CN105662965B - A kind of nanometer anti-acne lotion containing nano-particle and preparation method thereof - Google Patents
A kind of nanometer anti-acne lotion containing nano-particle and preparation method thereof Download PDFInfo
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Abstract
The present invention provides a kind of nanometer anti-acne lotion containing nano-particle and preparation method thereof, and concrete operation step is：(1) after ginseng and matrimony vine being shone dry grinding respectively, immerse in deionized water and be ultrasonically treated 30 45min, be placed in boiling 60min in pressure cooker, filter, respectively obtain the extract of ginseng supernatant and matrimony vine containing ginsengenin；(2) the ginseng supernatant containing ginsengenin is placed in 2 3h of heating hydrolysis in the mixed solution of tartaric acid and water, obtains the ginseng extract containing protopanaxatriol；(3) by weight, the extract of 35 parts of ginseng extract and 58 parts of matrimony vine is uniformly mixed to obtain plant compounding extract, 24 parts of nano silver, 13 parts of bamboo charcoal nano, 10 20 parts of emulsifying agent, 15 25 parts of grease and 50 70 parts of solvent will be added in 57 parts of plant compounding extract, the nanometer anti-acne lotion containing nano-particle is obtained after constant temperature high-speed stirred.
Description
Technical field：
The invention belongs to amenities technical field, and in particular to a kind of nanometer anti-acne lotion and its system containing nano-particle
Preparation Method.
Background technology：
Nanometer technology is that manipulation atom and molecule are processed material in the scale in 0.1-100nm spaces, makes product
One of technology with feature and function, research hotspot of the nanometer technology as forefront, infiltrates through industry-by-industry and field.
Acne, also referred to as small pox, are a kind of chronic inflammation of pilosebaceous follicle, the generation of acne and sebum secretion, hair follicle
Sebaceous gland duct angle is excessively and the infection of acne bacillus formicicum is related.Anti-acne is comprehensive process, it is necessary to adjust fat secretion, is changed
It is apt to skin keratin process, it is necessary to penetrate into below cuticula, suppresses the activity of Propiobacterium, and anti-inflammatory, promotes being cured for scar
Close.Acne seriously affects beautiful and life, therefore the daily maintenance of skin be unable to do without product for resolving poxes.In traditional product for resolving poxes
Anti-acne active ingredient is mostly tretinoin medicines, but such material is of limited application there are larger irritation.
Nanoemulsions are the alternating dispersions that a liquid-like phase is scattered in the second phase with drops, and grain size is in 10-
Between 200nm, system is homogeneous, is not in precipitation or floccule.Anti-acne nanoemulsions based on nanometer technology generation are
There is more report.A kind of compound anti-acne lipid nanometer disclosed in Chinese patent CN 102784085B (publication date 2012.11.21)
Grain lotion and preparation method thereof, prepares liquid oil phase, with steaming by Mihoization Vitex negundo var cannabifolia extract, Gotu Kola P.E, tetrahydrochysene pipering
Distilled water obtains compound anti-acne lipid nanoparticle emulsion several times through high pressure homogenizer circulation homogeneous.Chinese patent CN
The answering in anti-acne and treatment skin disease of gingko extract nanometer liposome disclosed in 103751231A (publication date 2014.4.30)
With the ginkgo biloba extract mentioned from the positions such as the leaf of ginkgo, fruit, exosper, rhizome is using thin-film ultrasonic, high-pressure homogeneous method
Preparation forms nano liposomes.Plant nanometer breast nti-freckle disclosed in Chinese patent CN 104606125A (publication date 2015.5.13)
Cosmetic cream, by scouring rush's safflower quickly eliminating stain, honeysuckle Cypress ethereal oil mite killing removing acne and freckle, girl's agate vitamin nti-freckle, radix scutellariae Angelica sinensis
Anti-ageing wrinkle resistant nti-freckle, Semen Coicis indigo naturalis desinsection willow bacterium nti-freckle, aloe PORIA ALBA anti-acne scar eliminating nti-freckle, lucid asparagus ginkgo leaf are dispelled color spot
The nanometer emulsified spot cosmetic cream composition of chloasma.From the above-mentioned prior art, the anti-acne nanoemulsions used at present are all to plant
Active ingredient in thing carries out whose phase is nanometer pulverization be made, then is mixed with oil phase, obtains nti-freckle nanoemulsions.The system of this method
Emulsion particle is only existed in the emulsion system of standby nanoemulsions, it is not good enough in the stability of dilution and temperature change these two aspects,
Technology is also immature, can't apply in daily skin care item.
