CN105663762A

CN105663762A - Formula of wild-like fresh Dendrobium officinale safflower Chinese angelica oral liquid and preparation method thereof

Info

Publication number: CN105663762A
Application number: CN201610014664.2A
Authority: CN
Inventors: 王升贵; 方玉占; 蒋正剑; 魏明泽
Original assignee: Hangzhou Tai Rentang Biological Polytron Technologies Inc
Current assignee: Hangzhou Tai Rentang Biological Polytron Technologies Inc
Priority date: 2016-01-11
Filing date: 2016-01-11
Publication date: 2016-06-15

Abstract

The invention provides a formula of a wild-like fresh Dendrobium officinale safflower Chinese angelica oral liquid and a preparation method thereof. The oral liquid comprises the following raw materials by weight: 56-66 parts of wild-like fresh Dendrobium officinale, 5-10 parts of safflower, 5-10 parts of Chinese angelica, 8-15 parts of Salvia miltiorrhiza, 2-3 parts of xylitol, and 0.3-0.5 part of citric acid. The preparation method comprises the steps of: performing fresh extraction: steaming the wild-like fresh Dendrobium officinale green and performing sterilization, using a grinder to conduct superfine grinding, then conducting 200-mesh pumping filtration, and keeping the filtrate for standby use; conducting extraction and concentration: mixing Dendrobium officinale filter residue with safflower, Chinese angelica and Salvia miltiorrhiza according to the formula ratio and performing extraction, and subjecting the extracted liquid to filtering concentration for standby use; putting the Dendrobium officinale fresh extracted filtrate with the safflower, Chinese angelica and Salvia miltiorrhiza concentrated solution into an oral liquid preparation tank, then adding xylitol and citric acid into the preparation tank, performing stirring dissolving, carrying out sterilization and standing for 12-18h, then conducting filtering, filling, sterilization, labeling and packaging, thus obtaining the oral liquid. The wild-like fresh Dendrobium officinale safflower Chinese angelica oral liquid has the efficacy of promoting blood circulation to remove meridian obstruction, and can make skin restore qi and blood and elasticity.

Description

The formula of a kind of nearly wild fresh Herba Dendrobii Flos Carthami Chinese angelica oral liquid and method for making thereof

Technical field

The invention belongs to medicinal plants manufacture field, be specifically related to formula and the method for making thereof of a kind of nearly wild fresh Herba Dendrobii Flos Carthami Chinese angelica oral liquid.

Background technology

1.1 Herba Dendrobii summaries

Herba Dendrobii, perennial the orchid family herbaceous plant, it is divided into Herba Dendrobii, Dendrobium nobile, dendrobium loddigesii Rolfe, HERBA DENDROBII, Herba Dendrobii oculati etc. more than 70 to plant by kind preciousness degree, wherein Herba Dendrobii is come out top. Herba Dendrobii (DendrobiumofficinaleKimuraetMigo) is Chinese Second Class Key Protected Plant, has extraordinary health preserving and medical value. In the culture of health preserving that China is long, Herba Dendrobii, because of its outstanding effect, becomes ancient Chinese medicine doctor and the health preserving superfine product of nobility's high praise.

In the Shennong's Herbal in Eastern Han Dynasty's last years of a dynasty or reign, in connection with in the record of Herba Dendrobii. Product above are all included wherein, are claimed its " tonifying five ZANG-organs asthenia, manages gastric qi, controls deficient labor weak, and clothes are made light of one's life by commiting suicide for a long time, prolongs life, and sedate is except frightened " by successive dynasties famous doctor's allusion quotations such as the Chinese " Mingyi Bielu ", bright Compendium of Material Medica and clear essentials of Matea Medica.

Taoist school doctor's allusion quotation " Taoist Scriptures " between Katyuan year the Tang Dynasty, iron sheet stone is pushed into the first place of " nine big Herba mesonae chinensis ", before being listed in Herba Saussureae Involueratae, three double Radix Ginsengs, the hundred vicennial Radixs Polygoni Multiflori, the Poria of cycle of sixty years, Herba Cistanches, remote mountains Ganoderma, seabed Margarita, Cordyceps, it is seen that medicinal effects is extraordinary. Successive dynasties well-known doctor such as Huatuo, Zhang Zhongjing, Sun Simiao, Li Shizhen (1518-1593 A.D.) etc. are considered as " in medicine celestial product " it especially, are used for curing critical patient.

Since the Tang and Song Dynasty, Herba Dendrobii is just listed in tribute, for royalty's life lengthening, becomes health preserving superfine product the most honorable. According to Historical Data Data About, Wu Tse-tien took the party for 50 years, and year still preserves agerasia to old age; Qianrong Supreme Being's group minister of often feting must drink Herba Dendrobii soup, 60 years in place, becomes the emperor that the time is the longest, the longevity in year is the highest that holds power on Chinese history, and effect of Herba Dendrobii life prolonging is as can be seen here.

Herba Dendrobii nature and flavor: sweet, are slightly cold, and enter stomach, kidney channel. Property belong to clear and rich, have benefit in clear, invigorating middle warmer has clearly.

The efficacy effect of Herba Dendrobii, the successive dynasties, well-known doctor was respectively arranged with discussion:

" explaining abstruseness of the canon of materia medica " cloud: " Herba Dendrobii, sweet energy pleases spleen, salty energy kidney tonifying, therefore many merits are dirty in water and soil two: but gas width delays, and without the merit that victory is played, ancients are with this generation tea, on very clear diaphragm. "

Supplementary Amplifications of the Compendium of Materia Medica cloud: " Herba Dendrobii clearing stomach except deficiency-heat, promote the production of body fluid and strain, with for tea, merit is with joining stilbene. "

In " property of medicine ", load Herba Dendrobii " for tea, promote the production of body fluid and wet one's whistle, reinforcing YIN-essence strong foot power by summer. " visible, Herba Dendrobii is long-standing as the high tonic being of illnesses and fitness. The traditional Chinese medical science is thought, Herba Dendrobii can extensive use in the disease treatments such as atrophic gastritis, tumor, diabetes, pharyngolaryngitis and cataract. Herba Dendrobii has multiple pharmacological effect, such as the immunocompetence of enhancing body, antioxidation, defying age, reduction blood glucose, YIN nourishing and the production of body fluid promoting etc. The traditional Chinese medical science is thought, " YIN and YANG in a relative equilibrium, life activities being normally maintained. " as empty in cloudy body fluid deficiency, it is impossible to containing sun, sun is floating without system, and equilibrium between yin and yang is destroyed, then all diseases are grown thickly. "

" Ling Shu Miraculous Pivot or Divine Axis Benshen's section " is said: " the main store essential substances person of the five internal organs also, can not hinder, and wound is then fallen into enemy hands and the deficiency of YIN, the deficiency of YIN then depletion of QI, and depletion of QI is then dead. " Herba Dendrobii Yin-nourishing and body fluid promoting key medicine just, the human world thus be referred to as " help Herba mesonae chinensis ".

Shennong's Herbal: main damaging the spleen and stomach, eliminating impediment, the therapeutic method to keep the adverse QI flowing downwards, tonifying five ZANG-organs asthenia weakness and emaciation, the thick the intestines and stomach of reinforcing YIN-essence, for a long time clothes.

