CN105030887A - Traditional Chinese medicine preparation for treating infantile diarrhea with damp-heat syndrome and its preparation method - Google Patents
Traditional Chinese medicine preparation for treating infantile diarrhea with damp-heat syndrome and its preparation method Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicine and discloses a traditional Chinese medicine preparation for treating infantile diarrhea with damp-heat syndrome and its preparation method. The traditional Chinese medicine preparation is elaborately made into oral preparations, especially granules, from medicinal materials, namely, shrub Althea flower, leaf of paniculate Microcos, paniculigera Starwort herb, leaf or flower of littleleaf cinquefoil, kudzuvine root and fried white hyacinth bean according to a certain weight ratio; the traditional Chinese medicine preparation is convenient to use and fragrant and sweet, enables higher medication compliance in children and is capable of treating infantile diarrhea, maximally protecting the intestinal tract, regulating gastrointestinal functions, and expelling virus and maintaining vital qi. The traditional Chinese medicine preparation has a simple formula, has good effect and high cure rate and has no toxic and side effects.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation and preparation method thereof for the treatment of children's's damp-heat type diarrhoea.
Background technology
Infantile diarrhea is high with 6 months-2 years old infant morbidity, increase with times of defecation and change into feature with stool, often there are the symptoms such as Nausea and vomiting, heating, stomachache clinically, easily cause dehydration and electrolyte disturbance, being the one of the main reasons causing infantile malnutrition and dysplasia, is children's's frequently-occurring disease in period, commonly encountered diseases, is the modal digestive tract syndrome of China's infant, infective agent and non-infective agent can be comprised, caused by its physiological characteristics.Children's digestive system developmental immaturity, digestive enzyme is secreted less and poor activity, and its growth promoter is vigorous, and gastrointestinal burden is heavy, and body defenses function is poor, and normal the gut flora is not set up completely, easily occurs symptom of digestive tract with factors such as nursing are unreasonable in addition.
Primary disease belongs to the traditional Chinese medical science and " to have loose bowels " category.Children's's internal organs are tender and lovely, and shape gas does not fill, and no matter being invaded by exogenous pathogen, internal damage caused by infantile dyspepsia all can cause spleen and stomach function disorder imbalance and have loose bowels.The pathological characteristic of the physiological characteristics that children's has " pure-yang constituent " and " easily cold easily heat ".Cause the reason of infantile diarrhea a lot, and often make clinical syndrome complicated and changeable.The key points in differentiation of primary disease is point poor, heat, empty, real, and therefore diarrhea due to improper diet, diarrhea due to cold pathogen, diarrhea of heat type and splenoasthenic diarrhea are the most fundamental types of clinical syndrome differentiation.
Forefathers' meaning " does not become to rush down without wet ", " wet and become five kinds of diarrhea more ".Illustrate various have loose bowels all can press from both sides wet, the most remarkable with the wet performance of diarrhea of heat type folder clinically, and the most common.Visible in infantile diarrhea, damp-heat type is a very important type.Summer and autumn, hot climate, wet soil commandant.If diseases caused by exogenous pathogenic factor pathogenic summer-heat, inside accumulate damp and hot, injure taste, spleen lose the lucid yang sending up, stomach-QI being unable to descend normally, turbid damp regardless of, bet large intestine, initiation is had loose bowels.Its main disease is frequently lower for rushing down, and day more than ten times, stool is as water sample, and color is green or yellow, or has a little mucus, anus purple, and gauffer is thick and swell hard, the few yellow skin of urine amount, and red tongue, yellow and greasy fur, fingerprint is purple.
GEGEN QINLIAN TANG is often selected to add and subtract (Radix Puerariae, Rhizoma Coptidis, Radix Sophorae Flavescentis, Herba Pogostemonis, Semen Lablab Album, Semen Plantaginis, dry Petiolus nelumbinis, Poria, Yi Yuan San Powder Beneficial to Vitality) for damp-heat type diarrhoea.Right children's's vital organs of the human body are not strengthened entirely, have both been unable to undergo pathogen and have wrecked, more unbearably medicine is rash.The many bitter tastes of existing Chinese patent medicine taste, infant compliance is poor.
Summary of the invention
Inventor thinks that children's is the matter that bud is tender, visceral-qi is clever clearly, with dialling with turning, Selection drug is valued for spirit clearly, gentle, Discontinue medication as soon as get effect, consult existing reasonable formula simultaneously, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, Exploration and conclusion goes out a kind of new formula for the treatment of the Chinese medicine preparation of children's's damp-heat type diarrhoea repeatedly, and infant can be made in the short period of time to recover normal.
The technical solution used in the present invention is as follows:
Treat a Chinese medicine preparation for children's's damp-heat type diarrhoea, it is medicinal raw material by Flos Hibisci, Folium Microcoris paniculatae, Herba Stellariae paniculigerae, Herba Onychii japonici, Radix Puerariae, Semen Lablab Album (parched), forms according to certain weight is refining.
The weight of medicinal raw material of the present invention gropes to sum up to draw through inventor in a large number, and each medicinal raw material all has good curative effect in following weight parts scope: Flos Hibisci (doing) 12-15 part, Folium Microcoris paniculatae 7-11 part, Herba Stellariae paniculigerae 4-6 part, Herba Onychii japonici 8-12 part, Radix Puerariae 3-5 part, Semen Lablab Album (parched) 7-10 part.
Wherein Flos Hibisci described above can substitute by fresh goods.
Fang Xie: Flos Hibisci clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; Herba Onychii japonici clearing away heat-damp and promoting diuresis, two medicine compatibility clearing away heat-damp and promoting diuresis, subduing swelling and detoxicating are monarch drug.The sweet temperature of Semen Lablab Album, spleen invigorating and in, removing dampness antidiarrheal is ministerial drug.Folium Microcoris paniculatae can clearing away heat-damp and promoting diuresis, and the stagnation that can disappear again is rushed down, and is adjuvant drug.Herba Stellariae paniculigerae is burnt in regulating the flow of vital energy and mediating, and removing dampness heat is stagnant, and removing toxic substances of stimulating the menstrual flow of invigorating blood circulation is adjuvant.Radix Puerariae a surname sends out clear sun, and ascending the clear and descending the turbid is for making medicine.Fang Jian of the present invention effect is good, mild in medicine property and, heat clearing away is not forgotten to protect taste, regulating QI machine.
Preferably, treat a Chinese medicine preparation for children's's damp-heat type diarrhoea, it is characterized in that it is made up of the medicinal raw material of following weight portion: Flos Hibisci (doing) 13 parts, Folium Microcoris paniculatae 10 parts, Herba Stellariae paniculigerae 5 parts, Herba Onychii japonici 10 parts, Radix Puerariae 4 parts, Semen Lablab Album (parched) 9 parts.
The pharmaceutical research present situation of the present invention's medicinal raw material used is as follows: Flos Hibisci: be the flower of Malvaceae plant Hibiscus syriacus L..Sweet, flat.Function cures mainly: clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling.For dysentery, bleeding hemorrhoids, leucorrhea; Furuncle carbuncle is controlled in external, scalds.
Folium Microcoris paniculatae: light, micro-acid is flat.Function cures mainly: clearing away summer-heat, helps digestion, and reduces phlegm.For flu, heatstroke, dyspepsia, dyspepsia, diarrhoea.
Herba Stellariae paniculigerae: pungent is flat, nontoxic.Function cures mainly: regulate the flow of vital energy, and removing dampness is invigorated blood circulation, removing food stagnancy, removing toxic substances.Treat for stomachache, jaundice, stool hematochezia, menoxenia, children's's food stagnation, furuncle." Kweiyang medicinal herbs among the people ": " promoting the circulation of blood is regulated the flow of vital energy, removing toxic substances of stimulating the menstrual flow, and removing dampness heat is stagnant.”
Herba Onychii japonici: heat clearing away, dampness removing, removing toxic substances, hemostasis.Control anemopyretic cold, acute gastroenteritis, dysentery, jaundice, hemoptysis, spit blood, have blood in stool, hematuria, furuncle, wound swells and ache.
Radix Puerariae: sweet, pungent, cool.Return spleen, stomach warp.Function cures mainly: expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels; Hypertension neck pain.
Semen Lablab Album: sweet, tepor.Return spleen, stomach warp.Function cures mainly: invigorating the spleen for eliminating dampness, and in relieve summer heat.For weakness of the spleen and stomach, inappetence, diarrhea, leukorrhagia, heat-damp in summer is vomited and diarrhoea, abdominal distention uncomfortable in chest.The present invention uses Semen Lablab Album (parched) to strengthen invigorating the spleen to arrest diarrhea effect.
Chinese medicine preparation of the present invention is active component by Flos Hibisci, Folium Microcoris paniculatae, Herba Stellariae paniculigerae, Herba Onychii japonici, Radix Puerariae, Semen Lablab Album (parched) or its water and/or its extractive with organic solvent or its volatile oil, adds pharmaceutically acceptable adjuvant or/and complementary composition is prepared into pharmaceutically conventional peroral dosage form.As: tablet, capsule, granule, syrup, oral liquid etc.
Preferably, described peroral dosage form is granule.
A kind of Chinese medicine granules for the treatment of children's's damp-heat type diarrhoea, its preparation method is as follows: get Flos Hibisci (under rear), Folium Microcoris paniculatae, Herba Stellariae paniculigerae, Herba Onychii japonici, Radix Puerariae, Semen Lablab Album (parched) Six-element medical material decocts with water secondary, each 1.5-2.0 hour, collecting decoction, filter, filtrate reduced in volume to relative density is the clear paste of 1.05-1.15 (when 60 DEG C), add the ethanol of 1.5-2.0 times of weight portion, stir, leave standstill 12 hours, filter, filtrate recycling ethanol, be evaporated to the clear paste that relative density is 1.10 ~ 1.20 (when 60 DEG C), add adjuvant, mixing, granulate, dry, obtain.
Adjuvant described above can be in diluent, sweeting agent, solid essence one or more.
Diluent described above is selected from one or more in sucrose, starch, dextrin, lactose, mannitol, xylitol, chitosan, SHUANGQITANG.
Sweeting agent described above is sucralose.
Described solid essence is selected from one or more in strawberry essence, peach flavor, Fructus Myricae rubrae essence.
The usage of Chinese medicine granules of the present invention: warm water is taken after dissolving, or takes together with milk powder, rice water, less than 3 years old each one bag.
Zoopery shows: Chinese medicine preparation of the present invention has obviously suppression small intestine movement of mice ahead running and the effect that significantly caused by suppression neostigmine, intestinal motility is hyperfunction.
Clinical trial shows: compare two groups of cure rates and total effective rate can find, Chinese medicine preparation treatment group of the present invention is apparently higher than matched group, illustrate thus, Chinese medicine preparation treatment infantile diarrhea of the present invention has good clinical effectiveness, effectively can improve the cure rate for the treatment of, be worth promoting in clinical practice.
Beneficial effect of the present invention: prescription of the present invention is simplified, good effect, and cure rate is high, has no side effect; Easy to use, gas fragrance is sweet, improves the compliance of children; While treatment infantile diarrhea, intestinal can be protected to greatest extent, integrated regulation gastrointestinal function, reach the object of driving away pathogenic factor, reinforcing body resistance.
Detailed description of the invention
Further describe the present invention below by way of detailed description of the invention, but the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, Chinese medicine preparation of the present invention is suitably improved, replaces the identical component of effect, will become apparent to those skilled in the art that they are all deemed to be included within scope of the present invention.
Embodiment 1
Prescription: Flos Hibisci 13 parts, Folium Microcoris paniculatae 10 parts, Herba Stellariae paniculigerae 5 parts, Herba Onychii japonici 10 parts, Radix Puerariae 4 parts, Semen Lablab Album (parched) 9 parts;
Preparation method: get Flos Hibisci (rear under), Folium Microcoris paniculatae, Herba Stellariae paniculigerae, Herba Onychii japonici, Radix Puerariae, Semen Lablab Album (parched) Six-element medical material decoct with water secondary, each 1.5-2.0 hour, collecting decoction, filter, filtrate reduced in volume to relative density is the clear paste of 1.10 (when 60 DEG C), adds the ethanol of 1.7 times of weight portions, stirs, leave standstill 12 hours, filter, filtrate recycling ethanol, is evaporated to the clear paste that relative density is 1.15 (when 60 DEG C), add adjuvant, mixing, granulates, dry, every bag of 1.5g, is equivalent to containing crude drug 2.55g.
Embodiment 2
Prescription: Flos Hibisci 12 parts, Folium Microcoris paniculatae 8 parts, Herba Stellariae paniculigerae 4 parts, Herba Onychii japonici 8 parts, Radix Puerariae 4 parts, Semen Lablab Album (parched) 8 parts;
Preparation method: get Flos Hibisci (rear under), Folium Microcoris paniculatae, Herba Stellariae paniculigerae, Herba Onychii japonici, Radix Puerariae, Semen Lablab Album (parched) Six-element medical material decoct with water secondary, each 1.5-2.0 hour, collecting decoction, filter, filtrate reduced in volume to relative density is the clear paste of 1.07 (when 60 DEG C), adds the ethanol of 1.8 times of weight portions, stirs, leave standstill 12 hours, filter, filtrate recycling ethanol, is evaporated to the clear paste that relative density is 1.16 (when 60 DEG C), add adjuvant, mixing, granulates, dry, every bag of 1.5g, is equivalent to containing crude drug 2.4g.
Embodiment 3
Prescription: Flos Hibisci 12 parts, Folium Microcoris paniculatae 10 parts, Herba Stellariae paniculigerae 5 parts, Herba Onychii japonici 12 parts, Radix Puerariae 3 parts, Semen Lablab Album (parched) 7 parts;
Preparation method: get Flos Hibisci (rear under), Folium Microcoris paniculatae, Herba Stellariae paniculigerae, Herba Onychii japonici, Radix Puerariae, Semen Lablab Album (parched) Six-element medical material decoct with water secondary, each 1.5-2.0 hour, collecting decoction, filter, filtrate reduced in volume to relative density is the clear paste of 1.12 (when 60 DEG C), adds the ethanol of 1.5 times of weight portions, stirs, leave standstill 12 hours, filter, filtrate recycling ethanol, is evaporated to the clear paste that relative density is 1.10 (when 60 DEG C), add adjuvant, mixing, granulates, dry, every bag of 1.5g, is equivalent to containing crude drug 2.6g.
Embodiment 4
Prescription: Flos Hibisci 14 parts, Folium Microcoris paniculatae 8 parts, Herba Stellariae paniculigerae 6 parts, Herba Onychii japonici 12 parts, Radix Puerariae 3.5 parts, Semen Lablab Album (parched) 10 parts;
Preparation method: get Flos Hibisci (rear under), Folium Microcoris paniculatae, Herba Stellariae paniculigerae, Herba Onychii japonici, Radix Puerariae, Semen Lablab Album (parched) Six-element medical material decoct with water secondary, each 1.5-2.0 hour, collecting decoction, filter, when filtrate reduced in volume to relative density is 1.0560 DEG C) clear paste, add the ethanol of 2.0 times of weight portions, stir, leave standstill 12 hours, filter, filtrate recycling ethanol, is evaporated to the clear paste that relative density is 1.18 (when 60 DEG C), adds adjuvant, mixing, granulate, dry, pack and get final product.
Embodiment 5
Prescription: Flos Hibisci 13 parts, Folium Microcoris paniculatae 9 parts, Herba Stellariae paniculigerae 4 parts, Herba Onychii japonici 9 parts, Radix Puerariae 4.5 parts, Semen Lablab Album (parched) 9 parts;
Preparation method: get Flos Hibisci (rear under), Folium Microcoris paniculatae, Herba Stellariae paniculigerae, Herba Onychii japonici, Radix Puerariae, Semen Lablab Album (parched) Six-element medical material decoct with water secondary, each 1.5-2.0 hour, collecting decoction, filter, filtrate reduced in volume to relative density is the clear paste of 1.10 (when 60 DEG C), add the ethanol of 1.6 times of weight portions, stir, leave standstill 12 hours, filter, filtrate recycling ethanol, is evaporated to the clear paste that relative density is 1.17 (when 60 DEG C), adds adjuvant, mixing, granulate, dry, pack and get final product.
Zoopery experimental example 1: medicine of the present invention is on the impact of small intestine movement of mice ahead running
Get healthy mice 40, fasting 16 hours, by the Chinese medicine granules of the gastric infusion of dosage shown in table 1 embodiment 1, only carbon powder arabic gum mixed liquor 0.2ml/ is filled with after 0.5 hour, 15min puts to death animal, without taking out small intestinal with caring for, measures the percentage ratio that carbon powder forward position length accounts for small intestinal overall length, SPSS17.0 statistical software is adopted to carry out statistical analysis, with mean ± standard deviation
represent, compare employing one way analysis of variance between group, with P < 0.05 for difference has statistical significance.The results are shown in Table 1.Chinese medicine preparation of the present invention can obviously suppress mouse small intestine ahead running, and action intensity is weak compared with berberine hydrochloride.
Table 1: medicine of the present invention is on the impact of mouse small intestine ahead running
Note: with blank group than * P < 0.05; * P < 0.01.
Zoopery experimental example 2: the impact that medicine of the present invention causes Small intestine advance activity hyperfunction on neostigmine
Get healthy mice 50, fasting can't help water 16 hours, by the Chinese medicine granules of table 2 dosage perfusion embodiment 1, after 0.5 hour, except blank group, all the other each group of groups press 0.125mg/kg dosage lumbar injection neostigmine methylsulfate, only fill with carbon powder arabic gum mixed liquor 0.2ml/ immediately, animal is put to death after 15min, get small intestinal, calculate carbon powder forward position and account for small intestinal overall length percentage rate, the results are shown in Table 2, neostigmine significantly can promote Small intestine advance activity, the bowel movement that pharmaceutical composition causes Xin Siming is hyperfunction obvious inhibitory action, and drug dose is large, and then inhibition strength is large.
Table 2: the impact that medicine of the present invention causes intestinal motility hyperfunction on neostigmine
Note: with blank group than * P < 0.05; * P < 0.01.
Clinical trial embodiment 1
1. physical data: select 160 routine children's's damp-heat type diarrhea patients that between year October in July, 2013 to 2014, my institute accepts for medical treatment, and the age was 6 months ~ 3 one full year of life, wherein man 88 example, female 72 example; Clinical manifestation is that times of defecation increases (every day 3 ~ 5 times, even more than 10 times not etc.), excrement matter is thin or as water sample, color is deep yellow can accompany a small amount of mucus in foul smell, abdominal part is paroxysmal pain, the symptom such as companion's Nausea and vomiting, inappetence, tired, myasthenia of limbs, heating, mild dehydration, oliguria.Be divided into treatment group and each 80 examples of matched group at random, two groups of physical data comparing difference not statistically significants, P > 0.05, has comparability.
2. inclusive criteria: meet doctor trained in Western medicine Children's diarrhea vein diagnostic criteria person; Meet Syndrome Differentiation of Traditional Chinese Medicine and belong to the damp and hot person of rushing down; Age >=6 months ,≤3 one full year of life, male or female; Parents of hospitalized children can support tcm therapy, is willing to curer after informed consent.
3. exclusion standard: (1) does not meet inclusive criteria, the age is less than 6 months or was greater than for 3 one full year of life; (2) serious cardiovascular and cerebrovascular disease, immunodeficiency, moderate or more dehydration, mental disorder or hepatic and renal function injure and malignant tumor person is associated with; (3) other similar therapists are being accepted; (4) concurrent infection disease patient.
4. Therapeutic Method: treatment group: give Chinese medicine preparation granule prepared by the embodiment of the present invention 1, every day three times, each a bag; Be used in conjunction 3d; Matched group: 0.9% sodium chloride solution 100mL+ cefuroxime sodium for injection 0.35 ~ 0.5g, intravenous drip, qd; 5% glucose injection 150mL+ ribavirin 0.1g, intravenous drip, qd; Montmorillonite powder 0.5 ~ 1g, oral, tid, treats 3d continuously, or disappears to symptom of diarrhea; Period subtracts food according to infant situation, gives low fat, light diet;
5. criterion of therapeutical effect: with reference to State Administration of Traditional Chinese Medicine write " TCM Pediatrics disease Standardization of diagnosis and curative effect " (the 1st edition. Beijing: China Medical Science Press 2012) in the standard of curative effect evaluation of " having loose bowels ": (1) cures: stool is shaped, and General Symptoms disappears; Stool microscopy is without exception, and etiological examination is negative; (2) take a turn for the better: times of defecation and moisture reduce, and General Symptoms improves; Stool microscopy Oil globule or red, leukocyte is accidental; (3) do not heal: times of defecation and moisture do not improve, or exacerbation of symptoms.
6. statistical analysis: adopt SPSS17.0 statistical software to carry out statistical analysis, measurement data adopts t inspection, with mean ± standard deviation
represent, data of equal value compares employing X
2inspection, with P < 0.05 for difference has statistical significance.
