CN105561359A - Blood product treatment system based on riboflavin photochemical method - Google Patents
Blood product treatment system based on riboflavin photochemical method Download PDFInfo
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- CN105561359A CN105561359A CN201610070102.XA CN201610070102A CN105561359A CN 105561359 A CN105561359 A CN 105561359A CN 201610070102 A CN201610070102 A CN 201610070102A CN 105561359 A CN105561359 A CN 105561359A
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- bag
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- blood products
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- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 title claims abstract description 114
- 239000010836 blood and blood product Substances 0.000 title claims abstract description 81
- 229940125691 blood product Drugs 0.000 title claims abstract description 81
- 229960002477 riboflavin Drugs 0.000 title claims abstract description 57
- 239000002151 riboflavin Substances 0.000 title claims abstract description 57
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 title claims abstract description 56
- 235000019192 riboflavin Nutrition 0.000 title claims abstract description 56
- 238000000034 method Methods 0.000 title abstract description 49
- 239000008280 blood Substances 0.000 claims abstract description 87
- 210000004369 blood Anatomy 0.000 claims abstract description 86
- 239000010453 quartz Substances 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- 230000008569 process Effects 0.000 abstract description 19
- 230000002779 inactivation Effects 0.000 abstract description 17
- 244000052769 pathogen Species 0.000 abstract description 9
- 210000004698 lymphocyte Anatomy 0.000 abstract description 8
- 238000012545 processing Methods 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 5
- 239000000654 additive Substances 0.000 abstract description 2
- 230000000996 additive effect Effects 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 210000002381 plasma Anatomy 0.000 description 22
- 241000700605 Viruses Species 0.000 description 18
- 230000009849 deactivation Effects 0.000 description 17
- 210000001772 blood platelet Anatomy 0.000 description 10
- 239000007788 liquid Substances 0.000 description 7
- 230000001717 pathogenic effect Effects 0.000 description 7
- 230000001954 sterilising effect Effects 0.000 description 6
- 230000007306 turnover Effects 0.000 description 6
- FVTCRASFADXXNN-SCRDCRAPSA-N flavin mononucleotide Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O FVTCRASFADXXNN-SCRDCRAPSA-N 0.000 description 5
- 238000005286 illumination Methods 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 229950001574 riboflavin phosphate Drugs 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 238000004891 communication Methods 0.000 description 4
- 238000012423 maintenance Methods 0.000 description 4
- 229960000907 methylthioninium chloride Drugs 0.000 description 4
- 238000013461 design Methods 0.000 description 3
- 230000000415 inactivating effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000009514 concussion Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000005038 ethylene vinyl acetate Substances 0.000 description 2
- 208000024908 graft versus host disease Diseases 0.000 description 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 2
- 238000007639 printing Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000019155 Radiation injury Diseases 0.000 description 1
- 241000605008 Spirillum Species 0.000 description 1
- 238000004378 air conditioning Methods 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical group O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000004914 menses Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229940021317 other blood product in atc Drugs 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000009928 pasteurization Methods 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000006303 photolysis reaction Methods 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0047—Ultraviolet radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/26—Accessories or devices or components used for biocidal treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/025—Means for agitating or shaking blood containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0281—Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0286—Handling a large number of blood product units, e.g. storage cabinets, blood bank administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/22—Blood or products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3368—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention provides a blood product treatment system based on a riboflavin photochemical method. The blood product processing system comprises at least one blood product processing box body and a blood bag, wherein ultraviolet lamps and light treatment bag trays are arranged at the upper portion and the lower portion inside each box body, and the blood bag comprises a blood inlet pipe, a light treatment bag, a riboflavin adding part and a finished product bag. The blood product treatment system can effectively kill various pathogens and lymphocytes, does not need additive addition after inactivation treatment, is free of toxic and side effects and is simple in operation and high in safety. In addition, a constant temperature system is added, a blood product is controlled to be within an optimum temperature range, an inactivation treatment process is operated through an automatic system, a treatment state of the blood product can be quickly, conveniently and effectively observed and controlled, and automatic and intelligent operating process is achieved.
Description
Technical field
The invention belongs to field of medical device, particularly a kind for the treatment of of blood products system based on riboflavin photochemical method.
