CN105663926A - 一种降尿酸植物酵素及其制备方法 - Google Patents
一种降尿酸植物酵素及其制备方法 Download PDFInfo
- Publication number
- CN105663926A CN105663926A CN201610010272.9A CN201610010272A CN105663926A CN 105663926 A CN105663926 A CN 105663926A CN 201610010272 A CN201610010272 A CN 201610010272A CN 105663926 A CN105663926 A CN 105663926A
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- Prior art keywords
- uric acid
- pulp
- tea
- plant enzyme
- root
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Abstract
本发明属医药技术领域,涉及一种降尿酸植物酵素及其制备方法。由以下原料制成:茯砖黑茶10-20g、青砖黑茶10-20g、红茶菌菌种80-140g、火龙果红色果肉80-120g、熟番木瓜果肉40-60g、青番木瓜果肉40-60g、葡萄果40-60g、车前籽胶0.3-0.5g、薏苡仁20-40g、土茯苓20-40g、牛膝10-20g、萆薢10-20g、石菖蒲4-6g、猫须草30-40g、黄花地桃花10-20g、牡丹皮6-8g、赤芍8-10g、当归尾4-6g、银花藤20-40g、葡萄根6-8g、莞香树叶2-4g。通过原料处理、发酵、超高压力灭菌制得,保持强力生物活性,具安全、降尿酸、促健康特点。
Description
技术领域
本发明属于医药技术领域,特别涉及一种降尿酸植物酵素及其制备方法。
背景技术
据相关资料显示,目前我国高尿酸血症患者约有1亿左右,高发年龄为中老年男性和绝经后女性,但近年来有年轻化趋势。高尿酸血症是因体内尿酸生成过多和(或)排泄过少所致。高尿酸血症会导致痛风,出现关节肿痛、变形的症状,还与高血压、糖尿病、高血脂症、冠心病、泌尿系统结石、肾脏损害有因果关系。目前西医治疗高尿酸血症主要是采用尿酸合成抑制剂和促进尿酸排泄药,都能收到一定的疗效,但此类药物均有较大的副作用,易导致肝肾功能损害、骨髓抑制及胃肠道反应。中医药在治疗痛风方面已有相当长时间的探索和经验积累,诺贝尔奖中国得奖者屠呦呦在发掘中药青蒿治疗疟疾的应用上取得了举世公认的成果,这是对中草药防治疾病具有广阔研发前景的有力例证,因此,探索、优化中草药降尿酸方剂,寻求一种安全、高效的降尿酸、治疗高尿酸血症的天然植物酵素有极大的必要性和积极的现实意义,这正是本发明的目的。
发明内容
本发明人结合传统中医和现代医学对高尿酸血症、痛风症的认识,深入分析中西医对高尿酸血症在认识和治疗上的异同之处,探究其本质性所在,并通过反复实践、求证、终于发现:(1)抑制尿酸的形成和促进尿酸的排泄,在本质上,中西医都是目标一致的,但中医更注重整体机能的调节,尤其是增强肝、肾、脾、肺功能的协调上较为注重,这是非常重要的提示和启发;(2)在组方上,药理、功能的协调、增效互补、互相制约有极大的探索空间,复方是必要的选择;(3)天然食物、天然植物中含有很好的功能物质,有巨大的发掘潜能。经过长时间的试验和创新性的工艺改进,制得一种降尿酸植物酵素,完成了本发明。本发明产品具有天然、安全、无毒副作用、降尿酸效果显著、作用持久的特点,同时还有保护肾脏、增强整体机能、促进身体健康的作用,且风味、口感良好。
本发明的目的是这样实现的:
一种降尿酸植物酵素,由以下重量的原料制成:
