CN105561359B - A kind for the treatment of of blood products system based on riboflavin photochemical method - Google Patents
A kind for the treatment of of blood products system based on riboflavin photochemical method Download PDFInfo
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- CN105561359B CN105561359B CN201610070102.XA CN201610070102A CN105561359B CN 105561359 B CN105561359 B CN 105561359B CN 201610070102 A CN201610070102 A CN 201610070102A CN 105561359 B CN105561359 B CN 105561359B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0047—Ultraviolet radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/26—Accessories or devices or components used for biocidal treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/025—Means for agitating or shaking blood containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0281—Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0286—Handling a large number of blood product units, e.g. storage cabinets, blood bank administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/22—Blood or products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3368—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
Abstract
The present invention provides a kind for the treatment of of blood products systems based on riboflavin photochemical method, including at least one treatment of blood products cabinet and blood bag, the cabinet internal upper part and lower part are provided with ultraviolet lamp, lighting process bag pallet, and the blood bag includes that blood enters pipe, lighting process bag, riboflavin added volume, finished bag.The treatment of blood products system can effectively inactivate all kinds of pathogen and lymphocyte, removal additive is not needed after inactivation treatment, and toxic side effect is not present, it is easy to operate, it is highly-safe, while increasing constant temperature system, control blood product is within the temperature range of optimum, and by automated system operate inactivation treatment process, can it is more convenient, it is effective observation and control blood product processing status, realize automation, intelligentized operating process.
Description
Technical field
The invention belongs to field of medical device, in particular to a kind for the treatment of of blood products system based on riboflavin photochemical method
System.
Background technique
Blood product includes that menses propagate pathogen (virus, bacterium, protozoon, conveyor screw etc.) infection, blood cell safely
Transfusion-related graft-versus-host disease caused by (such as lymphocyte) etc..The common method of Viral inactivation techniques includes bar in blood plasma
This moral sterilization, S/D method, membrane filter method, methylene blue method and riboflavin photochemical method etc., wherein methylene blue method is applied at home
Relatively wide, but some are insufficient for this method, the loss of plasma protein is larger after residual toxicity, processing including serge blue, operation is numerous
It is trivial etc.；The method for preventing transfusion-related graft-versus-host disease is that (inactivation lymphocyte) is irradiated to blood.
The method that riboflavin photochemical method inactivation of viruses is considered to have development prospect, principle is: riboflavin is because of knot
Structure characteristic can be embedded in the nucleic acid of virus, under ultraviolet light irradiation, excited the transfer of its electronics, aoxidized the guanine on nucleic acid
Residue, viral nucleic acid are modified and are damaged, and cannot be replicated and be repaired again, to achieve the effect that inactivation of viruses, and core
Flavine is safe drug, without toxic side effect, without filtering out after addition processing.In the granted product of existing foreign countries, only
Riboflavin photochemical method is virus inactivated processing to blood platelet, and individual equipment once can only at most handle two treatments lists
Position.
Patent CN203017432U discloses a kind of flow-type blood-plasma virus killing equipment, including cabinet, fixed in cabinet
There is the ultraviolet lamp group that at least two groups are symmetrical set；Plasma flow pipe, the blood plasma stream are equipped between two groups of ultraviolet lamp groups
The blood plasma input terminal and blood plasma output end of dynamic pipe are separately positioned on outside the cabinet.However, flow-type blood-plasma virus killing equipment
It is only applicable to the batch processing of pooled plasma.
Patent CN204582023U discloses a kind of plaque virus inactivating device, including can anti-hemostasis bag supporting network and
The upper inactivation ultraviolet lamp and lower inactivation ultraviolet lamp being located above and below supporting network, upper inactivation ultraviolet lamp and lower inactivation are ultraviolet
The spacing of lamp and supporting network is adjustable, and upper inactivation ultraviolet lamp and lower inactivation ultraviolet lamp include lamp box, several purples in lamp box
Outer fluorescent tube and barn door.However, the patent equally only relates to plaque virus inactivating device, without complete matching technology, and
Inactivation process is completely dependent on manual operations.
Patent CN204582095U discloses a kind of conjuncted blood taking bag of leucocyte-removing inactivation of virus, including blood taking needle, whole blood
Bag, leukocyte depletion filter, leucocyte-removing whole blood bag, alserver's solution bag, threeway, plasma bags, methylenum careuleum element, easy folding piece, Asia
First indigo plant filter, product bag, the blood taking needle are connected on the inlet ducts of whole blood bag upper end by conduit, the whole blood bag upper end
Delivery channel leucocyte-removing whole blood bag, plasma bags and product bag are sequentially connected in series by import and export conduit.
