CN105597008B - 一种外用止痛中药制剂 - Google Patents
一种外用止痛中药制剂 Download PDFInfo
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Abstract
本发明涉及中医药技术领域，涉及一种外用止痛中药制剂，具体地说，是一种治疗腰椎间盘突出症的外用止痛中药制剂。本发明的外用止痛中药制剂，是由如下重量份数的成分组成的：姜黄2‑6份、白芷2‑6份、防风2‑6份、没药2‑6份、大黄2‑6份、秦艽1‑4份、延胡索2‑6份、三七2‑6份、桃仁6‑10份、红花2‑6份、乳香2‑6份、莪术1‑4份、细辛1‑2份、冰片1‑3份。所述外用止痛中药制剂可制成散剂、膏贴等。本发明提供的外用止痛中药制剂，由纯中药制成的治疗腰椎间盘突出症的有效药物，具有显著的活血化瘀、散寒止痛作用。具有组成简单、配伍得当、用量较小、疗效确切等优点。
Description
技术领域
本发明涉及中医药技术领域，涉及一种外用止痛中药制剂，具体地说，是一种治疗腰椎间盘突出症的外用止痛中药制剂。
背景技术
清代伤科名医钱秀昌所著的伤科名著《伤科补要》的代痛散，所含药味配伍应用于现代疗效，为大规模工业生产带来了有效物质提取、质量控制、成本控制等诸多不利因素，临床无法广泛直接应用。
腰椎间盘突出症是指腰椎间盘发生退行性变以后，在外力作用下，纤维环部分或全部破裂，单独或连同髓核、软骨终板向外突出，刺激或压迫窦椎神经和神经根引起的以腰腿痛为主要症状的一种病变。自1934年Mixter和Barr首先提出腰椎间盘突出症以来，对该病正确的认识至今已有70多年历史。从国内外流行病学调查发现其发病率呈逐年上升趋势。中药治疗包括中药内服和中药熏洗、药物外敷等。现代药理研究证实，中药外敷治疗腰椎间盘突出症有明显的活血化瘀、理伤软坚、消炎止痛作用，可以减轻炎性反应程度，缩短炎症期和减轻结缔组织的形成，促进变性神经纤维的恢复，减少胶质细胞和胶质纤维的增多，减轻瘢痕化对周围神经组织的挤压，以达到缓解疼痛的目的。
发明内容
针对上述问题，本发明提供一种配伍关系明确、实际针对性强、疗效确切显著的外用止痛中药制剂，用于治疗腰椎间盘突出症等退行性疾患。
为实现本发明的上述目的，本发明提供一种外用止痛中药制剂，是由如下重量份数的原料组成的：姜黄2-6份、白芷2-6份、防风2-6份、没药2-6份、大黄2-6份、秦艽1-4份、延胡索2-6份、三七2-6份、桃仁6-10份、红花2-6份、乳香2-6份、莪术1-4份、细辛1-2份、冰片1-3份。
所述外用止痛中药制剂可制成散剂、膏贴等传统形式。
在本发明组方中。
姜黄：辛苦，温。功能主治：破血，行气，通经，止痛。
白芷：性温，味辛，气芳香，微苦。功能主治：祛风湿，活血排脓，生肌止痛。
防风：味辛、甘，性微温。有祛风解表，胜湿止痛，止痉的功效。
没药：味辛、苦，性平。散瘀定痛，消肿生肌。
大黄：味苦而微涩。具有攻积滞、清湿热、泻火、凉血、祛瘀、解毒等功效。
秦艽：辛、苦，平。归胃、肝、胆经。祛风湿，清湿热，止痹痛。
延胡索：辛；苦；温；肝；胃；心；肺；脾经。活血；散瘀；理气；止痛。
三七：甘、微苦，温。归肝、胃经。散瘀止血，消肿定痛。
桃仁：苦、甘，平。归心、肝、大肠经。活血祛瘀，润肠通便，止咳平喘。
红花：性味：辛，温。归经：入心、肝经。功能主治：活血通经，去瘀止痛。
乳香：辛、苦，温。归心、肝、脾经。活血行气止痛，消肿生肌。
莪术：辛、苦，温。归肝、脾经。破血行气，消积止痛。
细辛：辛，温。归心、肺、肾经。解表散寒，祛风止痛，通窍，温肺化饮。
冰片：辛苦，凉。入心、肝经。通诸窍，散郁火，去翳明目，消肿止痛，清热散毒，散火解毒。
本发明的配伍释义：该方由姜黄4份、白芷4份、防风4份、没药4份、大黄4份、秦艽2份、延胡索4份、三七4份、桃仁8份、红花4份、乳香4份、莪术2份、细辛1份、冰片1.5份组成，具有活血化瘀、散寒止痛之功效。方中以姜黄为君药，姜黄性味辛、苦、温；归肝、脾经。破血行气，通经止痛，配白芷、防风，共奏祛风解表，胜湿止痛，桃仁，红花，三七温通经络，尤以温通四肢经脉。乳香、莪术：活血行气止痛，消积止痛。细辛：解表散寒，祛风止痛。佐以冰片：辛苦，凉。清热散毒，散火解毒。以综观全方，共奏温通经络，活血除痹之功，针对腰椎间盘突出症久病入络，瘀阻络痛。全方配伍合理，药证相符，故起效快，临床症状及体征明显缓解。
与现有技术相比本发明的有益效果。
