CN105663764A - Formula of wild-like fresh Dendrobium officinale extract and preparation method thereof - Google Patents
Formula of wild-like fresh Dendrobium officinale extract and preparation method thereof Download PDFInfo
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- CN105663764A CN105663764A CN201610016653.8A CN201610016653A CN105663764A CN 105663764 A CN105663764 A CN 105663764A CN 201610016653 A CN201610016653 A CN 201610016653A CN 105663764 A CN105663764 A CN 105663764A
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- herba dendrobii
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- dendrobium officinale
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Abstract
The invention provides a formula of a wild-like fresh Dendrobium officinale extract and a preparation method thereof. The raw materials include, by weight, 45-55 parts of wild-like fresh Dendrobium officinale, 15-20 parts of Maca powder, 8-15 parts of American ginseng, 8-15 parts of Poria cocos, and 6-10 parts of xylooligosaccharide.The preparation method consists of: performing fresh extraction: steaming the wild-like fresh Dendrobium officinale green and performing sterilization, using a grinder to conduct superfine grinding, then conducting 200-mesh pumping filtration, and keeping the filtrate for standby use; conducting extraction and concentration: mixing Dendrobium officinale filter residue with Maca powder, American ginseng and Poria cocos according to the formula ratio and performing extraction, and subjecting the extracted liquid to filtering concentration for standby use; putting the Dendrobium officinale fresh extracted filtrate and the herb concentrated solution into a paste making pot, conducting heating stirring and boiling, when the relative density of the paste is concentrated to 1.2-1.3 (65DEG C), adding the xylooligosaccharide, performing stirring for dissolving, thus obtaining a paste. The wild-like fresh Dendrobium officinale extract prepared by the method provided by the invention has the efficacy of nourishing Yin and tonifying Yang, enhancing immunity, relieving fatigue, delaying senility, regulating endocrine and improving cardiovascular functions, etc.
Description
Technical field
The invention belongs to medicinal plants manufacture field, be specifically related to formula and the method for making thereof of a kind of nearly wild fresh Herba Dendrobii extractum.
Background technology
1.1 Herba Dendrobii summaries
Herba Dendrobii, perennial the orchid family herbaceous plant, it is divided into Herba Dendrobii, Dendrobium nobile, dendrobium loddigesii Rolfe, HERBA DENDROBII, Herba Dendrobii oculati etc. more than 70 to plant by kind preciousness degree, wherein Herba Dendrobii is come out top. Herba Dendrobii (DendrobiumofficinaleKimuraetMigo) is Chinese Second Class Key Protected Plant, has extraordinary health preserving and medical value. In the culture of health preserving that China is long, Herba Dendrobii, because of its outstanding effect, becomes ancient Chinese medicine doctor and the health preserving superfine product of nobility's high praise.
In the Shennong's Herbal in Eastern Han Dynasty's last years of a dynasty or reign, in connection with in the record of Herba Dendrobii. Product above are all included wherein, are claimed its " tonifying five ZANG-organs asthenia, manages gastric qi, controls deficient labor weak, and clothes are made light of one's life by commiting suicide for a long time, prolongs life, and sedate is except frightened " by successive dynasties famous doctor's allusion quotations such as the Chinese " Mingyi Bielu ", bright Compendium of Material Medica and clear essentials of Matea Medica.
Taoist school doctor's allusion quotation " Taoist Scriptures " between Katyuan year the Tang Dynasty, iron sheet stone is pushed into the first place of " nine big Herba mesonae chinensis ", before being listed in Herba Saussureae Involueratae, three double Radix Ginsengs, the hundred vicennial Radixs Polygoni Multiflori, the Poria of cycle of sixty years, Herba Cistanches, remote mountains Ganoderma, seabed Margarita, Cordyceps, it is seen that medicinal effects is extraordinary. Successive dynasties well-known doctor such as Huatuo, Zhang Zhongjing, Sun Simiao, Li Shizhen (1518-1593 A.D.) etc. are considered as " in medicine celestial product " it especially, are used for curing critical patient.
Since the Tang and Song Dynasty, Herba Dendrobii is just listed in tribute, for royalty's life lengthening, becomes health preserving superfine product the most honorable. According to Historical Data Data About, Wu Tse-tien took the party for 50 years, and year still preserves agerasia to old age; Qianrong Supreme Being's group minister of often feting must drink Herba Dendrobii soup, 60 years in place, becomes the emperor that the time is the longest, the longevity in year is the highest that holds power on Chinese history, and effect of Herba Dendrobii life prolonging is as can be seen here.
Herba Dendrobii nature and flavor: sweet, are slightly cold, and enter stomach, kidney channel.Property belong to clear and rich, have benefit in clear, invigorating middle warmer has clearly. The efficacy effect of Herba Dendrobii, the successive dynasties, well-known doctor was respectively arranged with discussion:
" explaining abstruseness of the canon of materia medica " cloud: " Herba Dendrobii, sweet energy pleases spleen, salty energy kidney tonifying, therefore many merits are dirty in water and soil two: but gas width delays, and without the merit that victory is played, ancients are with this generation tea, on very clear diaphragm. "
Supplementary Amplifications of the Compendium of Materia Medica cloud: " Herba Dendrobii clearing stomach except deficiency-heat, promote the production of body fluid and strain, with for tea, merit is with joining stilbene. "
In " property of medicine ", load Herba Dendrobii " for tea, promote the production of body fluid and wet one's whistle, reinforcing YIN-essence strong foot power by summer. " visible, Herba Dendrobii is long-standing as the high tonic being of illnesses and fitness. The traditional Chinese medical science is thought, Herba Dendrobii can extensive use in the disease treatments such as atrophic gastritis, tumor, diabetes, pharyngolaryngitis and cataract. Herba Dendrobii has multiple pharmacological effect, such as the immunocompetence of enhancing body, antioxidation, defying age, reduction blood glucose, YIN nourishing and the production of body fluid promoting etc. The traditional Chinese medical science is thought, " YIN and YANG in a relative equilibrium, life activities being normally maintained. " as empty in cloudy body fluid deficiency, it is impossible to containing sun, sun is floating without system, and equilibrium between yin and yang is destroyed, then all diseases are grown thickly. "
" Ling Shu Miraculous Pivot or Divine Axis Benshen's section " is said: " the main store essential substances person of the five internal organs also, can not hinder, and wound is then fallen into enemy hands and the deficiency of YIN, the deficiency of YIN then depletion of QI, and depletion of QI is then dead. " Herba Dendrobii Yin-nourishing and body fluid promoting key medicine just, the human world thus be referred to as " help Herba mesonae chinensis ".
