CN105581026B - A kind of weanling pig resisting stress special feed and its application - Google Patents
A kind of weanling pig resisting stress special feed and its application Download PDFInfo
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Abstract
The present invention discloses a kind of weanling pig resisting stress special feed and its application.It is by popcorn 400-500g/kg, dregs of beans 150-300g/kg, fermented bean dregs 50-70g/kg, expanded soybean 50-60g/kg fish meal 50-60g/kg, lactose 40-70g/kg, whey powder 50-70g/kg, acid supplement 1-4g/kg, vegetable oil 20-30g/kg, antioxidant 0.5-1.5g/kg, choline chloride 1-2g/kg, calcium carbonate 5-10g/kg, calcium monohydrogen phosphate 7-10g/kg, 1% pre-mixing feed additive 8-12g/kg composition.The features of the present invention: nutrition is comprehensive, full-featured, significant effect, and the oxidation resistance of piglet can be improved, and protects gut barrier function；Eliminate intestine of young pigs pathogen, maintain intestinal flora microecological balance, alleviation stress caused by piglet eupepsy weaken；Improve pigling immunity, alleviation stress caused by immunosupress, improve weaned piglets.
Description
Technical field
The invention belongs to technical field of animal husbandry, it is related to a kind of weanling pig resisting stress special feed and application.
Background technique
High efficiency is pursued in Pig Industry production, and early weaning piglet technology has obtained universal application, but how to subtract
The diarrhea of few early-weaned piglets, reduce the piglet death rate becomes the key for improving pig production efficiency again.It is estimated that China is every
Since the dead head number of diarrhea is more than 100,000,000, direct economic loss is more than 20,000,000,000 yuan for year weanling pig, and it is female to directly result in China
Pig productivity is low, and the market pig of the annual every sow production in the whole nation is only 13 or so, and developed country is up to 25-30 head,
It has a long way to go.Diarrhea after Piglets " Weaning is mainly caused by weaning stress, eats feed to stomach from eating breast milk and be transitioned into when weaned piglet
Enteron aisle be the largest stress, directly result in gastrointestinal allergy and diarrhea occur.How weanling pig is raised, reduces its stomach and intestine
Road stress reaction is to reduce weaning brash, and improving its speed of growth is most important research contents in piglet nutrition research.
1. there are many stressor during wean.The initial period after wean, piglet are separated with sow by suddenly, transport, grab
It catches, feed changes, mix group with other piglets that do not know each other, physical environment changes, the contact increase with pathogen, environmental form antigen
Etc. it is many stress, piglet must rapidly adapt to these stress.It stress will lead to growth performance drop when piglet does not adapt to these
The low and higher death rate.
2. the initial period piglet feed intake decline of wean.Gastrointestinal system, which has, to be digested and absorbs nutriment, maintains
Isohydria, secretion digestive ferment, mucin, immunoglobulin etc., and the barrier as host's resistance deleterious pathogens and antigen.
After weaned piglet, it must be rapidly adapted to from height can digest, agreeable to the taste liquid breast milk is to nondigestible, palatability is slightly worse
The transformation of solid-state daily ration.Therefore the initial period feed intake decline of weaned piglet, body condition variation, growth are affected.According to the study extremely
First weekend after wean, the intake of piglet metabolic energy are 60%~70% or so of taken in breast milk before weaning, are taken around 2 weeks
Time be restored to wean before metabolic energy intake it is horizontal.Have studied that low feed intake is formed from different daily rations and small intestine is viscous by scholar
Relationship between envelope barrier function, as a result first in 4 days after wean, daily ration composition is not to maintain gut barrier function
Key factor, but lasting low feed intake makes piglet that gut barrier function obstacle easily occur；Also studies have reported that after wean
Low feed intake accelerates the generation of intestinal inflammatory, is unfavorable for maintaining enteron aisle height of naps and Crypt depth.Feed intake decline causes
Piglet growth performance decline.It is reported that weight gain in first week will affect the number of days that piglet reaches 110kg market weight after wean.
When weight gain in first week is greater than 227g/ days pig after wean, reach the number of days of market weight than acquisition 0 in first week after wean~
The piglet of weight gain in 150g/ days shortens 6~10 days.Therefore, piglet is made to search for food and grow extremely important as quickly as possible after wean.
There is a degree of decline and is difficult to avoid in weight, and understands with the influence for the related low feed intake that weans and to growth performance
Influence helps preferably to prepare daily ration using the various feedstuffs that feed intake can be improved and additive, and can help to manage
Person alleviates weaning stress of piglet using other management means.
3. intestine of young pigs structure and function changes during wean.With low feed intake, the enteron aisle structure of weanling pig
There is physiology with function to sexually revise, these physiological changes will affect the absorbability of small intestine, to influence food utilization efficiency.