茯砖黑茶10-20g、青砖黑茶10-20g、红茶菌菌种80-140g、火龙果红色果肉80-120g、熟番木瓜果肉40-60g、青番木瓜果肉40-60g、葡萄果40-60g、车前籽胶0.3-0.5g、薏苡仁20-40g、土茯苓20-40g、牛膝10-20g、萆薢10-20g、石菖蒲4-6g、猫须草30-40g、黄花地桃花10-20g、牡丹皮6-8g、赤芍8-10g、当归尾4-6g、银花藤20-40g、葡萄根6-8g、莞香树叶2-4g;
上述一种降尿酸植物酵素的制备方法,在采用上述重量的原料的基础上,包括以下制备步骤:
(1)将茯砖黑茶、青砖黑茶混合,加入450g水,煮沸10min,滤去茶渣,得茶汤,冷却至30-35℃,备用;
(2)将火龙果红色果肉、熟番木瓜果肉、青番木瓜果肉、葡萄果分别用无菌水冲洗干净后切碎,然后混合一起,用打浆机打成果浆;
(3)将红茶菌菌种和步骤(1)所得的冷却至30-35℃的茶汤以及步骤(2)所得的果浆一起装入一个玻璃或瓷质容器中,搅拌均匀,用经过灭菌处理的棉纱布封住容器的开口,扎紧,恒温26℃发酵2天,再恒温30℃发酵1天;
(4)将薏苡仁、土茯苓、牛膝、萆薢、石菖蒲、猫须草、黄花地桃花、牡丹皮、赤芍、当归尾、银花藤、葡萄根、莞香树叶混合,用粉碎机打碎成粉状,加5倍重量的纯净水煮沸20min,加入车前籽胶,再煮沸3min,冷却至20℃,得有药渣和药液的中草药煎煮物;
(5)将步骤(4)所得的有药渣和药液的中草药煎煮物加入到步骤(3)已发酵了3天的发酵物中,继续恒温30℃发酵2天,5℃密封陈酿30天,经200目压榨过滤,将滤出液分装于软性包装瓶中,用30℃100MPa压力、15min第1次压力灭菌,24小时后,用-5℃低温和350MPa压力、15min第2次压力灭菌,制得一种降尿酸植物酵素。
本发明中各原料的作用:
茯砖黑茶:为黑茶中的一种,以含冠突散囊菌为特点,具有降血脂毒、降血糖、抗氧化、利尿功能。
青砖黑茶:为黑茶中的一种,以老青茶为原料,茶汤浓厚纯正,有降血糖、降血脂、降血压、利尿、杀菌止泻作用。
红茶菌菌种:含酵母菌、乳酸菌、醋酸菌,含丰富维生素C、维生素B,能发酵、分解碳水化合物及蛋白质,具有消脂、排毒、消炎、护肝作用。
火龙果红色果肉:火龙果为仙人掌科、量天尺属植物的果实,有白色果肉与红色果肉之不同品种。火龙果红色果肉含非常丰富的花青素,具有抗氧化作用,还含丰富的水溶性膳食纤维、碳水化合物、维生素C、维生素B、葡萄糖、植物白蛋白及酶,有降低胆固醇、减肥、解毒、抗氧化作用。
熟番木瓜果肉:为充分成熟的番木瓜去皮、籽后所得的果肉,含丰富的酵素,尤其含蛋白酶很丰富。番木瓜味甘、性平,有健胃、消食、舒筋通络作用。成熟的番木瓜含糖丰富。
青番木瓜果肉:为未成熟的青色番木瓜去皮、籽后所得的果肉,酵素含量比熟番木瓜果肉更高。
葡萄果:为葡萄科植物的成熟浆果,含丰富的葡萄糖、维生素B、维生素C、花青素,有生津、利尿、抗氧化作用。
车前籽胶:为车前草籽提取的胶体,含多糖,具有清热利尿、渗湿通淋、祛痰、降胆固醇作用。
薏苡仁:为药食两用原料,味甘、淡,性微寒,入脾、肺、肾经。有健脾利湿、清热排脓功能,用于治疗水肿脚气、关节疼痛。
土茯苓:为中药材,味甘、淡,性平,入肝、胃、脾经。有解毒、除湿、利关节功能。
牛膝:为中药材,味苦、酸,性平,入肝、肾经。有补肝肾、强筋骨、活血通经、利尿通淋功能。
萆薢:为中药材,味苦,性平,入肝、胃、膀胱经。有祛风、利湿功能,治风湿顽痹、腰膝疼痛、小便不利、淋浊等症。
石菖蒲:为中药材,味辛,性温,入胃、心经。有开窍、豁痰、理气、活血、散风、去湿功能。
猫须草:又名肾茶,为中草药,味甘、淡、微苦,性凉。有清热去湿、排石利尿功能,治肾炎、膀胱炎、尿路结石、风湿性关节炎。猫须草能明显增加肾小球滤过和肾循环血量,促进毒性代谢产物的排除,显著降低体内血尿酸。猫须草还具有较强抗菌、消炎作用,可使肾小管破坏减轻,肾小球细胞结构病变减少,完整肾小球数目增加,对肾组织的损伤有保护和改善作用。
