CN105663893A

CN105663893A - Junhuang intestinal protection mixture

Info

Publication number: CN105663893A
Application number: CN201610057812.9A
Authority: CN
Inventors: 刘明; 余晓玲; 庞永诚; 张桂兰; 刘庆彤; 龚瑞芸; 杨海玲; 郭施余
Original assignee: Kunming Hospital of Traditional Chinese Medicine
Current assignee: Kunming Hospital of Traditional Chinese Medicine
Priority date: 2016-01-28
Filing date: 2016-01-28
Publication date: 2016-06-15

Abstract

The invention provides a Junhuang intestinal protection mixture, relates to a traditional Chinese medicine preparation, in particular to a Junhuang intestinal protection mixture for treating intestinal fungal infection. The Junhuang intestinal protection mixture is characterized in that in terms of the mixture, astragalus membranaceus and heterophylly falsestarwort root are taken as monarch drugs, largehead atractylodes rhizome, poria cocos and coix seeds are taken as ministerial drugs, grassleaf sweelflag rhizome, coptis chinensis and virgate wormwood herb are taken as adjuvant drugs, and medicated leaven is taken as a messenger drug. The Junhuang intestinal protection mixture starts with the lungs and the spleen, the astragalus membranaceus and the heterophylly falsestarwort root are taken as the monarch drugs, the largehead atractylodes rhizome, the poria cocos and the coix seeds are taken as the ministerial drugs, the grassleaf sweelflag rhizome, the coptis chinensis and the virgate wormwood herb are taken as the adjuvant drugs, and the medicated leaven taken as the messenger drug, so that the Junhuang intestinal protection mixture has the functions of invigorating the spleen, replenishing qi, clearing heat and promoting diuresis, carries out treatment for the intestinal fungal infection on the basis of pathogenesis and has better clinical effect.

Description

Bacterium Huang protects intestinal mixture

Technical field

The present invention relates to a kind of Chinese medicine preparation, especially a kind of bacterium Huang for treating intestinal canal fungus infection protects intestinal mixture.

Background technology

The rising of deep fungal infections incidence rate, the enteric flora disturbance that antibiotic causes is used to have close relationship with patient's long-term, high-dose, antibiotic side effect is with enteric flora disturbance for starting point, increase with conditionality pathogenic bacterium, bacterial translocation is mark, ultimately causes the infection that case fatality rate is high.

In the especially old patient of danger disease, serious symptom, generally all there are positive QI-insufficiency, the basis that function is low. When owing to there is infectious disease or employing broad ectrum antibiotic or hormone for prophylaxis against infection diseases in this type of patient, it is easily caused internal dysbacteriosis, immunologic function declines further, easily there is fungal infection, but owing to constantly there being the appearance infecting fastbacteria pearl constantly to have new broad ectrum antibiotic to come out, fungal infection still betides danger disease, patient with severe symptoms again and again. Become the difficult point of infectious disease treatment.

At present, western medical treatment intestinal canal fungus infection clinic selects the medicine such as nystatin, fluconazol more, and mildew making usually and has the side effect such as nausea,vomiting,diarrhea, has been reported that adverse reaction rate is up to 15%; Fluconazol is a kind of medicine for the treatment of Systemic fungal infections, for broad-spectrum antifungal medicine, the fungal infection of humans and animals is all had therapeutical effect, has several dosage form of tablet, capsule, injectable powder and injection in the market. Its mechanism of action is mainly the activity of the cytochrome P-450 of high selectivity interference fungus, thus suppressing the biosynthesis of ergosterol on fungal cell membrane, fungal infection is had good therapeutical effect, but its untoward reaction is also comparatively obvious, it is embodied in: 1, common digestive tract reaction, shows as Nausea and vomiting, stomachache or diarrhoea etc.; , occasionally can there is serious exfoliative dermatitis in 2, anaphylaxis: can behave as erythra, often with liver function injury, erythema multiforme exudativu; 3, liver toxicity: slight transient serum amino transferase can be occurred in therapeutic process to raise, occasionally may occur in which liver toxicity symptom, especially easily betides the patient of serious underlying diseases; 4, visible dizziness, headache etc.; 5, some patient, especially has the patient of serious underlying diseases (such as acquired immune deficiency syndrome (AIDS) and cancer), in fact it could happen that the phenomenons such as renal dysfunction. Modern study shows that garlicin is effective to deep fungal infection, but not at the report of wide clinical application. At present, Chinese medicine, in treatment fungal infection especially intestinal canal fungus infection, has scholar to have the report that some Empirical formula are treated, and Chinese patent medicine or hospital preparation is few to intestinal canal fungus infection research report.