Patent CN201418870Y discloses a kind of blood bag for riboflavin whole blood virus inactivation, and successively being coupled by pipeline is one
The whole blood of body acquires three collection bags, and riboflavin addition element is arranged in series on collection bag bleeding pipeline.However, above-mentioned blood
The design of bag is complicated, and when using single bag of photoinactivation virus, excessive component will affect lighting effect, it is important that this bag
Ultraviolet permeability is very low, is not suitable for ultraviolet treatment with irradiation, simultaneously because being not provided with fixed device blood bag must be placed on
On the pallet for inactivating equipment, and pallet meeting shielding light is according to the process of inactivation of viruses, final to influence inactivation efficiency.
To overcome the shortcomings of existing technologies, the present invention provides one kind to be based on riboflavin photochemical method treatment of blood products system
System.
Summary of the invention
When the present invention not only solves blood product using single bag of inactivating pathogens due to the limitation of blood bag support member and
Have the defects that shielding light photograph, realizes the pathogen inactivated automation of blood product, it is pathogen inactivated to improve blood product
Safety and simplicity, while can also to the processing of including but not limited to single blood product, i.e., to blood plasma, blood platelet,
Red blood cell or whole blood be virus inactivated, bacteria inactivation and inactivates to the lymphocyte in these blood products.
One aspect of the present invention provides a kind for the treatment of of blood products system based on riboflavin photochemical method, including at least one
A treatment of blood products cabinet and blood bag；The blood bag include blood enter pipe, lighting process bag, riboflavin added volume and at
Connecting component is arranged in product bag, the lighting process bag tip edge and bottom edge；Be provided in the cabinet ultraviolet lamp,
Lighting process bag pallet, the lighting process bag pallet includes horizontally disposed frame, is provided with illumination on the frame
Handle bag fixation member；The connecting component is connected with lighting process bag fixation member puts the parallel ultraviolet lamp of lighting process bag
It sets.
Treatment of blood products cabinet of the present invention is preferably the cabinet being protected from light, and prevents spoke of the operator by ultraviolet light
Shoot evil wounded.The treatment of blood products cabinet is provided with chamber door, and visual window is arranged on the chamber door, is used for lighting process bag
Disengaging and inside observation and maintenance.
Ultraviolet lamp of the present invention is located in the box body two sides up and down, it is preferred that the ultraviolet lamp is UVA joint
The mode of UVB arranges, it is furthermore preferred that the ultraviolet lamp is the pairs of cross arrangement of UVA combined U VB, most preferably, the purple
Outer light irradiation intensity is identical, ensure that ultraviolet lamp to the uniform irradiation of two sides above and below lighting process bag.In specific reality of the invention
It applies in mode, the ultraviolet lamp and cabinet pass through the vertical connection of roll adjustment arm, the adjustable ultraviolet lamp of roll adjustment arm and illumination
Distance between bag processing pallet, the needs of with different parameters (UV intensity) needed for meeting different blood products.
The blood of lighting process bag of the present invention enters pipe setting and connects on lighting process bag top and lighting process bag
It connects.
The connecting component of lighting process bag of the present invention is selected from one or both of hard plate, fixation hole and snap-fastener
Above combination.Preferably, the quadrangle of lighting process bag tip edge and bottom edge is arranged in the connecting component.It is more excellent
Choosing, the connecting component is hard plate and fixation hole, and the fixation hole is arranged on hard plate.
Lighting process bag pallet of the present invention includes horizontally disposed frame, it is preferred that the lighting process bag
Pallet further includes quartz plate, and the quartz plate is embedded in frame.The lighting process bag pallet will not cover upper and lower two
The irradiation of a direction ultraviolet lamp.Lighting process bag fixation member of the present invention is preferably one in clip, hook and snap-fastener
Kind or two or more combinations.When the lighting process bag fixation member being arranged on the frame is clip, light can be clamped
According to the hard plate of processing bag tip edge and bottom edge, so that blood bag holding level be made to fix.It is arranged when on the frame
Lighting process bag fixation member be hook when, can be connected by the fixation hole of lighting process bag tip edge and bottom edge
It connects, so that blood bag holding level be made to fix.It, can be with when the lighting process bag fixation member being arranged on the frame is snap-fastener
It is connected by lighting process bag tip edge with the snap-fastener of bottom edge, so that blood bag holding level be made to fix.Preferably, illumination
The quadrangle of lighting process bag pallet or frame is arranged in processing bag fixation member.It is furthermore preferred that being set between the cabinet and pallet
There is telescopic device, pallet can be stretched access device cabinet.It, can be with it is furthermore preferred that be connected with multidirectional rocking equipment on pallet
It realizes the slight horizontal concussion of pallet and swings, make blood product uniform irradiation in lighting process bag, most preferably, described is more
It is connection yaw motors to rocking equipment.
