CN108464974A - A kind of external preparation for skin pad pasting of DEEP5 Transdermal absorptions - Google Patents
A kind of external preparation for skin pad pasting of DEEP5 Transdermal absorptions Download PDFInfo
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- CN108464974A CN108464974A CN201810401842.6A CN201810401842A CN108464974A CN 108464974 A CN108464974 A CN 108464974A CN 201810401842 A CN201810401842 A CN 201810401842A CN 108464974 A CN108464974 A CN 108464974A
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- phases
- pad pasting
- added
- functional additive
- polyacrylate
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- 238000002360 preparation method Methods 0.000 title claims abstract description 37
- 230000009102 absorption Effects 0.000 title claims abstract description 33
- 238000010521 absorption reaction Methods 0.000 title claims abstract description 33
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 42
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 36
- 239000013538 functional additive Substances 0.000 claims abstract description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 18
- 235000011187 glycerol Nutrition 0.000 claims abstract description 18
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims abstract description 18
- 229920000058 polyacrylate Polymers 0.000 claims abstract description 18
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 18
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims abstract description 18
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000000661 sodium alginate Substances 0.000 claims abstract description 17
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 17
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 17
- 238000003756 stirring Methods 0.000 claims abstract description 13
- 238000004132 cross linking Methods 0.000 claims abstract description 5
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 5
- 238000004090 dissolution Methods 0.000 claims abstract description 3
- 239000002994 raw material Substances 0.000 claims description 13
- 239000012153 distilled water Substances 0.000 claims description 12
- 239000011159 matrix material Substances 0.000 claims description 8
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 6
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 6
- 241001116389 Aloe Species 0.000 claims description 4
- 235000011399 aloe vera Nutrition 0.000 claims description 4
- 238000004806 packaging method and process Methods 0.000 claims description 4
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- 241000220324 Pyrus Species 0.000 claims 1
- 238000004821 distillation Methods 0.000 claims 1
- 235000021017 pears Nutrition 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 13
- 230000000694 effects Effects 0.000 abstract description 11
- 239000000654 additive Substances 0.000 abstract description 3
- 230000000996 additive effect Effects 0.000 abstract description 3
- 206010020751 Hypersensitivity Diseases 0.000 abstract description 2
- 208000026935 allergic disease Diseases 0.000 abstract description 2
- 230000007815 allergy Effects 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 3
- 244000248349 Citrus limon Species 0.000 description 2
- 235000005979 Citrus limon Nutrition 0.000 description 2
- 235000014676 Phragmites communis Nutrition 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000008204 material by function Substances 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Abstract
The present invention relates to the external preparation for skin pad pastings of DEEP5 Transdermal absorptions, externally used pad pasting soft texture can effectively be solved, with the application of skin well can be fabulous promotion functions additive Transdermal absorption, improve the Transdermal absorption effect of functional additive, reduce cost simultaneously, problem easy to produce, method is, first Sodium Polyacrylate 3~8%, crosslinked polyacrylate 2~5%, polyvinyl alcohol 1~4%, sodium alginate 0.05~0.15%, sorbierite 1~3% are added in glycerine 30~40%, stir evenly to obtain A phases；Again by the water dissolution of citric acid 0.1~1%, B phases are obtained；Functional additive 5~10% is added in remaining water, C phases are obtained；C phases are added drop-wise in A phases, are stirred, B phases are added, first quickly stir 2 minutes, stirring at low speed 10 15 minutes again, are coated on medical non-woven fabrics, stand crosslinking, preparation method of the present invention is simple, it is easy to produce, it is at low cost, it is easy to use, effect is good, drugloading rate is big, with skin good biocompatibility, non-stimulated no allergy, stick it is comfortable.
Description
Technical field
The present invention relates to medicine, especially a kind of external preparation for skin pad pasting of DEEP5 Transdermal absorptions.
Background technology
In recent years, how the research of external preparation for skin pad pasting mainly overcomes the cuticula obstacle of skin, reduces function addition
Agent enters the barrier of body, and develops many new methods, including practice of pharmacy, chemical method and physics method.
