CN112569129A - Formula and preparation method of acidic skin-care hydrogel - Google Patents
Formula and preparation method of acidic skin-care hydrogel Download PDFInfo
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- CN112569129A CN112569129A CN201910921851.2A CN201910921851A CN112569129A CN 112569129 A CN112569129 A CN 112569129A CN 201910921851 A CN201910921851 A CN 201910921851A CN 112569129 A CN112569129 A CN 112569129A
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- 230000002378 acidificating effect Effects 0.000 title claims abstract description 34
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
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- 239000002253 acid Substances 0.000 claims abstract description 36
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- 238000003756 stirring Methods 0.000 claims description 25
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- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims description 4
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- UOQHWNPVNXSDDO-UHFFFAOYSA-N 3-bromoimidazo[1,2-a]pyridine-6-carbonitrile Chemical compound C1=CC(C#N)=CN2C(Br)=CN=C21 UOQHWNPVNXSDDO-UHFFFAOYSA-N 0.000 claims description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 3
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- 239000011975 tartaric acid Substances 0.000 claims description 3
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- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 claims description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
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- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
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- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 2
- 229920006317 cationic polymer Polymers 0.000 claims description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 2
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 claims description 2
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 2
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- 238000006386 neutralization reaction Methods 0.000 claims description 2
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 claims description 2
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Images
Classifications
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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Abstract
The invention provides an acidic skin-care hydrogel formula and a preparation method thereof, wherein the acidic skin-care hydrogel formula comprises 1-30% of acid, 1-30% of thickening agent, 1-30% of humectant, 20-80% of deionized water and 0-10% of anti-allergy soothing agent. The acidic skin-care hydrogel disclosed by the invention is thickened by nonionic or cationic high-molecular polymers, the used acid is free acid, and the pH value of a final product is 2-3. The acidic skin-care hydrogel has the advantages of high acid content, good gel forming property, good stability, small irritation, convenient use and the like, and the preparation method is simple and controllable and has good repeatability. The invention solves the problems of difficult thickening and difficult use of an acid system, remarkably reduces the irritation of an acid substance to the skin, well solves the technical problems of inconvenient use and easy diffusion caused by the fact that an aqueous solution cannot stay, better exerts the effects of resisting inflammation, conditioning keratinocytes, relieving inflammation, improving skin appearance and enhancing skin cell metabolism of an acid active ingredient, and has the effects of moisturizing, whitening, controlling oil, cleaning and reducing pores and resisting allergy and removing dandruff by matching with other active ingredients.
Description
Technical Field
The invention relates to a formula of an acidic skin-care hydrogel in a cosmetic formula preparation technology and a preparation method thereof.
Background
Acids are a common component in skin external products, and acidic preparations are the most effective chemical skin-rejuvenation method in addition to medical beauty. The acid preparation can controllably damage skin of a certain layer, promote epidermis regeneration and dermis reconstruction, and thus can treat skin flaws located in epidermis or dermis shallow layer. Commonly used acids for external application to the skin are fruit acids (AHAs) and salicylic acid (BHA). Fruit acids were used in skin science since 1974. Fruit acids used in dermatology include citric acid, lactic acid, glycolic acid, lactobionic acid, etc. Salicylic acid, also known as beta-hydroxy acid (BHA), is present in many plants, such as: willow bark, betula dulcis bark and beautyberry have a long history of application, and are widely used for arthritis, analgesia and the like. The acid product has the effects of resisting inflammation and removing acnes, softening cutin, controlling oil, cleaning and shrinking pores, promoting epidermal cell growth, resisting skin photoaging and the like, and the tartaric acid, the salicylic acid and other acids are widely applied to cosmetics and Over The Counter (OTC) medicines as very important active ingredients to treat skin-related diseases such as keratotic plug, pockmark, acne, skin wrinkle, pigmentation, freckle and the like caused by sebum blockage and are very effective in preparing cosmetic formulas.
