CN108619448A - 一种治疗骨质增生症的膏药及其制备方法 - Google Patents
一种治疗骨质增生症的膏药及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种能有效治疗骨质增生症的膏药及其制备方法,本发明膏药所采用的中药是经精心选择的以小九架、琥珀、麝香、穿山甲、全蝎、蜈蚣、皂刺、蟾酥、血竭等30余种名贵药材为主要原料制成的纯中药膏药,将上述药物进行科学组合后使得各药物功效产生协同作用,具有软坚散结、祛瘀消肿、舒筋活络、散寒定痛功效。从而达到消除无菌性炎症、解除肌肉痉挛、缓解疼痛、软化增生骨质的效果。经临床使用观察,一般情况下,试用本药膏2—3贴后可明显缓解症状,继续使用3‑‑‑6个月的时间能够彻底治愈骨质增生症,复发率极低,疗效能够稳定在3—5年以上。
Description
技术领域
本发明涉及一种膏药,更具体地说,涉及一种治疗骨质增生症的膏药及其制备方法。
背景技术
目前,国内外针对骨质增生症的治疗手段,临床上基本都是通过理疗、局部封闭、中药熏蒸、中药外洗、中药热敷、西药、中成药、传统膏药、手术等手段进行治疗的。实践证明:理疗,只是治标而不治本,只能缓解一时的疼痛,且病情易复发;局部封闭,暂时性治疗有疼痛症状的患者具有立竿见影的效果,但因药物中加有一定剂量的糖皮质激素,多次反复注射,一方面易引起或加重骨质疏松症的发生;另一方面,易导致局部尤其是关节部位的感染;中药熏蒸、中药外洗、中药热敷虽然当时也有一定的疗效,但远期疗效明显不佳,且应用麻烦,每天还要留有充足的时间、配备一定的器具、要有一定的环境才能进行治疗,疗程长,一般患者不易坚持疗程;西药品种繁多,疗效不稳定,复发率高,而且有的药物价格昂贵,毒副作用较大,尤其对肠胃反应剧烈;中成药同样不能消除骨质增生症引起的症状,而是通过舒筋活络、活血化瘀、行气止痛、祛风除湿的药理作用而临时减轻症状的;传统膏药治疗骨质增生症已有几百年历史,确实有一定的疗效,但存在疗效不稳定、含铅量大、毒性大、副作用多、易过敏、易污染衣服、局部不易清洗干净等诸多不足;手术治疗风险大、费用过高、复发率高、后遗症及并发症多。因此,最终从结果上看,这些治疗方案均达不到理想的治疗效果。
发明内容
本发明的目的在于克服现有技术中存在的缺陷,提供一种能有效治疗骨质增生症的膏药及其制备方法,该种膏药经与经穴掺药相互作用,相得益彰,从而发挥扶正与祛邪两大优势,具有疗效好、治愈率高、使用安全、无毒副作用的特点。
本发明膏药所采用的中药是经精心选择的小九架、琥珀、麝香、穿山甲、全蝎、蜈蚣、皂刺、蟾酥、血竭等30余种名贵药材为主要原料制成的纯中药膏药。将上述药物进行科学组合后使得各药物功效产生协同作用,具有软坚散结、祛瘀消肿、舒筋活络、散寒定痛功效。从而达到消除无菌性炎症、解除肌肉痉挛、缓解疼痛、软化增生骨质的效果。其中选用经上百次反复试验,成功研制出的小九架(陕西省延安市黄龙山特产中药材,见《黄龙县志》,目前国内尚未见有应用此药治疗骨质增生症的相关报道)。该药物具有活血化瘀、行水散结、深入筋骨,抑制骨质增生的作用;麝香具有活血消痈,散瘀止痛的效果;全蝎具有通络止痛、解毒散结疗效;血竭用来祛瘀止痛,止血生肌;穿山甲具有活血通经、消肿溃痈作用;当归是用来补血、活血。