Compendium of Material Medica: reinforcing YIN-essence benefit essence. Clothes for a long time, thick the intestines and stomach, never sufficient in benefit, flat gastric qi, longue meat, by skin pathogenic heat miliaria gas, it is weak that foot knee joint aches cold numbness, determines intelligence except frightened, makes light of one's life by commiting suicide and prolong life.

" detailed outline is picked up any lost article from the road ": clearing stomach remove deficiency-heat, promote the production of body fluid the sixth of the twelve Earthly Branches strain, with for tea, appetite promoting and the spleen strengthening. Wind, energy town saliva expectorant, sweet virtue sending down the abnormal ascending QI are treated in arresting convulsion.

" medicineization justice ": controlling lung qi prolonged deficiency, cough is more than.

" not Lu ": benefit essence is never sufficient in mending, flat gastric qi, longue meat, by skin pathogenic heat gas, foot knee joint pain weakness, strong sun, the long-pending essence of the kidney invigorating.

" Japan hanako materia medica ": controlling deficient bad weak strengthening bone and muscle, warming the kidney, Fructus Alpiniae Oxyphyllae, flat gastric qi, by exogenous pathogen.

" book on Chinese herbal medicine is new again ": reason gastric qi, clearing stomach fire. Except excessive thirst, treatment kidney channel deficiency-heat, arresting convulsion of calming the nerves in the heart, solve night sweat, summer-heat can be dissipated.

1.2 Herba Dendrobii efficacy studies

Modern medicine study shows, Herba Dendrobii has Yin-nourishing and body fluid promoting, health invigorating, strengthens the spleen and stomach, hepatoprotective function of gallbladder promoting, bone and muscle strengthening, reduction blood glucose, suppress tumor, promote circulation, bright eyes, nourish the effects such as skin. Suitable at the beginning of daily health caring, prolonged illness more, impairment of YIN of staying up late, dinner party drink, fatigue of driving.

1.2.1 tonify Qi of the kidney

Qing Dynasty's " property of medicine opinion " says that essence, nourishing stomach-YIN, physical strength profiting are amassed in Herba Dendrobii energy the kidney invigorating. Modern medicine shows, Herba Dendrobii takes a tonic or nourishing food to build up one's health renal system, carries nutrition for systemic circulation, makes QI and blood, spirit sufficient, indefatigability.

1.2.2 lung heat clearing toxin expelling

Qing Dynasty's well-known doctor's ZHAO Xue-Min records Herba Dendrobii " strain in the sixth of the twelve Earthly Branches of promoting the production of body fluid " in supplementary Amplifications of the Compendium of Materia Medica. Be meant to Herba Dendrobii and can promote the generation of internal water liquid, conditioning weakness caused by the five internal organs fatigue, have promote the production of body fluid, lung moistening, toxin expelling effect.

1.2.3 hepatoprotective function of gallbladder promoting

Ancient Chinese medicine doctor all thinks that " Herba Dendrobii " has the effect of nourishing hepatic yin, is the rare medicinal herbs treating various liver-gallbladder disease, and the treatment being beneficial to the liver and gall diseases such as hepatitis, cholecystitis, cholelithiasis recovers. The antioxidation of Herba Dendrobii can reduce the damage of internal liver function, simultaneously by the function of hepatoprotective, clearing heat secreting bile, the preventing and treating of liver-gallbladder disease is had unique auxiliary curative effect.

1.2.4 tumor is suppressed

Some cell of the malignant tumor such as pulmonary carcinoma, ovarian cancer and promyelocytic leukemia is had killing action by Herba Dendrobii, has stronger anti-tumor activity. Clinical experiment shows, Herba Dendrobii, for the auxiliary treatment of malignant tumor, can improve the symptom of tumor patient, alleviates the side effect of Radiotherapy chemotherapy, enhancing immunity, improves life quality, extends life span.

1.2.5 bright eyes

The traditional Chinese medical science is thought, the vital essence of the vital organs of the human body is all passed through on arteries and veins, notes in eyes, and whether vigorous the physiological and pathological of liver " having one's ideas straightened out in order " eyes is in close relations in the cloudy essence of liver, and Herba Dendrobii has YIN nourishing to support purpose function, by the ancient Chinese medicine doctor good merchantable brand as eye-protecting. Modern pharmacology research confirms: Herba Dendrobii does not only have retarding action to preventing and treating senile cataract, it is possible to keep lenticular transparency 36.8%, and the enzymatic activity ANOMALOUS VARIATIONS caused by galactose has suppression or role of correcting.

1.2.6 blood glucose is reduced

The traditional Chinese medical science is thought, the generation of diabetes (diabetes), and mainly with deficiency of the kidney yin, lung stomach early heat is basic pathogenesis, and with deficiency of both QI and YIN for its pathological characteristic, Herba Dendrobii replenishing YIN and removing heat is moisturized, and treats the medicine dedicated of diabetes since ancient times exactly. Clinical research shows, Herba Dendrobii is possible not only to strengthen insulin active, can significantly reduce blood sugar level simultaneously, make blood sugar recovery normal.

1.2.7 strong muscle blood fat reducing

After people enters the middle age, cloudy Tianjin of " people's half of YIN QI consumed " human body starts weak, and muscles and bones function is faded, Herba Dendrobii energy vital essence replenishing, lubricating joint, thus reaching strengthening the tendons and bones, fluent joint, strengthening antiheumatic effect. Modern pharmacological research shows, Herba Dendrobii can improve stress ability, has good resisting fatigue, resisting oxygen lack; Can be made moist sering, expands blood vessel, thus blood circulation promoting, significantly improves blood stasis symptom, reduces cholesterolemia and triglyceride, it is provided that high density lipoprotein sterol levels, it is possible to treatment blood cerebrovascular disease.

1.2.8 reinforcing stomach reg fluid

Herba Dendrobii reinforcing stomach reg fluid, all on the books in Shennong's Herbal, " book on Chinese herbal medicine is new again ", it is called " medicine for enterogastritis ". Modern medicine confirms, pathogenic bacterium helicobacter pylori common in the spleen-stomach disease is had good inhibiting effect by Herba Dendrobii, contributes to the disease of the Helicobacter pyloris such as treatment atrophic gastritis, superficial gastritis, duodenal ulcer; Oral Herba Dendrobii decocting liquid can promote the secretion of gastric juice simultaneously, strengthens the emptying ability of stomach, helps digest.

1.2.9 slow down aging

Herba Dendrobii is classified as by Shennong's Herbal has the panacea that " make light of one's life by commiting suicide and prolong life " acts on. After human body enters the middle age, internal cloudy liquid reduces day by day, and skin is aging rapidly. Herba Dendrobii can promote the generation of blood of human body, body fluid, body fluid, nourishes rough skin. Modern pharmacology research confirms: Herba Dendrobii contains various trace elements, and the good health and a long life for human body have close relationship, to the anti-aging effects of human body than general medicine more extensively, more comprehensively.

1.2.10 sleep is improved

The traditional Chinese medical science thinks that the cause of disease of chronic insomnia is that yin and yang imbalance, the deficiency of YIN can not suppress yang hyperactivity fire to move to cause. Herba Dendrobii just has the magical effect of " tonifying five ZANG-organs asthenia ", by YIN nourishing qi-restoratives, fundamentally solves solidity insomnia problem.