Summary of the invention

To be solved by this invention is exactly Western medicine deficiency in treatment intestinal canal fungus infection problem, it is provided that a kind of invigorating the spleen and benefiting QI, clearing away heat-damp and promoting diuresis effect, for treating the determined curative effect of intestinal canal fungus infection, safety, low-cost bacterium Huang guarantor's intestinal mixture.

The bacterium Huang of the present invention protects intestinal mixture, it is characterised in that this mixture, and with the Radix Astragali, Radix Pseudostellariae for monarch drug, the Rhizoma Atractylodis Macrocephalae, Poria, Semen Coicis are ministerial drug, and Rhizoma Acori Graminei, Rhizoma Coptidis and Herba Artemisiae Scopariae are adjuvant drug, and Massa Medicata Fermentata is for making medicine, and is prepared by following steps:

(1) taking 150-450 mass divides the Radix Astragali, 100-300 mass to divide Radix Pseudostellariae, 50-150 mass to divide the Rhizoma Atractylodis Macrocephalae, 75-225 mass to divide Poria, 150-450 mass to divide divert attention song, 50-150 mass of Semen Coicis, 75-225 mass to divide Rhizoma Coptidis, 50-150 mass to divide Herba Artemisiae Scopariae and 50-150 mass to divide Rhizoma Acori Graminei;

(2) putting in container by the medicine of step (1), the water adding weight 4-8 times of weight of parent drugs decocts, and continues to decoct 45-90 minute, be then filtered with 80 mesh sieves, obtain 2800-17500ml filtrate A after solution seethes with excitement;

(3) taking the medicine obtained after filtering in step (2), the water continuously adding weight 2-8 times of weight of parent drugs decocts, and continues to decoct 45-90 minute, be filtered with 80 mesh sieves, obtain 1300-13500ml liquor B after solution seethes with excitement;

(4) liquor B that the filtrate A obtained in step (2) obtains with step (3) is mixed, 1500-10000ml it is concentrated into after mixing, obtain admixing medical solutions, admixing medical solutions adds 1 ‰ sodium benzoate and 0.5 ‰ ethyl hydroxybenzoates, obtain bacterium Huang after uniform stirring and protect intestinal mixture.

The sweet tepor of the Radix Astragali in side, the sweet micro-hardship of Radix Pseudostellariae is put down, and all enters lung, spleen two warp, plays the gas of tonification lung spleen altogether, with strengthening vital QI to eliminate pathogenic factors, is monarch drug altogether; Rhizoma Atractylodis Macrocephalae hardship temperature, replenishing QI to invigorate the spleen dampness, Poria, Semen Coicis are sweet light product, light can eliminating dampness by diuresis, make damp go from urine, reach the use for the treatment of diarrhea by diuretics, the Rhizoma Atractylodis Macrocephalae, Poria, Semen Coicis three strengthen the merit of monarch drug replenishing QI to invigorate the spleen, are ministerial drug altogether; Rhizoma Acori Graminei removing dampness by means of aromatics stomach function regulating, Rhizoma Coptidis heat clearing and damp drying, Herba Artemisiae Scopariae function of gallbladder promoting dehumidifies, spleen preferring dryness to dampness, and along its property for mending, Rhizoma Acori Graminei, Rhizoma Coptidis and Herba Artemisiae Scopariae three assist ministerial drug to dehumidify, and are adjuvant drug altogether; Massa Medicata Fermentata spleen benefiting and stimulating the appetite, and middle antidiarrheal, for making medicine. All medicine compatibilities, have invigorating the spleen and benefiting QI, effect of clearing away heat-damp and promoting diuresis.

Intestinal canal fungus infection patient is many with abdominal pain diarrhea for main clinic symptoms, study carefully have loose bowels because of, do not become what rush down to say with or without wet, so wet institute gives birth to, and relevant to lung splenic function mistake department, the method dried also is started with from lung spleen. Therefore, the bacterium Huang of the present invention is protected intestinal mixture and is just being hited the pathogenesis of intestinal canal fungus infection, therefore clinic can obtain better effects.