为了达到更好的治疗效果,本发明药物还与生乳香、生没药、鸡血藤、川牛膝组合。这是因为根据现代研究,此四味药物都具有活血止痛、消肿生肌的作用,同时川牛膝还用来祛瘀,治疗风寒湿痹;鸡血藤用来舒筋活络。
为了获得最佳疗效,本发明在上述药物基础上还加入威灵仙、骨碎补、狗脊、生川乌、生草乌。这是因为威灵仙能祛风除湿、通络止痛;骨碎补、狗脊补肾续骨,活血止痛、强腰膝祛风湿,同时还助阳;生川乌、生草乌能搜风除湿、散寒止痛,外用溃坚祛腐;冰片清热止痛;真实薰衣草是目前芳香疗法中最重要的一种精油,一直是最知名也是最受欢迎的传统青草,它是一种常绿亚灌木,整株植物皆充满香气,是非常好的止痛剂,对各种疼痛都有很好的缓解效果;月桂氮唑酮是近年来新开发的一种高效透皮促进剂,具备最理想的透皮促进条件,能够使药物直达病所。
本发明膏药所采用的中药中各药物组分用量为在下述范围都具有较好的疗效:
小九架10g、琥珀30g、生乳香10g、生没药10g、血竭30g、冰片2g、当归10g、生牡蛎20g、生川乌10g、生草乌10g、生马钱子10g、穿山甲10g、皂角刺10g、细辛10g、蟾酥10g、全虫20g、土鳖虫20g、白芥子10g、杜仲10g、川续断10g、鹿角霜10g、骨碎补20g、威灵仙20g、狗脊10g、蜈蚣10g、葛根20g、鸡血藤10g、熟地20g、川牛膝20g、地龙10g、木鳖子20g、白僵蚕20g、莪术15g、三棱15g、月桂氮唑酮15g、真实薰衣草15g。
本发明膏药的制备方法为:
(1)将上述各组分药物水煎三次,前两次煎三小时过滤,第三次煎两小时过滤,合并三次滤液熬成流浸膏;
(2)将医用压敏热溶胶1000克,放入锅内加热融化,先将药粉徐徐加入搅拌均匀,然后再加入上述步骤(1)所制备的流浸膏、50毫升氮酮及麝香1克,继续搅拌,然后摊至膏药辅料上。
上述方案中的膏药辅料主要由由纯棉白布背衬层及无毒白色塑料纸组成。
上述治疗骨质增生症的药物均为来自于大自然、绿色、环保、名贵、地道中药材为原料制成的制剂,优选为膏药。本发明药物具有:①临床使用证明,使用安全,载药量大、高效、无毒副作用,不刺激皮肤、不过敏、不沾染衣物;②原料均为常用药,价格合理,且制备方法简单,成本低廉;③经大量临床使用观察,一般情况下,试用本药膏2—3贴后可明显缓解症状,继续使用3---6个月的时间能够彻底治愈骨质增生症,复发率极低,疗效能够稳定在3—5年以上。
本发明膏药具有以下效果:
1.消除无菌性炎症:软组织无菌性炎症病变是骨质增生症发病因素中的复发因素。通过改善病变软组织的血液循环,发挥以下治疗作用:①促进炎症的吸收、消散;②促进炎症胞浆素的形成,从而松解粘连及瘢痕;③促进受损组织的修复,消除导致无菌性炎症的致炎因子。
2.解除肌肉痉挛:可舒筋通络,能使痉挛的肌肉等软组织放松,从而切断“无菌性炎症—肌痉挛”这一软组织劳损性疼痛的恶性循环。
3.缓解疼痛:通过消除无菌性炎症及解除肌肉痉挛,可以从根本上解除疼痛。除此以外,本发明膏药与经穴掺药配合,还可激发机体某些内源性镇痛物质,如内啡肽、脑啡肽等的释放,也可对传导经路和神经中枢产生抑制效应,从而增加人体对疼痛的耐受性。
4.软化增生的骨质,促进椎间盘突出物的还纳:在治疗椎管内病变过程中,不仅能使神经根周围及硬脊周围的脂肪组织的无菌性炎症病变吸收消退。而且通过部分病例的观察,发现具有软化骨质增生、促进椎间盘突出物还纳等现象。