1.3 nearly dendrobium officinale

The planting patterns of Herba Dendrobii is varied, has potted plant growth, the plantation of booth seedbed, basswood plantation, attached tree planting etc. Yueqing City Herba Dendrobii association is declaring of specification Herba Dendrobii planting patterns, the planting patterns imitating dendrobium officinale growing environment is referred to as " nearly wild planting ", utilizes the Herba Dendrobii that this planting patterns is planted to become nearly dendrobium officinale. Dendrobium officinale is often grown in, on the overhanging cliff away from signs of human habitation or old trees that reach into the skies, growing in its natural state. Nearly dendrobium officinale alleged by this patent is exactly simulate environment and the growth pattern of dendrobium officinale, planting base selects in the mountain region luxuriant with concentrating residential block (guaranteeing that water quality, air, soil are not contaminated), vegetation away from industrial occupancy or forest land, Herba Dendrobii is directly planted on the live body tree in field, and has passed through GAP (GAP) and organic products certification. Herba Dendrobii planting process in the present invention does not use chemical fertilizer and pesticide, polysaccharide content of dendrobium candidum is up to 39.6% (States Pharmacopoeia specifications polysaccharide content of dendrobium candidum standard is 25%), EN that is rare and that be referred to as " anticancer factor " can also be detected, be the upper product in Herba Dendrobii.

1.4 Flos Carthami effect summaries

Flos Carthami is again thorn Flos Carthami, belongs to the one of Flos Chrysanthemi class. Blade is wire body shape, carefully grows, and smelling has a kind of special fragrance, and taste is more pained. There is effect of latus rectum of invigorating blood circulation, eliminating stasis to stop pain, for amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury. Its main chemical compositions is Carthamus yellow (saffloryellow, SY), S-A Hydroxysafflor yellow A (hydroxysaffloryellowA, HSYA), saffloside, Flos Carthami quinone and neocarthamin etc., its effect is subject to the big quantity research of Chinese scholars.

1.4.1 anticoagulation, antithrombotic

Platelet activating factor PAF (plateletavtivatingfactor) is the strongest platelet aggregation activator, blood circulation disease rises important mediation, water soluble ingredient Carthamus yellow in Flos Carthami is mainly containing chalcones composition, the PAF platelet aggregation caused can be suppressed, and present obvious dose-effect relationship. Flos Carthami can also stop thrombosis to develop further and can progressively alleviate thrombosis, reduce cholesterol, can improve the microcirculation disturbance of cardiac muscle and cerebral tissue preferably, play the effect for the treatment of coronary atherosclerotic heart disease and cerebral thrombosis.

1.4.2 antioxidation, anti-aging effects

Carthamus yellow can make various endogenous anti-oxidative enzyme (SOD, glutathion peroxidase) rising in various degree, reduce the generation of lipid peroxidation, reduce the generation of lipid peroxidation product malonaldehyde (MDA), reduce ischemic myocardium free radical and generate and stop radical damage. Its antioxidative effect is also one of basis of its treatment cardiovascular and cerebrovascular disease such as myocardial ischemia, cerebral ischemia. Research also shows, each dosage group of SY can raise aging model hepatic mitochondria membrane phospholipid composition PC (phosphatidylcholine), the content of PE (PHOSPHATIDYL ETHANOLAMINE) and CL (cuorin) and Ca to some extent²⁺Content, reduces PLA₂(phospholipase A₂) content, it was shown that it has obvious anti-aging effects.

1.4.3 the effect to cardiovascular system

Heart is had slight excitation by Flos Carthami, can make that heart beating is strong, amplitude strengthens, and myocardial ischemia is useful, and Carthamus yellow has significantly expands blood vessel function. Flos Carthami also can improve the organ microcirculation of asthmatic patient, make microcirculation increase thick, flow velocity is accelerated, fluidised form recovers normal.

1.4.4 antitumor action

Flos Carthami clinically can inhibition of endothelial cell proliferation. Antineoplastic vascular regenerative therapy is a study hotspot of therapeutic field of tumor, vascular endothelial cell proliferation is the most basic and most important link that blood vessel occurs and develops, thus suppress vascular endothelial cell proliferation that new vessels just can be suppressed to generate, thus the growth of suppression tumor, this effect of Flos Carthami points out it can be used for the treatment of tumor as the anti-angiogenic drugs of a kind of Chinese medicine.

1.4.5 antiinflammatory

Plurality of active ingredients in Flos Carthami can affect immunologic function, antagonism platelet activating factor (PAF) receptor, improves internal nitric oxide (NO) level, scavenging activated oxygen, moreover it is possible to the antagonism inflammation factor, effectively good antiinflammatory action.

1.4.6 anoxia enduring

Anoxia encephalopathy caused by acute ischemia caused by total tremulous pulse is had protective effect by Safflower extracting solution. SY has alleviates the effect that isoproterenol Myocardial Ischemia cardiac function declines, and has significant anoxia enduring, antifatigue effect, and increases the coronary flow of heart and myocardial ischemia, improves the anoxia of heart, ischemia pathology state.

1.4.7 liver there is protective effect

Flos Carthami injection can substantially suppress the rising of alanine aminotransferase (ALT) in isolated perfusion, liver perfusate, makes flow increase and close to normal, favorably improves liver function. Endotoxic hepatic injury can be reduced the content of Serum ALT, Aspartate aminotransferase (AST) by Flos Carthami injection, also reduces serum NO level, weakens iNOS (INO_S) positive expression, thus alleviating hepatic injury, play the protective effect to liver.

1.5 Radix Angelicae Sinensis effect summaries

When being classified as samphire, the root of Radix Angelicae Sinensis has the medication history of more than one thousand years in China. " book on Chinese herbal medicine is just " is said: " Radix Angelicae Sinensis, its sweet in the mouth and weigh, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, invigorating middle warmer has, has benefit in row, and the gas medicine in sincere blood, also the panacea in blood is also. Then mending to mend of about assistant, therefore nutrition blood can be supported, QI invigorating spermatogenesis, settling five organs, strong body, benefit mind, all tangible deficient diseases, unsuitable without institute. " Radix Angelicae Sinensis has effect of replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation, is widely used in each section of tcm clinical practice. Using in the Chinese medicine that frequency is the highest at 25 kinds, Radix Angelicae Sinensis occupies the 8th, so there being the reputation of " ten side's rules for doing division with a one-digit divisor on the abacus ", " king of medicine ".

1.5.1 strengthen heart blood supply, reduce myocardial oxygen consumption

Radix Angelicae Sinensis injection can make coronary flow substantially increase, and coronary resistance reduces, and cardiac muscle consumption is also decreased obviously. Radix Angelicae Sinensis aqueous extract also can make coronary vasodilation, and perfusion flow increases, and Myocardial Infarction has obvious antagonism.