Background technology
Blood products comprises safely menses and spreads disease that substance (virus, antibacterial, protozoon, spirillum etc.) infects, the GVHD etc. that causes of blood cell (as lymphocyte).The method that in blood plasma, Viral inactivation techniques is common comprises Pasteurization, S/D method, membrane filter method, methylene blue method and riboflavin photochemical method etc., wherein, methylene blue method is applied wider at home, but some is not enough for the method, comprise that the loss of plasma protein after the residual toxicity of serge blue, process is comparatively large, complex operation etc.; Prevent the method for GVHD from being carry out irradiation (deactivation lymphocyte) to blood.
Riboflavin photochemical method inactivation of viruses is considered to the method with development prospect, its principle is: riboflavin because of architectural characteristic can embed virus nucleic acid in, under ultraviolet radiation, excite the transfer of its electronics, the guanine residue on oxidation nucleic acid, the nucleic acid of virus is impaired by modifying, can not carry out again copying and repairing, thus reach the effect of inactivation of viruses, and riboflavin be safe medicine, there is no toxic and side effects, add after processing without the need to filtering.In existing granted product, only have riboflavin photochemical method to carry out viral inactivation treatment to platelet abroad, and individual equipment once can only process at most two treatment units.
Patent CN203017432U discloses a kind of flow-type blood-plasma virus killing equipment, comprises casing, is installed with the uviol lamp group that at least two groups are symmetrical set in casing; Be provided with blood plasma flow duct between described two groups of uviol lamp groups, blood plasma input and the blood plasma outfan of described blood plasma flow duct are separately positioned on outside described casing.But flow-type blood-plasma virus killing equipment is only applicable to the batch process of pooled plasma.
Patent CN204582023U discloses a kind of plaque virus inactivating device, comprise can anti-hemostasis bag supporting network and lay respectively at upper deactivation uviol lamp above and below supporting network and lower deactivation uviol lamp, the spacing of upper deactivation uviol lamp and lower deactivation uviol lamp and supporting network is adjustable, and upper deactivation uviol lamp and lower deactivation uviol lamp include lamp box, be contained in some ultraviolet lamp tubes in lamp box and dark slide.But this patent equally only relates to plaque virus inactivating device, there is no complete supporting technology, and inactivation process relies on manual operations completely.
Patent CN204582095U discloses the conjuncted blood taking bag of a kind of leucocyte-removing inactivation of virus, comprise blood taking needle, whole blood bag, leukocyte depletion filter, leucocyte-removing whole blood bag, alserver's solution bag, threeway, plasma bags, methylene blue element, easily folding piece, methylene blue filter, product bag, described blood taking needle is by tubes connection on the inlet ducts of whole blood bag upper end, and the delivery channel of described whole blood bag upper end to be connected leucocyte-removing whole blood bag, plasma bags and product bag successively by import and export conduit.
Patent CN201418870Y discloses a kind of blood bag for riboflavin whole blood virus inactivation, the collecting whole blood be connected as one successively by pipeline three collection bags, the hemorrhage pipeline of collection bag is arranged in series riboflavin and adds element.But, the design of above-mentioned blood bag is complicated, when adopting single bag of photoinactivation virus, too much parts can affect lighting effect, importantly the ultraviolet permeability of this bag is very low, is not suitable for ultraviolet radiation process, must be placed on the pallet of deactivation equipment owing to not arranging fixture blood bag simultaneously, and pallet meeting shading light is according to the process of inactivation of viruses, finally affect deactivation efficiency.
For overcoming the defect of prior art, the invention provides a kind of based on riboflavin photochemical method treatment of blood products system.
Summary of the invention
The present invention not only solves the defect that there is shading light photograph when blood products adopts single bag of inactivating pathogens due to the restriction of blood bag support component, achieve the automatization that blood products is pathogen inactivated, improve the pathogen inactivated safety of blood products and simplicity, simultaneously can also to the process including but not limited to single blood products, namely inactivation of virus, bacteria inactivation and to the lymphocyte deactivation in these blood products are carried out to blood plasma, platelet, erythrocyte or whole blood.
One aspect of the present invention provides a kind for the treatment of of blood products system based on riboflavin photochemical method, comprises at least one treatment of blood products casing and blood bag; Described blood bag comprises blood and enters pipe, photo-irradiation treatment bag, riboflavin interpolation part and finished bag, and described photo-irradiation treatment bag tip edge and bottom edge arrange link; Be provided with uviol lamp, photo-irradiation treatment bag pallet in described casing, described photo-irradiation treatment bag pallet comprises horizontally disposed frame, described frame is provided with photo-irradiation treatment bag fixed part; Described link is connected with photo-irradiation treatment bag fixed part makes the parallel uviol lamp of photo-irradiation treatment bag place.
