lauric acid sodium taurocholate 3 parts, sodium cocoyl glycinate 3 parts, lauroylamidopropyl betaine 2.5 parts, microcrystalline Cellulose 0.3 part, hydroxypropyl emthylcellulose 0.3 part, EDETATE SODIUM 0.1 part, allantoin 0.12 part, polyquaternary ammonium salt-70.6 parts, mannitol 0.8 part, potassium hydroxide 5 parts, CI778910.2 part, CI774910.2 part, leaf of Mentha piperita extract 4 parts, diazolidinyl urea 0.2 part, iodine propilolic alcohol butyl mephenesin Carbamate 0.002 part, 0.15 part, essence, water To100.
Performance test
Performance test is carried out to the embodiment of the present invention 1 ~ 3 products obtained therefrom, contrasts with comparative example 1; Get Ig embodiment 1 ~ 3 products obtained therefrom and comparative example 1 product respectively, random selecting 400 volunteers, wherein male 100, women 300, wherein face has pox person to account for 80%.The test anti-acne effective percentage of cleansing milk, moisture retention and clean after sense organ, in addition, to product safety and sanitation performance detect, result is as following table:
Table 1 properties of product test data
As can be seen from Table 1, the anti-acne rate of embodiment 1-3 is obviously greater than the anti-acne rate of comparative example 1, visible, adds leaf of Mentha piperita extract nano-liposome and has better anti-acne effect than common leaf of Mentha piperita extract.
The above, it is only preferred embodiment of the present invention, not any pro forma restriction is done to the present invention, therefore all contents not departing from technical solution of the present invention, according to technical spirit of the present invention to any simple modification made for any of the above embodiments, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.
Claims (3)
1. an anti-acne facial cleanser, is characterized in that: be made up of following raw material: stearic acid 15-20 part, lauric acid 5 ~ 10 parts, myristic acid 4 ~ 8 parts, Palmic acid 3 ~ 6 parts, glycol distearate 1 ~ 2 part, tocopherol acetas 0.1 ~ 0.5 part, ceteareth-60 myristyl glycol 0.1 ~ 0.5 part, butylated hydroxytoluene 0.1 ~ 0.2 part, methyl hydroxybenzoate 0.1 ~ 0.2 part, propyl hydroxybenzoate 0.05 ~ 0.15 part, glycerol 15 ~ 25 parts, propylene glycol 0.1 ~ 0.5 part, modified corn starch 2 ~ 5 parts, lauric acid sodium taurocholate 2 ~ 4 parts, sodium cocoyl glycinate 2 ~ 4 parts, lauroylamidopropyl betaine 2 ~ 4 parts, microcrystalline Cellulose 0.1 ~ 0.5 part, hydroxypropyl emthylcellulose 0.1 ~ 0.5 part, EDETATE SODIUM 0.05 ~ 0.2 part, allantoin 0.05 ~ 0.2 part, polyquaternary ammonium salt-70.5 ~ 1 part, mannitol 0.5 ~ 1 part, potassium hydroxide 4.5 ~ 6.5 parts, CI778910.1 ~ 0.5 part, CI774910.1 ~ 0.5 part, leaf of Mentha piperita extract nano-liposome 0.5 ~ 5 part, diazolidinyl urea 0.1 ~ 0.5 part, iodine propilolic alcohol butyl mephenesin Carbamate 0.002 ~ 0.0075 part, 0.1 ~ 0.5 part, essence, water To100.
2. a kind of anti-acne facial cleanser according to claim 1, it is characterized in that: be made up of following raw material: stearic acid 18 parts, lauric acid 7 parts, myristic acid 4 parts, Palmic acid 5 parts, glycol distearate 1.5 parts, tocopherol acetas 0.2 part, ceteareth-60 myristyl glycol 0.3 part, butylated hydroxytoluene 0.1 part, methyl hydroxybenzoate 0.2 part, propyl hydroxybenzoate 0.1 part, glycerol 20 parts, propylene glycol 0.2 part, modified corn starch 4 parts, lauric acid sodium taurocholate 3 parts, sodium cocoyl glycinate 3 parts, lauroylamidopropyl betaine 2.5 parts, microcrystalline Cellulose 0.3 part, hydroxypropyl emthylcellulose 0.3 part, EDETATE SODIUM 0.1 part, allantoin 0.12 part, polyquaternary ammonium salt-70.6 parts, mannitol 0.8 part, potassium hydroxide 5 parts, CI778910.2 part, CI774910.2 part, leaf of Mentha piperita extract nano-liposome 4 parts, diazolidinyl urea 0.2 part, iodine propilolic alcohol butyl mephenesin Carbamate 0.002 part, 0.15 part, essence, water To100.
3. a kind of anti-acne facial cleanser according to claim 1 and 2, it is characterized in that: its preparation method comprises the steps: first to add in oil tank by stearic acid, lauric acid, myristic acid, Palmic acid, glycol distearate, tocopherol acetas, ceteareth-60 myristyl glycol, butylated hydroxytoluene, methyl hydroxybenzoate, propyl hydroxybenzoate, stir, be warming up to 80 DEG C; Deionized water is added water pot, be heated to 65 DEG C, add glycerol, propylene glycol, modified corn starch, lauric acid sodium taurocholate, sodium cocoyl glycinate, lauroylamidopropyl betaine, microcrystalline Cellulose, hydroxypropyl emthylcellulose, EDETATE SODIUM, allantoin, polyquaternary ammonium salt-7, mannitol successively, be warming up to 80 DEG C; Main tank is preheating to 45 DEG C, be evacuated down to-0.8mpa, material body ready in oil tank and water pot is all drawn into main tank, drove homogenizer with 2500r/ minute, homogenizing is after 10 minutes, and constant temperature starts cooling for 20 minutes, when being cooled to 50 DEG C, add potassium hydroxide successively, leaf of Mentha piperita extract nano-liposome, CI77891, CI77491 stir, be cooled to 45 DEG C, add diazolidinyl urea, iodine propilolic alcohol butyl mephenesin Carbamate, essence successively; Be cooled to 40 DEG C, discharging when detection pH value is 5-7.
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| CN105616188A (en) * | 2016-03-09 | 2016-06-01 | 广州千百度化妆品有限公司 | Acne-removal facial cleanser and preparation method thereof |
| CN105708718A (en) * | 2016-04-13 | 2016-06-29 | 广州丹奇日用化工厂有限公司 | Acne-removal cosmetic composition containing nano-zinc |
| CN105997618A (en) * | 2016-05-18 | 2016-10-12 | 广州丹奇日用化工厂有限公司 | Acne-removal cleanser and preparation method thereof |
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