CN103405353A - Externally-applied skin pasting film and intensive penetration production technology thereof - Google Patents

Abstract

An externally-applied skin pasting film is composed of a water-soluble polymer material, a function additive and distilled water, and concretely comprises sodium polyacrylate, cross-linked polyacrylate, polyvinyl alcohol, sodium alginate, sorbitol, citric acid, glycerin, the function additive and distilled water, wherein the function additive is anyone of or a mixture comprising several of a skin humectants, a skin whitening agent, a cutin softener, a skin anti-wrinkling agent and a skin reparing agent; the skin humectant is anyone of or a mixture comprising several of chondroitin sulfate, allantoin, elastin, lactic acid, hyaluronic acid, sodium alginate, chitosan, chitin, casein, soybean protein, wheat gluten protein and lactalbumin; and the function additive is processed to prepare a water-soluble polymer system, has the characteristics of large drug loading, good biocompatibility with skins, no excitation, no allergy, comfortable application and the like, simultaneously enhances the hydration of the skins and the percutaneous absorption of functional substances, and improves the percutaneous absorption effect.

Description

A kind of external preparation for skin pad pasting and intensive infiltration production technology thereof

Technical field

The present invention relates to facial film production technical field in cosmetics, specifically relate to a kind of external preparation for skin pad pasting and airtight infiltration production technology thereof.

Background technology

In recent years, the research of external preparation for skin pad pasting is mainly the horny layer obstacle that how to overcome skin, reduces functional additive and enters the barrier of body, and developed many new methods, comprises practice of pharmacy, chemical method and physics method.The practice of pharmacy of most study is to use the Transdermal absorption penetrating agent to overcome the horny layer obstacle of skin, also has in recent years research to use the Transdermal absorption of the particulate carrier promotion functions additives such as liposome, carrier, pharmacosomes, nanoparticle, polymer micelle.In addition the functional additive molecular structure is carried out to the chemical constitution modification, obtain having the chemical method of the prodrug molecule of better infiltration rate.These methods in the process of implementing or comparatively loaded down with trivial details, or exist the phenomenon that cost price is higher, are difficult to product formation industrialization and scale.

Therefore, consumers in general are urgent, and a kind of technology that is applied to the external preparation for skin pad pasting is developed in expectation, the external preparation for skin pad pasting quality softness of producing by the method, with the applying ointment or plaster property of skin well can be fabulous the Transdermal absorption of promotion functions additive, improve the Transdermal absorption effect of functional additive.Cost price is lower simultaneously, and production process is simple.

Summary of the invention

The object of the invention is to overcome the deficiency of above-mentioned technology, a kind of external preparation for skin pad pasting and airtight infiltration production technology thereof are provided, utilize the water soluble polymer carrier, by with the fitting tightly of skin, strengthen the hydration of skin, functional additive is realized to intensive infiltration.

For achieving the above object, the present invention by the following technical solutions: a kind of external preparation for skin pad pasting, it is comprised of water-soluble high-molecular material, functional additive and distilled water, each component and weight percentage are as follows:

Sodium polyacrylate 3% ~ 8% Acusol772 Acusol771 2% ~ 5%

Polyvinyl alcohol 1% ~ 4% sodium alginate 0.05% ~ 0.15%

Sorbitol 1% ~ 3% citric acid 0.1% ~ 1%

Glycerol 30% ~ 40% functional additive 5% ~ 10%

Distilled water surplus

Above-mentioned each component percentage composition sum is 100%.

Described functional additive technique is any one or a few mixture in skin wetting agent, skin whitening agent, keratolytic, external skin wrinkling-preventing agent, skin renovation agent;

Described skin wetting agent is any one or a few mixture in chondroitin sulfate, allantoin, elastin, lactic acid, hyaluronic acid, sodium alginate, chitosan, chitin, casein, soybean protein, wheat gluten protein, lactalbumin;

Described skin whitening agent is any one or a few mixture in hydroquinone, arbutin, kojic acid, Azelaic Acid, tretinoin, fruit acid, linolenic acid, linoleic acid, hydrolyzed pearl, fibroin, collagen protein, the whitening elite factor, Radix Glycyrrhizae extract, green tea extract, Aloe extract, Fructus Hippophae extract, Rhizoma Atractylodis Macrocephalae extract dimension, Flos Nelumbinis extract, vitamin C and vitamin E and derivant thereof;

Described keratolytic is Oleum Vitis viniferae, safflower oil, Radix Oenotherae erythrosepalae oil, lanoline, Jojoba oil, Oleum Helianthi, angle Trionyx sinensis Wiegmann alkane, dissolves any one or a few mixture in keratinase;

Described external skin wrinkling-preventing agent is any one or a few mixture in nicotinic acid, cigarette phthalein amine, D mono-pantothenic acid, vitamin E, hydrolytic collagen, Fructus actinidiae chinensis extract;

Described skin renovation agent is any one or a few mixture in Radix Hamamelidis Mollis extract, Aloe extract, retinoic acid, hydrolytic collagen, ubiquinone, allantoin, salicylic acid, lactic acid, glycyrrhizic acid, ethanol.