Studies have found that the cuticula that a small amount of nano silver can infiltrate through skin mitigates local inflammation, promote skin
Healing because nano silver have the function that broad-spectrum antiseptic, promotion epithelium regeneration, diminish inflammation, nano silver blemish clearing gel by
Confirm that anti-acne effect is obvious, and have no adverse reaction.Therefore the present invention is using stable nano particle and natural plant extracts phase
With reference to the nanometer anti-acne skin care item for preparing stabilization.
The content of the invention：
The technical problem to be solved in the present invention is to provide a kind of nanometer anti-acne lotion containing nano-particle and preparation method thereof,
Using nano silver and bamboo charcoal nano as nano-functional material, it is combined, adopts with ginseng extract, wolfberry fruit extract and other auxiliary agents
The nanometer anti-acne emulsion compositions containing nano-particle are formed with self-emulsification.Use and receive in nanometer anti-acne lotion prepared by this method
The special effects of rice corpuscles, with reference to the auxiliary of auxiliary agent, functional materials is wanted to gather with nano-particle, form receiving for stable system
Rice anti-acne lotion, is conducive to prepare daily anti-acne skincare product.
In order to solve the above technical problems, the technical scheme is that：
A kind of nanometer anti-acne lotion containing nano-particle, it is characterised in that in the nanometer anti-acne lotion comprising nano silver,
Bamboo charcoal nano, ginseng extract, wolfberry fruit extract and auxiliary agent.
Preferably, the auxiliary agent includes emulsifying agent, grease and solvent.
The present invention also provides a kind of preparation method of the nanometer anti-acne lotion containing nano-particle, it is characterised in that：Including with
Lower step：
(1) after ginseng and matrimony vine being shone dry grinding respectively, immerse in deionized water and be ultrasonically treated 30-45min, be placed in high pressure
Boiling 60min in pot, is filtered, and respectively obtains the extract of ginseng supernatant and matrimony vine containing ginsengenin；
(2) the ginseng supernatant containing ginsengenin is placed in heating hydrolysis 2-3h in the mixed solution of tartaric acid and water,
Obtain the ginseng extract containing protopanaxatriol；
(3) by weight, the extract of 3-5 parts of ginseng extract and 5-8 parts of matrimony vine is uniformly mixed and is planted
Thing compounds extract, 2-4 parts of nano silver, 1-3 parts of bamboo charcoal nano, 10-20 will be added in 5-7 parts of plant compounding extract
Part emulsifying agent, 15-25 parts of grease and 50-70 parts of solvent, obtain the nanometer containing nano-particle after constant temperature high-speed stirred and dispel
Acne lotion.
As the preferred of above-mentioned technical proposal, in the step (1), the quality point of the ginseng supernatant containing ginsengenin
Number is 5-9wt%, and the mass fraction of the extract of matrimony vine is 8-16wt%.
As the preferred of above-mentioned technical proposal, in the step (2), the volume ratio of tartaric acid and water is 1:0.1-2.
As the preferred of above-mentioned technical proposal, in the step (2), the temperature of heating is 65-80 DEG C.
As the preferred of above-mentioned technical proposal, in the step (2), the quality point of the ginseng extract containing protopanaxatriol
Number is 2.5-4wt%.
As the preferred of above-mentioned technical proposal, in the step (3), emulsifying agent is lecithin, and grease is beeswax, and solvent is
Distilled water.