Treatment of blood products casing of the present invention is preferably the casing of lucifuge, prevents operator to be subject to ultraviolet radiation injury.Described treatment of blood products casing is provided with chamber door, and described chamber door arranges visual window, for the turnover of photo-irradiation treatment bag and the observation of inside and maintenance.
Uviol lamp of the present invention is positioned at the both sides up and down of casing, preferably, described uviol lamp is that the mode of UVA combined U VB arranges, preferred, described uviol lamp is the paired cross arrangement of UVA combined U VB, most preferred, described ultra violet lamp intensity is identical, ensure that the uniform irradiation of uviol lamp to the upper and lower both sides of photo-irradiation treatment bag.In the specific embodiment of the present invention, described uviol lamp is connected by roll adjustment arm is vertical with casing, described roll adjustment arm can regulate the distance between uviol lamp and illumination bag process pallet, with the demand of different parameters (UV intensity) needed for satisfied different blood products.
The blood of photo-irradiation treatment bag of the present invention enters pipe and is arranged on photo-irradiation treatment bag top and is connected with photo-irradiation treatment bag.
The link of photo-irradiation treatment bag of the present invention is selected from hard plate, fixing hole and by one or more the combination smashed.Preferably, described link is arranged on the corner of photo-irradiation treatment bag tip edge and bottom edge.Preferred, described link is hard plate and fixing hole, and described fixing hole is arranged on hard plate.
Photo-irradiation treatment bag pallet of the present invention comprises horizontally disposed frame, and preferably, described photo-irradiation treatment bag pallet also comprises quartz plate, and described quartz plate is embedded in frame.Described photo-irradiation treatment bag pallet can not cover the irradiation of upper and lower both direction uviol lamp.Photo-irradiation treatment bag fixed part of the present invention is preferably clip, hook and by one or more the combination smashed.When the photo-irradiation treatment bag fixed part arranged on described frame is clip, the hard plate of photo-irradiation treatment bag tip edge and bottom edge can be clamped, thus blood bag maintenance level is fixed.When the photo-irradiation treatment bag fixed part arranged on described frame is for hook, can be connected with the fixing hole of bottom edge by photo-irradiation treatment bag tip edge, thus blood bag maintenance level is fixed.When the photo-irradiation treatment bag fixed part arranged on described frame is snap-fastener, can be connected with the snap-fastener of bottom edge by photo-irradiation treatment bag tip edge, thus blood bag maintenance level is fixed.Preferably, photo-irradiation treatment bag fixed part is arranged on the corner of photo-irradiation treatment bag pallet or frame.Preferred, be provided with retractor device between described casing and pallet, can stretch pallet access device casing.Preferred, pallet is connected with multidirectional rocking equipment, can realize the slight level concussion of pallet and swing, making photo-irradiation treatment bag inner blood goods uniform irradiation, most preferred, described multidirectional rocking equipment is for connecting yaw motors.
The blood of photo-irradiation treatment bag of the present invention enters pipe top and is also provided with syringe needle, for puncturing former blood plasma, platelet or whole blood bag.
The riboflavin interpolation part of blood bag of the present invention is arranged on photo-irradiation treatment bag top and is connected with photo-irradiation treatment bag, preferably, described riboflavin is added part and is connected with photo-irradiation treatment bag by easy folding piece, when blood to enter after pipe enters photo-irradiation treatment bag by blood, easy folding piece fractureed, riboflavin is mixed in the blood of photo-irradiation treatment bag.Or the riboflavin of described blood bag adds part and is arranged on on blood vessel, and when blood products, from entering, vessel flow is fashionable adds part by riboflavin, and riboflavin is mixed into blood products and carries out illumination inactivation of virus.Preferred, it is tubbiness tubulose that described riboflavin adds part, and capacity is 1-4mL, is prepared by hard material.Most preferred; it is that translucent parts or described riboflavin interpolation part are outside equipped with light-avoiding coat that described riboflavin adds part; protection riboflavin is not by photodissociation on the one hand, and after being convenient to observe inflow blood plasma or platelet on the other hand, whether riboflavin is dissolved almost completely.Particularly preferred, it is liquid or powder that riboflavin of the present invention adds riboflavin in part.
