CN105663171B - 用于口服递送的活细胞制剂 - Google Patents
用于口服递送的活细胞制剂 Download PDFInfo
- Publication number
- CN105663171B CN105663171B CN201610034562.7A CN201610034562A CN105663171B CN 105663171 B CN105663171 B CN 105663171B CN 201610034562 A CN201610034562 A CN 201610034562A CN 105663171 B CN105663171 B CN 105663171B
- Authority
- CN
- China
- Prior art keywords
- cells
- dried
- bile
- cholestyramine
- capsule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (14)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0900350.0A GB0900350D0 (en) | 2009-01-09 | 2009-01-09 | Formulations of viable bacteria for oral delivery |
GB0900350.0 | 2009-01-09 | ||
CN2010800104104A CN102341100A (zh) | 2009-01-09 | 2010-01-11 | 用于口服递送的活细胞制剂 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2010800104104A Division CN102341100A (zh) | 2009-01-09 | 2010-01-11 | 用于口服递送的活细胞制剂 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105663171A CN105663171A (zh) | 2016-06-15 |
CN105663171B true CN105663171B (zh) | 2020-09-22 |
Family
ID=40379384
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2010800104104A Pending CN102341100A (zh) | 2009-01-09 | 2010-01-11 | 用于口服递送的活细胞制剂 |
CN201610034562.7A Active CN105663171B (zh) | 2009-01-09 | 2010-01-11 | 用于口服递送的活细胞制剂 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2010800104104A Pending CN102341100A (zh) | 2009-01-09 | 2010-01-11 | 用于口服递送的活细胞制剂 |
Country Status (13)
Country | Link |
---|---|
US (1) | US10016467B2 (zh) |
EP (1) | EP2384190B1 (zh) |
JP (1) | JP5779762B2 (zh) |
CN (2) | CN102341100A (zh) |
AU (1) | AU2010204159B2 (zh) |
DK (1) | DK2384190T3 (zh) |
ES (1) | ES2640979T3 (zh) |
GB (1) | GB0900350D0 (zh) |
HK (1) | HK1220134A1 (zh) |
HU (1) | HUE034713T2 (zh) |
PL (1) | PL2384190T3 (zh) |
PT (1) | PT2384190T (zh) |
WO (1) | WO2010079343A2 (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6724379B2 (ja) * | 2016-01-20 | 2020-07-15 | 住友ゴム工業株式会社 | 空気入りタイヤ |
US10869840B2 (en) * | 2016-03-09 | 2020-12-22 | Incube Labs, Llc | Methods and articles for delivering viable cells into solid tissue |
WO2019148278A1 (en) * | 2018-01-30 | 2019-08-08 | Pharmascience Inc. | Cholestyramine formulations and methods of use |
WO2020092421A1 (en) * | 2018-10-30 | 2020-05-07 | Ranas, Llc | Oral delivery of therapeutic mammalian cells |
US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
EP4124342A1 (en) | 2021-07-28 | 2023-02-01 | Prokarium Limited | Cancer therapy with live attenuated bacteria |
CA3238816A1 (en) | 2021-12-09 | 2023-06-15 | Prokarium Limited | Combination cancer therapy |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1060110A (zh) * | 1990-09-05 | 1992-04-08 | 保宁新药株式会社 | 制备口服用活伤寒疫苗的培养方法 |
CN1348384A (zh) * | 1999-04-19 | 2002-05-08 | 阿斯特拉曾尼卡有限公司 | 一种回肠给药的含有回肠胆汁酸转运抑制剂化合物的口服制剂 |
CN1357037A (zh) * | 1999-06-22 | 2002-07-03 | 埃里克·爱德华·沃勒尔 | 生物活性材料的保存方法 |
CN1444495A (zh) * | 2000-07-28 | 2003-09-24 | 霍夫曼-拉罗奇有限公司 | 新型药物组合物 |
JP2004250338A (ja) * | 2003-02-18 | 2004-09-09 | Sunstar Inc | 有用生菌製剤 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2811492A (en) * | 1953-06-04 | 1957-10-29 | R J Strasenburgh Company | Polyamine sulfonic acid type adsorption compound |