As the preferred of above-mentioned technical proposal, in the step (3), the temperature of constant temperature high-speed stirred is 85-95 DEG C, at a high speed
The speed of stirring is 850-1000rpm/min, and the time of constant temperature high-speed stirred is 50-90min.
As the preferred of above-mentioned technical proposal, in the step (3), nanoparticle in the nanometer anti-acne lotion containing nano-particle
The particle diameter of son is 35-129nm.
Compared with prior art, the invention has the advantages that：
(1) ginseng contained in the present invention belongs to rare Chinese medicine, contains saponin, amino acid, peptide, vitamin, flavones, volatilization
Oil and trace element etc., wherein panaxoside are the active ingredient of ginseng, the panoxadiol extracted from panaxoside or
Panaxatriol molecular weight compared with panaxoside is smaller, fat-soluble enhancing, it is easier to is absorbed, has than people by the skin of human body
Join the more outstanding skin effect of saponin, there is crease-resistant, whitening, tender skin, anti-acne, nti-freckle, uvioresistant etc..
(2) wolfberry fruit extract contained in the present invention is matrimony vine proteoglycan, is a kind of soluble polysaccharide, includes Arab
Sugar, glucose, galactolipin, mannose, xylose, rhamnose, wolfberry fruit extract have the function of that enhancing is immune and it is immune to adjust, also
, can be pre- anti-aging with antioxidation.
(3) nano silver and bamboo charcoal nano contained in the present invention has broad-spectrum sterilization, and bamboo charcoal nano has superpower suction
The extract of ginseng extract and matrimony vine, can be adsorbed onto material surface by attached ability, form stabilising system, and have and dehumidify,
The property of adjusting ambient temperature, has effects that to sterilize anti-acne, bleaching skin makeup.
Embodiment：
Below in conjunction with specific embodiment, the present invention will be described in detail, herein illustrative examples and explanation of the invention
For explaining the present invention, but it is not as a limitation of the invention.
Embodiment 1：
(1) after ginseng and matrimony vine being shone dry grinding respectively, immerse in deionized water and be ultrasonically treated 30min, be placed in pressure cooker
Middle boiling 60min, filtering, respectively obtains the extraction of the ginseng supernatant containing ginsengenin of 5wt% and the matrimony vine of 8wt%
Thing.
(2) count by volume, the ginseng supernatant containing ginsengenin of 1 volume is placed in the tartaric acid of 50 parts by volume
With in the mixed solution of water, the volume ratio of its mesotartaric acid and water is 1:0.1,65 DEG C of heating hydrolysis 2h, obtains containing for 2.5wt%
The ginseng extract of protopanaxatriol.
(3) by weight, the extract of 3 parts of ginseng extract and 5 parts of matrimony vine is uniformly mixed to obtain plant and answered
With extract, 2 parts of nano silver, 1 part of bamboo charcoal nano, 10 parts of lecithin breast will be added in 5 parts of plant compounding extract
Agent, 15 parts of beeswax grease and 50 parts of distillation aqueous solvent, at 85 DEG C, with the speed of 850rpm/min, constant temperature high-speed stirring
After mixing 50min, the nanometer anti-acne lotion of the nano-particle containing 129nm is obtained.
Embodiment 2：
(1) after ginseng and matrimony vine being shone dry grinding respectively, immerse in deionized water and be ultrasonically treated 45min, be placed in pressure cooker
Middle boiling 60min, filtering, respectively obtains the extraction of the ginseng supernatant containing ginsengenin of 9wt% and the matrimony vine of 16wt%
Thing.
(2) count by volume, the ginseng supernatant containing ginsengenin of 1 volume is placed in the tartaric acid of 80 parts by volume
With in the mixed solution of water, the volume ratio of its mesotartaric acid and water is 1:2,65 DEG C of heating hydrolysis 3h, obtain 4wt% contains protoplast
Join the ginseng extract of triol.