Observe emergency department's inpatient, Monilia Enteritis patient totally 60 example, be randomly divided into treatment group and each 30 examples of matched group, wherein:

1, male 22 examples for the treatment of group, female 8 example, 21～88 years old age, average 64.533 ± 13.03 years old; 2～25 days courses for the treatment of, average 7.6 ± 4.87 days, 6.86 ± 3.69 days effective courses for the treatment of; Pulmonary heart disease coronary heart disease 8 example in protopathy, upper gastrointestinal hemorrhage 5 example, acute gastroenteritis 3 example, hypertension and type Ⅱdiabetes mellitus, each 2 examples of gastrointestinal dysfunction, right fracture of tibia and fibula, L3 compression fracture, fl tuberosity fracture, pyogenic cholangitis, pulmonary carcinoma, carcinoma vulvae, myocardial infarction, each 1 example of chronic colitis;

2, matched group man 20 examples, female 10 example, 24～82 years old age, average 65.3 ± 12.37 years old; 2～12 days courses for the treatment of, average 5.9 ± 2.49 days, 5.2 ± 3.57 days effective courses for the treatment of; Pulmonary heart disease upper gastrointestinal hemorrhage 10 example in protopathy, chronic colitis 5 example, hypertensive cardiopathy and each 4 examples of gastrointestinal dysfunction, colon cancer 3 example, acute gastroenteritis and each 2 examples of myocardial infarction;

Two groups there was no significant difference through statistical procedures in age, the course for the treatment of, effective course for the treatment of, therefore have comparability,

Therapeutic Method:

1, treatment group is protected intestinal mixture with bacterium Huang and is treated, and bacterium Huang is protected intestinal mixture and is distributed into 200ml/ bottle, usage: bfore meals, every day three times, each 30ml;

2, matched group uses fluconazol to take orally, 400mgBid on the firstth, later every day 200mg.

Filling in observation table before medication in detail, respectively make routine blood test, liver function and kidney function test once before and after taking, treatment judges curative effect after terminating, and methods of sample collection position intestinal stays fresh stool smear and cultivation.

Criterion of therapeutical effect: 1. recovery from illness: treatment postoperative infection symptom and sign disappear, continuous three the result feminine genders of specimen candidiasis inspection; 2. effective: treatment postoperative infection transference cure, sign is clearly better, and specimen candidiasis checks double feminine gender; 3. effective: after treatment, symptom and sign take a turn for the better, specimen candidiasis inspection is once negative or be still the positive; 4. invalid: after treatment, symptom and sign is without improvement, and specimen candidiasis inspection is still positive.

Comparitive study adopts chi-square criterion, and therapeutic outcome is shown in following table:

As can be seen from the above table, treatment group and matched group curative effect are through statistical procedures P > 0.05, illustrate that said preparation treatment there was no significant difference with fluconazol.

In high spirits turn of patient after treatment group medication, other double diseases have improvement in various degree. Routine blood test change without exception; Serum BUN, Cr, GOT, GPT etc. are normal, and before having few patients's medication, the slight of BUN and Cr raises, and has no and raise after medication. Whole treatment group patient's medication processes have no untoward reaction; After matched group fluconazol, having 15 example patients to see nauseating, 2 examples are shown in headache, and 1 example is shown in stomachache.

Bacterium Huang is protected the acute toxicity testing that intestinal mixture does: the fasting healthy mice of 12 hours 20 before experiment, male and female half and half, intestinal mixture concentrated solution is protected to bacterium Huang by the mice maximum gavage disposable gavage of capacity, dosage is 30g/kg body weight, and animal consumption is equivalent to 133.33 times of people's consumption by kg body weight conversion. The situation observing the aspects such as mouse diet, defecation, activity and hair color for continuous 7 days is raised routinely after administration. The all healthy survival of the whole mice of result, has no overt toxicity reaction. Show oral administration amount safety.

Owing to Monilia Enteritis is that to infect " mould " on the basis of body " weakened body resistance " evil and obtain, and " mould " is evil has heat, poison, wet feature for trouble more, therefore often shows as the card of deficiency in origin and excess in superficiality, simulataneous insufficiency and excessive clinically. For disease feature, in total rule for the treatment of, taking the method for strengthening vital QI to eliminate pathogenic factors, treating both the principal and secondary aspects of a disease, and in conjunction with determining the pathogenesis of ZANG-FU disease based on the differentiation of symptoms and signs, have invigorating the spleen and benefiting QI, the bacterium Huang of clearing away heat-damp and promoting diuresis is protected intestinal mixture and is treated Monilia Enteritis respectively, to reaching the purpose of " vital QI recovered after pathogens eliminated ". According to clinical verification, this mixture truly has good curative effect. Modern study is early it has proven convenient that fungal infection is lowly in close relations with the imbalance of body normal flora and body's immunity.