US3072528A (en) * | 1957-07-13 | 1963-01-08 | Med Fabrik Chemisch Pharmazeut | Ingestible dry microorganism preparations |
BE580490A (fr) | 1958-07-15 | 1960-01-08 | Merck & Co Inc | Compositions et procédés pour abaisser la teneur en cholestérol du sang |
US3308020A (en) | 1961-09-22 | 1967-03-07 | Merck & Co Inc | Compositions and method for binding bile acids in vivo including hypocholesteremics |
US3383281A (en) * | 1961-09-22 | 1968-05-14 | Merck & Co Inc | Method for binding bile acids in vivo |
US3499960A (en) | 1965-01-25 | 1970-03-10 | Merck & Co Inc | Palatable coated particles of an anion exchange resin |
NL7017227A (zh) | 1969-12-27 | 1971-06-29 | ||
DE3272059D1 (en) | 1982-01-18 | 1986-08-28 | Mitsubishi Petrochemical Co | Cholesterol lowering drug |
US5482718A (en) * | 1994-03-23 | 1996-01-09 | Hoffmann-La Roche Inc. | Colon-targeted delivery system |
JP3098401B2 (ja) * | 1995-07-12 | 2000-10-16 | 株式会社エルティーティー研究所 | 経鼻投与用製剤 |
CZ126996A3 (en) * | 1996-05-02 | 1997-11-12 | Josef Palicka | Tablet of vegetables with nutrient and supporting effects on human organism |
US6468782B1 (en) | 1996-12-05 | 2002-10-22 | Quadrant Healthcare (Uk) Limited | Methods of preserving prokaryotic cells and compositions obtained thereby |
ES2258841T3 (es) * | 1998-04-01 | 2006-09-01 | Ganeden Biotech, Inc. | Procedimientos para reducir el colesterol con esporas de bacillus coagulans, sistemas y composiciones asociados. |
US6811786B1 (en) * | 1999-04-01 | 2004-11-02 | Ganeden Biotech, Inc. | Methods for reducing cholesterol using Bacillus coagulans spores, systems and compositions |
US6610531B1 (en) | 1998-09-24 | 2003-08-26 | The United States Of America As Represented By The Secretary Of The Navy | Viable dried bacteria produced by drying in the presence of trehalose and divalent cation |
JP3363438B2 (ja) | 2000-05-02 | 2003-01-08 | ビオフェルミン製薬株式会社 | 噴霧乾燥による菌体乾燥物 |
JPWO2003013559A1 (ja) * | 2001-08-10 | 2004-11-25 | 北海道ティー・エル・オー株式会社 | 胆汁酸吸収、吸着剤 |
JP3621958B2 (ja) * | 2002-02-08 | 2005-02-23 | 株式会社アンデルセン・パン生活文化研究所 | 胆汁酸を結合する、加熱殺菌処理された乳酸菌菌体およびその乳酸菌菌体を含有する食品素材・食品 |
US7939061B2 (en) | 2003-02-28 | 2011-05-10 | Micropharma Limited | Cell and enzyme compositions for modulating bile acids, cholesterol and triglycerides |
GB0321228D0 (en) | 2003-09-10 | 2003-10-08 | Inpharmatica Ltd | Modulating cell activity |
ES2470340T3 (es) | 2005-12-28 | 2014-06-23 | Advanced Bionutrition Corporation | Vehículo de administración para bacterias probi�ticas que comprende una matriz seca de polisac�ridos, sac�ridos y polioles en forma vítrea |
WO2007112747A1 (en) * | 2006-03-31 | 2007-10-11 | Curalogic A/S | Immunogen combinations |
WO2007140613A1 (en) | 2006-06-06 | 2007-12-13 | Mcgill University | Fermented milk product and use thereof |
US20080124355A1 (en) * | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
EP2133092B1 (en) * | 2007-03-19 | 2015-12-09 | Morishita Jintan Co., Ltd. | Oral vaccine |
WO2011026111A1 (en) * | 2009-08-31 | 2011-03-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Oral delivery of a vaccine to the large intestine to induce mucosal immunity |
-
2009
