CN105675754B - 高效液相色谱法测定利格列汀对映异构体含量的方法 - Google Patents
高效液相色谱法测定利格列汀对映异构体含量的方法 Download PDFInfo
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- CN105675754B CN105675754B CN201610044595.XA CN201610044595A CN105675754B CN 105675754 B CN105675754 B CN 105675754B CN 201610044595 A CN201610044595 A CN 201610044595A CN 105675754 B CN105675754 B CN 105675754B
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
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Description
名称 | S/N平均值 | 按照S/N=3:1计算检测限 |
利格列汀对映异构体 | 4.0 | 0.0240% |
名称 | S/N平均值 | 按照S/N=10:1计算定量限 |
利格列汀对映异构体 | 8.3 | 0.0479% |
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CN106290621A (zh) * | 2016-07-31 | 2017-01-04 | 合肥远志医药科技开发有限公司 | 一种利格列汀异构体的检测方法 |
CN111751461B (zh) * | 2020-06-01 | 2022-11-01 | 江苏华阳制药有限公司 | 一种那格列汀对映异构体的检测方法 |
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US9056112B2 (en) * | 2011-12-28 | 2015-06-16 | Dr. Reddy's Laboratories Limited | Process for preparation of pure linagliptin |
US9353114B2 (en) * | 2012-08-17 | 2016-05-31 | Glenmark Pharmaceuticals Limited | Process for the preparation of dipeptidylpeptidase inhibitors |
CN104496989A (zh) * | 2014-12-26 | 2015-04-08 | 寿光富康制药有限公司 | 一种利格列汀工业化制备工艺 |
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