Shennong's Herbal: main damaging the spleen and stomach, eliminating impediment, the therapeutic method to keep the adverse QI flowing downwards, tonifying five ZANG-organs asthenia weakness and emaciation, the thick the intestines and stomach of reinforcing YIN-essence, for a long time clothes.
Compendium of Material Medica: reinforcing YIN-essence benefit essence. Clothes for a long time, thick the intestines and stomach, never sufficient in benefit, flat gastric qi, longue meat, by skin pathogenic heat miliaria gas, it is weak that foot knee joint aches cold numbness, determines intelligence except frightened, makes light of one's life by commiting suicide and prolong life.
" detailed outline is picked up any lost article from the road ": clearing stomach remove deficiency-heat, promote the production of body fluid the sixth of the twelve Earthly Branches strain, with for tea, appetite promoting and the spleen strengthening. Wind, energy town saliva expectorant, sweet virtue sending down the abnormal ascending QI are treated in arresting convulsion.
" medicineization justice ": controlling lung qi prolonged deficiency, cough is more than.
" not Lu ": benefit essence is never sufficient in mending, flat gastric qi, longue meat, by skin pathogenic heat gas, foot knee joint pain weakness, strong sun, the long-pending essence of the kidney invigorating.
" Japan hanako materia medica ": controlling deficient bad weak strengthening bone and muscle, warming the kidney, Fructus Alpiniae Oxyphyllae, flat gastric qi, by exogenous pathogen.
" book on Chinese herbal medicine is new again ": reason gastric qi, clearing stomach fire. Except excessive thirst, treatment kidney channel deficiency-heat, arresting convulsion of calming the nerves in the heart, solve night sweat, summer-heat can be dissipated.
1.2 Herba Dendrobii efficacy studies
Modern medicine study shows, Herba Dendrobii has Yin-nourishing and body fluid promoting, health invigorating, strengthens the spleen and stomach, hepatoprotective function of gallbladder promoting, bone and muscle strengthening, reduction blood glucose, suppress tumor, promote circulation, bright eyes, nourish the effects such as skin. Suitable at the beginning of daily health caring, prolonged illness more, impairment of YIN of staying up late, dinner party drink, fatigue of driving.
1.2.1 tonify Qi of the kidney
Qing Dynasty's " property of medicine opinion " says that essence, nourishing stomach-YIN, physical strength profiting are amassed in Herba Dendrobii energy the kidney invigorating. Modern medicine shows, Herba Dendrobii takes a tonic or nourishing food to build up one's health renal system, carries nutrition for systemic circulation, makes QI and blood, spirit sufficient, indefatigability.
1.2.2 lung heat clearing toxin expelling
Qing Dynasty's well-known doctor's ZHAO Xue-Min records Herba Dendrobii " strain in the sixth of the twelve Earthly Branches of promoting the production of body fluid " in supplementary Amplifications of the Compendium of Materia Medica. Be meant to Herba Dendrobii and can promote the generation of internal water liquid, conditioning weakness caused by the five internal organs fatigue, have promote the production of body fluid, lung moistening, toxin expelling effect.
1.2.3 hepatoprotective function of gallbladder promoting
Ancient Chinese medicine doctor all thinks that " Herba Dendrobii " has the effect of nourishing hepatic yin, is the rare medicinal herbs treating various liver-gallbladder disease, and the treatment being beneficial to the liver and gall diseases such as hepatitis, cholecystitis, cholelithiasis recovers. The antioxidation of Herba Dendrobii can reduce the damage of internal liver function, simultaneously by the function of hepatoprotective, clearing heat secreting bile, the preventing and treating of liver-gallbladder disease is had unique auxiliary curative effect.
1.2.4 tumor is suppressed
Some cell of the malignant tumor such as pulmonary carcinoma, ovarian cancer and promyelocytic leukemia is had killing action by Herba Dendrobii, has stronger anti-tumor activity.Clinical experiment shows, Herba Dendrobii, for the auxiliary treatment of malignant tumor, can improve the symptom of tumor patient, alleviates the side effect of Radiotherapy chemotherapy, enhancing immunity, improves life quality, extends life span.
1.2.5 bright eyes
The traditional Chinese medical science is thought, the vital essence of the vital organs of the human body is all passed through on arteries and veins, notes in eyes, and whether vigorous the physiological and pathological of liver " having one's ideas straightened out in order " eyes is in close relations in the cloudy essence of liver, and Herba Dendrobii has YIN nourishing to support purpose function, by the ancient Chinese medicine doctor good merchantable brand as eye-protecting. Modern pharmacology research confirms: Herba Dendrobii does not only have retarding action to preventing and treating senile cataract, it is possible to keep lenticular transparency 36.8%, and the enzymatic activity ANOMALOUS VARIATIONS caused by galactose has suppression or role of correcting.
1.2.6 blood glucose is reduced
The traditional Chinese medical science is thought, the generation of diabetes (diabetes), and mainly with deficiency of the kidney yin, lung stomach early heat is basic pathogenesis, and with deficiency of both QI and YIN for its pathological characteristic, Herba Dendrobii replenishing YIN and removing heat is moisturized, and treats the medicine dedicated of diabetes since ancient times exactly. Clinical research shows, Herba Dendrobii is possible not only to strengthen insulin active, can significantly reduce blood sugar level simultaneously, make blood sugar recovery normal.