Airtight infiltration production technology of the present invention is:

(1) take sodium polyacrylate, Acusol772 Acusol771, polyvinyl alcohol, sodium alginate, the sorbitol of recipe quantity, then join in the glycerol of recipe quantity, stir and obtain glycerol phase ((A phase);

(2) citric acid that takes recipe quantity is dissolved in the water of 50% recipe quantity, obtains water (B phase);

(3) take the functional additive of recipe quantity, join in the water of residue 50% recipe quantity, obtain medicine phase (C phase);

(4) C is slowly joined mutually A mutually in, slow stirring at low speed 10 ~ 15min, then add the B phase, first high-speed stirred 2min, then stirring at low speed 10 ~ 15min, obtain mixed-matrix;

(5) substrate is coated on medical adhesive-bonded fabric, be prepared into the external preparation for skin pad pasting through cutting, standing crosslinked, packing.

Advantage of the present invention and good effect are: functional additive is prepared into to the water soluble polymer system, have drug loading large, with the skin good biocompatibility, non-stimulated without irritated, stick the characteristics such as comfortable; When strengthening the hydration of skin, the enhancement function material Transdermal absorption, improve its Transdermal absorption effect.

The specific embodiment

Embodiment 1

A kind of external preparation for skin pad pasting, it is comprised of water-soluble high-molecular material, functional additive and distilled water, and each component and weight percentage are as follows:

Sodium polyacrylate 3% Acusol772 Acusol771 2%

Polyvinyl alcohol 1% sodium alginate 0.05%

Sorbitol 1% citric acid 0.1%

Glycerol 30% allantoin 5% ~ 10%

Distilled water surplus

Above-mentioned each component percentage composition sum is 100%.

Airtight infiltration production technology of the present invention is:

(1) take sodium polyacrylate, Acusol772 Acusol771, polyvinyl alcohol, sodium alginate, the sorbitol of recipe quantity, then join in the glycerol of recipe quantity, stir and obtain glycerol phase ((A phase);

(2) citric acid that takes recipe quantity is dissolved in the water of 50% recipe quantity, obtains water (B phase);

(3) take the functional additive of recipe quantity, join in the water of residue 50% recipe quantity, obtain medicine phase (C phase);

(4) C is slowly joined mutually A mutually in, slow stirring at low speed 10min, then add the B phase, first high-speed stirred 2min, then stirring at low speed 15min, obtain mixed-matrix;

(5) substrate is coated on medical adhesive-bonded fabric, be prepared into the external preparation for skin pad pasting through cutting, standing crosslinked, packing.

Embodiment 2

A kind of external preparation for skin pad pasting, it is comprised of water-soluble high-molecular material, functional additive and distilled water, and each component and weight percentage are as follows:

Sodium polyacrylate 8% Acusol772 Acusol771 5%

Polyvinyl alcohol 4% sodium alginate 0.15%

Sorbitol 3% citric acid 1%

Glycerol 40% elastin 10%

Distilled water surplus

Above-mentioned each component percentage composition sum is 100%.

Airtight infiltration production technology of the present invention is:

(1) take sodium polyacrylate, Acusol772 Acusol771, polyvinyl alcohol, sodium alginate, the sorbitol of recipe quantity, then join in the glycerol of recipe quantity, stir and obtain glycerol phase ((A phase);

(2) citric acid that takes recipe quantity is dissolved in the water of 50% recipe quantity, obtains water (B phase);

(3) take the functional additive of recipe quantity, join in the water of residue 50% recipe quantity, obtain medicine phase (C phase);

(4) C is slowly joined mutually A mutually in, slow stirring at low speed 15min, then add the B phase, first high-speed stirred 2min, then stirring at low speed 15min, obtain mixed-matrix;

(5) substrate is coated on medical adhesive-bonded fabric, be prepared into the external preparation for skin pad pasting through cutting, standing crosslinked, packing.

Embodiment 3

A kind of external preparation for skin pad pasting, it is comprised of water-soluble high-molecular material, functional additive and distilled water, and each component and weight percentage are as follows:

Sodium polyacrylate 5% Acusol772 Acusol771 3%

Polyvinyl alcohol 3% sodium alginate 0.1%

Sorbitol 2% citric acid 0.6%

Glycerol 35% collagen protein 7%

Distilled water surplus

Above-mentioned each component percentage composition sum is 100%.