本发明膏药治疗范围为:
1.各型、各类骨质增生症;
2.股骨头无菌性坏死、骨坏死、老年性退行性关节病引起的疼痛;
3.骨质增生、骨折、颈椎病、腰椎病、腰椎间盘突出引起的疼痛、麻木、肢体酸困、乏力不适等;
4.风湿性关节炎、类风湿性关节炎、肩周炎、坐骨神经痛引起的疼痛;
5.软组织损伤、无名肿胀疼痛、肿瘤后期引起的疼痛。
具体实施方式
以下通过实施例来对本发明所述一种治疗骨质增生症的膏药做进一步的阐述:
1、本发明所述药物的制备方法及使用方法:
(1)制备方法
①称取小九架10g、琥珀30g、生乳香10g、生没药10g、血竭30g、冰片2g、当归10g、生牡蛎20g、生川乌10g、生草乌10g、生马钱子10g、穿山甲10g、皂角刺10g、细辛10g、蟾酥10g、全虫20g、土鳖虫20g、白芥子10g、杜仲10g、川续断10g、鹿角霜10g、骨碎补20g、威灵仙20g、狗脊10g、蜈蚣10g、葛根20g、鸡血藤10g、熟地20g、川牛膝20g、地龙10g、木鳖子20g、白僵蚕20g、莪术15g、三棱15g、小九架10g、月桂氮唑酮15g、真实薰衣草15g。
②本发明药物将处方药物水煎三次,头两次煎三小时过滤,第三次煎两小时过滤,合并三次滤液熬成流浸膏。医用压敏热溶胶1000克,放入锅内加热融化,先将药粉徐徐加入搅拌均匀,然后再加入流浸膏、50毫升氮酮及麝香1克,继续搅拌,然后摊膏。膏药辅料由纯棉白布背衬层、松香、永磁材料、基质、无毒白色塑料纸组成。
(2)使用方法:先将患处清洗干净,贴予患处,每7天更换膏药一次。
2、本发明治疗骨质增生症的中药薄贴(膏药)的临床观察
(1)一般资料
本发明药膏用于临床治疗2232例病人,其中,男684例,女1548例;年龄18--75岁,病程1--3年312例,4--7年702例,8年以上198例(其中病程长达15年以上63例)。
上述患者皆经X线片或CT检查确诊为骨质增生症。
(2)诊断标准:按照国家中医药管理局颁发的《中华人民共和国中医行业标准中医病症诊断疗效标准》ZY—T001.1—001.9—94;治疗方法为对符合急慢性疼痛病,不分期分型,统一使用本发明灸具,在专科医师的指导下或按照说明在病变部位进行治疗,十日为一个疗程,按照复诊记录、回访记录统计疗效。
颈椎骨质增生症患者:患者以中、老年人较多,头、颈、肩疼痛、麻木并伴有相应的压痛点;且范围与颈脊神经所支配的区域相一致,X线片上颈椎显示曲度改变或椎间关节不稳、节段性不稳定或枢椎关节骨质增生、椎体后缘骨质增生、椎管狭窄、有失稳或退变.影象学证实存在脊髓压迫;压头试验或臂丛牵拉试验(+);临床上出现颈脊强损害的表现;曾有猝倒发作并伴有颈性眩晕;旋颈试验(+);多伴有头晕、眼花、耳鸣、手麻、心动过速、心前区疼痛等一系列交感神经症状;椎动脉造影(-);颈椎椎体前鸟嘴样增生压迫食管引起吞咽困难(经食管钡剂检查证实)等。
腰椎骨质增生症患者:患者多为40岁以上中老年人,伴有腰部僵硬疼痛或出现下肢麻木等症状,查体可见部分病人腰椎生理曲度异常,腰椎两侧肌肉有压痛;X线片显示:腰椎曲度异常、腰椎侧弯、腰椎椎体间隙变窄、腰椎椎体及小关节突增生、腰椎滑脱、椎间孔狭窄等改变。