The practice of pharmacy of most study is the cuticula obstacle that skin is overcome using Transdermal absorption penetrating agent, also has research to make in recent years
With the Transdermal absorption of the particulate carriers promotion functions additive such as liposome, carrier, pharmacome, nanoparticle, polymer micelle.Also
Have and modifying for chemical structure is carried out to functional additive molecular structure, obtains the change with the prodrug molecule of preferable infiltration rate
Method.These methods are during implementation or relatively complicated, or there is the higher phenomenons of cost price, it is difficult to product
Industrialization and scale are formed, can not meet the actual needs of consumers in general, therefore, it is industry to develop new external preparation for skin pad pasting
Interior desired the technical issues of solving.
Invention content
For the above situation, to overcome the defect of the prior art, the purpose of the present invention to be just to provide a kind of transdermal suctions of DEEP5
The external preparation for skin pad pasting of receipts can effectively solve externally used pad pasting soft texture, with the application of skin well can be fabulous promotion work(
The Transdermal absorption of energy additive, improves the Transdermal absorption effect of functional additive, while reducing cost, problem easy to produce.
The technical solution that the present invention solves is that a kind of external preparation for skin pad pasting of DEEP5 Transdermal absorptions, is by following weight hundred
The raw material than meter is divided to be made：Sodium Polyacrylate 3~8%, crosslinked polyacrylate 2~5%, polyvinyl alcohol 1~4%, alginic acid
Sodium 0.05~0.15%, sorbierite 1~3%, citric acid 0.1~1%, glycerine 30~40%, functional additive 5~10% and remaining
Amount is distilled water, total amount 100%；
The functional additive is uniformly mixed by Sodium Hyaluronate and aloe frozen-dried powder and is made, Sodium Hyaluronate and reed
Luxuriant growth freeze-dried powder weight ratio is 2-5 ︰ 5-7；
Wherein, Sodium Polyacrylate, crosslinked polyacrylate, polyvinyl alcohol, sodium alginate, sorbierite are first added to glycerine
In, stir evenly to obtain A phases；
Again by citric acid water dissolution, B phases are obtained；Functional additive is added in remaining water, C phases are obtained；
C phases are added drop-wise in A phases, are stirred 10-15 minutes, B phases are added, first quickly stirring 2 minutes, then stirring at low speed 10-
15 minutes, mixed-matrix is obtained, mixed-matrix is coated on medical non-woven fabrics, thickness 1-2mm stands crosslinking, cuts cutification
Skin externally used pad pasting, sterilizing, packaging.
In said components, wherein Sodium Polyacrylate, crosslinked polyacrylate, polyvinyl alcohol, sodium alginate, sorbierite,
Citric acid, glycerine constitute water-soluble high-molecular material, that is to say, that the present invention is added by water-soluble high-molecular material, function
Agent and distilled water are made.
Abundant raw material of the present invention, preparation method is simple, easy to produce, at low cost, easy to use, and effect is good, and function is added
Agent is prepared into water soluble polymer system, have drugloading rate it is big, with skin good biocompatibility, non-stimulated no allergy, stick it is easypro
The features such as suitable；While enhancing the aquation of skin, enhances the Transdermal absorption of functional materials, improve its Transdermal absorption
Effect is the innovation on external preparation for skin pad pasting, there is good economic and social benefit.
Specific implementation mode
Below in conjunction with concrete condition and embodiment, elaborate to the specific implementation mode of the present invention.
The present invention can be provided in specific implementation by following embodiment.
Embodiment 1
A kind of external preparation for skin pad pasting of DEEP5 Transdermal absorptions of the present invention, is made of the raw material of following weight percent meter：
Sodium Polyacrylate 3%, crosslinked polyacrylate 3%, polyvinyl alcohol 1.5%, sodium alginate 0.1%, sorbierite 2%, citric acid
0.4%, glycerine 35.5%, functional additive 7% and surplus are distilled water, total amount 100%；
The functional additive is uniformly mixed by Sodium Hyaluronate and aloe frozen-dried powder and is made, Sodium Hyaluronate and reed
Luxuriant growth freeze-dried powder weight ratio is 2-5 ︰ 5-7；
Wherein, Sodium Polyacrylate, crosslinked polyacrylate, polyvinyl alcohol, sodium alginate, sorbierite are first added to glycerine
In, stir evenly to obtain A phases；
Citric acid is dissolved in the water of recipe quantity 50% again, obtains B phases；Functional additive is added to remaining recipe quantity
In 50% water, C phases are obtained；
C phases are added drop-wise in A phases, are stirred 10-15 minutes, B phases are added, first quickly stir 2 minutes, then be slowly stirred 10-
15 minutes, mixed-matrix is obtained, mixed-matrix is coated on medical non-woven fabrics, crosslinking is stood, cuts into external preparation for skin pad pasting, go out
Bacterium, packaging.