Airtight infiltration production technology of the present invention is:

(1) take sodium polyacrylate, Acusol772 Acusol771, polyvinyl alcohol, sodium alginate, the sorbitol of recipe quantity, then join in the glycerol of recipe quantity, stir and obtain glycerol phase ((A phase);

(2) citric acid that takes recipe quantity is dissolved in the water of 50% recipe quantity, obtains water (B phase);

(3) take the functional additive of recipe quantity, join in the water of residue 50% recipe quantity, obtain medicine phase (C phase);

(4) C is slowly joined mutually A mutually in, slow stirring at low speed 12min, then add the B phase, first high-speed stirred 2min, then stirring at low speed 3min, obtain mixed-matrix;

(5) substrate is coated on medical adhesive-bonded fabric, be prepared into the external preparation for skin pad pasting through cutting, standing crosslinked, packing.

Utilize functional additive to be hyaluronate sodium and aloe frozen-dried powder mixture, the external preparation for skin pad pasting that utilizes airtight infiltration technology to prepare is compared with the replenishing water and preserving moisture effect of the external preparation for skin pad pasting that utilizes conventional method to prepare, having tested respectively it is 20 degrees centigrade in temperature, and relative humidity is the replenishing water and preserving moisture rate under 60% environment.

Claims (1)

1. external preparation for skin pad pasting, it is characterized in that: it is comprised of water-soluble high-molecular material, functional additive and distilled water, and each component and weight percentage are as follows:

Sodium polyacrylate 3% ~ 8% Acusol772 Acusol771 2% ~ 5%

Polyvinyl alcohol 1% ~ 4% sodium alginate 0.05% ~ 0.15%

Sorbitol 1% ~ 3% citric acid 0.1% ~ 1%

Glycerol 30% ~ 40% functional additive 5% ~ 10%

Distilled water surplus

Above-mentioned each component percentage composition sum is 100%;

Described functional additive technique is any one or a few mixture in skin wetting agent, skin whitening agent, keratolytic, external skin wrinkling-preventing agent, skin renovation agent;

Described skin wetting agent is any one or a few mixture in chondroitin sulfate, allantoin, elastin, lactic acid, hyaluronic acid, sodium alginate, chitosan, chitin, casein, soybean protein, wheat gluten protein, lactalbumin;

Described skin whitening agent is any one or a few mixture in hydroquinone, arbutin, kojic acid, Azelaic Acid, tretinoin, fruit acid, linolenic acid, linoleic acid, hydrolyzed pearl, fibroin, collagen protein, the whitening elite factor, Radix Glycyrrhizae extract, green tea extract, Aloe extract, Fructus Hippophae extract, Rhizoma Atractylodis Macrocephalae extract dimension, Flos Nelumbinis extract, vitamin C and vitamin E and derivant thereof;

Described keratolytic is Oleum Vitis viniferae, safflower oil, Radix Oenotherae erythrosepalae oil, lanoline, Jojoba oil, Oleum Helianthi, angle Trionyx sinensis Wiegmann alkane, dissolves any one or a few mixture in keratinase;

Described external skin wrinkling-preventing agent is any one or a few mixture in nicotinic acid, cigarette phthalein amine, D mono-pantothenic acid, vitamin E, hydrolytic collagen, Fructus actinidiae chinensis extract;

Described skin renovation agent is any one or a few mixture in Radix Hamamelidis Mollis extract, Aloe extract, retinoic acid, hydrolytic collagen, ubiquinone, allantoin, salicylic acid, lactic acid, glycyrrhizic acid, ethanol;

Airtight infiltration production technology of the present invention is:

(1) take sodium polyacrylate, Acusol772 Acusol771, polyvinyl alcohol, sodium alginate, the sorbitol of recipe quantity, then join in the glycerol of recipe quantity, stir and obtain glycerol phase ((A phase);

(2) citric acid that takes recipe quantity is dissolved in the water of 50% recipe quantity, obtains water (B phase);

(3) take the functional additive of recipe quantity, join in the water of residue 50% recipe quantity, obtain medicine phase (C phase);

(4) C is slowly joined mutually A mutually in, slow stirring at low speed 10 ~ 15min, then add the B phase, first high-speed stirred 2min, then stirring at low speed 10 ~ 15min, obtain mixed-matrix;

(5) substrate is coated on medical adhesive-bonded fabric, be prepared into the external preparation for skin pad pasting through cutting, standing crosslinked, packing.