There is acute, long-term structure and function and changes in the reports such as Pluske and Boudry wean meeting inducing intestinal, including suede after wean
Hair shortens and Crypt depth increases.Piglet there is also the reduction of brush border digestive enzyme activity after wean.The report such as Lalles, wean
2nd~5 day lactase and aminopeptidase activities decline afterwards, and maltase activity declined from after wean second day, then existed
It improves within 8th~15 day, alkaline phosphatase also declines, and alkaline phosphatase is one kind in pathogenic bacteria lipopolysaccharide endotoxin detoxification
In work and influence the enzyme of intestinal inflammatory.These change digestion, absorption and the secretion capacity for influencing small intestine, and then influence enteron aisle
Barrier function, lead to Diarrhea after Piglets " Weaning.
4. consequence relevant to wean further includes generating to gut barrier function other than abilities of digestive and absorption is impacted
Adverse effect.First barrier of the gut lumen epithelial layer as body defenses function, to protect piglet from small intestine lumen
The influence of various harmful microorganisms, toxin or antigen.When Gut barrie r is by destroying, the permeability of enteron aisle enhances, so that toxin,
Bacterium or antigen relevant to feed pass through epithelium layer, cause inflammatory reaction, malabsorption, diarrhea, and then reduce growth
Performance.The change that other immune responses during wean are pro-inflammatory cytokines occurs.Pro-inflammatory cytokine and nutrition
The permeability of substance is related with transport, therefore influences the integrality and epithelium function of enteron aisle.Research shows that wean is thin with proinflammatory
The early stage up-regulation of intracellular cytokine gene is related, may cause function of intestinal canal disorder and diarrhea.
When expressing related inflammation with the height of pro-inflammatory cytokine and occurring, it stress be likely to occur metabolism in order to cope with and change
Become.The immune function and metabolic process of body is adjusted in pro-inflammatory cytokine, therefore weaning stress will affect enteron aisle structure and change
Become and active immunity responsing reaction.After immune system is activated, feed feed intake, utilization rate, the speed of growth and lean tissue
Deposition can be reduced.Therefore alleviate weaning stress to change intestine of young pigs structure and the effect of inflammatory immune response activation, to mentioning
The growth performance of high piglet is most important.
Heat shock protein plays on mitigating negative effect effect related with wean and the activation of pro-inflammatory cytokine
Certain effect.Heat shock protein has various kinds of cell defencive function related with various types of stress reactions.Heat shock
Albumen is generated by epithelial cell with to that stress respond, to protect the cell under stress situation.Increase relevant to wean
Heat shock protein, potentially contributes to reduce the negative effect of inflammation and weaning stress by their cellular defense mechanism, and packet is lived
Inhibit the proliferation of pro-inflammatory cytokine and cell.
In conclusion weaning pig feeding problem has seriously affected the production efficiency of China's pig breeding industry, it has also become limit me
The bottleneck of state's pig breeding industry sustainable health development.The adverse effect that this patent generates alleviation weaning stress to piglet, raising are adopted
Appetite, survival rate and growth performance, the economic benefit for significantly improving scale pig production are of great significance.
Summary of the invention
The invention discloses a kind of weanling pig resisting stress special feeds, it is characterised in that per kilogram is by following raw material groups
At:
Popcorn 400-500g/kg dregs of beans 150-300g/kg
Fermented bean dregs 50-70g/kg expanded soybean 50-60g/kg
Fish meal 50-60g/kg lactose 40-70g/kg
Whey powder 50-70g/kg acid supplement (benzoic acid) 1-4g/kg
Vegetable oil 20-30g/kg antioxidant (ethoxyquinoline) 0.5-1.5g/kg
Choline chloride 1-2g/kg calcium carbonate 5-10g/kg
Calcium monohydrogen phosphate 7-10g/kg, 1% pre-mixing feed additive 8-12g/kg composition
Wherein 1% pre-mixing feed additive is vitamin A 0.24%, vitamin D by weight percent30.08%, it ties up
Raw element E2.4%, vitamin K30.03%, vitamin B10.04%, vitamin B20.06%, vitamin B60.04%, vitamin
B120.02%, Catergen %, folic acid 0.02%, niacinamide 0.3%, calcium pantothenate 0.15%, ferrous sulfate 2%, manganese sulfate 1.5%, nanometer
Zinc oxide 10%, copper sulphate 5%, potassium iodide 0.6%, sodium selenite 0.3%, ammonia tie up happy iron 4%, yeast selenium 1%, lysine 30%, sweet taste
Substance 2%, fragrance matter 4%, complex enzyme formulation 15%, phytase 1%, sodium butyrate 7%, theanine 4%, popcorn 7.22% mix
It is formulated.
The preparation method of weanling pig resisting stress special feed of the present invention:
(1) the various raw materials in 1% pre-mixing feed additive are hybridly prepared into 1% pre-mixing feed additive, it is spare.