黄花地桃花:为中草药,味苦,性寒。有利尿化石功能,治石淋、感冒风热表证。
牡丹皮:为中药材,味辛、苦,性凉,入心、肝、肾经。有清热凉血、活血散瘀功能,能治风湿热痹。
赤芍:为中药材,气微香,味微苦、酸涩。有活血通经、凉血散瘀、清热解毒功能。
当归尾:为中药材,味甘、辛,性温,入肝、心、脾经。有补血活血、祛瘀功能。
银花藤:为中药材,味甘,性寒,入肺、胃经。有清热解毒、疏风通络功能。
葡萄根:为中药材,味甘、涩,性平。有除风湿,利小便功能。
莞香树叶:为瑞香科沉香属乔木莞香树的树叶,主产于广东省东莞市,莞香树是产沉香的树体。本发明人发现莞香树的树叶有行气、解郁、镇痛作用,有类似陈皮的功能,但无陈皮的燥性,还有化浊、开窍的作用。
本发明的有益效果如下:
(1)“仙方活命饮”是传统中医女科十大名著之一的《校注妇人大全良方》中记载的一个方剂,经过历代医家的实践,证明确是“治一切疮疡,未成者即散,已成者即溃,又止痛消毒之良剂也”(见《校注妇人良方》卷24)。本发明人曾将此方运用于高尿酸血症患者出现关节红、肿、热、痛症状的治疗,取得较为满意的效果,但在临床观察中发现,虽然患者关节红、肿、热、痛的这些表面症状得以显著缓解,但导致这些症状出现的病因,即高浓度尿酸以及尿酸石仍未得以显著消除,因而使症状不易彻底消除,并且容易复发,从本质上说,是治标未治本。为了达到标本兼治的目的,本发明人吸取了仙方活命汤中活血、和血、消除瘀热凝滞的理念,重新全面创建组方:以归尾活血、化瘀、和血,以牡丹皮、赤芍清热痹、凉血,配合清血中瘀热毒邪,在善于清热、解肿毒的银花藤大力协同和莞香树叶芳香行气的引领下,有效地消除气血的瘀滞郁热,加上组方中有利湿消肿功能的土茯苓、薏苡仁、葡萄根的配合,使尿酸引起的红、肿、热、痛、炎性反应有效消除,既起到了治标的作用,又为治本创造了良好的生态环境;在降尿酸方面,利用红色火龙果肉、番木瓜果肉、葡萄果、红茶菌中含有的花青素、酶、维生素C、维生素B综合形成抑制5-磷酸核苷酸-1-焦磷酸合成酶活性、增强次黄嘌呤鸟嘌呤磷酸核糖转移酶活性的作用,从而减少尿酸的形成、改善尿酸代谢;以萆薢、猫须草、薏苡仁、土茯苓、黄花地桃花组合形成利尿、化石、清热解毒的功能,更在石菖蒲和莞香树叶的芳香通窍,以及牛膝强肾支持下,形成强有力的促进排泄尿酸作用;其中,火龙果红色果肉、番木瓜果肉、薏苡仁、土茯苓、车前籽胶中的多糖物质能结合黄花地桃花的化石功能物质引入到人体骨关节的软组织中,起到促进尿酸结晶的溶解作用;茯砖黑茶和青砖黑茶既能配合番木瓜果肉、火龙果红色果肉、葡萄果为红茶菌生长繁殖提供营养,又能产生综合而强大的降血肥、抗氧化、降血糖、增强肝功能作用,与降尿酸作用形成良性协同、增益效果。
(2)在制备工艺,即制备方法上,为达到尽可能保留植物的活性物质和发挥酶、益生菌的有益药理作用,本发明人利用熟番木瓜果肉、葡萄果和火龙果红色果肉所含丰富的葡萄糖、碳水化合物,以及黑茶中的营养物质,通过其自身含酶的活力和红茶菌菌种的作用进行有效发酵,产生强大的复合酶活力和多种功能性肽物质,对改善人体尿酸代谢有良好的作用。
(3)组方中的中草药原料经粉碎、短时间水煮,使药物处于松软、容易释放的状态,并达到灭菌目的,然后将药液及药渣一起投入已经初步发酵而达到高活性状态的红茶菌发酵物中一同继续发酵、低温陈酿、浸渍,使药物有效成份充分释放、融合,并产生综合功效,风味也进一步优化。将经过陈酿后的发酵物进行过滤、分装后,采用超高压力灭菌方式进行处理,在达到有效灭菌以利于保质和贮存的同时,尽量地保持酶的活性和热敏感物质的稳定,使产品功效更为强大。30℃100Mpa压力15min的第1次压力灭菌,目的是将一般细菌和已长芽的芽孢菌杀灭,24小时后,让未长芽的存活芽孢菌长出了芽,再采用-5℃低温和350Mpa压力15min进行第2次灭菌,以达到最佳的灭菌效果,但对酶及活性物质影响甚小。