The blood of lighting process bag of the present invention enters tube top end and is additionally provided with syringe needle, for puncturing former blood plasma, blood
Platelet or whole blood bag.
The riboflavin added volume setting of blood bag of the present invention is connect on lighting process bag top with lighting process bag, excellent
Choosing, the riboflavin added volume is connected by easy folding piece with lighting process bag, enters light when blood enters pipe by blood
After processing bag, easy folding piece is fractureed, riboflavin is mixed into the blood of lighting process bag.Alternatively, the riboflavin of the blood bag
Added volume setting is on blood vessel, and when blood product is from fashionable by riboflavin added volume into vessel flow, riboflavin is mixed into blood
Product carries out illumination inactivation of virus.It is furthermore preferred that the riboflavin added volume is tubbiness tubulose, capacity 1-4mL, by hard
Material preparation.Most preferably, the riboflavin added volume is to be arranged outside translucent component or the riboflavin added volume
There is light-avoiding coat, on the one hand protect riboflavin not by photodissociation, on the other hand convenient for riboflavin after observation inflow blood plasma or blood platelet
Whether be dissolved almost completely.Particularly preferred, riboflavin is liquid or powder in riboflavin added volume of the present invention.
Blood bag of the present invention further includes finished bag, and the finished bag passes through communicating pipe and lighting process bag bottom end phase
Even, flow-stopping clip is provided on the communicating pipe.The finished bag can be common plasma bags or blood platelet bag, preferably
, the finished bag is normal 200mL plasma bags.For containing treated blood plasma or blood platelet or whole blood.Preferably, institute
The finished bag stated can be 1-3.
The blood of blood bag of the present invention enters pipe and/or is provided with flow-stopping clip on communicating pipe, and the flow-stopping clip is used
The sealing orifice after blood plasma or blood platelet/or whole blood flow into, prevents from flowing backwards.
Lighting process bag of the present invention preferably uses ultra-thin high ultraviolet light material, including but not limited to ethylene-thoroughly
Vinyl acetate co-polymer (EVA) material, ensure that the illumination efficiency of ultraviolet light, inactivate ultraviolet light when lighting process effectively
All kinds of pathogen.
Blood bag of the present invention preferably passes through sterilization treatment, when in the riboflavin added volume be liquid riboflavin
When, blood bag sterilization treatment can take whole mode canned after sterilizing, when being powder riboflavin in the riboflavin added volume
When, blood bag sterilization treatment can take the sterilization treatment mode an of monoblock type.
It is additionally provided with finished bag placing component in treatment of blood products cabinet of the present invention, for placing finished bag.
Preferably, the finished bag placing component can be hook, pallet, supporting network etc..
The riboflavin photochemical method treatment of blood products system of the present invention that is based on further includes having constant temperature component, preferably
, the constant temperature component includes heating device (such as heater), cooling device (such as air-conditioning fan processed) and thermometer.Constant temperature
Component can control the intracorporal temperature of case, detects, protects to the temperature of blood plasma after the temperature and processing into blood plasma after equipment
Card blood plasma is controlled always from outflow temperature is entered in about 4 ± 2 DEG C of ranges, and blood platelet controls always from outflow temperature is entered
About 22 ± 2 DEG C of ranges.
The riboflavin photochemical method treatment of blood products system of the present invention that is based on further includes control panel, the control
Panel and telescopic device processed, multidirectional rocking equipment communication connection.Preferably, the control panel includes liquid crystal display and behaviour
Make button, the liquid crystal display shows processing status, the temperature inside the box, time of processing etc., and the operation button includes
Power knob, disengaging button, setting button etc., may be implemented processing time of disengaging and control of pallet etc..
The riboflavin photochemical method treatment of blood products system of the present invention that is based on further includes bar code printing device, barcode scanning
Device and meausring apparatus.Bar code printing device, barcode scanning device and the meausring apparatus be preferably bar code printer, barcode scanning gun and
Platform scale, by weighing, printing bar code, paste bar code, swepting slip code, convenient for the management to illumination blood product.