(2) by popcorn, dregs of beans, fermented bean dregs, expanded soybean, fish meal, lactose, whey powder, acid supplement (benzoic acid),
Vegetable oil, choline chloride, calcium carbonate, calcium monohydrogen phosphate, 1% premix, mixes antioxidant (ethoxyquinoline) in proportion, i.e.,
It can.
The measure of weanling pig resisting stress disclosed by the invention specifically includes that
(1) piglet anti-oxidation stress ability is improved, the research of gut barrier function is protected
A kind of common stress disease of grice diarrhoea syndrome, and harmfulness is larger, mostly occurs in after wean 5 days or so
Piglet.Main cause is the inadaptable feed converted suddenly of piglet after wean, causes lientery, with piglet
Resistance decline, makes the mass propagations hyperplasia such as pathogenic bacteria such as Escherichia coli, generates toxin, exacerbates intestinal tract injury and digestion
It is in disorder.In recent years, domestic and foreign scholars have done about the Forming Mechanism that oxidative stress after wean causes intestines problem and have largely ground
Study carefully.The study found that oxidative stress passes through the close connection between destruction cell[2], cause water and numerous ions quilt from intestinal mucosa
It is dynamic to be diffused into enteric cavity, and it is further development of diarrhea.Close connection is mainly sticked point by Occludin, claudins, connection
Son and tricellulin 4 kinds of transmembrane proteins composition, they with connect complex proteins (ZO-1, ZO-2, ZO-3, p130,7H6,
Symplekin), cytoskeletal structure (micro-pipe, middle silk, microfilament) collectively forms tight junction complex.It is now recognized that oxidation is answered
Swash that mainly closely to connect GAP-associated protein GAP by phosphorylation adjusted, or by improving metal proteinase activity and promoting scorching
Sex factor is expressed to destroy close connection.Elias etc. is the study found that on free radical phosphorylation occludin protein 39 8/402
Tyrosine residue, to damage intercellular close connection.The report such as Kawauchiya, the phosphorylation of ZO-1 caused by free radical
And its degradation will cause claudin-4 and occludin to separate from cell tight junction compound.The freedom of high concentration
Base can improve the activity of iuntercellular metalloproteinases, and metalloproteinases can directly decompose cell tight junction albumen.In addition, from
By base can also by promoting the secretion of interferon activate small G-protein (RhoA), the latter by up-regulation Rho kinases (ROCK) because
Son causes intercellular tight junction compound to disintegrate.To make harmful intestinal tract bacteria enter intestinal mucosa, induces body and generate strongly
Inflammatory reaction.The inflammatory factor and free radical of generation can play synergistic effect, aggravate the damage of intestinal mucosa.It is new studies have shown that
The generation of intestinal inflammatory substance promotes the nerve modulation of enteron aisle, makes intestinal secretion dysfunction, enterocinesia accelerates or even convulsion
Contraction eventually leads to the generation of diarrhea and bloody stool.
Free radical is removed in enteron aisle there is enzyme and non-enzymatic defense system, antioxidase is first of defense system, including
Superoxide dismutase catalase glutathione peroxidase etc..Non-enzymatic defense system includes vitamin antioxidants
(vitamin C vitamin E, bata-carotene etc.), microelement kind antioxidant (Se, Zn, Ge etc.), Antioxidative Factors (paddy Guang
Sweet peptide, cysteine, lipoic acid etc.) functional drug, natural plants and effective component etc..Vitamin C is lacked by slowing down enteron aisle
The oxidative damage that hemorrhagic Reperfu- sion generates regulates and controls the expression of metalloprotein, improves the ability that enteron aisle resists oxidative stress.Vitamin
E itself has the function of maintenance, promotes enteric epithelium structural integrity and perfect in shape and function, and scholar begins to focus on vitamin E to intestines at present
The intervention effect of road oxidative damage.The lipophilic characteristics of vitamin E can repair the damage of intestinal epithelial cell membrane lipid peroxidatio,
Promote intestinal growth, plays an important role to maintenance intestinal absorption ability.Theanine can alleviate oxidative stress to a certain extent
It is damaged caused by Intestinal Tract Morphology structure, the appropriate exogenous theanine of addition has small intestine caused by improving total parenteral nutrition
The effect of mucosa injury.
(2) eliminate intestine of young pigs pathogen, maintain intestinal flora microecological balance, alleviation stress caused by piglet eupepsy
The research of decrease
In the presence of a large amount of normal microbial floras in animal gastrointestinal tract, this slightly raw flora establishes a kind of mutual with host
Tiny ecosystem relationship that is interdependent, mutually restricting constitutes a unified entirety, forms a dynamic equilibrium system.In animal
Under body normal physiological conditions, these gastrointestinol microorganism floras are focused in maintenance animal health, nutrien utilization etc. performance
The effect wanted.The gastrointestinol microorganism environment of weanling pig is very unstable.Piglet is by absorption easy to digest of searching for food originally after wean
Liquid breast milk become the bad solid feed of mouthfeel of searching for food, the variation of weaning stress and ration ingredient is so that in piglet gastrointestinal tract
Environment is changed, thus the field planting site of the quantity of microorganism and specified microorganisms also can be with changing in gastrointestinal tract
Become.
Some researches show that the linear downward trend of the quantity of Bacillus acidi lactici in weanling pig enteron aisle is reduced compared with suckling pig
14.3%, and Escherichia coli quantity linearly increases trend, increase 5.4% compared with suckling pig.This is because weanling pig stomach
Middle pH value increases, Bacillus acidi lactici quantity decline, so that Escherichia coli are largely proliferated.And the proliferation of Escherichia coli further functions as
Inhibit the effect of Bacillus acidi lactici quantity.In addition, pH value is lower in nursery-age pig stomach, the cause of disease invaded from oral cavity can be inhibited
Bacterium.And after weaning, stomach inner pH value significantly increases, it disappears to the inhibiting effect of pathogen, thus pathogen can run through stomach simultaneously
It is colonized in enteron aisle.Theanine can effectively inhibit the pathogens such as Escherichia coli, and lactic acid bacteria is promoted to be proliferated in enteron aisle,
Maintain intestinal flora balance.
(3) improve pigling immunity, alleviation stress caused by immunosupress, improve weaned piglets research
Vitamin E plays an important role to developing immune system, when vitamin E and selenium (Se) lack, mucous membrane growth by
It destroys, mucous membrane and thymus gland medium size lymphocyte quantity are reduced, but also be will affect T cell and showed the reaction that mitosis stimulates
Special influence T cell differentiation out.Theanine can be improved growth enteron aisle early period slgA content, the content of later period serum IL-2 and
The content of full period serum I FN- γ, to enhance its body's immunity.
The partial size of nano zine oxide belongs to the addition of forth generation microelement between 1~100nm, also known as ultra-fine zinc oxide
Agent is the nanoscale microelement product of comparative maturity.In feed add nano zine oxide can be improved antioxidant ability of organism,
Strengthen immunity reduces diarrhea rate and improves breeding performonce fo animals, promotes animal growth, improves animal product quality, increases
Strong disease resistance simultaneously improves animal reproduction performance.Nano zine oxide that the present invention selects, theanine have antibacterial, antiviral, anti-
Stress.It simultaneously can be with: improving the oxidation resistance of piglet, protect gut barrier function；Eliminate intestine of young pigs pathogen, dimension
Hold intestinal flora microecological balance.The immune function of piglet is adjusted, premunition is improved, promotes piglet growth, improves the price of deed.
Another object of the present invention is to disclose weanling pig resisting stress special feed to the anti-oxidant energy for improving piglet
Power protects gut barrier function；Eliminate intestine of young pigs pathogen, maintain intestinal flora microecological balance, alleviation stress caused by
Piglet eupepsy weakens；Improve pigling immunity, alleviation stress caused by immunosupress, improve weaned piglets etc.
Using.The present invention is had found by experimental study: the application method for the weanling pig resisting stress special feed developed, generally from son
Pig is weaned to be begun to use for first 1 week, to wean after terminate within 2 weeks, be freely eaten, drink water.
In order to further explain using effect of the invention, following test is provided:
One, feeding effect of the theanine to weanling pig
28 age in days weanling pig 120 is chosen in test, and male and female is fifty-fifty, is randomly divided into 4 groups, respectively control group, test 1
3 groups of group, 2 groups of test and test.The common mixed feed of control group fed, test group feeding respectively add 200mg/kg theanine,
The mixed feed of 400mg/kg theanine and 1000mg/kg theanine composition.
(1) theanine influences Growth Performance of Weaning Piglets
As shown in table 1, the average daily gain of 400mg/kg and 1000mg/kg theanine addition group and average daily gain are aobvious
Write be higher than 200mg/kg theanine group and control group (P< 0.05), and four group feed-weight ratio differences it is not significant (P> 0.05).Wherein,
400mg/kg theanine group feed-weight ratio ratio 1000mg/kg theanine addition group low 2.3%.
Influence of 1 theanine of table to Growth Performance of Weaning Piglets
The different capitalization of data shoulder mark of going together indicates that difference is extremely significant (P < 0.01), different small of colleague's data shoulder mark
Lowercase alphabet shows significant difference (P<0.05), identical or not significant (P>0.05) without letter expression difference.Following table is same.