(4)综上所述,本发明通过创新的原料组合,使各原料功效产生互助、协同、增益效果,从而发挥出显著的降尿酸、消肿除痛、改善代谢、增强体质的治疗效果,尤其使身体的整体状态向良性的方向逆转,这是目前治高尿酸血症的西药无法达到的效果。本发明又以创新的制备方法尽量保留并增强了原料的综合活性成份,使药效得以更好利用和发挥,生物发酵与超高压力灭菌的组合更令优势彰显、效果显著。降尿酸、降血脂、促排泄、强机能的协同作用,从整体上改善了体质机能,达到标本、内外兼治的效果。
具体实施方式
下面通过具体实施例对本发明作进一步说明。
实施例。
优选的,一种降尿酸植物酵素的制备方法,包括以下制备步骤:
(1)称取以下重量的原料:
茯砖黑茶15g、青砖黑茶15g、红茶菌菌种110g、火龙果红色果肉100g、熟番木瓜果肉50g、青番木瓜果肉50g、葡萄果50g、车前籽胶0.4g、薏苡仁30g、土茯苓30g、牛膝15g、萆薢15g、石菖蒲5g、猫须草35g、黄花地桃花15g、牡丹皮7g、赤芍9g、当归尾5g、银花藤30g、葡萄根7g、莞香树叶3g;
(2)将茯砖黑茶、青砖黑茶混合,加入450g水,煮沸10min,滤去茶渣,得茶汤,冷却至30-35℃,备用;
(3)将火龙果红色果肉、熟番木瓜果肉、青番木瓜果肉、葡萄果分别用无菌水冲洗干净后切碎,然后混合一起,用打浆机打成果浆;
(4)将红茶菌菌种和步骤(2)所得的冷却至30-35℃的茶汤以及步骤(3)所得的果浆一起装入一个玻璃或瓷质容器中,搅拌均匀,用经过灭菌处理的棉纱布封住容器的开口,扎紧,恒温26℃发酵2天,再恒温30℃发酵1天;
(5)将薏苡仁、土茯苓、牛膝、萆薢、石菖蒲、猫须草、黄花地桃花、牡丹皮、赤芍、当归尾、银花藤、葡萄根、莞香树叶混合,用粉碎机打碎成粉状,加5倍重量的纯净水煮沸20min,加入车前籽胶,再煮沸3min,冷却至20℃,得有药渣和药液的中草药煎煮物;
(6)将步骤(5)所得的有药渣和药液的中草药煎煮物加入到步骤(4)已发酵了3天的发酵物中,继续恒温30℃发酵2天,5℃密封陈酿30天,经200目压榨过滤,将滤出液分装于软性包装瓶中,用30℃100MPa压力、15min第1次压力灭菌,24小时后,用-5℃低温和350MPa压力、15min第2次压力灭菌,制得一种降尿酸植物酵素。
应用例1:李某,女,53岁,右脚大拇趾红肿疼痛,予“仙方活命饮”两剂煎服,服后红肿退减,继续服两剂,仍未能全部消肿,经检验,血尿酸水平为495μmol/L,显示为高尿酸血症,给予本发明制品服用,每天3次,每次服50mL,服至第4天,红肿疼痛全部消除,血尿酸水平降至358μmol/L。
应用例2:周某,男,62岁,患高尿酸血症多年,第一跖趾关节、踝、膝部经常出现红肿热痛,服用本发明制品,每天2次,每次服60mL,服一个月后,血尿酸水平降至正常范围,关节未出现红肿热痛,坚持每天服一次,每次50mL,一年来病情没有再复发。
以上所述实施例仅表达了本发明的较佳实施方式,其描述较为具体和详细,但并不能因此而理解对本发明专利范围的限制,本发明专利的保护范围以所附权利要求为准。
Claims (2)
1.一种降尿酸植物酵素,其特征在于,由以下重量的原料制成:
茯砖黑茶10-20g
青砖黑茶10-20g
红茶菌菌种80-140g
火龙果红色果肉80-120g
熟番木瓜果肉40-60g
青番木瓜果肉40-60g
葡萄果40-60g
车前籽胶0.3-0.5g
薏苡仁20-40g
土茯苓20-40g
牛膝10-20g
萆薢10-20g
石菖蒲4-6g
猫须草30-40g
黄花地桃花10-20g
牡丹皮6-8g
赤芍8-10g
当归尾4-6g
银花藤20-40g
葡萄根6-8g
莞香树叶2-4g。
2.权利要求1所述的一种降尿酸植物酵素的制备方法,其特征在于,在采用权利要求1
所述重量的原料的基础上,包括以下制备步骤:
(1)将茯砖黑茶、青砖黑茶混合,加入450g水,煮沸10min,滤去茶渣,得茶汤,冷