Embodiment 2
A kind of external preparation for skin pad pasting of DEEP5 Transdermal absorptions of the present invention, is made of the raw material of following weight percent meter：
Sodium Polyacrylate 5%, crosslinked polyacrylate 2.5%, polyvinyl alcohol 2%, sodium alginate 0.08%, sorbierite 1.5%, lemon
Acid 0.9%, glycerine 32%, functional additive 8% and surplus are distilled water, and total amount 100%, the preparation method is the same as that of Example 1.
Embodiment 3
A kind of external preparation for skin pad pasting of DEEP5 Transdermal absorptions of the present invention, is made of the raw material of following weight percent meter：
Sodium Polyacrylate 7%, crosslinked polyacrylate 4%, polyvinyl alcohol 3%, sodium alginate 0.13%, sorbierite 2.5%, citric acid
0.5%, glycerine 38%, functional additive 6% and surplus are distilled water, and total amount 100%, the preparation method is the same as that of Example 1.
Embodiment 4
A kind of external preparation for skin pad pasting of DEEP5 Transdermal absorptions of the present invention, is made of the raw material of following weight percent meter：
Sodium Polyacrylate 4%, crosslinked polyacrylate 4.5%, polyvinyl alcohol 3.5%, sodium alginate 0.06%, sorbierite 3%, lemon
Acid 0.2%, glycerine 36%, functional additive 9% and surplus are distilled water, and total amount 100%, the preparation method is the same as that of Example 1.
Embodiment 5
A kind of external preparation for skin pad pasting of DEEP5 Transdermal absorptions of the present invention, is made of the raw material of following weight percent meter：
Sodium Polyacrylate 4-6%, crosslinked polyacrylate 3-4%, polyvinyl alcohol 2-3%, sodium alginate 0.07~0.12%, sorbierite
1.5-2.5%, citric acid 0.3~0.7%, glycerine 33~36%, functional additive 7-9% and surplus are distilled water, and total amount is
100%, the preparation method is the same as that of Example 1.
In the use of the present invention, the protective layer of external preparation for skin pad pasting is taken off, fit closely naturally on the skin 30~
40min enhances the aquation of skin with fitting closely for skin, realizes Transdermal absorption to functional additive, and through answering on the spot
With and experiment, achieve extraordinary advantageous effects, external preparation for skin pad pasting prepared by the present invention with utilize conventional method system
The replenishing water and preserving moisture effect of standby external preparation for skin pad pasting is tested by contrast, and it is 20 degrees Celsius to test it respectively in temperature, relatively wet
Degree is the replenishing water and preserving moisture rate such as following table in the environment of 60%：
Table 1
Table 2
| Time (min) | 0 | 30 | 60 | 90 | 120 |
| Routine techniques pad pasting 1 | 30.1 | 48.7 | 40.2 | 37.3 | 30.3 |
| Routine techniques pad pasting 2 | 29 | 54.8 | 40.9 | 36.4 | 29.5 |
| Routine techniques pad pasting 3 | 29.8 | 48.3 | 40.9 | 33.4 | 29.8 |
| Routine techniques pad pasting 4 | 29.8 | 48.3 | 40.9 | 33.4 | 29.8 |
| Routine techniques pad pasting 5 | 29.9 | 47.7 | 40.9 | 35.1 | 30.3 |
| DEEP5 Transdermal absorptions 1 | 29.9 | 60.6 | 52.6 | 41.6 | 37.9 |
| DEEP5 Transdermal absorptions 2 | 29.5 | 60.3 | 50.6 | 40 | 35.5 |
| DEEP5 Transdermal absorptions 3 | 29.1 | 61 | 53.4 | 41.6 | 33.1 |
| DEEP5 Transdermal absorptions 4 | 29.1 | 61 | 53.4 | 41.6 | 33.1 |
| DEEP5 Transdermal absorptions 5 | 29.9 | 60.6 | 47.9 | 40.3 | 33.1 |
Table 3
The clear above external preparation for skin pad pasting soft texture for showing the method for the present invention and preparing, it is good with the application of skin, it is close
Collection infiltration, promotes the Transdermal absorption of functional additive, improves the Transdermal absorption effect of functional additive, hence it is evident that better than existing
External preparation for skin pad pasting prepared by technology, and any bad phenomenon is not found in test, show that product quality is stable, reliable, effect
Fruit is definite, while improving the Transdermal absorption effect of functional additive, can reduce production cost 30-40%, and produce letter
Single, easy to operate, production efficiency improves 50% or more, and getting well for effect was not expected, and in process of production without environment dirt
Dye, there is good economic and social benefit.
