CN105675754A - 高效液相色谱法测定利格列汀对映异构体含量的方法 - Google Patents
高效液相色谱法测定利格列汀对映异构体含量的方法 Download PDFInfo
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- CN105675754A CN105675754A CN201610044595.XA CN201610044595A CN105675754A CN 105675754 A CN105675754 A CN 105675754A CN 201610044595 A CN201610044595 A CN 201610044595A CN 105675754 A CN105675754 A CN 105675754A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N2030/022—Column chromatography characterised by the kind of separation mechanism
- G01N2030/027—Liquid chromatography
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Abstract
Description
名称 | S/N平均值 | 按照S/N=3:1计算检测限 |
利格列汀对映异构体 | 4.0 | 0.0240% |
名称 | S/N平均值 | 按照S/N=10:1计算定量限 |
利格列汀对映异构体 | 8.3 | 0.0479% |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106290621A (zh) * | 2016-07-31 | 2017-01-04 | 合肥远志医药科技开发有限公司 | 一种利格列汀异构体的检测方法 |
CN111751461A (zh) * | 2020-06-01 | 2020-10-09 | 江苏华阳制药有限公司 | 一种那格列汀对映异构体的检测方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013098775A1 (en) * | 2011-12-28 | 2013-07-04 | Dr. Reddy's Laboratories Limited | Improved process for preparation of pure linagliptin |
WO2014033746A2 (en) * | 2012-08-17 | 2014-03-06 | Glenmark Pharmaceuticals Limited; Glenmark Generics Limited | Process for the preparation of dipeptidylpeptidase inhibitors |
CN104496989A (zh) * | 2014-12-26 | 2015-04-08 | 寿光富康制药有限公司 | 一种利格列汀工业化制备工艺 |
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2016
- 2016-01-22 CN CN201610044595.XA patent/CN105675754B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013098775A1 (en) * | 2011-12-28 | 2013-07-04 | Dr. Reddy's Laboratories Limited | Improved process for preparation of pure linagliptin |
WO2014033746A2 (en) * | 2012-08-17 | 2014-03-06 | Glenmark Pharmaceuticals Limited; Glenmark Generics Limited | Process for the preparation of dipeptidylpeptidase inhibitors |
CN104496989A (zh) * | 2014-12-26 | 2015-04-08 | 寿光富康制药有限公司 | 一种利格列汀工业化制备工艺 |
Non-Patent Citations (3)
Title |
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CHITTABATHINA VENKATA RAGHUNADHA BABU等: "Estimation of Enantiomeric Impurity in Piperidin-3-Amine by Chiral HPLC With Precolumn Derivatization", 《CHIRALITY》 * |
STEFAN BLECH等: "The Metabolism and Disposition of the Oral Dipeptidyl Peptidase-4 Inhibitor, Linagliptin, in Humans", 《DRUG METABOLISM AND DISPOSITION》 * |
ZENG-WEI LAI等: "Discovery of highly potent DPP-4 inhibitors by hybrid compound design based on linagliptin and alogliptin", 《EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106290621A (zh) * | 2016-07-31 | 2017-01-04 | 合肥远志医药科技开发有限公司 | 一种利格列汀异构体的检测方法 |
CN111751461A (zh) * | 2020-06-01 | 2020-10-09 | 江苏华阳制药有限公司 | 一种那格列汀对映异构体的检测方法 |
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CN105675754B (zh) | 2017-12-08 |
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