The acid products such as fruit acid and salicylic acid can keep the activity to the maximum extent only under the condition of free acid (undissociated acid) under the acidic condition. Because of the high acidity, the existing aqueous thickening system is difficult to maintain the gel state under the low pH condition, so that most of the acidic products on the market are aqueous systems. The use of aqueous systems makes it difficult for the aqueous agent to remain on the skin for a long time or even to diffuse on the skin due to the fluidity of water, resulting in failure of the preparation to function sufficiently or even irritation and damage due to diffusion.
The acidic skin-care hydrogel is thickened by nonionic or cationic high molecular polymers, and forms transparent or semitransparent acidic hydrogel at a low temperature stage under the condition of not using alkali, so that the acidic skin-care hydrogel can stably stay on the skin and fully play the role of acid in the application process. Meanwhile, the whole preparation process does not contain ethanol and does not add a strong base neutralizer, and the defects of the traditional water aqua formula are overcome, so that the skin is less stimulated, the curative effect is improved, and the side effect is reduced, so that the medicine is easier to tolerate by a patient.
Few documents in the prior art disclose the formulation of acidic hydrogels for use in external skin products. Even if present, for example, in patent application CN 105188650A (entitled soothing cosmetic composition based on salicylic acid), patent application CN105147596A (entitled water-soluble supramolecular salicylic acid hydrogel technique), patent application CN110013441A (entitled aqueous solution for solubilizing salicylic acid, method for preparing same and cosmetic composition comprising same) and patent application CN108403458A (a powerful acne-removing skin-care cosmetic and method for preparing same), although different formulations comprising salicylic acid were prepared, the salicylic acid content was lower, which is not conducive to the addition and use of salicylic acid in the finished cosmetic product; and the preparation raw materials and the process are complex, strong alkali neutralization or ultrasonic treatment and silica gas hydrogel encapsulation are needed for vacuum treatment, the requirement on production equipment is high, the neutralized salicylic acid cannot play a role, and the operation steps are complicated.
Based on the application of the prior art, the acidic skin-care hydrogel prepared by the method has high free acid content in the formula and good gel formability, and can be directly smeared for use; improving the stability of the acid in a non-buffered, low pH aqueous system, sufficient retention on the skin and simultaneously reducing the skin irritation of the acidic formulation to non-use areas.
Disclosure of Invention
The invention aims to solve the technical problem of providing a formula of an acidic skin-care hydrogel and a preparation method thereof. After the acidic skin-care hydrogel is thickened by using a nonionic or cationic high molecular polymer, water-soluble acid or prepared salicylic acid nano hydrogel is added to form stable transparent or semitransparent gel, so that the retention of the acid on the skin is prolonged, the diffusion of the acid on the skin is prevented, and the bioavailability of the acid is improved; meanwhile, the operation is simple and convenient, and the safe and continuous production can be realized.
In order to achieve the purpose, the invention is realized by the following technical scheme:
1. the raw materials and the weight ratio in the formula are respectively as follows:
1 to 30 percent of acid
1 to 30 percent of thickening agent
1 to 30 percent of humectant
20 to 80 percent of deionized water
0 to 10 percent of anti-allergy soothing agent
The acid is one or more of salicylic acid, glycolic acid, citric acid, mandelic acid, malic acid, tartaric acid, lactic acid, aldobionic acid, lactobionic acid, etc. commonly used for skin;
the thickening agent is one or more of PEG-240/HDI copolymer bis-decyl tetradecyl alcohol polyether-20 ether, poloxamer 407, poloxamer 188, polyacrylate-1, poloxamer 338, poloxamer 237, polyquaternary ammonium salt-37, PPG-13-decyl tetradecyl alcohol polyether-24, polyacrylamide, laureth-4, glycerol polyacrylate and other nonionic or cationic polymers;
the humectant is one or more of polyethylene glycol, dipropylene glycol, propylene glycol, 1, 3-propylene glycol, butanediol, glycerol, diglycerol, polyglycerol-10, 1, 2-hexanediol, betaine, polyglycerol-3, pentanediol and the like;
the anti-allergy agent is one or more of dipotassium glycyrrhizinate, menthol, aloe barbadensis leaf extract, menthol lactate and the like;
2. the preparation method of the acidic skin-care hydrogel comprises the following steps:
(1) weighing the humectant, the thickener and the deionized water according to the formula proportion, uniformly dispersing, heating to 85-90 ℃, mixing, stirring and dissolving at a certain rotating speed until the mixture is uniform, keeping the temperature for half an hour, and then stirring and cooling;
(2) adding water-soluble acid and/or pre-prepared oil-soluble acid nano water-based gel at 50-60 ℃, and slowly stirring uniformly;
(3) weighing the anti-allergic agent, the freshener and the like according to the formula proportion, adding the anti-allergic agent, the freshener and the like at 45 ℃, stirring and dissolving the anti-allergic agent, the freshener and the like uniformly at a certain rotating speed, and then continuously cooling.