1.2.7 strong muscle blood fat reducing
After people enters the middle age, cloudy Tianjin of " people's half of YIN QI consumed " human body starts weak, and muscles and bones function is faded, Herba Dendrobii energy vital essence replenishing, lubricating joint, thus reaching strengthening the tendons and bones, fluent joint, strengthening antiheumatic effect. Modern pharmacological research shows, Herba Dendrobii can improve stress ability, has good resisting fatigue, resisting oxygen lack; Can be made moist sering, expands blood vessel, thus blood circulation promoting, significantly improves blood stasis symptom, reduces cholesterolemia and triglyceride, it is provided that high density lipoprotein sterol levels, it is possible to treatment blood cerebrovascular disease.
1.2.8 reinforcing stomach reg fluid
Herba Dendrobii reinforcing stomach reg fluid, all on the books in Shennong's Herbal, " book on Chinese herbal medicine is new again ", it is called " medicine for enterogastritis ". Modern medicine confirms, pathogenic bacterium helicobacter pylori common in the spleen-stomach disease is had good inhibiting effect by Herba Dendrobii, contributes to the disease of the Helicobacter pyloris such as treatment atrophic gastritis, superficial gastritis, duodenal ulcer; Oral Herba Dendrobii decocting liquid can promote the secretion of gastric juice simultaneously, strengthens the emptying ability of stomach, helps digest.
1.2.9 slow down aging
Herba Dendrobii is classified as by Shennong's Herbal has the panacea that " make light of one's life by commiting suicide and prolong life " acts on. After human body enters the middle age, internal cloudy liquid reduces day by day, and skin is aging rapidly. Herba Dendrobii can promote the generation of blood of human body, body fluid, body fluid, nourishes rough skin. Modern pharmacology research confirms: Herba Dendrobii contains various trace elements, and the good health and a long life for human body have close relationship, to the anti-aging effects of human body than general medicine more extensively, more comprehensively.
1.2.10 sleep is improved
The traditional Chinese medical science thinks that the cause of disease of chronic insomnia is that yin and yang imbalance, the deficiency of YIN can not suppress yang hyperactivity fire to move to cause. Herba Dendrobii just has the magical effect of " tonifying five ZANG-organs asthenia ", by YIN nourishing qi-restoratives, fundamentally solves solidity insomnia problem.
1.3 nearly dendrobium officinale
The planting patterns of Herba Dendrobii is varied, has potted plant growth, the plantation of booth seedbed, basswood plantation, attached tree planting etc. Yueqing City Herba Dendrobii association is declaring of specification Herba Dendrobii planting patterns, the planting patterns imitating dendrobium officinale growing environment is referred to as " nearly wild planting ", utilizes the Herba Dendrobii that this planting patterns is planted to become nearly dendrobium officinale.Dendrobium officinale is often grown in, on the overhanging cliff away from signs of human habitation or old trees that reach into the skies, growing in its natural state. Nearly dendrobium officinale alleged by this patent is exactly simulate environment and the growth pattern of dendrobium officinale, planting base selects in the mountain region luxuriant with concentrating residential block (guaranteeing that water quality, air, soil are not contaminated), vegetation away from industrial occupancy or forest land, Herba Dendrobii is directly planted on the live body tree in field, and has passed through GAP (GAP) and organic products certification. Herba Dendrobii planting process in the present invention does not use chemical fertilizer and pesticide, polysaccharide content of dendrobium candidum is up to 39.6% (States Pharmacopoeia specifications polysaccharide content of dendrobium candidum standard is 25%), EN that is rare and that be referred to as " anticancer factor " can also be detected, be the upper product in Herba Dendrobii.
1.4 Radix Panacis Quinquefoliis
Radix Panacis Quinquefolii, is Araliaceae Panax herbaceos perennial, popular name U.S. Radix Ginseng, and Radix Panacis Quinquefolii, Radix Panacis Quinquefolii, east ginseng, main product is at America & Canada, and medicinal effects is dry root. Radix Panacis Quinquefolii is cool in nature, sweet in the mouth, micro-hardship, boosting qi and nourishing yin, clearing away heat and promoting production of body fluid. For deficiency of vital energy yin deficiency, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired of tired, quenches one's thirst, and dry mouth larynx is done. China uses the Radix Panacis Quinquefolii history of existing more than 200 year, and the past is dependence on import always. Since 1975, the ground such as three provinces in the northeast of China of China, Beijing, Hebei, Shandong, Yunnan, Guizhou, Fujian are in succession introduced a fine variety and succeed, in recent years, Radix Panacis Quinquefolii has been carried out substantial amounts of pharmacology and the research of toxicology aspect by domestic and international many scholars, achieves gratifying achievement.
1.4.1 central nervous system function is strengthened
Saponin in Radix Panacis Quinquefolii can effectively strengthen nervus centralis, reach with all worries set aside with fixed attention, the effect such as allaying tiredness, memory reinforcing, be applicable to the symptoms such as insomnia, agitation, hypomnesis and senile dementia.
1.4.2 cardiovascular system is protected
Informal dress Radix Panacis Quinquefolii can arrhythmia, resist myocardial ischemia, anti-cardiac muscle oxidation, strengthening cardiac contractility ability, patients with coronary heart disease Symptoms be deficiency of both QI and YIN, palpitation and short breath can long-term taking Radix Panacis Quinquefolii, significant curative effect. Effect of Radix Panacis Quinquefolii also resides in and can regulate blood pressure, can effectively reduce temporary and persistency blood pressure, contribute to the recovery of the diseases such as hypertension, arrhythmia, coronary heart disease, acute myocardial infarction, cerebral thrombosis.
1.4.3 immunity is improved
Radix Panacis Quinquefolii is as qi-tonifying health-care first-selection medical material, it is possible to promote serum albumin synthesis, bone marrow protein synthesis, organ protein's synthesis etc., improves immunity of organisms, it is suppressed that growth of cancer cells, is effective against cancer.
1.4.4 blood vigor is promoted
The long Radix Panacis Quinquefolii that takes can reduce blood coagulability, suppresses platelet aggregation, atherosclerosis and promote Growth of red blood cells, increases hematochrome.
1.4.5 diabetes are treated
Radix Panacis Quinquefolii can reduce blood glucose, regulates insulin secretion, promote carbohydrate metabolism and lipid metabolism, and treatment diabetes are had certain assosting effect.