Claims (6)
1. a kind of external preparation for skin pad pasting of DEEP5 Transdermal absorptions, which is characterized in that by the raw material system of following weight percent meter
At：Sodium Polyacrylate 3~8%, crosslinked polyacrylate 2~5%, polyvinyl alcohol 1~4%, sodium alginate 0.05~0.15%, sorb
Alcohol 1~3%, citric acid 0.1~1%, glycerine 30~40%, functional additive 5~10% and surplus are distilled water, total amount 100%；
The functional additive is uniformly mixed by Sodium Hyaluronate and aloe frozen-dried powder and is made, and Sodium Hyaluronate freezes with aloe
Dry powder weight ratio is 2-5 ︰ 5-7
Wherein, first Sodium Polyacrylate, crosslinked polyacrylate, polyvinyl alcohol, sodium alginate, sorbierite are added in glycerine,
Stir evenly to obtain A phases；
Again by citric acid water dissolution, B phases are obtained；Functional additive is added in remaining water, C phases are obtained；
C phases are added drop-wise in A phases, are stirred 10-15 minutes, B phases are added, first quickly stirring 2 minutes, then 10-15 points of stirring at low speed
Clock obtains mixed-matrix, and mixed-matrix is coated on medical non-woven fabrics, thickness 1-2mm, stands crosslinking, cuts into outside skin
With pad pasting, sterilizing, packaging.
2. the external preparation for skin pad pasting of EEP5 Transdermal absorptions according to claim 1, which is characterized in that by following weight percent
Raw material than meter is made：Sodium Polyacrylate 3%, crosslinked polyacrylate 3%, polyvinyl alcohol 1.5%, sodium alginate 0.1%, sorbierite
2%, citric acid 0.4%, glycerine 35.5%, functional additive 7% and surplus are distilled water, total amount 100%；
Wherein, first Sodium Polyacrylate, crosslinked polyacrylate, polyvinyl alcohol, sodium alginate, sorbierite are added in glycerine,
Stir evenly to obtain A phases；
Citric acid is dissolved in the water of recipe quantity 50% again, obtains B phases；Functional additive is added to the water of remaining recipe quantity 50%
In, obtain C phases；
C phases are added drop-wise in A phases, are stirred 10-15 minutes, B phases are added, first quickly stir 2 minutes, then are slowly stirred 10-15 points
Clock obtains mixed-matrix, and mixed-matrix is coated on medical non-woven fabrics, stands crosslinking, cuts into external preparation for skin pad pasting, sterilize,
Packaging.
3. the external preparation for skin pad pasting of EEP5 Transdermal absorptions according to claim 1, which is characterized in that by following weight percent
Raw material than meter is made：Sodium Polyacrylate 5%, crosslinked polyacrylate 2.5%, polyvinyl alcohol 2%, sodium alginate 0.08%, sorb
Alcohol 1.5%, citric acid 0.9%, glycerine 32%, functional additive 8% and surplus are distilled water, and total amount 100%, preparation method is the same as power
Profit requires 1.
4. the external preparation for skin pad pasting of EEP5 Transdermal absorptions according to claim 1, which is characterized in that by following weight percent
Raw material than meter is made：Sodium Polyacrylate 7%, crosslinked polyacrylate 4%, polyvinyl alcohol 3%, sodium alginate 0.13%, sorbierite
2.5%, citric acid 0.5%, glycerine 38%, functional additive 6% and surplus are distilled water, total amount 100%, the same right of preparation method
It is required that 1.
