CN112569129A - Formula and preparation method of acidic skin-care hydrogel - Google Patents
Formula and preparation method of acidic skin-care hydrogel Download PDFInfo
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- CN112569129A CN112569129A CN201910921851.2A CN201910921851A CN112569129A CN 112569129 A CN112569129 A CN 112569129A CN 201910921851 A CN201910921851 A CN 201910921851A CN 112569129 A CN112569129 A CN 112569129A
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- Prior art keywords
- acid
- skin
- hydrogel
- acidic skin
- care
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- 239000000017 hydrogel Substances 0.000 title claims abstract description 37
- 230000002378 acidificating effect Effects 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 238000009472 formulation Methods 0.000 title description 5
- 239000002253 acid Substances 0.000 claims abstract description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000008367 deionised water Substances 0.000 claims abstract description 8
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 8
- 239000000499 gel Substances 0.000 claims abstract description 7
- 239000003906 humectant Substances 0.000 claims abstract description 7
- 239000002562 thickening agent Substances 0.000 claims abstract description 7
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 5
- 230000003266 anti-allergic effect Effects 0.000 claims abstract description 4
- 125000002091 cationic group Chemical group 0.000 claims abstract description 4
- 229920000642 polymer Polymers 0.000 claims abstract description 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 34
- 238000003756 stirring Methods 0.000 claims description 25
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 17
- 229960004889 salicylic acid Drugs 0.000 claims description 17
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- 238000001816 cooling Methods 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 15
- 238000005303 weighing Methods 0.000 claims description 10
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 9
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 9
- -1 bis-decyl tetradecyl Chemical group 0.000 claims description 9
- 229940041616 menthol Drugs 0.000 claims description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 6
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 5
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 5
- 239000000043 antiallergic agent Substances 0.000 claims description 5
- 229960003237 betaine Drugs 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N 1-Tetradecanol Natural products CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 claims description 4
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims description 4
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims description 4
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims description 4
- 229920001992 poloxamer 407 Polymers 0.000 claims description 4
- 229940044476 poloxamer 407 Drugs 0.000 claims description 4
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 4
- UOQHWNPVNXSDDO-UHFFFAOYSA-N 3-bromoimidazo[1,2-a]pyridine-6-carbonitrile Chemical compound C1=CC(C#N)=CN2C(Br)=CN=C21 UOQHWNPVNXSDDO-UHFFFAOYSA-N 0.000 claims description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 3
- 239000003513 alkali Substances 0.000 claims description 3
- 239000001140 aloe barbadensis leaf extract Substances 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 3
- 239000004310 lactic acid Substances 0.000 claims description 3
- 235000014655 lactic acid Nutrition 0.000 claims description 3
- 229940099563 lactobionic acid Drugs 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 239000011975 tartaric acid Substances 0.000 claims description 3
- 235000002906 tartaric acid Nutrition 0.000 claims description 3
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 claims description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 2
- 229920002884 Laureth 4 Polymers 0.000 claims description 2
- 229920002511 Poloxamer 237 Polymers 0.000 claims description 2
- 229920002517 Poloxamer 338 Polymers 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical class [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 2
- YOOPHLDCWPOWDX-QCICJENWSA-N beta-D-GlcpA-(1->6)-beta-D-Galp Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)O[C@@H]1CO[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 YOOPHLDCWPOWDX-QCICJENWSA-N 0.000 claims description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- 229920006317 cationic polymer Polymers 0.000 claims description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 2
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 claims description 2
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 2
- 229940061515 laureth-4 Drugs 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 229960002510 mandelic acid Drugs 0.000 claims description 2
- 238000006386 neutralization reaction Methods 0.000 claims description 2
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 claims description 2
- 229920001993 poloxamer 188 Polymers 0.000 claims description 2
- 229940044519 poloxamer 188 Drugs 0.000 claims description 2
- 229920002401 polyacrylamide Polymers 0.000 claims description 2
- 229920000058 polyacrylate Polymers 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000006185 dispersion Substances 0.000 claims 1
- 230000008961 swelling Effects 0.000 claims 1
- 210000003491 skin Anatomy 0.000 abstract description 18
- 230000000694 effects Effects 0.000 abstract description 7