In a specific embodiment of the invention, 2-10 lighting process is provided in the treatment of blood products cabinet
Bag pallet, is more preferably provided with 6-8 lighting process bag pallet.The treatment of blood products system equipment includes 1-10 blood
Liquid product handles cabinet, and e.g. 4-6 is a.The cabinet of the treatment of blood products can be arranged vertically, can also be with horizontal row
Column.Communication connection between the treatment of blood products cabinet, for recording the operation conditions of the equipment and being handled by the equipment
Whole blood product relevant information (such as blood product number, weight, processor, processing time), and according to demand by it
Record information is connected in LIS system in the record of the blood product.For example, to realize extensive treatment of blood products, it is described
Treatment of blood products system cabinet in 4-8 lighting process bag pallet or the treatment of blood products system can be set
System includes hierarchal arrangement 2-5 layers for the treatment of of blood products cabinet, wherein each lighting process bag pallet can be individually operated, controls respectively
System disengaging, does not influence the operation of other layers, realizes full-time uninterrupted continuous operation, without waiting, maximumlly improves benefit
Use efficiency.
On the one hand of the invention also provides a kind for the treatment of of blood products equipment, including at least one treatment of blood products case
Body, ultraviolet lamp, lighting process bag pallet are provided in the cabinet, and the ultraviolet lamp is located in the box body two sides up and down, institute
It states lighting process bag pallet and is set to middle part in cabinet, the lighting process bag pallet includes horizontally disposed frame, described
Frame on be provided with lighting process bag fixation member.
Blood product of the present invention includes whole blood, blood plasma, blood platelet or other blood products.
Treatment of blood products system of the present invention can effectively inactivate all kinds of pathogen (such as bacterium, virus, protozoon
Deng) and lymphocyte, removal additive is not needed after inactivation treatment, and Side effect is not present, easy to operate, safety
Property it is higher, while increasing constant temperature and keeping system, control blood product is within the temperature range of optimum, and passes through Department of Automation
System operation inactivation treatment process, can it is more convenient, it is effective observation and control blood product processing status, realize automation, intelligence
The operating process of energyization.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of riboflavin photochemical method treatment of blood products system of the present invention.
Fig. 2 is the structural schematic diagram of the treatment of blood products system with 3 cabinets of the horizontally-arranged placement of the present invention.
Fig. 3 is that the structure for the treatment of blood products system with 4 lighting process bag pallets that vertical setting of types of the present invention is placed is shown
It is intended to.
Fig. 4 is the structural schematic diagram of the blood bag of riboflavin photochemical method treatment of blood products system of the present invention.
Fig. 5 is the structure of the blood bag for the riboflavin photochemical method treatment of blood products system that the present invention has 1 finished bag
Schematic diagram (two bags).
Fig. 6 is the blood bag of another riboflavin photochemical method treatment of blood products system with 1 finished bag of the present invention
Structural schematic diagram (two bags).
Fig. 7 is the structure of the blood bag for the riboflavin photochemical method treatment of blood products system that the present invention has 3 finished bags
Schematic diagram (tetrad bag).
Wherein, 100- treatment of blood products cabinet, 102- chamber door, 200- ultraviolet lamp, 201- roll adjustment arm, 300- lighting process
Bag pallet, 301- frame, 302- lighting process bag fixation member, 303- telescopic device, the multidirectional rocking equipment of 304-, 305- quartz
Plate, 400- finished bag placing component, 501- thermometer, 502- constant temperature fan, 600- control panel, 601- display screen, 602- operation
Button, 701- bar code printer, 702- barcode scanning gun, 703- platform scale, 800- computer；
901- blood enter pipe, 902- lighting process bag, 903- riboflavin added volume, 904- syringe needle, 905- flow-stopping clip,
906- finished bag, 907- communicating pipe, 911- hard plate, 912- fixation hole.