1.5.2 expand blood vessel, reduce vascular resistance, improve organic blood flow volume

Radix Angelicae Sinensis injection can make myocardial ischemia-reperfusion after left indoor pressure, the maximum rising of left chamber pressure and fall off rate significantly improve, reduce the increasing degree of serum phosphate creatine kinase activity and mda content after Reperfu-sion. When showing Radix Angelicae Sinensis injection to myocardial ischemia-reperfusion, cardiac function reduction and myocardial cell injury have significant protective effect. Ca in myocardial cell after filling again with Radix Angelicae Sinensis²⁺、Na⁺All relatively matched group is low for accumulation, lipid peroxidation product generation, creatine kinase, lactic acid dehydrogenase, glutamic oxaloacetic transaminase, GOT release, coronary vascular resistance and myocardial water content; it is good that heart function recovery and myocardial ultrastructure change relatively matched group, it was shown that Radix Angelicae Sinensis has good myocardium protecting action.

1.5.3 immunity is strengthened

In immune deterioration, the decline of thymus function is the most obvious. It is demonstrated experimentally that Radix Angelicae Sinensis polysaccharide can significantly improve thymic weight, reduce the content of lipid peroxidation metabolite, it was shown that Radix Angelicae Sinensis has certain effect strengthening immunity.

1.5.4 slow down aging

Apoptosis is close with Senescence. Apoptotic result is to make the cell quantity that somatic cell particularly has critical function reduce, and causing what it formed vitals is senile Progressive symmetric erythrokeratodermia pathological process. Aging model research is made with D-galactose inducing mouse, give the Radix Angelicae Sinensis water decoction of various dose simultaneously, observe the Radix Angelicae Sinensis impact on brain tissue apoptosis and thymus index, find that Radix Angelicae Sinensis can substantially suppress Mice brain tissues apoptosis, improve thymus index, infer that Radix Angelicae Sinensis anti-aging effects is likely to relevant with inhibited apoptosis accordingly.

1.5.5 memory is improved

Radix Angelicae Sinensis polysaccharide (ASP) can significantly improve mouse aging learning memory, improve brain cell degeneration and downright bad situation, reduce apoptosis amount index, strengthen mice serum and Brain Tissue SOD Vigor, minimizing lipid peroxidation product malonaldehyde (MDA) content. It is demonstrated experimentally that Radix Angelicae Sinensis polysaccharide can improve mouse aging learning and memory function, the aging of cerebral tissue should be delayed.

1.5.6 antitumor action

In Radix Angelicae Sinensis, Radix Angelicae Sinensis polysaccharide has antitumor action. Radix Angelicae Sinensis polysaccharide can suppress the hepatocarcinogenesis of aflatoxin B1, also can extend the life span of the mice of intraperitoneal inoculation ehrlich ascites cell after lumbar injection Radix Angelicae Sinensis polysaccharide. Transplanted tumor is had a degree of inhibitory action by Radix Angelicae Sinensis polysaccharide sample, and has synergism with some chemotherapeutics, can alleviate the side effect of chemotherapeutics.

1.5.7 radiation resistance

Hemopoietic tissue and hematopoietic cell by irradiation mice is had certain protective action by the preventative Radix Angelicae Sinensis polysaccharide that gives, and can remarkably promote bone marrow and spleen endogenous hematopoiesis stove is formed, improve frangments smear. It is right that Radix Angelicae Sinensis injection intraperitoneal administration can accelerate⁶⁰Mouse ovarian form after the damage of Co-r x radiation x and the recovery of function.

1.6 Radix Salviae Miltiorrhizae effect summaries

Radix Salviae Miltiorrhizae is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae, main product in Anhui, Jiangsu, Shandong, Hebei, Sichuan etc. economize, cultivation or wild. General autumn excavates, and removes stem and leaf, silt, fibrous root, dries. Radix Salviae Miltiorrhizae bitter in the mouth, cold in nature. There is effect of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, nourishing blood to tranquillize the mind. For menoxenia, dysmenorrhea, amenorrhea, postpartum stagnation, chest and abdomen or limbs pain due to blood stasis. Carbuncle sore tumefacting virus, vexed insomnia. Should not with Rhizoma et radix veratri (Radix Rhizoma Veratri) with using. The medical value important due to it and widely pharmacological action, Radix Salviae Miltiorrhizae increasingly causes the concern of people. The main component of Radix Salviae Miltiorrhizae is containing crystallinity phenanthrenequione compounds: Tanshinone I, tanshinone ⅡA, Tanshinone II B, cryptotanshinone, hydroxyl TANSHINONES etc., wherein cryptotanshinone is antibacterial principle active component.

1.6.1 the protective effect to cerebral ischemia

Research shows, Radix Salviae Miltiorrhizae can reduce the M & M of pallasiomy and infarction area after cerebral middle artery occlusion in rats, the cerebral edema caused after alleviating ischemia. Also can reduce the peroxidation of cerebral tissue TXB2, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 and antagonism LDL (low density lipoprotein, LDL). Ischemia-reperfusion injury model can make c-fos gene expression rise and Endothelin (ET) down regulation of gene expression, reduce brain NO and lipid peroxidation, in addition, Radix Salviae Miltiorrhizae can also make the immunoreation of fibroblast growth factor (BFGF) sample strengthen, and has reinforcement nutrition and repair. With ferric chloride partial smearing injured blood vessel, form the thrombus model of intraluminal middle cerebral artery occlusion in rats, observe the acetyl salvianolic acid A preventive effect to local cerebral ischemia caused by middle cerebral artery thrombosis, visible acetyl salvianolic acid A intravenous can significantly inhibit the formation of thrombosis in middle cerebral artery, reduce the scope of rat cerebral infarction, improve behavior disorder. Prompting acetyl salvianolic acid A is possibly through suppressing cerebral thrombosis, thus alleviating the local cerebral ischemia loss caused by thrombosis.

1.6.2 coronary circulation is improved

Radix Salviae Miltiorrhizae Injection can open the isolated heart of Cavia porcellus and rabbit equally also the effect increasing coronary flow. To the dog of experimental acute myocardial infarction and cat, in vitro cat, pig coronary artery, constant speed perfusion Radix Salviae Miltiorrhizae water-soluble monomer β-3,4-dihydroxy lactic acid (danshensu) energy substantially coronary artery dilator, make coronary blood flow substantially increase, promote that Doppler flow mapping does not increase ventricle acting and myocardial oxygen consumption. And can to anti-morphine ab, the blockage effect of propranolol. Use coronary arterial tree casting, tectology, observe Coronary Collateral Circulation, it has been found that after intravenous sodium tanshinone IIA sulfate, the depletion of blood in the myocardial infarction district after coronary artery ligation 5 hours is obviously reduced for area or disappears. Interval in the ischemic region of heart and non-ischemia, collateral anastomosis of blood vessel is open, points out its mechanism of resisting myocardial ischemia with increase Doppler flow mapping, the blood supply of ischemic region is relevant. Utilize patch clamp technique, molecular level confirm tanshinone ⅡA on original cuiture Porcine coronary artery because potassium channel (KATP) sensitive for ATP and calcium activated potassium channel (Kca) all have direct activation, this is likely to also be one of the important mechanisms of they diastole arteria coronaria.