- 206010061218 Inflammation Diseases 0.000 abstract description 3
- 239000004480 active ingredient Substances 0.000 abstract description 3
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- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 230000019522 cellular metabolic process Effects 0.000 abstract 1
- 230000003750 conditioning effect Effects 0.000 abstract 1
- 230000001276 controlling effect Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 210000002510 keratinocyte Anatomy 0.000 abstract 1
- 230000003020 moisturizing effect Effects 0.000 abstract 1
- 230000037075 skin appearance Effects 0.000 abstract 1
- 210000004927 skin cell Anatomy 0.000 abstract 1
- 230000002087 whitening effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 description 10
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- 150000007513 acids Chemical class 0.000 description 6
- 239000004698 Polyethylene Substances 0.000 description 5
- 229920000573 polyethylene Polymers 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- 150000001277 beta hydroxy acids Chemical class 0.000 description 3
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
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- 210000002615 epidermis Anatomy 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- IMRGQGFAAGFVNH-UHFFFAOYSA-N 11-decyltetracosan-11-ol Chemical compound C(CCCCCCCCC)C(CCCCCCCCCCCCC)(O)CCCCCCCCCC IMRGQGFAAGFVNH-UHFFFAOYSA-N 0.000 description 1
- 208000020154 Acnes Diseases 0.000 description 1
- 235000003932 Betula Nutrition 0.000 description 1
- 241000219429 Betula Species 0.000 description 1
- 235000017595 Callicarpa japonica Nutrition 0.000 description 1
- 240000003690 Callicarpa japonica Species 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 206010051246 Photodermatosis Diseases 0.000 description 1
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- 230000036592 analgesia Effects 0.000 description 1
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Images
Classifications
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A61K8/042—Gels
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Botany (AREA)
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- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
Description
Composition (I) | Mass percent (%) |
Polyethylene glycol-8 | 3 |
Poloxamer 407 | 4 |
Glycerol | 3 |
Salicylic acid nanogels | 50 |
1, 3-butanediol | 3 |
Menthol | 0.3 |
Water (W) | 36.7 |
Composition (I) | Mass percent (%) |
Polyethylene glycol-8 | 2 |
Polyacrylate-1 | 8 |
Diglycerol | 5 |
Citric acid | 3 |
Betaine | 4 |
Menthol | 0.2 |
Water (W) | 77.8 |
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910921851.2A CN112569129A (en) | 2019-09-27 | 2019-09-27 | Formula and preparation method of acidic skin-care hydrogel |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910921851.2A CN112569129A (en) | 2019-09-27 | 2019-09-27 | Formula and preparation method of acidic skin-care hydrogel |
Publications (1)
Publication Number | Publication Date |
---|---|
CN112569129A true CN112569129A (en) | 2021-03-30 |
Family
ID=75109713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910921851.2A Withdrawn CN112569129A (en) | 2019-09-27 | 2019-09-27 | Formula and preparation method of acidic skin-care hydrogel |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN112569129A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113332160A (en) * | 2021-07-22 | 2021-09-03 | 杭州彼心生物科技有限公司 | Cosmetic composition for conditioning peritrichotic skin |
CN113546015A (en) * | 2021-07-26 | 2021-10-26 | 天津市海尔斯科技有限公司 | Honeycomb hydrogel based on citrus fruit extract and preparation process thereof |
CN115212126A (en) * | 2022-05-30 | 2022-10-21 | 绽妍生物科技有限公司 | Soothing anti-inflammatory composite acid conditioning skin refreshing liquid and preparation method thereof |
CN115337211A (en) * | 2022-08-16 | 2022-11-15 | 上海交通大学医学院附属第九人民医院 | Mild and hypoallergenic moisturizing acne-removing gel and preparation method thereof |
CN117137844A (en) * | 2023-09-28 | 2023-12-01 | 广东领康日用品有限公司 | Acne-removing and oil-controlling skin care composition and preparation method thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120244097A1 (en) * | 2011-03-21 | 2012-09-27 | Broda Technologies Co., Ltd. | Reversely thermo-reversible hydrogel compositions |
US20160287703A1 (en) * | 2012-11-13 | 2016-10-06 | Galderma S.A. | Bpo wash gel composition |
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CN113332160A (en) * | 2021-07-22 | 2021-09-03 | 杭州彼心生物科技有限公司 | Cosmetic composition for conditioning peritrichotic skin |
CN113546015A (en) * | 2021-07-26 | 2021-10-26 | 天津市海尔斯科技有限公司 | Honeycomb hydrogel based on citrus fruit extract and preparation process thereof |
CN115212126A (en) * | 2022-05-30 | 2022-10-21 | 绽妍生物科技有限公司 | Soothing anti-inflammatory composite acid conditioning skin refreshing liquid and preparation method thereof |
CN115212126B (en) * | 2022-05-30 | 2023-09-15 | 绽妍生物科技有限公司 | Soothing anti-inflammatory compound acid conditioning skin-refreshing liquid and preparation method thereof |
CN115337211A (en) * | 2022-08-16 | 2022-11-15 | 上海交通大学医学院附属第九人民医院 | Mild and hypoallergenic moisturizing acne-removing gel and preparation method thereof |
CN115337211B (en) * | 2022-08-16 | 2023-12-12 | 上海交通大学医学院附属第九人民医院 | Mild hyposensitization moisturizing acne-removing gel and preparation method thereof |
CN117137844A (en) * | 2023-09-28 | 2023-12-01 | 广东领康日用品有限公司 | Acne-removing and oil-controlling skin care composition and preparation method thereof |
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