The bacterium Huang of the present invention protects intestinal mixture, start with from lung spleen, with the Radix Astragali, Radix Pseudostellariae for monarch drug, the Rhizoma Atractylodis Macrocephalae, Poria, Semen Coicis three are ministerial drug, and Rhizoma Acori Graminei, Rhizoma Coptidis and Herba Artemisiae Scopariae three are adjuvant drug, and Massa Medicata Fermentata is for making medicine, there is invigorating the spleen and benefiting QI, effect of clearing away heat-damp and promoting diuresis, the pathogenesis of the intestinal canal fungus infection that hits, clinical effectiveness is better.

Detailed description of the invention

Embodiment 1: a kind of bacterium Huang protects intestinal mixture, is prepared by following steps:

(1) Rhizoma Acori Graminei of the 150g Radix Astragali, 100g Radix Pseudostellariae, the 50g Rhizoma Atractylodis Macrocephalae, 75g Poria, 150g Semen Coicis, 75g Massa Medicata Fermentata, 50g Rhizoma Coptidis, 50g Herba Artemisiae Scopariae and 50g is taken;

(2) medicine of step (1) being amounted to 750g and put in container, the water adding 3000g decocts, and continues to decoct 45-90 minute, be then filtered with 80 mesh sieves, obtain 2800ml filtrate A after solution seethes with excitement;

(3) taking the medicine obtained after filtering in step (2), the water continuously adding 1500g decocts, and continues to decoct 45-90 minute, be filtered with 80 mesh sieves, obtain 1300ml liquor B after solution seethes with excitement;

(4) liquor B that the filtrate A obtained in step (2) obtains with step (3) is mixed, 1500ml it is concentrated into after mixing, obtain admixing medical solutions, admixing medical solutions adds 1 ‰ sodium benzoate and 0.5 ‰ ethyl hydroxybenzoates, obtain bacterium Huang after uniform stirring and protect intestinal mixture.

Embodiment 2: a kind of bacterium Huang protects intestinal mixture, is prepared by following steps:

(1) the 450g Radix Astragali, 300g Radix Pseudostellariae, the 150g Rhizoma Atractylodis Macrocephalae, 225g Poria, 450g Semen Coicis, 225g Massa Medicata Fermentata, 150g Rhizoma Coptidis, 150g Herba Artemisiae Scopariae and 150g Rhizoma Acori Graminei are taken;

(2) medicine of step (1) being amounted to 2250g and put in container, the water adding 18000g decocts, and continues to decoct 45-90 minute, be then filtered with 80 mesh sieves, obtain 17500ml filtrate A after solution seethes with excitement;

(3) taking the medicine obtained after filtering in step (2), the water continuously adding 18000g decocts, and continues to decoct 45-90 minute, be filtered with 80 mesh sieves, obtain 13500ml liquor B after solution seethes with excitement;

(4) liquor B that the filtrate A obtained in step (2) obtains with step (3) is mixed, 10000ml it is concentrated into after mixing, obtain admixing medical solutions, admixing medical solutions adds 1 ‰ sodium benzoate and 0.5 ‰ ethyl hydroxybenzoates, obtain bacterium Huang after uniform stirring and protect intestinal mixture.

Embodiment 3: a kind of bacterium Huang protects intestinal mixture, is prepared by following steps:

(1) the 300g Radix Astragali, 200g Radix Pseudostellariae, the 75g Rhizoma Atractylodis Macrocephalae, 150g Poria, 300g Semen Coicis, 150g Massa Medicata Fermentata, 75g Rhizoma Coptidis, 100g Herba Artemisiae Scopariae and 100g Rhizoma Acori Graminei are taken;

(2) medicine of step (1) is amounted to 1450g and put in container, add 8700g water and decoct, continue to decoct 45-90 minute after solution seethes with excitement, be then filtered with 80 mesh sieves, obtain 8000ml filtrate A;

(3) take the medicine obtained after filtering in step (2), continuously add 8700g water and decoct, continue to decoct 45-90 minute after solution seethes with excitement, be filtered with 80 mesh sieves, obtain 7500ml liquor B;

(4) liquor B that the filtrate A obtained in step (2) obtains with step (3) is mixed, 6000ml it is concentrated into after mixing, obtain admixing medical solutions, admixing medical solutions adds 1 ‰ sodium benzoate and 0.5 ‰ ethyl hydroxybenzoates, obtain bacterium Huang after uniform stirring and protect intestinal mixture.

Claims

1. a bacterium Huang protects intestinal mixture, it is characterised in that this mixture is prepared by following steps: