CN105593225B - 新型glp-1受体调节剂 - Google Patents
新型glp-1受体调节剂 Download PDFInfo
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- CN105593225B CN105593225B CN201480044849.7A CN201480044849A CN105593225B CN 105593225 B CN105593225 B CN 105593225B CN 201480044849 A CN201480044849 A CN 201480044849A CN 105593225 B CN105593225 B CN 105593225B
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- Peptides Or Proteins (AREA)
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910207853.5A CN109867630A (zh) | 2013-06-11 | 2014-06-11 | 新型glp-1受体调节剂 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361833737P | 2013-06-11 | 2013-06-11 | |
| US61/833,737 | 2013-06-11 | ||
| US201461981643P | 2014-04-18 | 2014-04-18 | |
| US61/981,643 | 2014-04-18 | ||
| PCT/US2014/041997 WO2014201172A1 (en) | 2013-06-11 | 2014-06-11 | Novel glp-1 receptor modulators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910207853.5A Division CN109867630A (zh) | 2013-06-11 | 2014-06-11 | 新型glp-1受体调节剂 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105593225A CN105593225A (zh) | 2016-05-18 |
| CN105593225B true CN105593225B (zh) | 2019-04-16 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480044849.7A Expired - Fee Related CN105593225B (zh) | 2013-06-11 | 2014-06-11 | 新型glp-1受体调节剂 |
| CN201910207853.5A Pending CN109867630A (zh) | 2013-06-11 | 2014-06-11 | 新型glp-1受体调节剂 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910207853.5A Pending CN109867630A (zh) | 2013-06-11 | 2014-06-11 | 新型glp-1受体调节剂 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9260427B2 (enExample) |
| EP (1) | EP3008056B8 (enExample) |
| JP (1) | JP6573604B2 (enExample) |
| KR (1) | KR102271179B1 (enExample) |
| CN (2) | CN105593225B (enExample) |
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| HK1202119A1 (en) | 2011-12-12 | 2015-09-18 | Celgene International Ii Sàrl | Novel glp-1 receptor modulators |
| CN105593225B (zh) | 2013-06-11 | 2019-04-16 | 赛尔基因第二国际有限公司 | 新型glp-1受体调节剂 |
| CN107074820B (zh) * | 2014-07-25 | 2021-05-18 | 赛尔基因第二国际有限公司 | Glp-1受体调节剂 |
| KR102497644B1 (ko) * | 2014-12-10 | 2023-02-08 | 리셉토스 엘엘씨 | Glp-1 수용체 조절제 |
| CN114539273A (zh) | 2016-06-07 | 2022-05-27 | 北京加科思新药研发有限公司 | 可用作shp2抑制剂的新型杂环衍生物 |
| HRP20241239T1 (hr) | 2017-03-23 | 2024-12-06 | Jacobio Pharmaceuticals Co., Ltd. | Novi heterociklički derivati korisni kao shp2 inhibitori |
| WO2018200833A1 (en) * | 2017-04-28 | 2018-11-01 | Celgene International Ii Sarl | Novel glp-1 receptor modulators |
| WO2020063760A1 (en) | 2018-09-26 | 2020-04-02 | Jacobio Pharmaceuticals Co., Ltd. | Novel heterocyclic derivatives useful as shp2 inhibitors |
| CN109608524B (zh) * | 2018-11-09 | 2022-06-03 | 北京志道生物科技有限公司 | 兼具dpp-4抑制及glp1r激活活性的多肽衍生物、制备和应用 |
| DK4097099T3 (da) | 2020-02-07 | 2024-07-15 | Gasherbrum Bio Inc | Heterocyckliske GLP1-agonister |
| CN111548311B (zh) * | 2020-06-04 | 2021-04-23 | 山西医科大学 | 一种小分子glp-1r激动剂及其应用 |
| CR20230066A (es) | 2020-08-06 | 2023-05-29 | Gasherbrum Bio Inc | Agonistas del glp-1 heterocíclicos |
| US20250188103A1 (en) | 2022-03-09 | 2025-06-12 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| US20250206757A1 (en) | 2022-03-21 | 2025-06-26 | Gasherbrum Bio, Inc. | 5,8-dihydro-1,7-naphthyridine derivatives as glp-1 agonists for the treatment of diabetes |
| JP2025513071A (ja) | 2022-04-14 | 2025-04-22 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環式glp-1アゴニスト |
| CN114989204A (zh) * | 2022-06-16 | 2022-09-02 | 西北工业大学 | 一种葡萄糖响应自修复凝胶用的二苯乙炔类液晶态交联剂的制备方法 |
| TW202521533A (zh) | 2023-09-14 | 2025-06-01 | 香港商歌禮製藥(中國)有限公司 | Glp-1r 激動劑及其治療方法 |
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- 2014-06-11 HK HK16110427.4A patent/HK1222176A1/zh unknown
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- 2014-06-11 CA CA2913791A patent/CA2913791A1/en not_active Abandoned
- 2014-06-11 CN CN201910207853.5A patent/CN109867630A/zh active Pending
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- 2014-06-11 BR BR112015031040A patent/BR112015031040A8/pt not_active Application Discontinuation
- 2014-06-11 EP EP14736554.8A patent/EP3008056B8/en active Active
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| JP2016528180A (ja) | 2016-09-15 |
| BR112015031040A2 (enExample) | 2017-07-25 |
| KR20160042868A (ko) | 2016-04-20 |
| AU2014278183A1 (en) | 2016-01-07 |
| WO2014201172A1 (en) | 2014-12-18 |
| MX2015016831A (es) | 2016-04-04 |
| US10259823B2 (en) | 2019-04-16 |
| US9598430B2 (en) | 2017-03-21 |
| CA2913791A1 (en) | 2014-12-18 |
| CN109867630A (zh) | 2019-06-11 |
| NZ715006A (en) | 2021-02-26 |
| EP3008056B1 (en) | 2020-12-09 |
| ES2864349T3 (es) | 2021-10-13 |
| AU2014278183B2 (en) | 2018-10-04 |
| US20160214993A1 (en) | 2016-07-28 |
| CN105593225A (zh) | 2016-05-18 |
| EP3008056A1 (en) | 2016-04-20 |
| EA201592281A1 (ru) | 2016-05-31 |
| MX370666B (es) | 2019-12-19 |
| JP6573604B2 (ja) | 2019-09-11 |
| EA030857B1 (ru) | 2018-10-31 |
| EP3008056B8 (en) | 2021-03-03 |
| US20170313717A1 (en) | 2017-11-02 |
| BR112015031040A8 (pt) | 2018-01-02 |
| US20150011527A1 (en) | 2015-01-08 |
| HK1222177A1 (zh) | 2017-06-23 |
| US9260427B2 (en) | 2016-02-16 |
| KR102271179B1 (ko) | 2021-07-01 |
| HK1222176A1 (zh) | 2017-06-23 |
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