1.6.3 the protective effect to myocardial cell

Showing by studying, the rabbit that pituitrin is caused or Acute Myocardial Ischemia in Rats, Radix Salviae Miltiorrhizae decoct, FUFANG DANSHEN ZHUSHEYE can improve or resist its Electrocardiographic unusual condition. Rats by intraperitoneal injection radix Salviae Miltiorrhizae water extract, the acute myocardial ischemia caused for following coronary artery occlusion has obvious preventive effect, and left room myocardial ischemia-area significantly reduces, and electrocardiogram " S-T " section improved due to myocardial ischemia is significantly less than matched group. It is open that tanshinone ⅡA, FUFANG DANSHEN ZHUSHEYE can accelerate crown collateral anastomosis of blood vessel significantly, thus alleviating the extent of damage of acute stage myocardial ischemia, and accelerate the recovery of myocardial ischemia or damage, in addition heart tissue electron microscopic observation is more active to the phagocyte of compound Salviae Miltiorrhizae group specimen, necrotic myocardium relic is less, fibroblast differentiation degree and interstitial proliferation degree are all more apparent, and blood capillary loss is also less.

1.6.4 microcirculation is improved

Pathological model to Experimental Rabbit Peripheral Microcirculation obstacle, Radix Salviae Miltiorrhizae Injection can make microcirculation blood flow dramatically speed up, the open increased number of capillary network, and blood fluidised form improves, showing as hemocyte and have Segregation in various degree, blood flowing is become normally from granular or broken string shape. Microcirculation disturbance intravenous rabbit injection various dose Radix Salviae Miltiorrhizae Injection and danshensu, both of which can increase the number of hits of microcirculation disturbance eyeball and mesenteric microvessels, is conducive to increasing the foundation of the microcirculatory hemoperfusion of local organization and Doppler flow mapping. In identical rabbit model of microcirculation obstacle and mice Mesentery microcirculation Disorder Model are tested, to can substantially increase rabbit bulbar conjunctiva capillary vessel number after danshensu, reduce rabbit plasma lactic acid content, and see danshensu and can expand mice and be in the mesentery arteriole of contraction state, accelerate velocity of blood flow, promote the foundation of Doppler flow mapping, make microcirculation function recover. Why prompting Radix Salviae Miltiorrhizae has function of promoting blood circulation to disperse blood clots, and one of its mechanism is to improve microcirculation

1.6.5 the impact on blood

Radix Salviae Miltiorrhizae can make the blood viscosity of the patients such as coronary heart disease, acute myocardial infarction, pulmonary heart disease, old myocardial infarction substantially reduce, and other indexs such as index such as erythrocyte electrophoretic time, hematocrit, Fibrinogen is all improved in varying degrees. Radix Salviae Miltiorrhizae may act on multiple thrombin resisting blood coagulation effect. The Radix Salviae Miltiorrhizae impact on thrombin time, prompting Radix Salviae Miltiorrhizae mainly acts on the phase III of blood coagulation. The water soluble ingredient danshensu of Radix Salviae Miltiorrhizae has the effects such as obvious antithrombus formation, antiplatelet aggregation and promotion fibrin (former) degraded. Sodium tanshinone IIA sulfate also has the effect of protected protein degeneration. And improve the mechanical strength of erythrocyte membrane, thus play protection erythrocyte effect.

1.6.6 anti-hepatic fibrosis

Hepatic disease is had effect of anti hepatic fibrosis by salvianolic acid B. The activation of hepatic stellate cell (HSC) is the key link that hepatic fibrosis occurs, develops, and transforming growth factor-beta 1 (TGF-β 1) is the most important cytokine promoting HSC activation. Fat-storing cells of liver (FSC) is a kind of liver parenchymal cell, a large amount of hypertrophy after being activated under pathological conditions, producing the ability hypertrophy ten times of extracellular matrix (ECM), therefore, FSC also functions to important function in process of hepatic fibrosis simultaneously. Salvianolic acid B can suppress the HSC intracellular signal transduction of TGF-β 1 and the expression of receptor protein thereof, thus antagonism TGF-β 1 short HSC activation, and can suppress activate FSC hypertrophy, it is suppressed that FSC cellulation epimatrix and reduce collagen fiber deposition in liver. This is the mechanism of salvianolic acid B anti-hepatic fibrosis.

1.6.7 blood fat reducing and atherosclerosis

To atherosclerotic rabbit, Radix Salviae Miltiorrhizae decoct can reduce the triacylglycerol in blood regulating liver-QI and can reduce the permeability of rabbit aorta inner membrance. To experimental atherosclerosis, Radix Salviae Miltiorrhizae can reduce the cholesterol level of atherosclerosis of aorta area and aorta wall. Danshensu also has lipotropism protein oxidation effect, and oxidation protein electrophoretic mobility can be made substantially to slow down, and in oxidized lipoprotein, lipid peroxide contents significantly reduces, and the toxic action of cell is substantially weakened by oxidized lipoprotein. It is the main mechanism that restenosis is formed after atherosclerosis (AS) and coronary angioplasty that tunica media of artery smooth muscle cell (SMC) moves with hyper-proliferative to inner membrance. Radix Salviae Miltiorrhizae Injection can suppress the propagation of SMC and the picked-up to 3H-TdR thereof, provides new pharmacology's foundation for Radix Salviae Miltiorrhizae for preventing AS and arteria coronaria from forming postoperative restenosis.

Summary of the invention

The purpose of the present invention is precisely in order to overcome the deficiency of above-mentioned technology, and formula and the method for making thereof of a kind of nearly wild fresh Herba Dendrobii Flos Carthami Chinese angelica oral liquid are provided, apply nearly dendrobium officinale compatibility Flos Carthami, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae so that it is effect cooperative compensating, enhance product efficacy.

It is an object of the invention to complete by following technical solution. The formula of this nearly wild fresh Herba Dendrobii Flos Carthami Chinese angelica oral liquid, the weight of its each raw material is as follows: nearly wild fresh Herba Dendrobii 56～66 parts, 5～10 parts of Flos Carthami, Radix Angelicae Sinensis 5～10 parts, Radix Salviae Miltiorrhizae 8～15 parts, xylitol 2～3 parts, citric acid 0.3～0.5 part.

The method for making of the formula of this nearly wild fresh Herba Dendrobii Flos Carthami Chinese angelica oral liquid, fresh extraction: nearly dendrobium officinale is after steaming blue or green sterilizing, carries out superfine grinding with grinder, then carries out 200 order sucking filtration, and filtrate is standby; Extract concentration: Herba Dendrobii filtering residue mixes with the Flos Carthami of formula ratio, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae and extracts, and extracting solution filtering and concentrating is standby; Fresh for Herba Dendrobii extraction filtrate is put in oral liquid preparing tank with Flos Carthami, Radix Angelicae Sinensis, Salvia mitiorrhiza liquid, then xylitol, citric acid are added preparing tank, be stirred to dissolve, sterilizing, stand 12～18 hours, filter, fill, sterilizing, labeling, packaging, to obtain final product.

Nearly dendrobium officinale cultivating process is as follows:

(1) source screening, is planted: screening Wild Goose and Reed Marsh Mountains dendrobium officinale is as generation kind source;

(2), group training: culture medium: 1/2～1MS, 15～25% Rhizoma Solani tuber osi Aqueous extracts, 6～10% banana puree; Medium sterilization condition: 121 DEG C, 1.1Mpa; Seed asepsis sprouting condition: temperature 25 ± 1 DEG C, 500～1000Lux illumination 12 hour/day;

(3), differentiation, strong sprout: after cultivating 40 days: add 1.0～3.0mg/LBA, 0.1～0.3mg/LNAA; After cultivating 60 days: add 0.1～0.3mg/LBA, 1.0～3.0mg/LNAA;

(4), acclimation: fertilizer: Bombyx mori L. 55%～65%, Cortex Cunninghamiae Lanceolatae 45%～55% heap, cover film, natural fermentation 90 days; Booth: temperature 25 ± 3 DEG C, humidity 40%～75%, light application time 8～12 hours; Seedbed: lay fertilizer, thickness 10～20cm; By bottle transplantation of seedlings to taming seedbed, set 5～10min/h automatic watering function;

(5) tree that, lives selects: the jujube tree of diameter 20～40cm or pear tree 100～150/mu;

(6), pluck: the growth selection plant of more than 3 years.

Fresh extraction specifically comprises the following steps that

(1), cleaning: after nearly dendrobium officinale is plucked, defoliation, purified water 1:20～30 rinse 30～60min, then rinse 3 times by purified water;

(2), sterilizing: clean Herba Dendrobii is put in steaming machine, with the steam sterilization 5～10min of 95～105 DEG C, cooling;

(3), cutting: the Herba Dendrobii that sterilizing is good is cut into the segment of 0.5～1.5cm;

(4), grind: Herba Dendrobii section is put in grinder, add purified water by 1:8～12, grind to form the fresh juice that fineness is 250～300 μm;

(5), filter: the fresh juice of Herba Dendrobii after grinding carries out vacuum filtration, respectively coarse filtration and fine straining, and coarse filtration medium is the nylon gauze of 80～100, and fine straining medium is 200 order nylon gauzes, and filtrate is standby, and filtering residue forwards abstraction process to.

Extract concentration specifically comprise the following steps that Flos Carthami, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae and Herba Dendrobii filtering residue united extraction: 10～12 times of water, with Flos Carthami, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae gross weight gauge; Boiling extraction 3 times, each 2h, extracting solution crosses 200 eye mesh screens, and it is 1.1～1.2 that merging filtrate is evaporated to relative density.

The invention have the benefit that the present invention is with nearly dendrobium officinale, Flos Carthami, Radix Angelicae Sinensis and Radix Salviae Miltiorrhizae for primary raw material, Herba Dendrobii Yin-nourishing and body fluid promoting, tonifying five ZANG-organs asthenia, its polysaccharide component can strengthen immunity, suppress tumor, slow down aging, for monarch; Flos Carthami, Radix Angelicae Sinensis are respectively provided with activity and stimulate the menstrual flow, effect of blood-activating analgetic, and the gynaecopathia such as dysmenorrhea, amenorrhea has positive effect, can help again Herba Dendrobii scavenging free radicals, slow down aging simultaneously; It is aided with Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, the relieving restlessness that clears away heart-fire, removing heat from blood eliminating carbuncle, strengthens this product to improving microcirculation, promoting the effect that tip is supported, and cardiovascular and cerebrovascular vessel can be protected, resist " three high ". Each component compatibility complements each other, and is especially suitable for the maintenance demand of modern female, promoting blood circulation to remove obstruction in the collateral, makes skin recover QI and blood and elasticity.

At process aspect, the present invention applies the compositions such as the polysaccharide in " fresh extraction " technology dendrobium officinale nearly, mannose, vitamin, EN, aminoacid and chlorophyll and fully extracts, and is greatly improved the value of rare medicinal herbs Herba Dendrobii; Secondly as directly process with fresh Herba Dendrobii, eliminate the cost of Herba Dendrobii dry run, it also avoid Herba Dendrobii and cause the risk of nutrient loss because baking temperature is too high; Again, application " fresh extraction " technique can make product retain the color and luster of fresh Herba Dendrobii, abnormal smells from the patient and mouthfeel, more can embody the natural value of product. In conjunction with techniques such as extraction, preparation, fills, make the oral solutions being easy to take, and absorb more quick compared with other dosage forms, be especially suitable for allegro work and the lives such as working, travelling. The present invention all has a clear superiority in from aspects such as the selection of raw material, prescription compatibility, processing technique, product forms than market like product, has good market prospect.

Accompanying drawing explanation

Fig. 1 is nearly dendrobium officinale cultivating technique flow chart;

Fig. 2 is the fresh extraction process chart of nearly dendrobium officinale;

Fig. 3 is extraction concentration technique flow chart;

Fig. 4 is nearly wild fresh Herba Dendrobii oral liquid preparation technology flow chart.

Wherein, in Fig. 1: 1* sterilising conditions, sterilization effect control; 2* culture medium and condition of tissue culture control; 3* differentiation condition controls; 4* condition in strong sprout controls; 5* fertilizer substrate, greenhouse-environment control; 6* Tree Species Selection, Planting pattern, disease pest defense controls; 7* plucks the time limit, the picking season controls.

In Fig. 2: 1* sterilising temp, time control; 2* grinds amount of water, fineness controls; 3* filtering accuracy controls.

In Fig. 3: 1* amount of water, extraction time, extraction time control; 2* thickening temperature, feed liquid relative density control.

In Fig. 4: 1* recipe ingredient inventory controls; 2* sterilising temp, time control; 3* filters rotating speed and controls; 4* loading amount, sealing control; 5* sterilising temp, time control, and defective work is rejected; 6* sterilising temp, time control.

Detailed description of the invention

Below by detailed description of the invention, the present invention is further elaborated, and embodiment will facilitate a better understanding of the present invention, but the present invention is not limited only to following embodiment.

The content that the present invention relates to includes the cultivation of Herba Dendrobii raw material, formula for a product and preparation technology, and every advantage is as follows:

1 nearly dendrobium officinale source advantage

Market majority Herba Dendrobii derives from greenhouse gardening, and uses chemical fertilizer and pesticide, even auxin in planting process, makes the safety of Herba Dendrobii can not get ensureing. The nearly dendrobium officinale that the present invention uses is by GAP and organic products certification, and polysaccharide content of dendrobium candidum, up to 39.6%, exceeds standards of pharmacopoeia 58.4%, also detected EN (content is 14.2mg/100g), and by organic products certification; Therefore no matter the nearly dendrobium officinale that the present invention applies is quality or safety, is above like product.

Nearly dendrobium officinale cultivates the basis that link is the present invention, and its process includes germplasm screening, group training, differentiation, strong sprout, live tree cultivation, harvesting etc., is specifically shown in table one.

The nearly dendrobium officinale cultivating process of table one and key parameter thereof

2 formula advantage

Inventive formulation is Herba Dendrobii, Flos Carthami, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, xylitol, citric acid, market like product mostly is the combinations such as Herba Dendrobii, Radix Panacis Quinquefolii, glucose or white sugar, and dosage form mostly is electuary or capsule, the present invention has obvious differentiation, it is also adaptable for diabetes patient to take simultaneously, has better market prospect.

Each component ratio refers to table two.

The nearly wild fresh Herba Dendrobii Flos Carthami Chinese angelica oral liquid formula of table two and proportioning thereof

3 process advantages

" fresh extraction " technique of present invention application is that nearly dendrobium officinale, after steaming blue or green sterilizing (utilizing steaming machine to carry out 5～10min steam sterilization), carries out superfine grinding with grinder, then carries out 200 order sucking filtration, and filtrate is standby. Herba Dendrobii filtering residue mixes with the Flos Carthami of formula ratio, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae and extracts, and extracting solution filtering and concentrating is standby. Fresh for Herba Dendrobii extraction filtrate is put in oral liquid preparing tank with Flos Carthami, Radix Angelicae Sinensis, Salvia mitiorrhiza liquid, then xylitol, citric acid are added preparing tank, be stirred to dissolve, sterilizing, stand 12～18 hours, filter, fill, sterilizing, labeling, packaging, to obtain final product. The advantage of this technique is: 1. Dendrobium officinale polysaccharide extracts conversion ratio (actual extracting amount and theoretical content ratio) up to more than 90%, and traditional direct water boiling and extraction conversion ratio is only 60%～70%; 2. the nutritional labeling of Herba Dendrobii at utmost retains, and Vitamin C content is that 85mg/100g (being 28 times of traditional decoction extraction process), chlorophyll content 65mg/100g (chlorophyll of traditional decoction technique is almost all destroyed), protein content also can reach for 9.3% (being about 1.5～1.8 times of traditional decoction extraction process); 3. the product that this technique is made has the fragrant that Herba Dendrobii is unique, more can embody Herba Dendrobii own characteristic; 4. oral liquid formulation market like product is comparatively rare, taking convenience, absorbs quickly, has obvious advantage.

Present invention process process concrete technology and parameter such as table three.

The nearly wild fresh Herba Dendrobii Flos Carthami Chinese angelica oral liquid preparation technology of table three and parameter thereof

(1) nearly dendrobium officinale is cultivated

1 kind of source screening

Wild Goose and Reed Marsh Mountains is the cradle of Herba Dendrobii, " Bencao Congxin " place of production of Herba Dendrobii is also had clear and definite record " Wenzhou is gone up most, takes second place in Guangxi; Guangdong under ", it is domestic that Wild Goose and Reed Marsh Mountains is seated in Wenzhou, is the main producing region of Herba Dendrobii, and its quality receives the high praise of ancient Chinese medicine doctor. Leqing is located in the foot of a hill or mountain, Wild Goose and Reed Marsh Mountains, and local villager excavates Herba Dendrobii centuries history, for the benefit of preservation of Herba Dendrobii, and they are also baked to, and are curled into spring-like, through being handed down from age to age and improving, is also the formation of the Herba Dendrobii in modern times! Produce and be called " genuine medicinal materials " in Herba Dendrobii here or Herba Dendrobii are by industry. The present invention follows the feature of Chinese crude drug Genuine producing area, the wild varieties planting selection Wild Goose and Reed Marsh Mountains, source of Herba Dendrobii.

2 groups of trainings

The growth of Herba Dendrobii is limited mainly by the impact of the factor such as illumination and temperature, is under periodicity of illumination at 12h/d, and now the chlorophyll content of plant and Net Photosynthetic Rate are higher, and growth is stronger with fertility. Select 1/2～1MS, 15～25% Rhizoma Solani tuber osi Aqueous extracts, 6～10% banana puree as culture medium, and 121 DEG C, culture medium is carried out sterilizing under the sterilising conditions of 1.1Mpa.

Select kind of a stem for source Herba Dendrobii, defoliation, Herba Dendrobii stem is carried out surface sterilization with the ethanol of 75% by aseptic operating platform, removes dust then the HgCl with 1%₂Sterilizing 5～10min, with aseptic water washing three times, so repeats 3 sterilizings, constantly to rock in sterilization process so that it is fully sterilizing.

By sterilized Radix Stephaniae Tetrandrae stem, being aseptically cut into the stem section with a stipes, be inoculated in inducing culture, temperature 25 ± 1 DEG C, 500～2000Lux illumination 12h/ day, induction is sprouted, and bud induces protocorm again.

3 differentiation, strong sprout

After cultivating 40～43 days, add 1.0～3.0mg/LBA, 0.1～0.3mg/LNAA, after cultivating 58～62 days, add 0.1～0.3mg/LBA, 1.0～3.0mg/LNAA, make protocorm differentiation, strong sprout, just high 5～9cm, 7～9, blade, the healthy and strong plant of root length 3～6cm can be turned out through about time a year and a half.

4 domestications

Owing to the primary growth condition such as temperature and illumination changes, need before transplanting through 1 week seedling exercising. Avoid during transplanting injuring tender tissue, clean the culture medium being attached to root, load kind is on seedbed, fertilizer (Bombyx mori L. 55%～65%, Cortex Cunninghamiae Lanceolatae 45%～55% heap are laid in seedbed, cover film, natural fermentation 90 days, sterilizing), fertilizer to loosen ventilative, laying depth 10～20cm. During transplanting, optimum temperature is 15～30 DEG C, temperature too low or too high be all not suitable for bottle outlet transplant. Greenhouse temperature 25 ± 3 DEG C, humidity 40%～75%, light application time transplant successful Herba Dendrobii in 8～12 hours, water in right amount after 1 week, set 5～10min/h auto spraying.

5 live sets cultivation

As it was previously stated, the Genuine producing area of Herba Dendrobii is positioned at Wild Goose and Reed Marsh Mountains, also build in the foot of a hill or mountain, Wild Goose and Reed Marsh Mountains for the planting base of Herba Dendrobii in this present invention. After booth seedbed grows 50～70 days, Herba Dendrobii length about 10～15cm, now can transplant to living on tree. The symbiosis of Herba Dendrobii and tree has certain selectivity, its root belongs to aerial root, easily it is attached to the surface of tree, therefore the growth of Herba Dendrobii is had important impact by the moisture of bark and texture thereof, according to experimentation, the present invention selects jujube tree and pear tree as cultivation seeds, trunk diameter 20～40cm jujube tree 100～150/mu, and cultivated areas illumination is fully (light application time 8～12h/ days).

Cultivation: during transplanting, optimum month is 2～May, and temperature is in 15～30 DEG C. Herba Dendrobii is extracted from seedbed, the Herba Dendrobii Seedling that screening is healthy and strong, clear up root substrate, root is wrapped up with lichen, with Caulis et Folium Oryzae rope, the root position of Herba Dendrobii is tied on trunk or thick branch (diameter >=5cm) again, minimum altitude 50cm, every 30～40cm plantation one circle. The position that automatic irrigation water pipe is pressed Seedling disposes shower nozzle, and pastes paper and biological insect-catching equipment in tree planting district suspension of living, and pastes paper 3～5/square, biological insect-catching equipment 2～3/10 meters. Automatic spray irrigation system opens auto spraying function, summertime 10～20min/h, more than 15 DEG C 5～10min/h of winter temperature in the non-rainy day.

6 pluck

Dendrobium officinale polysaccharide is the significant composition of Herba Dendrobii, shows after deliberation, and the content of Dendrobium officinale polysaccharide is relatively larger by growth year and seasonal effect, is specifically shown in table four.

Table four Dendrobium officinale polysaccharide growth year and seasonal variations (%)

As seen from the above table, the optimal harvest time of Herba Dendrobii is 3～May after growing 3 years, the florescence of Herba Dendrobii is generally for 5～June, feature according to biological heredity, the change of polysaccharide content of dendrobium candidum is limited mainly by the impact bloomed, therefore January after it is generally acknowledged Herba Dendrobii rational 3 years collection period, February, March, April, May and December.

(2) fresh extraction technique and parameter

After nearly dendrobium officinale is plucked, defoliation, purified water 1:20～30 rinse 30～60min, rinse 3 times by purified water again, put in steaming machine, with the steam sterilization 5～10min of 95～105 DEG C, cooling, it is cut into the segment of 0.5～1.5cm, placing in grinder, regulating fineness of grind is 250～350 μm, adds cryogenic purincation water (2～8 DEG C) by 1:10～20, open grinder, Herba Dendrobii is ground to form fresh juice.

The fresh juice of Herba Dendrobii after grinding carries out vacuum filtration, first carries out coarse filtration, and coarse filtration medium is the nylon gauze of 80～100; Coarse filtration liquid carries out fine straining again, and fine straining medium is 200 order nylon gauzes. Filtrate is standby, and coarse filtration slag merges with fine straining slag and forwards abstraction process to.

(3) extraction concentration technique and parameter

Weigh the Flos Carthami of formula ratio, Radix Angelicae Sinensis (section), Radix Salviae Miltiorrhizae (section), insert in pot for boiling chinese traditional medicine, again Herba Dendrobii slag one piece is put in decoction pot, pressing the total weight of Flos Carthami, Radix Angelicae Sinensis and Radix Salviae Miltiorrhizae, add 10～12 times of purified water, heated and boiled is extracted 3 times, each 2h, each extracting solution filters with 200 eye mesh screens, and it is 1.1～1.2 that merging filtrate is evaporated to relative density, standby.

(4) preparation

Nearly the fresh extraction liquid of dendrobium officinale, Flos Carthami and Radix Angelicae Sinensis, Salvia mitiorrhiza liquid vacuum pump squeeze into preparing tank, accurately weigh the xylitol of formula ratio, citric acid, insert in material-compound tank, open blender, and unlatching is steam heated to 60～65 DEG C, keeps 30min, make solution be uniformly dissolved.

(5) disinfection filtering

By the oral liquid solution warms prepared to 90～100 DEG C, sterilize with UHT sterilization machine, sterilization temperature 135～138 DEG C, keep 3～5 seconds, it is cooled to 25 DEG C, and with 200 eye mesh screens, solution is filtered to storage tank, stand 12～18h, filtering to storage tank with high speed centrifuge, centrifugal rotational speed is 10000r/min.

(6) fill

Select bottle: work before check clear out a gathering place situation, equipment, environment clean condition whether qualified. Produce required Bottle and bottle cap to getting the same day between depositing, by bottle being placed in Revolving disc, put neat, sort out broken, breach, breach, askew bottle defective work, record defective work number. Bottle place sent to laundry by qualified bottle.

Ultrasonic bottle washing machine: connect bottle washer power supply, bottle sprays (pressure is 0.2MPa) through twice recirculated water, compression air blow drying (pressure is 0.3MPa), (pressure is 0.2MPa) is rinsed again by a fresh purified water, after the punching of last compressed air is dry, incoming far infrared sterilizing and drying case.

Sterilizing-drying: opening far infrared sterilizing and drying case on and off switch, sterilising temp 260 DEG C, outlet blast keeps 10Pa, and entrance blast keeps 8Pa, opens conveyer belt switch, starts active conveying bottle, and operation is rolled in incoming filling.

Fill Zha Gai: check the quality certification of clearing out a gathering place, equipment, clean environment situation before work, produce after qualified, regulate dosing pump loading amount. After fill starts, selective examination loading amount extracts 8 every time in order, content is in prescribed limit, check bottle cap, take 8 successively, with or without damaged, compacting imprecision, in operating process and when terminating, check loading amount and roll lid situation, fill the semi-finished product sabot after rolling and deliver to sterilizing by pass-through box and hunt leak operation.

(7) sterilizing leak detection

Checking before work that whether upper batch of situation of clearing out a gathering place, equipment, clean environment situation be qualified, arranging sterilising temp is 105 DEG C, and sterilization time is 30min; The leak detection time: 3 minutes, hunt leak vacuum-70Pa, scavenging period 20 minutes. After operation, when interior chamber pressure reduces to zero, taking-up of can opening the door, it is put in transporting room, hangs up " hunting leak " labelling, indicate the name of an article, lot number, specification.

(8) lamp inspection

After checking, before work, the quality certification of clearing out a gathering place, to transporting room get semi-finished product, the verification name of an article, specification, quantity, lot number errorless after, the defective works such as foreign body, muddiness are sorted out in the range estimation of lamp inspection work, loading amount is not enough, compacting is not tight, predetermined processing is processed by defective work, certified products put into transporting room, often dish all puts into mark card the dated name of an article, lot number, specification, quantity.

(9) labeling

Open automatic labeling machine, commissioning test state, oral liquid is carried out labeling, monitor labeling quality.

(10) packaging

Packing specification according to setting is packed.

Finally it is pointed out that above example is only the more representational example of the present invention. Obviously, technical scheme is not limited to examples detailed above, it is also possible to have many deformation, all deformation that those of ordinary skill in the art can directly derive from present disclosure or associate, and is all considered as protection scope of the present invention.

Claims

1. the formula of a nearly wild fresh Herba Dendrobii Flos Carthami Chinese angelica oral liquid, it is characterised in that: the weight of its each raw material is as follows: nearly wild fresh Herba Dendrobii 56～66 parts, 5～10 parts of Flos Carthami, Radix Angelicae Sinensis 5～10 parts, Radix Salviae Miltiorrhizae 8～15 parts, xylitol 2～3 parts, citric acid 0.3～0.5 part.

2. the method for making of the formula of a nearly wild fresh Herba Dendrobii Flos Carthami Chinese angelica oral liquid, it is characterised in that: fresh extraction: nearly dendrobium officinale is after steaming blue or green sterilizing, carries out superfine grinding with grinder, then carries out 200 order sucking filtration, and filtrate is standby; Extract concentration: Herba Dendrobii filtering residue mixes with the Flos Carthami of formula ratio, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae and extracts, and extracting solution filtering and concentrating is standby; Fresh for Herba Dendrobii extraction filtrate is put in oral liquid preparing tank with Flos Carthami, Radix Angelicae Sinensis, Salvia mitiorrhiza liquid, then xylitol, citric acid are added preparing tank, be stirred to dissolve, sterilizing, stand 12～18 hours, filter, fill, sterilizing, labeling, packaging, to obtain final product.

3. the method for making of the formula of nearly wild fresh Herba Dendrobii Flos Carthami Chinese angelica oral liquid according to claim 2, it is characterised in that: nearly dendrobium officinale cultivating process is as follows:

(6), pluck: the growth selection plant of more than 3 years.

4. the method for making of the formula of nearly wild fresh Herba Dendrobii Flos Carthami Chinese angelica oral liquid according to claim 2, it is characterised in that: fresh extraction specifically comprises the following steps that

5. the method for making of the formula of nearly wild fresh Herba Dendrobii Flos Carthami Chinese angelica oral liquid according to claim 2, it is characterized in that: extract concentration specifically comprise the following steps that Flos Carthami, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae and Herba Dendrobii filtering residue united extraction: 10～12 times of water, with Flos Carthami, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae gross weight gauge; Boiling extraction 3 times, each 2h, extracting solution crosses 200 eye mesh screens, and it is 1.1～1.2 that merging filtrate is evaporated to relative density.