1.4.6 strengthening cardiac muscle and enhancing cardiomotility ability
Strong nervus centralis, stable body and mind also sets up, and has calmness and antialcoholism action, hypermnesis ability, Alzheimer has significant effect.
1.4.7 liver is had adjustment effect
The effect enhanced metabolism; Can physical strength reinforcing athlete is had greatly benefit.
1.4.8 anticancer growth, increases immunologic function
1.4.9 encourage digestion, help effect to chronic gastropathy and the intestines and stomach are weak.
1.5 Lepidinm meyenii Walp
Lepidinm meyenii Walp (Maca), have another name called Maca, Peruvianginseng, maka, maca-maca, maino, ayakchichira, ayakwillku etc., originate in the high and cold mountain area of more than South America Peru Andes height above sea level 3500-4500 rice, or two year raw herbaceous plant, formal name used at school Lepidiummeyenii annual for Cruciferae (Cruciferae) Lepidium (Lepidium).Lepidinm meyenii Walp is a kind of rare plateau plant, has integration of edible and medicinal herbs characteristic, in existing more than the 5800 year edible history of Peru, and main its block rhizome (outer image Radix Raphani or turnip) edible. Within 2011, pueraria root powder is approved as new resource food by China's Ministry of Public Health: Lepidinm meyenii Walp contains 50 multiple nutritional components on the one hand, and wherein vegetable protein, aminoacid, polysaccharide, unsaturated fatty acid, mineral potassium, magnesium, zinc equal size enrich; On the other hand Lepidinm meyenii Walp is rich in important biomolecule active substances such as glucosinolate, alkaloid, plant sterol, Maca alkene and macamide, has resisting fatigue, improves immune, anticancer, balance hormone, endocrine regulation, improves sexual function, treatment climacteric syndrome, promotes the multi-efficiencies such as fertility. Therefore, Lepidinm meyenii Walp has the good reputation such as " Peru's Radix Ginseng ", " plant viagra ", regards as Peru's national treasure, uses till today in imperial family of Spain.
1.5.1 fatigue alleviating
Lepidinm meyenii Walp contains abundant aminoacid, mineral zinc, taurine, vitamin B1 and B2, linoleic acid. Aminoacid is the most basic material constituting human body protein, and when human-body fatigue, supplementary Lepidinm meyenii Walp can strengthen body metabolism, has the discharge of interests metabolic waste and the timely conveying of human body energy; Zinc can strengthen antifatigue effect by adjustment neuro-endocrinology hormone level; Taurine promotes human body digesting and assimilating lipid material, strengthens myocardial contraction. Vitamin B1 and B2 maintain the metabolism of human normal; Linoleic acid regulates systema cariovasculare functional, it is ensured that body is metabolic to be smoothed out. Therefore Lepidinm meyenii Walp has resisting fatigue, strengthens muscular endurance, the effect of resisted movement fatigue.
1.5.2 immunity is improved
Lepidinm meyenii Walp can improve T-cellular immunization and make immune system recover normal, can promote the body resistivity to infecting the poison that development gradually is accumulated into.
1.5.3 sexual function is improved
Lepidinm meyenii Walp contains rich in protein, aminoacid, polysaccharide, mineral and exclusive bioactive substance Lepidinm meyenii Walp alkene, macamide. Phenylalanine, tyrosine and histidine are the requisite raw materials of synthesis neurotransmitter, and sexual activity has important regulating and controlling effect; Histidine is the premise material of histamine's synthesis, and the generation of ejaculation is had important regulating and controlling effect by the histamine in spongy body; Histidine and arginine have vasorelaxation action, can increase the blood flowing of sexual organ; Dextrin composition in Lepidinm meyenii Walp also can strengthen erection function. Being called " natural viagra " and " natural big elder sister " by people, can be used for solving the worry of middle-aged and elderly people, man and wife all can take.
1.5.4 fertility is improved
Lepidinm meyenii Walp contains alkaloid, arginine and fructose. Alkaloid stimulates reproductive system to make ovum be multiplied, and sperm produces number and also rolls up; Arginine is the main component of aminoacid composition in sperm, and can improve the mobility of sperm; The motion that fructose is sperm provides power.
1.5.5 anti-altitude acclimatization originality
Lepidinm meyenii Walp contains abundant rhodioloside, butyl alcohol, fat, tannin, flavone etc.; oxygen system can be improved; improve the body usage factor to oxygen and the toleration to anoxia, there is the effect of activating blood circulation to dissipate blood stasis, the free radical metabolism unbalance caused by environment of low oxygen plateau is had adjustment, protective effect. Therefore, it has the several functions such as anoxia enduring, cold resistance, resisting microwave radiation, raising work efficiency.
1.5.6 endocrine regulation system
It Lepidinm meyenii Walp contains alkaloid, sterol, glucosinolate and benzyl isothiocyanate.Alkaloid acts on hypothalamus and hypophysis cerebri, regulates the functions such as adrenal gland, pancreas, testis, reaches balance hormone level. Sterol, glucosinolate and benzyl isothiocyanate endocrine regulation system.
1.5.7 climacteric syndrome is improved
Women after sexual activity normal period, will be attenuated to, through one period of fertility and sexual activity, the process stopped completely in fertility gradually, and this process becomes climacteric. Climacteric syndrome is mainly due to ovarian failure, and sex hormone deficiency causes. At present, treatment climacteric syndrome mainly adopts Hormone Replacement Therapy (HRT), and namely direct supplemented with exogenous estrogen, has a better role to climacteric syndrome, but there is a lot of side effect. Lepidinm meyenii Walp itself is without gonadal hormone, and it acts on hypothalamus and hypophysis cerebri, and regulates the function of adrenal gland and pancreas, the hormone level in balanced body. Therefore, it can alleviate climacteric syndrome.
1.5.8 anemia is treated
Containing higher ferrum element in Lepidinm meyenii Walp, it improves Anemia.
1.5.9 antiviral, tumor
Butyl alcohol in Lepidinm meyenii Walp, polysaccharide, glucosinolate and benzyl isothiocyanate. Virus infected cell is had protective effect by butyl alcohol; Polysaccharide is replicated with process of inhibition to virus; Glucosinolate, benzyl isothiocyanate have antitumaous effect.