膝关节骨质增生症患者:患者局部疼痛,关节活动时弹响;关节肿胀;滑膜炎(局部发热、渗出滑膜增厚,关节压痛、肌肉无力和萎缩);关节活动受限;膝关节畸形和脱位。X线片显示膝关节有骨质增生存在。
(3)治疗方法:
先将患处清洗干净,然后将本发明药膏贴于患处,7天更换膏药一次。
(4)疗效评定标准:
治愈:疼痛消失,关节活动功能正常;
显效:疼痛减轻,关节活动功能基本正常;
好转:疼痛略有减轻,关节活动功能略有好转;
无效:疼痛症状无变化,关节活动功能无改变。
5)治疗结果(见下表1、表2及表3)
表1治疗时间与疗效观察
治疗时间 | 治愈 | 好转 | 显效 | 无效 |
1个月 | 240 | 827 | 1105 | 70 |
2个月 | 300 | 900 | 1002 | 30 |
3个月 | 352 | 936 | 1036 | 8 |
表2经治疗后疗效观察
表3经治疗后体征改善情况
症状 | 剧烈疼痛 | 活动受限 | 麻木无力 | 肌肉萎缩 |
治疗前(例) | 1323 | 325 | 449 | 135 |
治疗后(例) | 112 | 11 | 21 | 12 |
总有效率 | 91.5% | 96.6% | 95.3% | 91.2% |
总之,用本发明治疗上述骨质增生症患者,治愈1404例,显效576例,好转198例,无效54例;治愈率62.9%、显效率25.8%,好转率8.7%,有效率97.4%,无效率2.6%。
到目前为止,本发明所使用的具体典型案例有:
病例一:周某,男,48岁,教师,2005年4月就诊。
颈项部酸胀不适1年余,颈部活动时有关节弹响及骨摩擦音,因不影响工作和生活而未予治疗。1月前,无明显诱因,突感头晕,记忆力骤然减退、视物模糊,转动头颈部可加重头晕,有时尚有耳鸣,被诊断为动脉硬化、高血压,但反复测血压仅偶有增高现象。服降压药无效。近一周来患者心烦、气躁、失眠、多梦、思想负担很重。慕名前来咨询。经拍颈椎4位片。X线提示:颈椎生理曲度变直,5、6颈椎钩椎关节侧方移位,有轻微骨质增生,余无明显异常,诊断为颈动脉型颈椎病。后用本发明贴予颈椎,连续使用1月余,症状消失。
病例二:肖某,男,58岁,建筑工人,2007年8月就诊。
因长期重体力劳动,反复多次扭伤腰部。休息,口服止痛药或局部外贴麝香虎骨膏后,腰痛即慢慢缓解。但平日右侧腰臀、大腿部常感酸胀、乏力、僵硬,不敢弯腰搬抬重物,总怕闪了腰。偶有腰臀股后麻窜感。天气变化症状加重。经当地县医院CT检查:L3、4、5椎间盘膨出,确诊为腰椎间盘突出症。曾做按摩、理疗、封闭治疗,疗效不显。今因弯腰端洗脸盆转身时扭伤腰部,右侧腰腿疼痛剧烈,腰臀活动受限,保持一定姿势方可慢慢移动体位。侧卧位需健侧在下,翻身困难、站立需扶物,痛苦不堪。由两人搀扶来我所门诊求治。查:右侧腰肌板硬,脊柱左凸,右臀部上方大面积压痛,中间有一条索状物压痛,深压可向下麻串、但麻串不过膝、腘窝部憋胀感。右侧腰部广泛性压痛。直腿抬高50°受限,屈膝屈髋疼痛加重,屈颈试验(-),4字试验(-),叩击腰椎无疼痛及放射痛,髌腱反射、根尖反射正常。X线片提示:腰椎有不同程度的骨质增生。L4、5间隙右宽左窄,脊柱左突。经用本发明药膏3月余,疼痛消失,恢复正常工作。
病例三:边某,女,60岁,退休干部,2003年2月來诊。