(2) influence of the theanine to weanling pig blood parameters
Transaminase is the class of enzymes of transamination between catalytic amino acid and ketone acid.It is prevalent in animal, plant tissue
In microorganism, cardiac muscle, brain, liver, Shen Deng animal tissue.There are many type, in vivo except lysine, threonine China and foreign countries, remaining α-ammonia
The transaminase that base acid all can participate in transamination and respectively have its special.Wherein with glutamic-pyruvic transaminase (GPT) and glutamic-oxalacetic transaminease
(GOT) mostly important.Glutamic-pyruvic transaminase is the transamination being catalyzed between glutamic acid and pyruvic acid, and glutamic-oxalacetic transaminease is catalysis paddy
Transamination between propylhomoserin and oxaloacetic acid.Glutamic-oxalacetic transaminease is maximum with vigor in heart, is secondly liver；GPT is then with liver
Dirty middle vigor is maximum, and when liver cell damage, GPT is discharged into blood, and then blood inner enzyme vigor significantly increases.
From table 2 it can be seen that in blood parameters, the Gu Bingzhuan of 400mg/kg and 1000mg/kg theanine addition group
Adnosine deaminase (GPT), glutamic-oxalacetic transaminease (GOT) activity substantially less than 200mg/kg theanine group and control group (P< 0.05), and
The blood sugar concentration of 400mg/kg and 1000mg/kg theanine addition group is significantly higher than 200mg/kg theanine group and control group.
Influence of 2 theanine of table to the young blood parameters that wean
(3) influence of the theanine to weanling pig blood oxidation index
As shown in Table 3, the serum cortisol content of 400mg/kg and 1000mg/kg theanine addition group is substantially less than
200mg/kg theanine group and control group (P< 0.05)；Each group serum MDA level difference it is not significant (P> 0.05)；200mg/kg and
The serum GSH-PX activity of 400mg/kg theanine addition group be significantly higher than control group and 1000mg/kg theanine group (P>
0.05)；The Serum alkaline phosphatase activity of 400mg/kg and 1000mg/kg theanine addition group is substantially less than 200mg/kg tea ammonia
Acid group and control group (P< 0.05).
The result shows that antioxidant ability of organism can be enhanced in addition 400mg/kg theanine.
Influence of 3 theanine of table to weanling pig blood oxidation index
(4) influence of the theanine to the weanling pig haematogenic immunity factor
4 data of table show that the serum IgG content of 400mg/kg and 1000mg/kg theanine addition group is significantly higher than
200mg/kg theanine group and control group (P< 0.05)；The amount of three addition group serum IL-10 (IL-10) of theanine is significant
Lower than control group (P< 0.05), control group, 1 group of test, 2 groups of test and immunoglobulin A (IgA), the immune globulin of testing 3 groups
White M(IgM) between difference it is not significant (P> 0.05).
The result shows that immunity of organisms can be improved in addition theanine, it is horizontal to reduce internal inflammatory factor.
Influence of 4 theanine of table to the growing and fattening pigs haematogenic immunity factor
(5) influence of the theanine to weanling pig Endotoxin Levels
As shown in table 5, the Endotoxin Levels of 400mg/kg and 1000mg/kg theanine addition group are substantially less than
200mg/kg theanine group and control group (P< 0.05).Endotoxin Levels are low to illustrate that theanine can be effectively reduced intestines and glue
Membrane permeability protects intestinal mucosa from damage.
Influence of 5 theanine of table to weanling pig Endotoxin Levels
(6) influence of the theanine to Intestinal Microflora of Weanling Piglets
As shown in table 6, content of lactic acid bacteria significantly rises in 400mg/kg and 1000mg/kg theanine addition group piglet excrement
(P< 0.05), and Escherichia coli quantity be remarkably decreased (P> 0.05).Show that theanine can promote intestinal beneficial bacterium to be proliferated, presses down
Harmful bacteria proliferation processed.
Influence of 6 theanine of table to intestinal flora in weanling pig excrement
Two, influence of the different-grain diameter nano zine oxide to piglet growth performance and health status
Select source is identical, healthy 7 kg of weight or so 28 age in days Durocs × length it is white × great Bai three way cross wean son
Pig 120 (15 nests, 8, every nest), is randomly divided into 3 groups, every group of 5 repetitions, 8 pigs of every repetition.Three groups are control group (base
Plinth daily ration+3000 mg/Kg of zinc oxide, C group)；Test one group of (50 nm zinc oxide of basal diet+partial size 600 mg/kg, 50 nm
Group)；Test two groups (20 nm nano zine oxide of basal diet+partial size, 600 mg/Kg, 20 nm groups).The conventional colony house disinfection of progress,
Immune, feeding management.Test was since after wean 5 days, and phase experimental period 30 days.
(1) influence of the different-grain diameter nano zine oxide to piglet growth performance
As shown in table 7,20nm zinc oxide group piglet average daily gain is significantly higher than 50nm group and control group, and 50nm group with
Control group is compared, and difference is not significant.Three groups of average feed intake is without significant difference, and therefore, feed-weight ratio data show that 20nm group is aobvious
It writes and is lower than other two groups.
Influence of the 7 different-grain diameter nano zine oxide of table to Growth Performance of Weaning Piglets
(2) different-grain diameter nano zine oxide influences piglet health status
There is different degrees of diarrhea, morbidity even death condition in each group piglet after following table display wean.Wherein C group piglet
Health status is worst, and Post Weaning Diarrhea head number is more, and dead 2, and cad pig 1.50nm group and 20nm group health status are preferable,
Head number of falling ill is lower, and cures quickly after the onset, and wherein 20nm group does not occur dead and cad pig situation (table 8).
Influence of the 8 different-grain diameter nano zine oxide of table to weanling pig health status
Three, feeding effect of the nano zine oxide to weanling pig
Select source is identical, healthy weight 7Kg or so 28 age in days Durocs × length it is white × great Bai three way cross wean son
Pig 192 (24 nests, 8, every nest), RANDOMIZED BLOCK DESIGN are divided into 3 groups, i.e. control group (3000 mg/ of basal diet+zinc oxide
Kg, C group)；Test one group (300 mg/Kg of basal diet+20nm zinc oxide, T1 group)；Test two groups of (basal diet+20nm oxygen
Change 600 mg/Kg of zinc, T2 group).Every group of 8 nursing cotes, 8, every column, male and female is fifty-fifty, and every group amounts to 64 pigs.Carry out conventional circle
House disinfection, immune, feeding management.Experimental period 30 days.
(1) influence of the nano zine oxide to Growth Performance of Weaning Piglets
Table 9 shows that 600 mg/Kg nano zine oxide addition group piglet average daily gains are significantly higher than 300 mg/Kg nanometers
Zinc oxide group and control group (P< 0.05)；Three groups of piglet average daily gains without significant difference (P> 0.05).
Influence of 9 nano zine oxide of table to Growth Performance of Weaning Piglets
(2) weanling pig blood parameters
As shown in table 10, Zn in 600 mg/Kg nano zine oxide group weanling pig blood2+Concentration be significantly higher than control group (P
< 0.05) and 300 mg/Kg nano zine oxide groups.Hemoglobin and red in 600 mg/Kg nano zine oxide group weanling pig blood
Cell number be all remarkably higher than control group and 300 mg/Kg nano zine oxide groups (P<0.05).Enzyme sensitive to the relevant zinc of metabolism
(ALP, AST and LPH) enzyme assay is the results show that nano zine oxide addition group (T1 and T2) weanling pig serum ALP activity
Significantly reduce compared with the control group (P< 0.05)；Nano zine oxide addition group weanling pig Serum LDH and AST activity and control group
Not significant compared to difference (P> 0.05).
10 weanling pig blood parameters of table
Note: in column data, mark identical lowercase letter indication difference it is not significant (P> 0.05), different lowercases indicate
Significant difference (P< 0.05).HGB is hemoglobin, and RGB is red blood cell number, and ALP is alkaline phosphatase, and AST L-aminobutanedioic acid turns ammonia
Enzyme, LDH are lactic dehydrogenase.
(3) immune factor is horizontal
As shown in table 11, compared with the control group, the level of 600 mg/Kg nano zine oxide addition group serum IgAs and IgM are aobvious
Work raising (P< 0.05).
11 weanling pig serum immune globulin of table
Weanling pig resisting stress special feed disclosed by the invention is possessed compared with prior art to be had the active effect that
(1) weanling pig resisting stress special feed of the invention is high in technological content, and nutrition is comprehensive, balanced, young rich in wean
Various nutritional ingredients needed for pig reduce symptoms of stress after weaned piglet.
(2) oxidation resistance of piglet can be improved in weanling pig resisting stress special feed of the invention, protects gut barrier
Function.
(3) weanling pig resisting stress special feed of the invention can eliminate intestine of young pigs pathogen, maintain intestinal flora micro-
The ecological balance.
(4) immune function of piglet is adjusted in weanling pig resisting stress special feed of the invention, improves premunition.
(5) weanling pig resisting stress special feed of the invention can promote piglet growth, improve the price of deed.
Specific embodiment
By following embodiment, the invention will be further described, but not as limitation of the invention.Implementation of the invention
Example described in parts by weight raw material refer to gram, kilogram or ton, can according to produce it is actual needs be adjusted.Dimension therein
Raw element A, vitamin E, complex enzyme formulation, nano zine oxide, theanine etc. are commercially available.