(4) Stirring uniformly, cooling to room temperature, and defoaming to obtain the colorless transparent to semitransparent acidic skin-care hydrogel.
Drawings
FIG. 1 Process for preparing acidic skin-care hydrogel
Detailed Description
The above scheme is further illustrated below with reference to fig. 1 and the specific examples. The following description is only a preferred embodiment for embodying the object, effect and technical features of the present invention, and does not limit the scope of the present invention.
Example 1
Composition formula
| Composition (I) | Mass percent (%) |
| Polyethylene glycol-8 | 3 |
| Poloxamer 407 | 4 |
| Glycerol | 3 |
| Salicylic acid nanogels | 50 |
| 1, 3-butanediol | 3 |
| Menthol | 0.3 |
| Water (W) | 36.7 |
The preparation procedure for this example is as follows:
1. weighing 3% of polyethylene glycol-8, 4% of poloxamer 407, 3% of glycerol, 3% of 1, 3-butanediol and 36.7% of deionized water according to the formula proportion, uniformly dispersing, heating to 85-90 ℃, mixing, stirring and dissolving at a certain rotating speed until the mixture is uniform, keeping the temperature for half an hour, and then stirring and cooling;
2. adding prepared 50% salicylic acid nanogel at 50-60 ℃, and slowly stirring uniformly;
3. weighing 0.3% dipotassium glycyrrhizinate according to the formula proportion, adding at 45 ℃, stirring at a certain rotating speed to dissolve uniformly, and then continuously cooling.
4. Stirring uniformly, cooling to room temperature, and defoaming to obtain the colorless transparent to semitransparent skin-care hydrogel.
Example 2
Composition formula
| Composition (I) | Mass percent (%) |
| Polyethylene glycol-8 | 2 |
| Polyacrylate-1 | 8 |
| Diglycerol | 5 |
| Citric acid | 3 |
| Betaine | 4 |
| Menthol | 0.2 |
| Water (W) | 77.8 |
The preparation procedure for this example is as follows:
1. weighing 2% of polyethylene glycol-8, 8% of polyacrylate-1, 5% of diglycerol, 4% of betaine and 77.8% of deionized water according to the formula proportion, uniformly dispersing, heating to 85-90 ℃, mixing, stirring and dissolving at a certain rotating speed until the mixture is uniform, keeping the temperature for half an hour, and then stirring and cooling;
2. adding 3% citric acid at 50-60 deg.C, and slowly stirring;
3. weighing 0.2% menthol according to the formula proportion, adding the menthol at 45 ℃, stirring and dissolving the menthol uniformly at a certain rotating speed, and then continuously cooling.
4. Stirring uniformly, cooling to room temperature, and defoaming to obtain the colorless transparent to semitransparent skin-care hydrogel.
Example 3
Composition formula
The preparation procedure for this example is as follows:
1. weighing 3% of polyethylene glycol-8, 3% of PEG-240/HDI copolymer bis-decyltetradecanol polyether-20 ether, 3% of betaine and 65.7% of deionized water according to the formula proportion, uniformly dispersing, heating to 85-90 ℃, mixing, stirring and dissolving at a certain rotating speed until the mixture is uniform, preserving heat for half an hour, and stirring and cooling;
2. adding 20% salicylic acid nanometer gel prepared in advance at 50-60 deg.C, slowly stirring;
3. weighing 0.3% dipotassium glycyrrhizinate and 5% Aloe Barbadensis leaf extract according to formula ratio, adding at 45 deg.C, stirring at certain rotation speed for dissolving, and continuously cooling.