1.5.10 effect for reducing blood fat
Linoleic acid in Lepidinm meyenii Walp is combined into ester with cholesterol in vivo, it is easy to by cholesterol transport to extravascular tissue, reduces the deposition of Ink vessel transfusing cholesterol, and promotes cholesterol to be converted into bile acid and discharge. So blood fat can be reduced.
1.6 Poria
Poria is the dry sclerotia of On Polyporaceae Poria Poriacocos (Schw.) Wolf, has effect of eliminating dampness and diuresis, spleen invigorating mind calming. Be usually used in treatment edema oliguria clinically, the disease such as have loose bowels in dizziness due to fluid-retention, insufficiency of the spleen lack of appetite, loose stool, irritability, palpitation with fear insomnia. Poria is classified as top grade by Shennong's Herbal, often uses with other drug matching, and representing prescription has decoction of four noble drugs, WULING SAN, Ramuli Cinnamimi and Poriae Decoction etc. Modern pharmacology research shows, Poria main chemical compositions is polysaccharide and triterpenes components, has the effects such as suppression tumor, antiinflammatory, adjustment immunity.
Summary of the invention
The purpose of the present invention is precisely in order to overcome the deficiency of above-mentioned technology, and formula and the method for making thereof of a kind of nearly wild fresh Herba Dendrobii extractum are provided, apply nearly dendrobium officinale compatibility Lepidinm meyenii Walp, Radix Panacis Quinquefolii, Poria so that it is effect cooperative compensating, enhancing product efficacy, formula is comparatively novel.
It is an object of the invention to complete by following technical solution. The formula of this nearly wild fresh Herba Dendrobii extractum, the weight of its each raw material is as follows: nearly wild fresh Herba Dendrobii 45～55 parts, pueraria root powder 15～20 parts, Radix Panacis Quinquefolii 8～15 parts, 8～15 parts of Poria, oligomeric xylose 6～10 parts.
The method for making of the formula of this nearly wild fresh Herba Dendrobii extractum, fresh extraction: nearly dendrobium officinale is after steaming blue or green sterilizing, carries out superfine grinding with grinder, then carries out 200 order sucking filtration, and filtrate is standby; Extract concentration: Herba Dendrobii filtering residue mixes with the pueraria root powder of formula ratio, Radix Panacis Quinquefolii, Poria and extracts, and extracting solution filtering and concentrating is standby; Fresh for Herba Dendrobii extraction liquid, medical material concentrated solution are put in cream pot processed, heated and stirred infusion, when mastic relative density is concentrated into 1.2～1.3 (65 DEG C), then oligomeric xylose is added wherein, stirring makes it dissolve, and receives cream.
Nearly dendrobium officinale cultivating process is as follows:
(1) source screening, is planted: screening Wild Goose and Reed Marsh Mountains dendrobium officinale is as generation kind source;
(2), group training: culture medium: 1/2～1MS, 15～25% Rhizoma Solani tuber osi Aqueous extracts, 6～10% banana puree; Medium sterilization condition: 121 DEG C, 1.1Mpa; Seed asepsis sprouting condition: temperature 25 ± 1 DEG C, 500～1000Lux illumination 12 hour/day;
(3), differentiation, strong sprout: after cultivating 40 days: add 1.0～3.0mg/LBA, 0.1～0.3mg/LNAA; After cultivating 60 days: add 0.1～0.3mg/LBA, 1.0～3.0mg/LNAA;
(4), transplanting processes: fertilizer: Bombyx mori L. 55%～65%, Cortex Cunninghamiae Lanceolatae 45%～55% heap, cover film, natural fermentation 90 days; Booth: temperature 25 ± 3 DEG C, humidity 40%～75%, light application time 8～12 hours; Seedbed: lay fertilizer, thickness 10～20cm; By bottle transplantation of seedlings to taming seedbed, set 5～10min/h automatic watering function;
(5) tree that, lives selects: the jujube tree of diameter 20～40cm or pear tree 100～150/mu;
(6), pluck: the growth selection plant of more than 3 years.
Fresh extraction specifically comprises the following steps that
(1), cleaning: after nearly dendrobium officinale is plucked, defoliation, purified water 1:20～30 rinse 30～60min, then rinse 3 times by purified water;
(2), sterilizing: clean Herba Dendrobii is put in steaming machine, with the steam sterilization 5～10min of 95～105 DEG C, cooling;
(3), cutting: the Herba Dendrobii that sterilizing is good is cut into the segment of 0.5～1.5cm;
(4), grind: Herba Dendrobii section is put in grinder, add purified water by 1:8～12, grind to form the fresh juice that fineness is 250～300 μm;
(5), filter: the fresh juice of Herba Dendrobii after grinding carries out vacuum filtration, respectively coarse filtration and fine straining, and coarse filtration medium is the nylon gauze of 80～100, and fine straining medium is 200 order nylon gauzes, and filtrate is standby, and filtering residue forwards abstraction process to.
Extract concentration and specifically comprise the following steps that pueraria root powder, Radix Panacis Quinquefolii, Poria and Herba Dendrobii filtering residue united extraction: 10～12 times of water, with the gross weight gauge of pueraria root powder, Radix Panacis Quinquefolii and Poria; Boiling extraction 3 times, each 2h, extracting solution crosses 200 eye mesh screens, and it is 1.1～1.2 that merging filtrate is evaporated to relative density.
The invention have the benefit that the present invention is with nearly dendrobium officinale, Lepidinm meyenii Walp, Radix Panacis Quinquefolii, Poria for primary raw material, Herba Dendrobii Yin-nourishing and body fluid promoting, tonifying five ZANG-organs asthenia, for monarch; Lepidinm meyenii Walp fatigue alleviating, strengthens physique, and has tonifying YANG effect, Radix Panacis Quinquefolii boosting qi and nourishing yin, clearing away heat and promoting production of body fluid, for minister, can help Herba Dendrobii YIN nourishing and YANG strengthening, tonifying both YIN and YANG; It is aided with Poria diuretic spleen invigorating, again the performance of power-assisted Herba Dendrobii effect. We utilize the special efficacy of each component, reach YIN nourishing and YANG strengthening, strengthen immunity, fatigue alleviating, slow down aging, endocrine regulation and improve the multi-efficiencies such as cardiovascular function, are especially suitable for health care and the health preserving of sub-health population.