本发明提供的外用止痛中药制剂，是由纯中药制成的治疗腰椎间盘突出症的有效药物，具有显著的活血化瘀、散寒止痛作用。具有组成简单、配伍得当、用量较小、疗效确切等优点。外用止痛中药制剂在临床观察前后,对血、尿常规、肝肾功能、心电图等方面检查均无不良影响,未发现异常变化，具有较好的安全性。同时,经临床观察表明，治疗腰椎间盘突出症(寒湿痹阻症)疗效较好,是一种治疗腰椎间盘突出症安全有效且具有广泛市场前景的新品种。
具体实施方式
下面结合具体实施例进一步详细说明本发明。
实施例1。
本实施例提供一种外用止痛中药制剂，是由如下重量份数的原料组成的：姜黄4份、白芷4份、防风4份、没药4份、大黄4份、秦艽2份、延胡索4份、三七4份、桃仁8份、红花4份、乳香4份、莪术2份、细辛1份、冰片1.5份。所述外用止痛中药制剂为散剂，其制备方法为：将所取方药混合后粉碎至粉剂。
本实施例外用止痛中药散剂的使用方法为：（1）用30%浓度的酒精40ml，将41g止痛中药散剂调成糊状。（2）将已调成糊状的止痛中药散剂平铺于面积为12×17cm2丝绸上，药物厚度控制在2mm，药物直接贴服在患处（丝绸面直接接触皮肤），周围用防辐射面料覆盖。（3）将已预热特定电磁波谱治疗器辐射板对准治疗部位，辐射板与治疗部位距离约20-30cm，治疗部位止痛散表面温度控制在40℃±10℃，治疗时间为30min/次，2次/日。
患者1：夏某，以腰痛伴左下肢放射痛5个月为主诉就诊，查体：腰椎生理屈度变直，直腿抬高实验:左：40°(+),经外用止痛中药制剂系统治疗后，腰痛及左下肢放射痛症状明显缓解。随访3个月，症状未加重及复发。
患者2：铁某，腰痛伴双下肢放射痛5年为主诉就诊，腰椎间盘CT示：L4-5间盘突出，压迫硬膜囊及神经根。经外用止痛中药制剂系统治疗后，腰痛及双下肢放射痛症状明显缓解。
患者3：张某，右下肢放射痛反复发作9个月为主诉就诊，查体：右下肢外侧皮肤痛觉迟钝，经外用止痛中药制剂系统治疗后，腰痛及右下肢放射痛，及皮肤痛觉迟钝症状明显缓解。
患者4：王某，腰痛伴右下肢放射痛反复发作10余年为主诉就诊，腰椎间盘CT示：L4-5间盘向右后方突出，右侧神经根受压，侧隐窝狭窄。经外用止痛中药制剂系统治疗后，腰痛及双下肢放射痛症状明显缓解。
患者5：徐某，腰痛伴双下肢放射痛5年为主诉就诊，腰椎间盘CT示：L4-5间盘中央突出，突出块压迫硬膜囊及神经根。经外用止痛中药制剂系统治疗后，腰痛及双下肢放射痛症状明显缓解。
患者6：韩某，腰痛伴左下肢放射痛2天为主诉就诊，腰痛伴左下肢放射痛剧烈，夜间难以入睡。经外用止痛中药制剂系统治疗2周后，腰痛及左下肢放射痛症状明显缓解。
患者7：曹某，腰痛伴右下肢放射痛5年为主诉就诊，查体：直腿抬高实验：右：30°，（+），右小腿及足部外侧皮肤痛觉迟钝，腰椎间盘CT示：L4-5间盘向右后方突出，压迫硬膜囊及神经根。侧隐窝变窄。经外用止痛中药制剂系统治疗后，腰痛及右下肢放射痛症状明显缓解，随访6个月，无复发。
实施例2。
本实施例提供一种外用止痛中药制剂，是由如下重量份数的原料组成的：姜黄2份、白芷2份、防风2份、没药2份、大黄2份、秦艽1份、延胡索2份、三七2份、桃仁6份、红花2份、乳香2份、莪术1份、细辛1份、冰片1份。
实施例3。
本实施例提供一种外用止痛中药制剂，是由如下重量份数的原料组成的：姜黄3份、白芷3份、防风3份、没药3份、大黄3份、秦艽3份、延胡索3份、三七3份、桃仁7份、红花3份、乳香3份、莪术1份、细辛1份、冰片1份。
实施例4。
本实施例提供一种外用止痛中药制剂，是由如下重量份数的原料组成的：姜黄5份、白芷5份、防风5份、没药5份、大黄5份、秦艽2份、延胡索5份、三七5份、桃仁9份、红花5份、乳香5份、莪术1份、细辛1份、冰片2份。
实施例5。
本实施例提供一种外用止痛中药制剂，是由如下重量份数的原料组成的：姜黄6份、白芷6份、防风6份、没药6份、大黄6份、秦艽4份、延胡索6份、三七6份、桃仁10份、红花6份、乳香6份、莪术4份、细辛2份、冰片3份。
Claims (3)
1.一种外用止痛中药制剂，其特征在于，是由如下重量份数的原料组成：姜黄4份、白芷4份、防风4份、没药4份、大黄4份、秦艽2份、延胡索4份、三七4份、桃仁8份、红花4份、乳香4份、莪术2份、细辛1份、冰片1.5份。
2.一种外用止痛中药制剂，其特征在于，是由如下重量份数的原料组成：姜黄3份、白芷3份、防风3份、没药3份、大黄3份、秦艽3份、延胡索3份、三七3份、桃仁7份、红花3份、乳香3份、莪术1份、细辛1份、冰片1份。
3.一种外用止痛中药制剂，其特征在于，是由如下重量份数的原料组成：姜黄5份、白芷5份、防风5份、没药5份、大黄5份、秦艽2份、延胡索5份、三七5份、桃仁9份、红花5份、乳香5份、莪术1份、细辛1份、冰片2份。
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