Blood bag of the present invention also comprises finished bag, and described finished bag was connected with photo-irradiation treatment bag bottom by communicating pipe, and described communicating pipe is provided with flow-stopping clip.Described finished bag can be common plasma bags or platelet bag, and preferably, described finished bag is normal 200mL plasma bags.For the blood plasma after splendid attire process or platelet or whole blood.Preferably, described finished bag can be 1-3.
The blood of blood bag of the present invention enters on pipe and/or communicating pipe and is provided with flow-stopping clip, and described flow-stopping clip is used for blood plasma or platelet/or whole blood and flows into rear sealing orifice, prevents from flowing backwards.
Photo-irradiation treatment bag of the present invention preferably adopts the saturating ultraviolet light material of ultra-thin height, includes but not limited to ethylene-vinyl acetate copolymer (EVA) material, ensure that the illumination efficiency of ultraviolet light, all kinds of pathogen of the effective deactivation of ultraviolet light when making photo-irradiation treatment.
Blood bag of the present invention is preferably through sterilization treatment, when being liquid core flavin in described riboflavin interpolation part, mode canned after blood bag sterilization treatment can take overall sterilizing, when being powder riboflavin in described riboflavin interpolation part, blood bag sterilization treatment can take the sterilization treatment mode of Integratively formula.
Finished bag placing component is also provided with, for placing finished bag in treatment of blood products casing of the present invention.Preferably, described finished bag placing component can be hook, pallet, supporting network etc.
Of the present inventionly also include constant temperature parts based on riboflavin photochemical method treatment of blood products system, preferably, described constant temperature parts comprise heater (such as heater), chiller (such as air-conditioning fan processed) and thermometer.Constant temperature parts can control the temperature in casing, the temperature of blood plasma after access arrangement and the temperature of the rear blood plasma of process are detected, ensure that blood plasma controls about 4 ± 2 DEG C of scopes from entering into outflow temperature all the time, platelet controls about 22 ± 2 DEG C of scopes all the time from entering into outflow temperature.
Of the present inventionly also comprise control panel based on riboflavin photochemical method treatment of blood products system, described control panel is connected with retractor device, multidirectional rocking equipment communication.Preferably, described control panel comprises LCDs and action button, the time etc. of described LCDs display process state, the temperature inside the box, process, described action button comprises power knob, passes in and out button, arranges button etc., can realize the turnover of pallet and the processing time etc. of control.
Of the present inventionly also comprise bar code printing device, barcode scanning device and meausring apparatus based on riboflavin photochemical method treatment of blood products system.Described bar code printing device, barcode scanning device and meausring apparatus are preferably bar code printer, barcode scanning gun and platform scale, by bar code of weighing, print, paste bar code, sweep bar code, be convenient to the management to illumination blood products.
In the specific embodiment of the present invention, in described treatment of blood products casing, be provided with 2-10 photo-irradiation treatment bag pallet, be more preferably provided with 6-8 photo-irradiation treatment bag pallet.Described treatment of blood products system equipment comprises 1-10 treatment of blood products casing, such as, be 4-6.The casing of described treatment of blood products can be arranged vertically, also can be horizontal.Between described treatment of blood products casing, communication connects, for recording the relevant information (as blood products numbering, weight, processor, processing time) of the operation conditions of this equipment and the whole blood products through this device processes, and according to demand its recorded information is connected in the record of this blood products in LIS system.Such as, for realizing extensive treatment of blood products, 4-8 photo-irradiation treatment bag pallet can be set in the casing of described treatment of blood products system or described treatment of blood products system comprises hierarchal arrangement 2-5 layer treatment of blood products casing, wherein, each photo-irradiation treatment bag pallet can operate separately, controls turnover respectively, do not affect the operation of other layers, realizing full-time uninterrupted continued operation, without the need to waiting for, improve utilization ratio substantially.
Also one side of the present invention provides a kind for the treatment of of blood products equipment, comprise at least one treatment of blood products casing, uviol lamp, photo-irradiation treatment bag pallet is provided with in described casing, described uviol lamp is positioned at the both sides up and down of casing, described photo-irradiation treatment bag pallet is arranged at middle part in casing, described photo-irradiation treatment bag pallet comprises horizontally disposed frame, described frame is provided with photo-irradiation treatment bag fixed part.