At process aspect, the present invention applies the compositions such as the polysaccharide in " fresh extraction " technology dendrobium officinale nearly, mannose, vitamin, EN, aminoacid and chlorophyll and fully extracts, and is greatly improved the value of rare medicinal herbs Herba Dendrobii; Secondly as directly process with fresh Herba Dendrobii, the provinces and regions cost of Herba Dendrobii dry run, it also avoid Herba Dendrobii and cause the risk of nutrient loss because baking temperature is too high; Again, application " fresh extraction " technique can make product retain the color and luster of fresh Herba Dendrobii, abnormal smells from the patient and mouthfeel, more can embody the natural value of product.Boiling technique in conjunction with Chinese medicine unguentum, the drug effect giving full play of each component is worth. The present invention all has a clear superiority in from aspects such as the selection of raw material, prescription compatibility, processing technique than market like product, has good market prospect.
Accompanying drawing explanation
Fig. 1 is nearly dendrobium officinale cultivating technique flow chart;
Fig. 2 is the fresh extraction process chart of nearly dendrobium officinale;
Fig. 3 is extraction concentration technique flow chart;
Fig. 4 is nearly wild fresh Herba Dendrobii extractum preparation technology flow chart.
Wherein, in Fig. 1: 1* sterilising conditions, sterilization effect control; 2* culture medium and condition of tissue culture control; 3* differentiation condition controls; 4* condition in strong sprout controls; 5* fertilizer substrate, greenhouse-environment control; 6* Tree Species Selection, Planting pattern, disease pest defense controls; 7* plucks the time limit, the picking season controls.
In Fig. 2: 1* sterilising temp, time control; 2* grinds amount of water, fineness controls; 3* filtering accuracy controls.
In Fig. 3: 1* amount of water, extraction time, extraction time control; 2* thickening temperature, feed liquid relative density control.
In Fig. 4: 1 boils process temperature control, mastic is micro-to boil, and stirring is fully; Density domination during 2 receipts cream is accurate, it is ensured that oligomeric xylose dissolves fully.
Detailed description of the invention
Below by detailed description of the invention, the present invention is further elaborated, and embodiment will facilitate a better understanding of the present invention, but the present invention is not limited only to following embodiment.
The content that the present invention relates to includes the cultivation of Herba Dendrobii raw material, formula for a product and preparation technology, and every advantage is as follows:
1 nearly dendrobium officinale source advantage
Market majority Herba Dendrobii derives from greenhouse gardening, and uses chemical fertilizer and pesticide, even auxin in planting process, makes the safety of Herba Dendrobii can not get ensureing. The nearly dendrobium officinale that the present invention uses is by GAP and organic products certification, and polysaccharide content of dendrobium candidum, up to 39.6%, exceeds standards of pharmacopoeia 58.4%, also detected EN (content is 14.2mg/100g), and by organic products certification; Therefore no matter the nearly dendrobium officinale that the present invention applies is quality or safety, is above like product.
Nearly dendrobium officinale cultivates the basis that link is the present invention, and its process includes germplasm screening, group training, differentiation, strong sprout, live tree cultivation, harvesting etc., is specifically shown in table one.
The nearly dendrobium officinale cultivating process of table one and key parameter thereof
2 formula advantage
Inventive formulation is Herba Dendrobii, pueraria root powder, Radix Panacis Quinquefolii, Poria, Carcinia mangostana L. powder, oligomeric xylose, market like product mostly is the combinations such as Herba Dendrobii, Radix Panacis Quinquefolii, glucose or white sugar, the present invention has obvious differentiation, it is also adaptable for diabetes patient to take simultaneously, has better market prospect.
Each component ratio refers to table two.
The nearly wild fresh Herba Dendrobii extractum formula of table two and proportioning thereof
3 process advantages
" fresh extraction " technique of present invention application is that nearly dendrobium officinale, after steaming blue or green sterilizing (utilizing steaming machine to carry out 5～10min steam sterilization), carries out superfine grinding with grinder, then carries out 200 order sucking filtration, and filtrate is standby. Herba Dendrobii filtering residue mixes with the pueraria root powder of formula ratio, Radix Panacis Quinquefolii, Poria and extracts, and extracting solution filtering and concentrating is standby. Fresh for Herba Dendrobii extraction liquid, medical material concentrated solution are put in cream pot processed, heated and stirred infusion, when mastic relative density is concentrated into 1.2～1.3 (65 DEG C), then oligomeric xylose is added wherein, stirring makes it dissolve, and receives cream.The advantage of this technique is: 1. Dendrobium officinale polysaccharide extracts conversion ratio (actual extracting amount and theoretical content ratio) up to more than 90%, and traditional direct water boiling and extraction conversion ratio is only 60%～70%; 2. the nutritional labeling of Herba Dendrobii at utmost retains, and Vitamin C content is that 85mg/100g (being 28 times of traditional decoction extraction process), chlorophyll content 65mg/100g (chlorophyll of traditional decoction technique is almost all destroyed), protein content also can reach for 9.3% (being about 1.5～1.8 times of traditional decoction extraction process); 3. applying traditional extractum and boil technique, make each component fully merge, drug effect is supplemented mutually, and extractum has the nourishing effects that other dosage forms are all incomparable.
Present invention process process includes the fresh extraction of nearly dendrobium officinale, medicinal material extract concentrates, boil, receive cream, subpackage, packaging, concrete technology and parameter such as table three.