4. Stirring uniformly, cooling to room temperature, and defoaming to obtain the colorless transparent to semitransparent skin-care hydrogel.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (2)
1. An acidic skin-care hydrogel and a preparation method thereof, which are characterized in that: the raw materials and the weight ratio in the formula are respectively as follows:
1 to 30 percent of acid
1 to 30 percent of thickening agent
1 to 30 percent of humectant
20 to 80 percent of deionized water
0 to 10 percent of anti-allergy soothing agent
The acid is one or more of salicylic acid, glycolic acid, citric acid, mandelic acid, malic acid, tartaric acid, lactic acid, aldobionic acid, lactobionic acid, etc. commonly used for skin;
the thickening agent is one or more of PEG-240/HDI copolymer bis-decyl tetradecyl alcohol polyether-20 ether, poloxamer 407, poloxamer 188, polyacrylate-1, poloxamer 338, poloxamer 237, polyquaternary ammonium salt-37, PPG-13-decyl tetradecyl alcohol polyether-24, polyacrylamide, laureth-4, glycerol polyacrylate and other nonionic or cationic polymers;
the humectant is one or more of polyethylene glycol, dipropylene glycol, propylene glycol, 1, 3-propylene glycol, butanediol, glycerol, diglycerol, polyglycerol-10, 1, 2-hexanediol, betaine, polyglycerol-3, pentanediol and the like;
the anti-allergy soothing agent is one or more of dipotassium glycyrrhizinate, menthol, aloe barbadensis leaf extract, menthol lactate and the like;
the acidic skin-care hydrogel is characterized in that the pH of a 10% aqueous dispersion of the acidic skin-care hydrogel is 2.0-3.0;
the acidic skin-care hydrogel is characterized in that the viscosity of the acidic skin-care hydrogel is 500-100000 cps;
the acidic skin-care hydrogel is characterized in that the acidic skin-care hydrogel is colorless transparent to semitransparent hydrogel;
the acidic skin-care hydrogel is characterized in that the acidic skin-care hydrogel is thickened by nonionic or cationic high polymer, and does not need alkali swelling and neutralization;
the acidic skin-care hydrogel is characterized in that the acidic skin-care hydrogel acid is free acid and can better exert the efficacy.
2. The preparation method of the acidic skin-care hydrogel comprises the following steps:
(1) weighing the humectant, the thickener and the deionized water according to the formula proportion, uniformly dispersing, heating to 85-90 ℃, mixing, stirring and dissolving at a certain rotating speed until the mixture is uniform, keeping the temperature for half an hour, and then stirring and cooling;
(2) adding water-soluble acid and/or pre-prepared oil-soluble acid nano water-based gel at 50-60 ℃, and slowly stirring uniformly;
(3) weighing anti-allergic agent, algefacient, etc. according to the proportion of the formula, adding at 45 ℃, stirring at a certain rotation speed to dissolve uniformly, and then continuously cooling;
(4) stirring uniformly, cooling to room temperature, and defoaming to obtain the colorless transparent to semitransparent acidic skin-care hydrogel.
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| CN113546015A (en) * | 2021-07-26 | 2021-10-26 | 天津市海尔斯科技有限公司 | Honeycomb hydrogel based on citrus fruit extract and preparation process thereof |
| CN115212126A (en) * | 2022-05-30 | 2022-10-21 | 绽妍生物科技有限公司 | Soothing anti-inflammatory composite acid conditioning skin refreshing liquid and preparation method thereof |
| CN115337211A (en) * | 2022-08-16 | 2022-11-15 | 上海交通大学医学院附属第九人民医院 | Mild and hypoallergenic moisturizing acne-removing gel and preparation method thereof |
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