(3) by weight, the extract of 5 parts of ginseng extract and 8 parts of matrimony vine is uniformly mixed to obtain plant and answered
With extract, 4 parts of nano silver, 3 parts of bamboo charcoal nano, 20 parts of lecithin breast will be added in 7 parts of plant compounding extract
Agent, 25 parts of beeswax grease and 70 parts of distillation aqueous solvent, at 95 DEG C, with the speed of 1000rpm/min, constant temperature high-speed stirring
After mixing 90min, the nanometer anti-acne lotion of the nano-particle containing 35nm is obtained.
Embodiment 3：
(1) after ginseng and matrimony vine being shone dry grinding respectively, immerse in deionized water and be ultrasonically treated 40min, be placed in pressure cooker
Middle boiling 60min, filtering, respectively obtains the extraction of the ginseng supernatant containing ginsengenin of 6wt% and the matrimony vine of 10wt%
Thing.
(2) count by volume, the ginseng supernatant containing ginsengenin of 1 volume is placed in the winestone of 100 parts by volume
In the mixed solution of acid and water, the volume ratio of its mesotartaric acid and water is 1:1,65 DEG C of heating hydrolysis 2.5h, obtains 3.7wt%'s
Ginseng extract containing protopanaxatriol.
(3) by weight, the extract of 4 parts of ginseng extract and 7 parts of matrimony vine is uniformly mixed to obtain plant and answered
With extract, 3 parts of nano silver, 2 parts of bamboo charcoal nano, 15 parts of lecithin breast will be added in 6 parts of plant compounding extract
Agent, 20 parts of beeswax grease and 65 parts of distillation aqueous solvent, at 90 DEG C, with the speed of 900rpm/min, constant temperature high-speed stirring
After mixing 85min, the nanometer anti-acne lotion of the nano-particle containing 76nm is obtained.
Embodiment 4：
(1) after ginseng and matrimony vine being shone dry grinding respectively, immerse in deionized water and be ultrasonically treated 35min, be placed in pressure cooker
Middle boiling 60min, filtering, respectively obtains carrying for the ginseng supernatant containing ginsengenin of 6.5wt% and the matrimony vine of 14wt%
Take thing.
(2) count by volume, the ginseng supernatant containing ginsengenin of 1 volume is placed in the tartaric acid of 70 parts by volume
With in the mixed solution of water, the volume ratio of its mesotartaric acid and water is 1:0.5,65 DEG C of heating hydrolysis 3h, obtain 3wt% contains original
The ginseng extract of panaxatriol.
(3) by weight, the extract of 3 parts of ginseng extract and 7 parts of matrimony vine is uniformly mixed to obtain plant and answered
With extract, 2 parts of nano silver, 1 part of bamboo charcoal nano, 15 parts of lecithin will be added in 5-7 parts of plant compounding extract
Emulsifying agent, 19 parts of beeswax grease and 60 parts of distillation aqueous solvent, at 85 DEG C, with the speed of 1000rpm/min, constant temperature is at a high speed
After stirring 80min, the nanometer anti-acne lotion of the nano-particle containing 96nm is obtained.
Embodiment 5：
(1) after ginseng and matrimony vine being shone dry grinding respectively, immerse in deionized water and be ultrasonically treated 30min, be placed in pressure cooker
Middle boiling 60min, filtering, respectively obtains carrying for the ginseng supernatant containing ginsengenin of 7.6wt% and the matrimony vine of 12wt%
Take thing.
(2) count by volume, the ginseng supernatant containing ginsengenin of 1 volume is placed in the tartaric acid of 70 parts by volume
With in the mixed solution of water, the volume ratio of its mesotartaric acid and water is 1:1.5,65 DEG C of heating hydrolysis 2h, obtain containing for 2.5wt%
The ginseng extract of protopanaxatriol.
(3) by weight, the extract of 3 parts of ginseng extract and 6 parts of matrimony vine is uniformly mixed to obtain plant and answered
With extract, 3 parts of nano silver, 3 parts of bamboo charcoal nano, 20 parts of lecithin breast will be added in 5 parts of plant compounding extract
Agent, 20 parts of beeswax grease and 60 parts of distillation aqueous solvent, at 85 DEG C, with the speed of 850rpm/min, constant temperature high-speed stirring
After mixing 75min, the nanometer anti-acne lotion of the nano-particle containing 108nm is obtained.