Embodiment 1
Weanling pig resisting stress special feed formula composition (prepares 1 kg)
Popcorn 492g/kg dregs of beans 150g/kg fermented bean dregs 50g/kg
Expanded soybean 60g/kg fish meal 60g/kg lactose 60g/kg
Whey powder 60g/kg benzoic acid 4g/kg vegetable oil 30g/kg
Ethoxyquinoline 1g/kg choline chloride 5g/kg calcium carbonate 8g/kg
1% pre-mixing feed additive 10g/kg of calcium monohydrogen phosphate 10g/kg
Wherein 1% pre-mixing feed additive is vitamin A 0.24%, vitamin D by weight percent30.08%, it ties up
Raw element E2.4%, vitamin K30.03%, vitamin B10.04%, vitamin B20.06%, vitamin B60.04%, vitamin
B120.02%, Catergen %, folic acid 0.02%, niacinamide 0.3%, calcium pantothenate 0.15%, ferrous sulfate 2%, manganese sulfate 1.5%, nanometer
Zinc oxide (partial size 20nm) 10%, copper sulphate 5%, potassium iodide 0.6%, sodium selenite 0.3%, ammonia tie up happy iron 4%, yeast selenium 1%, rely ammonia
Sour 30%, sweet substance 2%, fragrance matter 4%, complex enzyme formulation 15%, phytase 1%, sodium butyrate 7%, theanine 4%, popcorn
7.22% mixed preparing forms.
Preparation method:
(1) the various raw materials in 1% pre-mixing feed additive are hybridly prepared into 1% pre-mixing feed additive, it is spare.
(2) by popcorn, dregs of beans, fermented bean dregs, expanded soybean, fish meal, lactose, whey powder, acid supplement (benzoic acid),
Vegetable oil, antioxidant (ethoxyquinoline), choline chloride, calcium carbonate, calcium monohydrogen phosphate, 1% pre-mixing feed additive are in proportion
Mixing.
Embodiment 2
Weanling pig resisting stress special feed formula composition (prepares 1 kg)
Popcorn 465g/kg dregs of beans 180g/kg fermented bean dregs 50g/kg
Expanded soybean 60g/kg fish meal 50g/kg lactose 60g/kg
Whey powder 70g/kg benzoic acid 4g/kg vegetable oil 30g/kg
Ethoxyquinoline 1g/kg choline chloride 2g/kg calcium carbonate 8g/kg
1% pre-mixing feed additive 10g/kg of calcium monohydrogen phosphate 10g/kg
Wherein 1% pre-mixing feed additive is vitamin A 0.24%, vitamin D by weight percent30.08%, it ties up
Raw element E2.4%, vitamin K30.03%, vitamin B10.04%, vitamin B20.06%, vitamin B60.04%, vitamin
B120.02%, Catergen %, folic acid 0.02%, niacinamide 0.3%, calcium pantothenate 0.15%, ferrous sulfate 2%, manganese sulfate 1.5%, nanometer
Zinc oxide (partial size 20nm) 6%, copper sulphate 5%, potassium iodide 0.6%, sodium selenite 0.3%, ammonia tie up happy iron 4%, yeast selenium 1%, rely ammonia
Sour 30%, sweet substance 2%, fragrance matter 4%, complex enzyme formulation 15%, phytase 1%, sodium butyrate 7%, theanine 8%, popcorn
7.22% mixed preparing forms.
Preparation method:
(1) the various raw materials in 1% pre-mixing feed additive are hybridly prepared into 1% pre-mixing feed additive, it is spare.
(2) by popcorn, dregs of beans, fermented bean dregs, expanded soybean, fish meal, lactose, whey powder, acid supplement (benzoic acid),
Vegetable oil, antioxidant (ethoxyquinoline), choline chloride, calcium carbonate, calcium monohydrogen phosphate, 1% pre-mixing feed additive are in proportion
Mixing.
Embodiment 3
Weanling pig resisting stress special feed formula composition (prepares 1 kg)
Popcorn 490g/kg dregs of beans 170g/kg fermented bean dregs 60g/kg
Expanded soybean 55g/kg fish meal 60g/kg lactose 50g/kg
Whey powder 50g/kg benzoic acid 4g/kg vegetable oil 30g/kg
Ethoxyquinoline 1g/kg choline chloride 2g/kg calcium carbonate 8g/kg
1% pre-mixing feed additive 10g/kg of calcium monohydrogen phosphate 10g/kg
Wherein 1% premix is vitamin A 0.24%, vitamin D by weight percent30.08%, vitamin E2 .4%,
Vitamin K30.03%, vitamin B10.04%, vitamin B20.06%, vitamin B60.04%, vitamin B120.02%, vitamin
C2%, folic acid 0.02%, niacinamide 0.3%, calcium pantothenate 0.15%, ferrous sulfate 2%, manganese sulfate 1.5%, nano zine oxide (partial size
20nm) 6%, copper sulphate 5%, potassium iodide 0.6%, sodium selenite 0.3%, the happy iron 4% of ammonia dimension, yeast selenium 1%, lysine 30%, sweet taste object
Matter 2%, fragrance matter 4%, complex enzyme formulation 13%, phytase 1%, sodium butyrate 7%, theanine 10%, the mixing of popcorn 7.22% are matched
It makes.