Specific embodiment
Fig. 1 be the present invention is based on the treatment of blood products system of riboflavin photochemical method, including inactivation of virus cabinet 100,
Ultraviolet lamp 200, ultraviolet 200 lamp position are connect by roll adjustment arm 201 in the two sides up and down in cabinet 100, with cabinet 100, can be adjusted
The distance between ultraviolet lamp and illumination bag processing pallet is saved, and the mode that ultraviolet lamp 200 is UVA combined U VB arranges.It is horizontally disposed
Frame 301, the lighting process bag fixation member 302 for being arranged in 301 4 jiaos of frame and the quartz plate 305 inlayed with frame 301
Collectively constitute lighting process bag pallet.Telescopic device 303 is equipped between cabinet 100 and pallet, it can be by the flexible disengaging cabinet of pallet
100.Multidirectional rocking equipment 304 is connected on pallet, the slight horizontal concussion of pallet and swing, make lighting process bag 902 after unlatching
Interior blood product uniform irradiation.Finished bag placing component 400 is additionally provided in cabinet 100, for placing and lighting process bag phase
Finished bag 906 even.Constant temperature component is additionally provided in cabinet 100, including constant temperature fan 502 and thermometer 501, constant temperature component are used for
Control cabinet body temperature.
Fig. 2 is the treatment of blood products system with 3 cabinets of the horizontally-arranged placement of the present invention, including 3 cabinets 100, often
Chamber door 102, display screen 601, operation button 602 are provided on a cabinet.Wherein, display screen 601 and operation button 602 form
Control panel, control panel and the intracorporal telescopic device 303 of case, 304 communication connection of multidirectional rocking equipment, are pressed by manipulation operations
Button 602 controls disengaging and the processing time of pallet.Meanwhile each cabinet 100 is connected with bar code printer 701, barcode scanning gun
702 and 703,3 cabinets 100 of platform scale finally with 800 communication connection of computer, for record blood inactivation operation information.
The treatment of blood products system with 4 cabinets that Fig. 3 places for vertical setting of types of the present invention, including 1 cabinet 100, on
Under it is penetrating, keep cabinet in integrally keep constant temperature, the vertically disposed lighting process bag pallet of 4 vertical setting of types is provided in cabinet 100
300, each lighting process bag pallet is respectively provided with ultraviolet lamp 200 up and down, and each lighting process bag pallet 300 is correspondingly arranged on
Chamber door 102 and control panel 300, each control panel 300 individually control the disengaging of pallet.
Fig. 4 is the blood bag of riboflavin photochemical method treatment of blood products system of the present invention, including blood enters pipe 901, light
According to processing bag 902, riboflavin added volume 903, blood enters pipe 901 and is arranged on 902 top of lighting process bag and lighting process bag
902 connections, the setting of riboflavin added volume 903 are connect with lighting process bag 902 by easy folding piece on 902 top of lighting process bag,
Riboflavine sodium phosphate liquid is housed in riboflavin added volume 903.Blood enters 901 top of pipe and is provided with syringe needle 904, and blood enters
Flow-stopping clip 905 is accompanied on pipe.The tip edge of lighting process bag 902 and the quadrangle of bottom edge are provided with interconnecting piece hard plate
911 and fixation hole 912.
When blood product needs to handle, pipe 901 is entered by blood, blood is conveyed into lighting process bag 902, fractureed
Easy folding piece mixes the Riboflavine sodium phosphate liquid in riboflavin added volume 903 in lighting process bag 902 with blood.By blood
Bag is put into pallet, and four angles of lighting process bag 902 are fixed in lighting process bag fixation member 302, make lighting process bag
902 parallel ultraviolet lamps 200 are placed, then the irradiation that ultraviolet lamp wiring can be unobstructed kills disease on the two sides of lighting process bag 902
Poison.
Fig. 5 and Fig. 6 is the blood bag for the riboflavin photochemical method treatment of blood products system that the present invention has 1 finished bag,
Usually two bags of blood plasma or blood platelet.The blood bag includes that blood enters pipe 901, lighting process bag 902, riboflavin and adds
Adding part 903, the tip edge of lighting process bag 902 and the quadrangle of bottom edge are provided with fixation hole 912 and/or hard plate 911,
The bottom end of lighting process bag 902 is connected by communicating pipe 907 and 1 finished bag 906, may be provided with flow-stopping clip on communicating pipe 907
905。
Wherein, the setting of riboflavin added volume 903 described in Fig. 5 enters on pipe 901 in blood, when use blood bag carries out cause of disease
When body or lymphocyte inactivate, pipe 901 is entered by blood, blood is conveyed into lighting process bag 902, blood is flowed through into blood
When into riboflavin added volume 903 on pipe 901, Riboflavine sodium phosphate pulvis therein flows into lighting process bag 902 simultaneously
It is mixed with blood.The advantages of Fig. 5 is designed is that in process of production, sterilization link is easier to operate, because of pulvis high temperature resistant.