- 2009-01-09 GB GBGB0900350.0A patent/GB0900350D0/en not_active Ceased
-
2010
- 2010-01-11 ES ES10700756.9T patent/ES2640979T3/es active Active
- 2010-01-11 DK DK10700756.9T patent/DK2384190T3/en active
- 2010-01-11 HU HUE10700756A patent/HUE034713T2/en unknown
- 2010-01-11 JP JP2011544921A patent/JP5779762B2/ja active Active
- 2010-01-11 PL PL10700756T patent/PL2384190T3/pl unknown
- 2010-01-11 CN CN2010800104104A patent/CN102341100A/zh active Pending
- 2010-01-11 CN CN201610034562.7A patent/CN105663171B/zh active Active
- 2010-01-11 AU AU2010204159A patent/AU2010204159B2/en active Active
- 2010-01-11 EP EP10700756.9A patent/EP2384190B1/en active Active
- 2010-01-11 WO PCT/GB2010/000035 patent/WO2010079343A2/en active Application Filing
- 2010-01-11 PT PT107007569T patent/PT2384190T/pt unknown
- 2010-01-11 US US13/143,829 patent/US10016467B2/en active Active
-
2016
- 2016-07-14 HK HK16108256.4A patent/HK1220134A1/zh unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1060110A (zh) * | 1990-09-05 | 1992-04-08 | 保宁新药株式会社 | 制备口服用活伤寒疫苗的培养方法 |
CN1348384A (zh) * | 1999-04-19 | 2002-05-08 | 阿斯特拉曾尼卡有限公司 | 一种回肠给药的含有回肠胆汁酸转运抑制剂化合物的口服制剂 |
CN1357037A (zh) * | 1999-06-22 | 2002-07-03 | 埃里克·爱德华·沃勒尔 | 生物活性材料的保存方法 |
CN1444495A (zh) * | 2000-07-28 | 2003-09-24 | 霍夫曼-拉罗奇有限公司 | 新型药物组合物 |
JP2004250338A (ja) * | 2003-02-18 | 2004-09-09 | Sunstar Inc | 有用生菌製剤 |
Non-Patent Citations (1)
Title |
---|
Formulation of a live bacterial vaccine for stable room temperature storage results in loss of acid, bile and bile salt resistance;Alexander D.Edwards et al.;《Vaccine》;20081023;第26卷(第45期);第5675-5678页,尤其是第5675页第1栏第1段、第5676页第1栏第1段至第2栏第1段、第5677页第1栏第1段 * |
Also Published As
Publication number | Publication date |
---|---|
PT2384190T (pt) | 2017-10-03 |
CN105663171A (zh) | 2016-06-15 |
HUE034713T2 (en) | 2018-02-28 |
HK1220134A1 (zh) | 2017-04-28 |
PL2384190T3 (pl) | 2018-01-31 |
AU2010204159B2 (en) | 2015-09-03 |
DK2384190T3 (en) | 2017-10-16 |
EP2384190B1 (en) | 2017-07-26 |
JP5779762B2 (ja) | 2015-09-16 |
US10016467B2 (en) | 2018-07-10 |
WO2010079343A2 (en) | 2010-07-15 |
EP2384190A2 (en) | 2011-11-09 |
ES2640979T3 (es) | 2017-11-07 |
GB0900350D0 (en) | 2009-02-11 |
JP2012514629A (ja) | 2012-06-28 |
CN102341100A (zh) | 2012-02-01 |
WO2010079343A3 (en) | 2010-09-02 |
US20120027811A1 (en) | 2012-02-02 |
AU2010204159A1 (en) | 2011-09-01 |
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REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1220134 Country of ref document: HK |
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Address after: British county Applicant after: CAMBRIDGE ENTERPRISE Ltd. Applicant after: Kebuer biologics Holdings Ltd. Address before: British county Applicant before: CAMBRIDGE ENTERPRISE Ltd. Applicant before: RECIPHARMCOBRA HOLDINGS Ltd. |
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Effective date of registration: 20200821 Address after: British county Applicant after: CAMBRIDGE ENTERPRISE Ltd. Applicant after: Procarrim Ltd. Address before: British county Applicant before: CAMBRIDGE ENTERPRISE Ltd. Applicant before: Kebuer biologics Holdings Ltd. |
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