7. result
Two groups of Clinical efficacy comparisons: Chinese traditional treatment group cures 42 examples, take a turn for the better 35 examples, total effective rate 96.25%; WM therapy group cures 26 examples, and take a turn for the better 30 examples, and total effective rate 70.0%, two groups of cure rates and total effective rate comparing difference have statistical significance (P < 0.05), and treatment group curative effect is obviously better than matched group, in table 3.
Table 3 liang group Clinical efficacy comparison: example (%)
Can find that treatment group is apparently higher than matched group by the treatment cure rate and total effective rate contrasting two groups of infants, illustrate thus, Chinese medicine preparation treatment infantile diarrhea of the present invention has good clinical effectiveness, effectively can improve the cure rate for the treatment of, be worth promoting in clinical practice.
Claims (10)
1. treat a Chinese medicine preparation for children's's damp-heat type diarrhoea, it is characterized in that it is that medicinal raw material is made by Flos Hibisci, Folium Microcoris paniculatae, Herba Stellariae paniculigerae, Herba Onychii japonici, Radix Puerariae, Semen Lablab Album (parched).
2. Chinese medicine preparation as claimed in claim 1, is characterized in that it is made up of the medicinal raw material of following preferred weight part: Flos Hibisci (doing) 12-15 part, Folium Microcoris paniculatae 7-11 part, Herba Stellariae paniculigerae 4-6 part, Herba Onychii japonici 8-12 part, Radix Puerariae 3-5 part, Semen Lablab Album (parched) 7-10 part.
3. Chinese medicine preparation as claimed in claim 2, is characterized in that it is made up of the medicinal raw material of following preferred weight part: Flos Hibisci (doing) 13 parts, Folium Microcoris paniculatae 10 parts, Herba Stellariae paniculigerae 5 parts, Herba Onychii japonici 10 parts, Radix Puerariae 4 parts, Semen Lablab Album (parched) 9 parts.
4. the Chinese medicine preparation as described in claim 1-3, is characterized in that it makes peroral dosage form.As: tablet, capsule, granule, syrup, oral liquid etc.
5. Chinese medicine preparation as claimed in claim 4, is characterized in that the agent of described peroral dosage form preferred particulates.
6. the Chinese medicine preparation as described in claim 1-5, it is characterized in that the preparation method of described granule is as follows: get Flos Hibisci (under rear), Folium Microcoris paniculatae, Herba Stellariae paniculigerae, Herba Onychii japonici, Radix Puerariae, Semen Lablab Album (parched) Six-element medical material decocts with water secondary, each 1.5-2.0 hour, collecting decoction, filter, filtrate reduced in volume to relative density is the clear paste of 1.05-1.15 (when 60 DEG C), add the ethanol of 1.5-2.0 times of weight portion, stir, leave standstill 12 hours, filter, filtrate recycling ethanol, be evaporated to the clear paste that relative density is 1.10 ~ 1.20 (when 60 DEG C), add adjuvant, mixing, granulate, dry, obtain.
7. Chinese medicine preparation as claimed in claim 6, is characterized in that described adjuvant is one or more in diluent, sweeting agent, solid essence.
8. Chinese medicine preparation as claimed in claim 7, its feature is one or more in sucrose, starch, dextrin, lactose, mannitol, xylitol, chitosan, SHUANGQITANG at described diluent.
9. Chinese medicine preparation as claimed in claim 7, its feature is sucralose at described sweeting agent.
10. Chinese medicine preparation as claimed in claim 7, its feature is one or more in strawberry essence, peach flavor, Fructus Myricae rubrae essence at described solid essence.
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| CN107080809A (en) * | 2017-04-27 | 2017-08-22 | 广西大学 | A kind of preparation method for treating the damp and hot oral liquid of stomach |
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| CN101461932B (en) * | 2009-01-16 | 2010-04-14 | 重庆希尔安药业有限公司 | Medicament composition for treating children's damp-heat diarrhea induced by spleen insufficiency and preparation method thereof |
| CN104225009A (en) * | 2014-09-16 | 2014-12-24 | 湖州品创科技咨询有限公司 | Traditional Chinese medicine composition for treating diarrhea |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107080809A (en) * | 2017-04-27 | 2017-08-22 | 广西大学 | A kind of preparation method for treating the damp and hot oral liquid of stomach |
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Application publication date: 20151111 |