The nearly wild fresh Herba Dendrobii extractum preparation technology of table three and parameter thereof
(1) nearly dendrobium officinale is cultivated
1 kind of source screening
Wild Goose and Reed Marsh Mountains is the cradle of Herba Dendrobii, " Bencao Congxin " place of production of Herba Dendrobii is also had clear and definite record " Wenzhou is gone up most, takes second place in Guangxi; Guangdong under ", it is domestic that Wild Goose and Reed Marsh Mountains is seated in Wenzhou, is the main producing region of Herba Dendrobii, and its quality receives the high praise of ancient Chinese medicine doctor. Leqing is located in the foot of a hill or mountain, Wild Goose and Reed Marsh Mountains, and local villager excavates Herba Dendrobii centuries history, for the benefit of preservation of Herba Dendrobii, and they are also baked to, and are curled into spring-like, through being handed down from age to age and improving, is also the formation of the Herba Dendrobii in modern times! Produce and be called " genuine medicinal materials " in Herba Dendrobii here or Herba Dendrobii are by industry. The present invention follows the feature of Chinese crude drug Genuine producing area, the wild varieties planting selection Wild Goose and Reed Marsh Mountains, source of Herba Dendrobii.
2 groups of trainings
The growth of Herba Dendrobii is limited mainly by the impact of the factor such as illumination and temperature, is under periodicity of illumination at 12h/d, and now the chlorophyll content of plant and Net Photosynthetic Rate are higher, and growth is stronger with fertility. Select 1/2～1MS, 15～25% Rhizoma Solani tuber osi Aqueous extracts, 6～10% banana puree as culture medium, and 121 DEG C, culture medium is carried out sterilizing under the sterilising conditions of 1.1Mpa.
Select kind of a stem for source Herba Dendrobii, defoliation, Herba Dendrobii stem is carried out surface sterilization with the ethanol of 75% by aseptic operating platform, removes dust then the HgCl with 1%2Sterilizing 5～10min, with aseptic water washing three times, so repeats 3 sterilizings, constantly to rock in sterilization process so that it is fully sterilizing.
By sterilized Radix Stephaniae Tetrandrae stem, being aseptically cut into the stem section with a stipes, be inoculated in inducing culture, temperature 25 ± 1 DEG C, 500～2000Lux illumination 12h/ day, induction is sprouted, and bud induces protocorm again.
3 differentiation, strong sprout
After cultivating 40～43 days, add 1.0～3.0mg/LBA, 0.1～0.3mg/LNAA, after cultivating 58～62 days, add 0.1～0.3mg/LBA, 1.0～3.0mg/LNAA, make protocorm differentiation, strong sprout, just high 5～9cm, 7～9, blade, the healthy and strong plant of root length 3～6cm can be turned out through about time a year and a half.
4 transplant
Owing to the primary growth condition such as temperature and illumination changes, need before transplanting through 1 week seedling exercising. Avoid during transplanting injuring tender tissue, clean the culture medium being attached to root, load kind is on seedbed, fertilizer (Bombyx mori L. 55%～65%, Cortex Cunninghamiae Lanceolatae 45%～55% heap are laid in seedbed, cover film, natural fermentation 90 days, sterilizing), fertilizer to loosen ventilative, laying depth 10～20cm.During transplanting, optimum temperature is 15～30 DEG C, temperature too low or too high be all not suitable for bottle outlet transplant. Greenhouse temperature 25 ± 3 DEG C, humidity 40%～75%, light application time transplant successful Herba Dendrobii in 8～12 hours, water in right amount after 1 week.
5 live sets cultivation
As it was previously stated, the Genuine producing area of Herba Dendrobii is positioned at Wild Goose and Reed Marsh Mountains, also build in the foot of a hill or mountain, Wild Goose and Reed Marsh Mountains for the planting base of Herba Dendrobii in this present invention. After booth seedbed grows 50～70 days, Herba Dendrobii length about 10～15cm, now can transplant to living on tree. The symbiosis of Herba Dendrobii and tree has certain selectivity, its root belongs to aerial root, easily it is attached to the surface of tree, therefore the growth of Herba Dendrobii is had important impact by the moisture of bark and texture thereof, according to experimentation, the present invention selects jujube tree and pear tree as cultivation seeds, trunk diameter 20～40cm jujube tree 100～150/mu, and cultivated areas illumination is fully (light application time 8～12h/ days).
Cultivation: during transplanting, optimum temperature is 15～30 DEG C. Herba Dendrobii is extracted from seedbed, without removing root substrate, directly wrap up root with lichen, then with Caulis et Folium Oryzae rope, the root position of Herba Dendrobii is tied on trunk or thick (diameter >=5cm) branch, minimum altitude 50cm, every 30～40cm plantation one circle. The position that automatic irrigation water pipe is pressed Seedling disposes shower nozzle, and pastes paper and biological insect-catching equipment in tree planting district suspension of living, and pastes paper 3～5/square, biological insect-catching equipment 2～3/10 meters. Automatic spray irrigation system opens auto spraying function, summertime 10～20min/h, winter 5～10min/h in the non-rainy day.
6 pluck
Dendrobium officinale polysaccharide is the significant composition of Herba Dendrobii, shows after deliberation, and the content of Dendrobium officinale polysaccharide is relatively larger by growth year and seasonal effect, is specifically shown in table four.
Table four Dendrobium officinale polysaccharide growth year and seasonal variations (%)
As seen from the above table, the optimal harvest time of Herba Dendrobii is 3～May after growing 3 years, the florescence of Herba Dendrobii is generally for 5～June, feature according to biological heredity, the change of polysaccharide content of dendrobium candidum is limited mainly by the impact bloomed, therefore January after it is generally acknowledged Herba Dendrobii rational 3 years collection period, February, March, April, May and December.
(2) fresh extraction technique and parameter
After nearly dendrobium officinale is plucked, defoliation, purified water 1:20～30 rinse 30～60min, rinse 3 times by purified water again, put in steaming machine, with the steam sterilization 5～10min of 95～105 DEG C, cooling, it is cut into the segment of 0.5～1.5cm, placing in grinder, regulating fineness of grind is 250～350 μm, adds cryogenic purincation water (2～8 DEG C) by 1:10～20, open grinder, Herba Dendrobii is ground to form fresh juice.
The fresh juice of Herba Dendrobii after grinding carries out vacuum filtration, first carries out coarse filtration, and coarse filtration medium is the nylon gauze of 80～100; Coarse filtration liquid carries out fine straining again, and fine straining medium is 200 order nylon gauzes. Filtrate is standby, and coarse filtration slag merges with fine straining slag and forwards abstraction process to.