Blood products of the present invention comprises whole blood, blood plasma, platelet or other blood products.
Treatment of blood products system of the present invention can effectively all kinds of pathogen of deactivation (as antibacterial, virus, protozoon etc.) and lymphocyte, do not need after inactivation treatment to remove additive, and there is not Side effect, simple to operate, safety is higher, increase constant temperature keeping system simultaneously, controlling blood products is in optimum temperature range, and by automated system operation inactivation treatment flow process, can more convenient, effective observation and control the treatment state of blood products, realize automatization, intelligentized operating process.
Accompanying drawing explanation
Fig. 1 is the structural representation of riboflavin photochemical method treatment of blood products system of the present invention.
Fig. 2 is the structural representation with the treatment of blood products system of 3 casings of the horizontally-arranged placement of the present invention.
Fig. 3 is the structural representation with the treatment of blood products system of 4 photo-irradiation treatment bag pallets that vertical setting of types of the present invention is placed.
Fig. 4 is the structural representation of the blood bag of riboflavin photochemical method treatment of blood products system of the present invention.
Fig. 5 is the structural representation (two bags) that the present invention has the blood bag of the riboflavin photochemical method treatment of blood products system of 1 finished bag.
Fig. 6 is the structural representation (two bags) that the present invention's another kind has the blood bag of the riboflavin photochemical method treatment of blood products system of 1 finished bag.
Fig. 7 is the structural representation (tetrad bag) that the present invention has the blood bag of the riboflavin photochemical method treatment of blood products system of 3 finished bags.
Wherein, 100-treatment of blood products casing, 102-chamber door, 200-uviol lamp, 201-roll adjustment arm, 300-photo-irradiation treatment bag pallet, 301-frame, 302-photo-irradiation treatment bag fixed part, 303-retractor device, the multidirectional rocking equipment of 304-, 305-quartz plate, 400-finished bag placing component, 501-thermometer, 502-constant temperature fan, 600-control panel, 601-display screen, 602-action button, 701-bar code printer, 702-barcode scanning gun, 703-platform scale, 800-computer;
901-blood enters pipe, 902-photo-irradiation treatment bag, 903-riboflavin interpolation part, 904-syringe needle, 905-flow-stopping clip, 906-finished bag, 907-communicating pipe, 911-hard plate, 912-fixing hole.
Detailed description of the invention
Fig. 1 is the treatment of blood products system that the present invention is based on riboflavin photochemical method, comprise inactivation of virus casing 100, uviol lamp 200, ultraviolet 200 lamp is positioned at the both sides up and down of casing 100, be connected by roll adjustment arm 201 with casing 100, can regulate the distance between uviol lamp and illumination bag process pallet, and the mode that uviol lamp 200 is UVA combined U VB arranges.Be horizontally disposed with frame 301, be arranged on the photo-irradiation treatment bag fixed part 302 of 301 4 jiaos, frame and jointly form photo-irradiation treatment bag pallet with the quartz plate 305 that frame 301 is inlayed.Retractor device 303 is provided with between casing 100 and pallet, can by pallet flexible turnover casing 100.Pallet is connected with multidirectional rocking equipment 304, after opening, the slight level concussion of pallet and swing, make photo-irradiation treatment bag 902 inner blood goods uniform irradiation.Finished bag placing component 400 is also provided with, for laying the finished bag 906 be connected with photo-irradiation treatment bag in casing 100.Also be provided with constant temperature parts in casing 100, comprise constant temperature fan 502 and thermometer 501, constant temperature parts are for controlling temperature in casing.
Fig. 2 is the treatment of blood products system with 3 casings of the horizontally-arranged placement of the present invention, comprises 3 casings 100, each casing is provided with chamber door 102, display screen 601, action button 602.Wherein, display screen 601 and action button 602 composition control panel, control panel is connected with the retractor device 303 in casing, multidirectional rocking equipment 304 communication, is controlled turnover and the processing time of pallet by manipulation operations button 602.Meanwhile, each casing 100 is connected with bar code printer 701, barcode scanning gun 702 and platform scale 703,3 casings 100 and is finally connected with computer 800 communication, for recording blood deactivation operation information.