却至30-35℃,备用;
(2)将火龙果红色果肉、熟番木瓜果肉、青番木瓜果肉、葡萄果分别用无菌水冲洗干净后切碎,然后混合一起,用打浆机打成果浆;
(3)将红茶菌菌种和步骤(1)所得的冷却至30-35℃的茶汤以及步骤(2)所得的果浆一起装入一个玻璃或瓷质容器中,搅拌均匀,用经过灭菌处理的棉纱布封住容器的开口,扎紧,恒温26℃发酵2天,再恒温30℃发酵1天;
(4)将薏苡仁、土茯苓、牛膝、萆薢、石菖蒲、猫须草、黄花地桃花、牡丹皮、赤芍、
当归尾、银花藤、葡萄根、莞香树叶混合,用粉碎机打碎成粉状,加5倍重量的纯净水煮沸20min,加入车前籽胶,再煮沸3min,冷却至20℃,得有药渣和药液的中草药煎煮物;
(5)将步骤(4)所得的有药渣和药液的中草药煎煮物加入到步骤(3)已发酵了3天的
发酵物中,继续恒温30℃发酵2天,5℃密封陈酿30天,经200目压榨过滤,将滤出液分装于软性包装瓶中,用30℃100MPa压力、15min第1次压力灭菌,24小时后,用-5℃低温和350MPa压力、15min第2次压力灭菌,制得一种降尿酸植物酵素。
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107495033A (zh) * | 2017-08-09 | 2017-12-22 | 山东博华高效生态农业科技有限公司 | 一种能缓解痛风的酵素饮品及其制作方法 |
CN112546124A (zh) * | 2020-12-28 | 2021-03-26 | 广东省微生物研究所(广东省微生物分析检测中心) | 白木香叶提取物在制备治疗痛风药物中的应用 |
CN113262276A (zh) * | 2021-05-31 | 2021-08-17 | 洛阳糠豪川禾科技有限公司 | 预防调理痛风的酵素制剂及其应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104162058A (zh) * | 2013-05-20 | 2014-11-26 | 陕西盘龙药业集团股份有限公司 | 一种治疗痛风的中药复方制剂及其制备方法 |
-
2016
- 2016-01-05 CN CN201610010272.9A patent/CN105663926A/zh active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104162058A (zh) * | 2013-05-20 | 2014-11-26 | 陕西盘龙药业集团股份有限公司 | 一种治疗痛风的中药复方制剂及其制备方法 |
Non-Patent Citations (3)
Title |
---|
刘福堃: "《微生物酵素及其应用》", 31 January 2014 * |
张彬等: "《茶之养》", 31 March 2015 * |
江晃荣: "《酵素》", 30 September 2014 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107495033A (zh) * | 2017-08-09 | 2017-12-22 | 山东博华高效生态农业科技有限公司 | 一种能缓解痛风的酵素饮品及其制作方法 |
CN112546124A (zh) * | 2020-12-28 | 2021-03-26 | 广东省微生物研究所(广东省微生物分析检测中心) | 白木香叶提取物在制备治疗痛风药物中的应用 |
CN113262276A (zh) * | 2021-05-31 | 2021-08-17 | 洛阳糠豪川禾科技有限公司 | 预防调理痛风的酵素制剂及其应用 |
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