Preparation method:
(1) the various raw materials in 1% pre-mixing feed additive are hybridly prepared into 1% pre-mixing feed additive, it is spare.
(2) by popcorn, dregs of beans, fermented bean dregs, expanded soybean, fish meal, lactose, whey powder, acid supplement (benzoic acid),
Vegetable oil, antioxidant (ethoxyquinoline), choline chloride, calcium carbonate, calcium monohydrogen phosphate, 1% pre-mixing feed additive are in proportion
Mixing.
Claims (5)
1. a kind of weanling pig resisting stress special feed, it is characterised in that per kilogram is made of following raw materials:
Popcorn 400-500g/kg dregs of beans 150-300g/kg
Fermented bean dregs 50-70g/kg expanded soybean 50-60g/kg
Fish meal 50-60g/kg lactose 40-70g/kg
Whey powder 50-70g/kg acid supplement 1-4g/kg
Vegetable oil 20-30g/kg antioxidant 0.5-1.5g/kg
Choline chloride 1-2g/kg calcium carbonate 5-10g/kg
Calcium monohydrogen phosphate 7-10g/kg, 1% pre-mixing feed additive 8-12g/kg composition；
Wherein the acid supplement refers to: benzoic acid；Antioxidant refers to: ethoxyquinoline；
1% pre-mixing feed additive is vitamin A 0.24%, vitamin D by weight percent30.08%, vitamin
E2.4%, vitamin K30.03%, vitamin B10.04%, vitamin B20.06%, vitamin B60.04%, vitamin B120.02%, it ties up
Raw element C2%, folic acid 0.02%, niacinamide 0.3%, calcium pantothenate 0.15%, ferrous sulfate 2%, manganese sulfate 1.5%, nano zine oxide 10%,
Copper sulphate 5%, potassium iodide 0.6%, sodium selenite 0.3%, ammonia tie up happy iron 4%, yeast selenium 1%, lysine 30%, sweet substance 2%, perfume
Taste substance 4%, complex enzyme formulation 15%, phytase 1%, sodium butyrate 7%, theanine 4%, 7.22% mixed preparing of popcorn form.
2. the application method of weanling pig resisting stress special feed described in claim 1, it is characterised in that 1 week before weaned piglet
Two weeks Direct-feds after to wean.
3. anti-oxidation stress ability of the weanling pig resisting stress special feed described in claim 1 in preparation as raising piglet,
Protect the application in terms of the feed of gut barrier function.
4. weanling pig resisting stress special feed described in claim 1, as intestine of young pigs pathogen is eliminated, maintains intestines in preparation
Road bacterial micro-ecological balance, alleviate stress caused by piglet eupepsy weaken feed in terms of application.
5. weanling pig resisting stress special feed described in claim 1 stress be made in preparation as pigling immunity, alleviation is improved
At immunosupress, improve the application in terms of the feed of weaned piglets.
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| CN106819452A (en) * | 2016-12-20 | 2017-06-13 | 新昌县柏克动物饲料技术开发有限公司 | Lift the feed addictive and preparation method of piglet stress ability |
| CN106879849A (en) * | 2017-04-14 | 2017-06-23 | 天津市浩生农牧科技有限公司 | Immunologic facilitation type piglet feed |
| CN107114322A (en) * | 2017-07-07 | 2017-09-01 | 郭桂香 | A kind of method for breeding for improving stress of baby pigs caused ablaction resistance |
| CN109258958A (en) * | 2018-12-12 | 2019-01-25 | 湖南百宜饲料科技有限公司 | A kind of feed addictive of weanling pig |
| CN109997960A (en) * | 2019-05-06 | 2019-07-12 | 北京绿摇饲料科技有限公司 | A kind of weanling pig Transition Materials and its application method |
| CN112617033A (en) * | 2020-12-14 | 2021-04-09 | 齐全农牧集团股份有限公司 | Feed for improving intestinal health of weaned piglets and preparation method thereof |
| CN113349288A (en) * | 2021-07-06 | 2021-09-07 | 湖南农业大学 | Application method of L-theanine for relieving vomitoxin damage to pig intestine barrier |
| CN114586895A (en) * | 2022-01-05 | 2022-06-07 | 安池(山东)动物营养研究院有限公司 | Functional bag for relieving piglet weaning stress and preparation method thereof |
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| CN102258156A (en) * | 2011-08-30 | 2011-11-30 | 武汉天龙饲料有限公司 | Antibiotic-free culture feed for piglets and preparation method thereof |
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