Fig. 3 is the treatment of blood products system with 4 casings that vertical setting of types of the present invention is placed, comprise 1 casing 100, penetrating up and down, keep overall in casing and keep constant temperature, 4 vertical setting of types vertically disposed photo-irradiation treatment bag pallets 300 are provided with in casing 100, each photo-irradiation treatment bag pallet all arranges uviol lamp 200 up and down, and each photo-irradiation treatment bag pallet 300 correspondence is provided with chamber door 102 and control panel 300, and each control panel 300 controls separately the turnover of pallet.
Fig. 4 is the blood bag of riboflavin photochemical method treatment of blood products system of the present invention, comprise blood and enter pipe 901, photo-irradiation treatment bag 902, riboflavin interpolation part 903, blood enters pipe 901 and is arranged on photo-irradiation treatment bag 902 top and is connected with photo-irradiation treatment bag 902, riboflavin interpolation part 903 is arranged on photo-irradiation treatment bag 902 top and is connected by easy folding piece with photo-irradiation treatment bag 902, in riboflavin interpolation part 903, riboflavin sodium phosphate liquid is housed.Blood enters pipe 901 top and is provided with syringe needle 904, and blood enters on pipe and accompanies flow-stopping clip 905.The tip edge of photo-irradiation treatment bag 902 and the corner of bottom edge are provided with connecting portion hard plate 911 and fixing hole 912.
When blood products needs process, enter pipe 901 by blood and blood transport is entered photo-irradiation treatment bag 902, fracture easy folding piece, and the riboflavin sodium phosphate liquid that riboflavin is added in part 903 mixes with blood in photo-irradiation treatment bag 902.Blood bag is put into pallet, four angles of photo-irradiation treatment bag 902 are fixed on photo-irradiation treatment bag fixed part 302, the parallel uviol lamp 200 of photo-irradiation treatment bag 902 is placed, then uviol lamp light unscreenedly can be radiated at the two sides of photo-irradiation treatment bag 902, kill virus.
Fig. 5 and Fig. 6 is the blood bag that the present invention has the riboflavin photochemical method treatment of blood products system of 1 finished bag, is generally blood plasma or platelet two bags.Described blood bag comprises blood and enters pipe 901, photo-irradiation treatment bag 902, riboflavin interpolation part 903, the tip edge of photo-irradiation treatment bag 902 and the corner of bottom edge are provided with fixing hole 912 and/or hard plate 911, the bottom of photo-irradiation treatment bag 902, by being connected with 1 finished bag 906 communicating pipe 907, communicating pipe 907 can be provided with flow-stopping clip 905.
Wherein, riboflavin interpolation part 903 described in Fig. 5 is arranged on blood and enters on pipe 901, when using blood bag to carry out pathogen or lymphocyte deactivation, enter pipe 901 by blood and blood transport is entered photo-irradiation treatment bag 902, blood flow through into blood enter riboflavin on pipe 901 add part 903 time, riboflavin sodium phosphate powder wherein flows in photo-irradiation treatment bag 902 simultaneously and mixes with blood.The advantage of Fig. 5 design is that in process of production, sterilization link is more easy to operate, because powder is high temperature resistant.
Wherein, riboflavin described in Fig. 6 adds part 903 and is arranged on photo-irradiation treatment bag 902 top, be connected by easy folding piece with photo-irradiation treatment bag 902, when using blood bag to carry out pathogen or lymphocyte deactivation, enter pipe 901 by blood and blood transport is entered photo-irradiation treatment bag 902, fracture easy folding piece, and the riboflavin sodium phosphate liquid that riboflavin is added in part 903 mixes with blood in photo-irradiation treatment bag 902.The advantage of Fig. 6 design is more suitable for the mode of liquid core flavin, can improve the incomplete problem of dissolving that powder riboflavin exists.
Fig. 7 is the blood bag that the present invention has the riboflavin photochemical method treatment of blood products system of 3 finished bags, is generally whole blood tetrad bag.Blood bag comprises blood and enters pipe 901, photo-irradiation treatment bag 902, riboflavin interpolation part 903.The tip edge of photo-irradiation treatment bag 902 and the corner of bottom edge are provided with fixing hole 912.The bottom of photo-irradiation treatment bag 902, by being connected with 1 or 3 finished bags 906 communicating pipe 907, is respectively arranged with flow-stopping clip 905 communicating pipe 907.