Embodiment 6：
(1) after ginseng and matrimony vine being shone dry grinding respectively, immerse in deionized water and be ultrasonically treated 30min, be placed in pressure cooker
Middle boiling 60min, filtering, respectively obtains carrying for the ginseng supernatant containing ginsengenin of 8.5wt% and the matrimony vine of 15wt%
Take thing.
(2) count by volume, the ginseng supernatant containing ginsengenin of 1 volume is placed in the winestone of 100 parts by volume
In the mixed solution of acid and water, the volume ratio of its mesotartaric acid and water is 1:2,65 DEG C of heating hydrolysis 2h, obtain containing for 2.5wt%
The ginseng extract of protopanaxatriol.
(3) by weight, the extract of 3 parts of ginseng extract and 7 parts of matrimony vine is uniformly mixed to obtain plant and answered
With extract, 4 parts of nano silver, 1 part of bamboo charcoal nano, 15 parts of lecithin breast will be added in 7 parts of plant compounding extract
Agent, 15 parts of beeswax grease and 70 parts of distillation aqueous solvent, at 85 DEG C, with the speed of 950rpm/min, constant temperature high-speed stirring
After mixing 75min, the nanometer anti-acne lotion of the nano-particle containing 87nm is obtained.
The application method of embodiment 1-6 is：After warm water cleaning skin, by the receiving containing nano-particle of this law invention preparation
A little apply of rice anti-acne lotion erases affected part, daily to smear 2-3 times, during which without using cosmetics and other external curing acnes
Medicine.
The patient for choosing all ages and classes level (20-30 Sui, 30-40 Sui) contains nano-particle using prepared by embodiment 1-6
Nanometer anti-acne lotion, cure rate, effective percentage and as follows to the result of skin adverse reaction after treatment 2 weeks：
The effect of patient of 20-30 Sui ages result：
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | |
| Cure rate (%) | 56.4 | 69.3 | 65.9 | 67.2 | 59.4 | 63.7 |
| Efficient (%) | 98.5 | 100 | 96.7 | 100 | 100 | 99.2 |
| To skin adverse reaction | Nothing | Nothing | Nothing | Nothing | Nothing | Nothing |
The effect of patient of 30-40 Sui ages result：
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | |
| Cure rate (%) | 61.4 | 69.8 | 68.4 | 65.9 | 66.7 | 64.8 |
| Efficient (%) | 97.5 | 98.3 | 95.4 | 100 | 99.7 | 98.5 |
| To skin adverse reaction | Nothing | Nothing | Nothing | Nothing | Nothing | Nothing |
As seen from the above table, cure rate and effective percentage of the nanometer anti-acne lotion containing nano-particle that prepared by the present invention to acne
It is all very high, and have no adverse reaction to skin.
The above-described embodiments merely illustrate the principles and effects of the present invention, not for the limitation present invention.It is any ripe
Know the personage of this technology all can carry out modifications and changes under the spirit and scope without prejudice to the present invention to above-described embodiment.Cause
This, those of ordinary skill in the art is complete without departing from disclosed spirit and institute under technological thought such as
Into all equivalent modifications or change, should by the present invention claim be covered.
