CN105705141B - 缓释微球及其制备方法 - Google Patents

缓释微球及其制备方法 Download PDF

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Publication number
CN105705141B
CN105705141B CN201480016260.6A CN201480016260A CN105705141B CN 105705141 B CN105705141 B CN 105705141B CN 201480016260 A CN201480016260 A CN 201480016260A CN 105705141 B CN105705141 B CN 105705141B
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CN
China
Prior art keywords
preparation
dispersed phase
betamethasone
sustained release
solvent
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Application number
CN201480016260.6A
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English (en)
Chinese (zh)
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CN105705141A (zh
Inventor
T·里奇
B·C·萨努
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Oakwood Laboratories LLC
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Oakwood Laboratories LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
CN201480016260.6A 2013-03-15 2014-03-14 缓释微球及其制备方法 Active CN105705141B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361790554P 2013-03-15 2013-03-15
US61/790,554 2013-03-15
PCT/US2014/028657 WO2014144309A1 (en) 2013-03-15 2014-03-14 Sustained release microspheres and method of producing the same

Publications (2)

Publication Number Publication Date
CN105705141A CN105705141A (zh) 2016-06-22
CN105705141B true CN105705141B (zh) 2018-12-28

Family

ID=51537672

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480016260.6A Active CN105705141B (zh) 2013-03-15 2014-03-14 缓释微球及其制备方法

Country Status (8)

Country Link
US (1) US9956177B2 (https=)
EP (1) EP2968184B1 (https=)
JP (2) JP2016515517A (https=)
CN (1) CN105705141B (https=)
CA (1) CA2909303C (https=)
ES (1) ES2697696T3 (https=)
MX (1) MX362187B (https=)
WO (1) WO2014144309A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9956177B2 (en) 2013-03-15 2018-05-01 Oakwood Laboratories LLC Sustained release microspheres and method of producing same
CN113766952B (zh) * 2019-03-29 2023-09-08 国立研究开发法人量子科学技术研究开发机构 放射性药品的制造方法及放射性药品
JP2023551508A (ja) * 2020-11-30 2023-12-08 エルジー・ケム・リミテッド カスパーゼ阻害剤を含有する注射用組成物及びその製造方法
US11992559B2 (en) 2021-02-24 2024-05-28 Oakwood Laboratories, Llc Microsphere formulations comprising lurasidone and methods for making and using the same
US20240148662A1 (en) * 2021-03-11 2024-05-09 Oakwood Laboratories, Llc Methods and systems for making polymer microspheres
CN116999412A (zh) * 2023-08-03 2023-11-07 四川迈可隆生物科技有限公司 一种含有倍他米松药物的缓释微球制剂及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002078673A1 (fr) * 2001-03-29 2002-10-10 Takeda Chemical Industries, Ltd. Procede de production d'un medicament sous forme de granules fins
CN102245201A (zh) * 2008-10-12 2011-11-16 麻省理工学院 免疫纳米疗法中的佐剂整合
WO2012019009A1 (en) * 2010-08-04 2012-02-09 Flexion Therapeutics Corticosteroids for the treatment of joint pain
WO2012112747A2 (en) * 2011-02-16 2012-08-23 Oakwood Laboratories, Llc Manufacture of microspheres using a hydrocyclone

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5945125A (en) 1995-02-28 1999-08-31 Temple University Controlled release tablet
US6046187A (en) * 1996-09-16 2000-04-04 Children's Medical Center Corporation Formulations and methods for providing prolonged local anesthesia
SE9704186D0 (sv) * 1997-11-14 1997-11-14 Astra Ab New composition of matter
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
JP2002356419A (ja) * 2001-03-29 2002-12-13 Takeda Chem Ind Ltd 微粒薬物の製造法
WO2005107714A2 (en) * 2004-05-05 2005-11-17 Alkermes Controlled Therapeutics, Inc. Method of forming microparticles that include a bisphosphonate and a polymer
GB2459910B (en) 2008-04-21 2010-03-31 Otonomy Inc Controlled Release Corticosteroid Compositions and Methods for the Treatment of Otic Disorders
US20100086596A1 (en) * 2008-10-06 2010-04-08 Oakwood Laboratories LLC Microspheres for releasing an octreotide compound without an initial time lag
US9956177B2 (en) 2013-03-15 2018-05-01 Oakwood Laboratories LLC Sustained release microspheres and method of producing same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002078673A1 (fr) * 2001-03-29 2002-10-10 Takeda Chemical Industries, Ltd. Procede de production d'un medicament sous forme de granules fins
CN102245201A (zh) * 2008-10-12 2011-11-16 麻省理工学院 免疫纳米疗法中的佐剂整合
WO2012019009A1 (en) * 2010-08-04 2012-02-09 Flexion Therapeutics Corticosteroids for the treatment of joint pain
WO2012112747A2 (en) * 2011-02-16 2012-08-23 Oakwood Laboratories, Llc Manufacture of microspheres using a hydrocyclone

Also Published As

Publication number Publication date
CA2909303C (en) 2021-10-19
MX2015012231A (es) 2016-05-05
MX362187B (es) 2019-01-08
JP2016515517A (ja) 2016-05-30
EP2968184B1 (en) 2018-10-24
US20160030351A1 (en) 2016-02-04
ES2697696T3 (es) 2019-01-25
JP6808777B2 (ja) 2021-01-06
BR112015022524A2 (pt) 2017-08-22
JP2019112471A (ja) 2019-07-11
WO2014144309A1 (en) 2014-09-18
CN105705141A (zh) 2016-06-22
EP2968184A4 (en) 2016-09-07
CA2909303A1 (en) 2014-09-18
EP2968184A1 (en) 2016-01-20
US9956177B2 (en) 2018-05-01

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