When using blood bag to carry out pathogen or lymphocyte deactivation, enter pipe 901 by blood and blood transport is entered photo-irradiation treatment bag 902, fracture easy folding piece, and the riboflavin sodium phosphate liquid that riboflavin is added in part 903 mixes with blood in photo-irradiation treatment bag 902.When pallet put into by blood bag, by photo-irradiation treatment bag fixed part through fixing hole 22, finished bag 906 is placed on finished bag placing component 400 place, blood bag level is fixed, carries out ultraviolet lighting inactivation treatment.After deactivation, the flow-stopping clip 905 on communicating pipe 907 is unclamped, make blood enter finished bag 906.
Above-described embodiment does not limit the present invention in any way, and the technical scheme that the mode that every employing is equal to replacement or equivalent transformation obtains all drops in protection scope of the present invention.
Claims (10)
1. a treatment of blood products system, comprise at least one treatment of blood products casing (100) and blood bag, it is characterized in that, described blood bag comprises blood and enters pipe (901), photo-irradiation treatment bag (902), riboflavin adds part (903) and finished bag (906), described photo-irradiation treatment bag (902) tip edge and bottom edge arrange link, uviol lamp (200) is provided with in described treatment of blood products casing, photo-irradiation treatment bag pallet, described photo-irradiation treatment bag pallet comprises horizontally disposed frame (301), described frame (301) is provided with photo-irradiation treatment bag fixed part (302), described link is connected with photo-irradiation treatment bag fixed part (302) makes the parallel uviol lamp of blood bag (200) place.
2. a kind for the treatment of of blood products system according to claim 1, is characterized in that, described photo-irradiation treatment bag fixed part (302) is selected from clip, hook and by one or more the combination smashed.
3. a kind for the treatment of of blood products system according to claim 1, is characterized in that, described link is selected from hard plate (911), fixing hole (912) and by one or more the combination smashed.
4. a kind for the treatment of of blood products system according to claim 1, is characterized in that, described photo-irradiation treatment bag pallet also comprises quartz plate (305), and described quartz plate (305) is embedded in frame (301).
5. a kind for the treatment of of blood products system according to claim 1, is characterized in that, is provided with retractor device (303) between described treatment of blood products casing (100) and pallet; Described pallet is provided with multidirectional rocking equipment (304).
6. a kind for the treatment of of blood products system according to claim 1, is characterized in that, described uviol lamp (200) is connected by roll adjustment arm (201) with casing (100).
7. a kind for the treatment of of blood products system according to claim 1, is characterized in that, is also provided with finished bag placing component (400) in described treatment of blood products casing (100); Described finished bag (906) is 1-3.
8. a kind for the treatment of of blood products system according to claim 1, is characterized in that, is provided with 2-10 photo-irradiation treatment bag pallet in described treatment of blood products casing (100); Or described treatment of blood products system equipment comprises 1,2,3,4,5 or 6 treatment of blood products casings (100).
9. a kind for the treatment of of blood products system according to claim 1, is characterized in that, is also provided with constant temperature parts in described treatment of blood products casing (100).
10. a treatment of blood products equipment, comprise at least one treatment of blood products casing (100), uviol lamp (200), photo-irradiation treatment bag pallet is provided with in described treatment of blood products casing (100), described uviol lamp (200) is positioned at the both sides up and down of casing (100), described photo-irradiation treatment bag pallet is arranged at middle part in casing (100), it is characterized in that, described photo-irradiation treatment bag pallet comprises horizontally disposed frame (301), and described frame (301) is provided with photo-irradiation treatment bag fixed part (302).
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610070102.XA CN105561359B (en) | 2016-02-02 | 2016-02-02 | A kind for the treatment of of blood products system based on riboflavin photochemical method |
| CN201910364662.XA CN109966574A (en) | 2016-02-02 | 2016-02-02 | A kind for the treatment of of blood products system based on riboflavin photochemical method |
| PCT/CN2017/071038 WO2017133422A1 (en) | 2016-02-02 | 2017-01-13 | Blood product processing system on the basis of riboflavin photochemical treatment |
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| CN201610070102.XA CN105561359B (en) | 2016-02-02 | 2016-02-02 | A kind for the treatment of of blood products system based on riboflavin photochemical method |
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| CN105561359B (en) | 2019-04-05 |
| CN109966574A (en) | 2019-07-05 |
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