Claims (9)
1. a kind of nanometer anti-acne lotion containing nano-particle, it is characterised in that nano silver is included in the nanometer anti-acne lotion, is received
Rice bamboo charcoal, ginseng extract, wolfberry fruit extract and auxiliary agent, the auxiliary agent include emulsifying agent, grease and solvent；
The preparation method of the nanometer anti-acne lotion containing nano-particle, comprises the following steps：
(1) after ginseng and matrimony vine being shone dry grinding respectively, immerse in deionized water and be ultrasonically treated 30-45min, be placed in pressure cooker
Boiling 60min, is filtered, and respectively obtains the extract of ginseng supernatant and matrimony vine containing ginsengenin；
(2) the ginseng supernatant containing ginsengenin is placed in heating hydrolysis 2-3h in the mixed solution of tartaric acid and water, obtained
Ginseng extract containing protopanaxatriol；
(3) by weight, the extract of 3-5 parts of ginseng extract and 5-8 parts of matrimony vine is uniformly mixed to obtain plant and answered
With extract, by add in 5-7 parts of plant compounding extract 2-4 parts nano silver, 1-3 parts of bamboo charcoal nano, 10-20 parts
Emulsifying agent, 15-25 parts of grease and 50-70 parts of solvent, obtains the nanometer anti-acne containing nano-particle after constant temperature high-speed stirred
Liquid.
A kind of 2. preparation method of the nanometer anti-acne lotion containing nano-particle, it is characterised in that：Comprise the following steps：
(1) after ginseng and matrimony vine being shone dry grinding respectively, immerse in deionized water and be ultrasonically treated 30-45min, be placed in pressure cooker
Boiling 60min, is filtered, and respectively obtains the extract of ginseng supernatant and matrimony vine containing ginsengenin；
(2) the ginseng supernatant containing ginsengenin is placed in heating hydrolysis 2-3h in the mixed solution of tartaric acid and water, obtained
Ginseng extract containing protopanaxatriol；
(3) by weight, the extract of 3-5 parts of ginseng extract and 5-8 parts of matrimony vine is uniformly mixed to obtain plant and answered
With extract, by add in 5-7 parts of plant compounding extract 2-4 parts nano silver, 1-3 parts of bamboo charcoal nano, 10-20 parts
Emulsifying agent, 15-25 parts of grease and 50-70 parts of solvent, obtains the nanometer anti-acne containing nano-particle after constant temperature high-speed stirred
Liquid.
A kind of 3. preparation method of nanometer anti-acne lotion containing nano-particle according to claim 2, it is characterised in that：Institute
State in step (1), the mass fraction of the ginseng supernatant containing ginsengenin is 5-9wt%, and the quality of the extract of matrimony vine is divided
Number is 8-16wt%.
A kind of 4. preparation method of nanometer anti-acne lotion containing nano-particle according to claim 2, it is characterised in that：Institute
State in step (2), the volume ratio of tartaric acid and water is 1:0.1-2.
A kind of 5. preparation method of nanometer anti-acne lotion containing nano-particle according to claim 2, it is characterised in that：Institute
State in step (2), the temperature of heating is 65-80 DEG C.
A kind of 6. preparation method of nanometer anti-acne lotion containing nano-particle according to claim 2, it is characterised in that：Institute
State in step (2), the mass fraction of the ginseng extract containing protopanaxatriol is 2.5-4wt%.
A kind of 7. preparation method of nanometer anti-acne lotion containing nano-particle according to claim 2, it is characterised in that：Institute
State in step (3), emulsifying agent is lecithin, and grease is beeswax, and solvent is distilled water.
A kind of 8. preparation method of nanometer anti-acne lotion containing nano-particle according to claim 2, it is characterised in that：Institute
State in step (3), the temperature of constant temperature high-speed stirred is 85-95 DEG C, and the speed of high-speed stirred is 850-1000rpm/min, constant temperature
The time of high-speed stirred is 50-90min.
A kind of 9. preparation method of nanometer anti-acne lotion containing nano-particle according to claim 2, it is characterised in that：Institute
State in step (3), the particle diameter of nano-particle is 35-129nm in the nanometer anti-acne lotion containing nano-particle.
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Effective date of registration: 20181101 Address after: 343900 6, Feng Fang, Liao Fang village, Xixi Town, Suichuan, Ji'an, Jiangxi. Patentee after: Liao Aihua Address before: 523000, 2, building 11, innovation and Technology Park, Songshan Lake high tech Industrial Development Zone, Dongguan, Guangdong Patentee before: Dongguan Jia Xin new Mstar Technology Ltd |
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