(3) extraction concentration technique and parameter
Weigh the pueraria root powder of formula ratio, Radix Panacis Quinquefolii (section) and Poria (dicing), insert in pot for boiling chinese traditional medicine, again Herba Dendrobii slag one piece is put in decoction pot, by the total weight of pueraria root powder, Radix Panacis Quinquefolii and Poria, adding 10～12 times of purified water, heated and boiled is extracted 3 times, each 2h, each extracting solution filters with 200 eye mesh screens, and it is 1.1～1.2 that merging filtrate is evaporated to relative density, standby.
(4) receipts cream is boiled
Boil: fresh for Herba Dendrobii extraction liquid, medical material concentrated solution are put in extractum boiler, open stirring paddle heated and boiled, start to boil concentration;
Receive cream: when paste density reaches 1.2～1.3 (65 DEG C), add the oligomeric xylose of formula ratio, continue to be stirred to dissolve, receive cream.
(5) filtering technique and parameter
Mastic is filtered while hot, and sieves mesh number is 100 orders.
(6) subpackage
Loading amount specification according to setting carries out subpackage.
(7) technology of the package
Packing specification according to setting is packed.
Finally it is pointed out that above example is only the more representational example of the present invention. Obviously, technical scheme is not limited to examples detailed above, it is also possible to have many deformation, all deformation that those of ordinary skill in the art can directly derive from present disclosure or associate, and is all considered as protection scope of the present invention.
Claims (5)
1. the formula of a nearly wild fresh Herba Dendrobii extractum, it is characterised in that: the weight of its each raw material is as follows: nearly wild fresh Herba Dendrobii 45～55 parts, pueraria root powder 15～20 parts, Radix Panacis Quinquefolii 8～15 parts, 8～15 parts of Poria, oligomeric xylose 6～10 parts.
2. the method for making of the formula of a nearly wild fresh Herba Dendrobii extractum, it is characterised in that: fresh extraction: nearly dendrobium officinale is after steaming blue or green sterilizing, carries out superfine grinding with grinder, then carries out 200 order sucking filtration, and filtrate is standby; Extract concentration: Herba Dendrobii filtering residue mixes with the pueraria root powder of formula ratio, Radix Panacis Quinquefolii, Poria and extracts, and extracting solution filtering and concentrating is standby; Fresh for Herba Dendrobii extraction liquid, medical material concentrated solution are put in cream pot processed, heated and stirred infusion, when mastic relative density is concentrated into 1.2～1.3 (65 DEG C), then oligomeric xylose is added wherein, stirring makes it dissolve, and receives cream.
3. the method for making of the formula of nearly wild fresh Herba Dendrobii extractum according to claim 2, it is characterised in that: nearly dendrobium officinale cultivating process is as follows:
(1) source screening, is planted: screening Wild Goose and Reed Marsh Mountains dendrobium officinale is as generation kind source;
(2), group training: culture medium: 1/2～1MS, 15～25% Rhizoma Solani tuber osi Aqueous extracts, 6～10% banana puree; Medium sterilization condition: 121 DEG C, 1.1Mpa; Seed asepsis sprouting condition: temperature 25 ± 1 DEG C, 500～1000Lux illumination 12 hour/day;
(3), differentiation, strong sprout: after cultivating 40 days: add 1.0～3.0mg/LBA, 0.1～0.3mg/LNAA; After cultivating 60 days: add 0.1～0.3mg/LBA, 1.0～3.0mg/LNAA;
(4), transplanting processes: fertilizer: Bombyx mori L. 55%～65%, Cortex Cunninghamiae Lanceolatae 45%～55% heap, cover film, natural fermentation 90 days; Booth: temperature 25 ± 3 DEG C, humidity 40%～75%, light application time 8～12 hours; Seedbed: lay fertilizer, thickness 10～20cm; By bottle transplantation of seedlings to taming seedbed, set 5～10min/h automatic watering function;
(5) tree that, lives selects: the jujube tree of diameter 20～40cm or pear tree 100～150/mu;
(6), pluck: the growth selection plant of more than 3 years.
4. the method for making of the formula of nearly wild fresh Herba Dendrobii extractum according to claim 2, it is characterised in that: fresh extraction specifically comprises the following steps that
(1), cleaning: after nearly dendrobium officinale is plucked, defoliation, purified water 1:20～30 rinse 30～60min, then rinse 3 times by purified water;
(2), sterilizing: clean Herba Dendrobii is put in steaming machine, with the steam sterilization 5～10min of 95～105 DEG C, cooling;
(3), cutting: the Herba Dendrobii that sterilizing is good is cut into the segment of 0.5～1.5cm;
(4), grind: Herba Dendrobii section is put in grinder, add purified water by 1:8～12, grind to form the fresh juice that fineness is 250～300 μm;
(5), filter: the fresh juice of Herba Dendrobii after grinding carries out vacuum filtration, respectively coarse filtration and fine straining, and coarse filtration medium is the nylon gauze of 80～100, and fine straining medium is 200 order nylon gauzes, and filtrate is standby, and filtering residue forwards abstraction process to.
5. the method for making of the formula of nearly wild fresh Herba Dendrobii extractum according to claim 2, it is characterized in that: extract concentration and specifically comprise the following steps that pueraria root powder, Radix Panacis Quinquefolii, Poria and Herba Dendrobii filtering residue united extraction: 10～12 times of water, with the gross weight gauge of pueraria root powder, Radix Panacis Quinquefolii and Poria; Boiling extraction 3 times, each 2h, extracting solution crosses 200 eye mesh screens, and it is 1.1～1.2 that merging filtrate is evaporated to relative density.
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| CN108185398A (en) * | 2018-02-06 | 2018-06-22 | 霍山县天下泽雨生物科技发展有限公司 | A kind of stem of noble dendrobium sauce production method |
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| CN103314858A (en) * | 2013-07-08 | 2013-09-25 | 重庆市秀山红星中药材开发有限公司 | Seed tissue culture propagation method of dendrobium candidum |
| CN104095231A (en) * | 2014-06-20 | 2014-10-15 | 云南省药物研究所 | Health-care product containing mair conditioning unita, dendrobium and American ginseng and preparation method thereof |
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