5. the external preparation for skin pad pasting of EEP5 Transdermal absorptions according to claim 1, which is characterized in that by following weight percent
Raw material than meter is made：Sodium Polyacrylate 4%, crosslinked polyacrylate 4.5%, polyvinyl alcohol 3.5%, sodium alginate 0.06%, mountain
Pears alcohol 3%, citric acid 0.2%, glycerine 36%, functional additive 9% and surplus are distilled water, and total amount 100%, preparation method is the same as power
Profit requires 1.
6. the external preparation for skin pad pasting of EEP5 Transdermal absorptions according to claim 1, which is characterized in that by following weight percent
Raw material than meter is made：Sodium Polyacrylate 4-6%, crosslinked polyacrylate 3-4%, polyvinyl alcohol 2-3%, sodium alginate 0.07~
0.12%, sorbierite 1.5-2.5%, citric acid 0.3~0.7%, glycerine 33~36%, functional additive 7-9% and surplus are distillation
Water, total amount 100%, preparation method is the same as claim 1.
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| CN201810401842.6A CN108464974A (en) | 2018-04-28 | 2018-04-28 | A kind of external preparation for skin pad pasting of DEEP5 Transdermal absorptions |
| CN202311133101.1A CN117100722A (en) | 2018-04-28 | 2018-04-28 | DEEP5 transdermal absorption skin external-use patch and preparation method thereof |
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| CN201810401842.6A CN108464974A (en) | 2018-04-28 | 2018-04-28 | A kind of external preparation for skin pad pasting of DEEP5 Transdermal absorptions |
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| CN202311133101.1A Division CN117100722A (en) | 2018-04-28 | 2018-04-28 | DEEP5 transdermal absorption skin external-use patch and preparation method thereof |
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| CN108464974A true CN108464974A (en) | 2018-08-31 |
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| CN202311133101.1A Pending CN117100722A (en) | 2018-04-28 | 2018-04-28 | DEEP5 transdermal absorption skin external-use patch and preparation method thereof |
| CN201810401842.6A Pending CN108464974A (en) | 2018-04-28 | 2018-04-28 | A kind of external preparation for skin pad pasting of DEEP5 Transdermal absorptions |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130046842A (en) * | 2011-10-28 | 2013-05-08 | 주식회사 제닉 | Adhesive hydrogel transdermal composition and method for preparing an adhesive hydrogel transdermal sheet using the same |
| CN103405353A (en) * | 2013-07-18 | 2013-11-27 | 石磊 | Externally-applied skin pasting film and intensive penetration production technology thereof |
| EP2939650A1 (en) * | 2014-04-29 | 2015-11-04 | LTS LOHMANN Therapie-Systeme AG | Plaster for the treatment of dermatitis |
| CN107638346A (en) * | 2017-10-12 | 2018-01-30 | 广州番禺职业技术学院 | A kind of Essence with moisture-keeping efficacy and preparation method thereof |
| CN107929178A (en) * | 2016-10-13 | 2018-04-20 | 曾俊平 | A kind of aloe moisture-keeping breast |
-
2018
- 2018-04-28 CN CN202311133101.1A patent/CN117100722A/en active Pending
- 2018-04-28 CN CN201810401842.6A patent/CN108464974A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130046842A (en) * | 2011-10-28 | 2013-05-08 | 주식회사 제닉 | Adhesive hydrogel transdermal composition and method for preparing an adhesive hydrogel transdermal sheet using the same |
| CN103405353A (en) * | 2013-07-18 | 2013-11-27 | 石磊 | Externally-applied skin pasting film and intensive penetration production technology thereof |
| EP2939650A1 (en) * | 2014-04-29 | 2015-11-04 | LTS LOHMANN Therapie-Systeme AG | Plaster for the treatment of dermatitis |
| CN107929178A (en) * | 2016-10-13 | 2018-04-20 | 曾俊平 | A kind of aloe moisture-keeping breast |
| CN107638346A (en) * | 2017-10-12 | 2018-01-30 | 广州番禺职业技术学院 | A kind of Essence with moisture-keeping efficacy and preparation method thereof |
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| CN117100722A (en) | 2023-11-24 |
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