双膝关节疼痛,伸屈受限两年余,久治不愈,上下楼梯困难,夜间疼痛剧烈难以入眠,天气变化时疼痛加重。查:双膝关节周围有多处明显压痛,X线片显示:双膝关节边缘有不同程度的骨质增生,诊断为:膝关节骨性关节炎。压痛点处用本发明后药膏1月后症状消失。能够参加各种活动及料理正常家务,多次随访疗效满意。
病例四:张某,女,52岁,工人2004年11月就诊
患者2000年秋末,下肢受凉后引起双下肢疼痛,因不愿影响工作而未予治疗。入冬后无明显诱因,双膝关节疼痛加重,以左膝关节为重,行走无力,在当地医院诊断为膝关节骨质增生症,经采用电子膜中药离子导入治疗,同时配合中药口服1个月,未见明显好转。1个月前,双膝关节疼痛再次加重,伴活动受限,活动后疼痛加重,休息后症状减轻,起步时疼痛明显加重。查:左膝关节肿胀,双膝眼饱满,浮髌试验(﹢),双膝髌周压痛(﹢),膝关节内外侧及腘窝部亦有压痛。活动度:左侧10°(伸)﹦80°(屈),右侧15°(伸)﹦85°(屈)。X线片提示:双膝关节间隙变窄,胫骨、髌骨边缘有骨质增生形成。诊断为:双膝膝关节骨性关节炎。经用本发明药膏治疗一个月后症状明显好转,3个月后症状完全消失。
病例五:贾某,男,58岁,退休职工,2007年5月就诊。
患者7年前,下沟砍柴时摔伤左膝关节,未予治疗。从此,左膝关节疼痛时轻时重。严重时影响工作、劳动,夜间痛得难以入眠,天气变化时,症状加重。曾在当地医院治疗半年,疼痛有所缓解,连续口服止痛药物就可以参加正常劳动。去年冬天,发现左腿变形,疼痛加重、僵硬,在当地县医院检查后诊断为膝关节骨质增生病,治疗3个月后,疗效不明显,经人介绍前来诊治。查:左膝关节已明显变形,膝周围压痛明显,活动障碍。X线片提示:关节间隙变窄,骨间嵴增生,髌骨上缘与胫骨平台处有骨刺生成。诊断为:左膝膝关节骨性关节炎。经用本发明药膏治疗3个月后症状明显好转,6个月后症状完全消失。至今未见复发。
Claims (3)
1.一种治疗骨质增生症的膏药及其制备方法,其特征在于:所采用的中药中各药物组分用量为:小九架10g、琥珀30g、生乳香10g、生没药10g、血竭30g、冰片2g、当归10g、生牡蛎20g、生川乌10g、生草乌10g、生马钱子10g、穿山甲10g、皂角刺10g、细辛10g、蟾酥10g、全虫20g、土鳖虫20g、白芥子10g、杜仲10g、川续断10g、鹿角霜10g、骨碎补20g、威灵仙20g、狗脊10g、蜈蚣10g、葛根20g、鸡血藤10g、熟地20g、川牛膝20g、地龙10g、木鳖子20g、白僵蚕20g、莪术15g、三棱15g、月桂氮唑酮15g、真实薰衣草15g。
2.根据权利要求1所述的一种治疗骨质增生症的膏药及其制备方法,其特征在于:其制备方法为:
(1)将上述各组分药物水煎三次,前两次煎三小时过滤,第三次煎两小时过滤,合并三次滤液熬成流浸膏;
(2)将医用压敏热溶胶1000克,放入锅内加热融化,先将药粉徐徐加入搅拌均匀,然后再加入上述步骤(1)所制备的流浸膏、50毫升氮酮及麝香1克,继续搅拌,然后摊至膏药辅料上。
3.根据权利要求2所述的一种治疗骨质增生症的膏药及其制备方法,其特征在于:所述膏药辅料主要由由纯棉白布背衬层及无毒白色塑料纸组成。
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