CN105683152B - 用于治疗高血压和/或纤维化的组合物 - Google Patents

用于治疗高血压和/或纤维化的组合物 Download PDF

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Publication number
CN105683152B
CN105683152B CN201480050979.1A CN201480050979A CN105683152B CN 105683152 B CN105683152 B CN 105683152B CN 201480050979 A CN201480050979 A CN 201480050979A CN 105683152 B CN105683152 B CN 105683152B
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China
Prior art keywords
fibrosis
treatment
pharmaceutically acceptable
hypertension
compound
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CN201480050979.1A
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English (en)
Chinese (zh)
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CN105683152A (zh
Inventor
凯伦·安妮特·达根
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Vectus Biosystems Pty Ltd
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Vectus Biosystems Pty Ltd
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Priority claimed from AU2013903573A external-priority patent/AU2013903573A0/en
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Publication of CN105683152A publication Critical patent/CN105683152A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201480050979.1A 2013-09-17 2014-09-17 用于治疗高血压和/或纤维化的组合物 Active CN105683152B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2013903573A AU2013903573A0 (en) 2013-09-17 Compositions for the treatment of hypertension and/or fibrosis
AU2013903573 2013-09-17
PCT/AU2014/000923 WO2015039173A1 (en) 2013-09-17 2014-09-17 Compositions for the treatment of hypertension and/or fibrosis

Publications (2)

Publication Number Publication Date
CN105683152A CN105683152A (zh) 2016-06-15
CN105683152B true CN105683152B (zh) 2017-03-22

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CN201480050979.1A Active CN105683152B (zh) 2013-09-17 2014-09-17 用于治疗高血压和/或纤维化的组合物

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US (1) US9458093B2 (enExample)
EP (1) EP3046901B1 (enExample)
JP (1) JP6122548B2 (enExample)
KR (1) KR101736416B1 (enExample)
CN (1) CN105683152B (enExample)
AP (1) AP2016009079A0 (enExample)
AU (1) AU2014324078B2 (enExample)
BR (1) BR112016005601B1 (enExample)
CA (1) CA2924356C (enExample)
DK (1) DK3046901T3 (enExample)
ES (1) ES2655455T3 (enExample)
IL (1) IL244621A (enExample)
MX (1) MX368865B (enExample)
MY (1) MY172557A (enExample)
NO (1) NO3046901T3 (enExample)
NZ (1) NZ717927A (enExample)
PH (1) PH12016500497B1 (enExample)
PL (1) PL3046901T3 (enExample)
RU (1) RU2635564C2 (enExample)
SG (1) SG11201601642WA (enExample)
UA (1) UA118111C2 (enExample)
WO (1) WO2015039173A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3284981B2 (ja) 1998-11-02 2002-05-27 株式会社デンソー 車両用交流発電機およびそのステータの製造方法
US9956166B2 (en) 2013-09-18 2018-05-01 Sorrento Therapeutics, Inc. Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin
SG11201707561RA (en) * 2015-03-18 2017-10-30 Vectus Biosystems Ltd Compositions for the treatment of fibrosis and fibrosis-related conditions
NZ736165A (en) * 2015-03-18 2022-07-01 Vectus Biosystems Ltd Compositions for the treatment of kidney and/or liver disease
EP3353147B1 (en) * 2015-09-22 2021-01-13 Vectus Biosystems Limited Synthesis of terphenyl compounds
CN120114438A (zh) * 2016-04-13 2025-06-10 内布拉斯加大学董事会 施用树脂毒素的方法和用树脂毒素治疗心血管疾病的方法
BR112019001510B1 (pt) 2016-07-28 2022-11-08 Vectus Biosystems Limited Composto, e, uso de um composto para manufatura de um medicamento para tratar profilática ou terapeuticamente fibrose pulmonar, ou uma enfermidade relacionada em um indivíduo com fibrose pulmonar ou em risco de desenvolver fibrose pulmonar

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1993137A (zh) * 2004-06-11 2007-07-04 维克特斯生物系统有限公司 用于治疗心血管疾病的组合物和方法
US20110082109A1 (en) * 2009-10-02 2011-04-07 Ajinomoto Co., Inc. Novel acyl guanidine derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2694288B1 (fr) * 1992-06-30 1994-09-09 Rhone Poulenc Agrochimie Phenylbenzamides fongicides et procédés pour les préparer.
AU2006322656B2 (en) * 2005-12-09 2012-03-08 Vectus Biosystems Limited VIP fragments and methods of use
US9630935B2 (en) * 2013-09-17 2017-04-25 Vectus Biosystems Limited Compositions for the treatment of hypertension and/or fibrosis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1993137A (zh) * 2004-06-11 2007-07-04 维克特斯生物系统有限公司 用于治疗心血管疾病的组合物和方法
US20110082109A1 (en) * 2009-10-02 2011-04-07 Ajinomoto Co., Inc. Novel acyl guanidine derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
A modular synthesis of teraryl-based a-helix mimetics, part 1:synthesis of core fragments with two electronically differentiated leaving groups;Martin Peters et al;《Chem.Eur.J.》;20130104;第19卷;2442-2449 *

Also Published As

Publication number Publication date
PL3046901T3 (pl) 2018-03-30
RU2016112257A (ru) 2017-10-20
PH12016500497B1 (en) 2017-12-13
MX2016003371A (es) 2016-10-21
MY172557A (en) 2019-12-02
CA2924356C (en) 2018-04-03
UA118111C2 (uk) 2018-11-26
IL244621A0 (en) 2016-04-21
MX368865B (es) 2019-08-02
KR20160074471A (ko) 2016-06-28
KR101736416B1 (ko) 2017-05-16
SG11201601642WA (en) 2016-04-28
JP2016532632A (ja) 2016-10-20
AP2016009079A0 (en) 2016-03-31
ES2655455T3 (es) 2018-02-20
NZ717927A (en) 2018-12-21
BR112016005601A8 (pt) 2020-02-18
NO3046901T3 (enExample) 2018-03-17
DK3046901T3 (en) 2018-01-02
IL244621A (en) 2017-04-30
PH12016500497A1 (en) 2016-06-13
RU2635564C2 (ru) 2017-11-14
JP6122548B2 (ja) 2017-04-26
WO2015039173A1 (en) 2015-03-26
CN105683152A (zh) 2016-06-15
AU2014324078B2 (en) 2016-12-15
EP3046901A1 (en) 2016-07-27
CA2924356A1 (en) 2015-03-26
US20160221933A1 (en) 2016-08-04
EP3046901B1 (en) 2017-10-18
US9458093B2 (en) 2016-10-04
AU2014324078A1 (en) 2016-04-07
BR112016005601B1 (pt) 2021-02-02
EP3046901A4 (en) 2017-04-12

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