Wherein, riboflavin added volume 903 described in Fig. 6 is arranged on 902 top of lighting process bag, with lighting process bag 902
It is connected by easy folding piece, when carrying out pathogen or lymphocyte inactivation using blood bag, pipe 901 is entered by blood blood is defeated
It is sent into lighting process bag 902, fracture easy folding piece, makes the Riboflavine sodium phosphate liquid in riboflavin added volume 903 in lighting process
It is mixed in bag 902 with blood.The advantages of Fig. 6 is designed is, more suitable for the mode of liquid riboflavin, can to improve powder riboflavin
The existing incomplete problem of dissolution.
Fig. 7 is the blood bag for the riboflavin photochemical method treatment of blood products system that the present invention has 3 finished bags, usually
Whole blood tetrad bag.Blood bag includes that blood enters pipe 901, lighting process bag 902, riboflavin added volume 903.Lighting process bag
902 tip edge and the quadrangle of bottom edge are provided with fixation hole 912.The bottom end of lighting process bag 902 passes through communicating pipe 907
It is connected with 1 or 3 finished bags 906, flow-stopping clip 905 is respectively arranged on communicating pipe 907.
When carrying out pathogen or lymphocyte inactivation using blood bag, pipe 901 is entered by blood, blood is conveyed into light
According to processing bag 902, fracture easy folding piece, makes the Riboflavine sodium phosphate liquid in riboflavin added volume 903 in lighting process bag 902
It is mixed with blood.When blood bag is put into pallet, lighting process bag fixation member is passed through into fixation hole 22, finished bag 906 is placed
At finished bag placing component 400, blood bag level is fixed, carries out ultraviolet lighting inactivation treatment.After inactivation, by communicating pipe 907
On flow-stopping clip 905 unclamp, so that blood is entered finished bag 906.
Above-described embodiment is not limit the invention in any way, all to be obtained by the way of equivalent substitution or equivalent transformation
Technical solution fall within the scope of protection of the present invention.
Claims (6)
1. a kind for the treatment of of blood products method, including at least one treatment of blood products cabinet (100) and blood bag, feature exist
In the blood bag includes that blood enters pipe (901), lighting process bag (902), riboflavin added volume (903) and finished bag
(906), connecting component, the treatment of blood products is arranged in lighting process bag (902) tip edge and bottom edge
Ultraviolet lamp (200), lighting process bag pallet are provided in cabinet, the lighting process bag pallet is by horizontally disposed frame
(301) it forms, is provided with lighting process bag fixation member (302), the connecting component and illumination on the frame (301)
Processing bag fixation member (302) connection places the parallel ultraviolet lamp of blood bag (200), and the connecting component is selected from hard plate
(911), the combination of one or more of fixation hole (912) and snap-fastener, the treatment of blood products cabinet (100) with
Telescopic device (303) are equipped between pallet；The pallet is provided with multidirectional rocking equipment (304).
2. a kind for the treatment of of blood products method described in claim 1, which is characterized in that the lighting process bag fixation member
(302) combination selected from one or more of clip, hook and snap-fastener.
3. a kind for the treatment of of blood products method described in claim 1, which is characterized in that the ultraviolet lamp (200) and cabinet
(100) it is connected by roll adjustment arm (201).
4. a kind for the treatment of of blood products method described in claim 1, which is characterized in that the treatment of blood products cabinet
(100) finished bag placing component (400) are additionally provided in；The finished bag (906) is 1-3.
5. a kind for the treatment of of blood products method described in claim 1, which is characterized in that the treatment of blood products cabinet
(100) 2-10 lighting process bag pallet is provided in；Alternatively, the treatment of blood products system equipment include 1,2,
3,4,5 or 6 treatment of blood products cabinets (100).
6. a kind for the treatment of of blood products method described in claim 1, which is characterized in that the treatment of blood products cabinet
(100) constant temperature component is additionally provided in.
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| CN201910364662.XA CN109966574A (en) | 2016-02-02 | 2016-02-02 | A kind for the treatment of of blood products system based on riboflavin photochemical method |
| CN201610070102.XA CN105561359B (en) | 2016-02-02 | 2016-02-02 | A kind for the treatment of of blood products system based on riboflavin photochemical method |
| PCT/CN2017/071038 WO2017133422A1 (en) | 2016-02-02 | 2017-01-13 | Blood product processing system on the basis of riboflavin photochemical treatment |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2017133422A1 (en) * | 2016-02-02 | 2017-08-10 | 汪相伯 | Blood product processing system on the basis of riboflavin photochemical treatment |
| CN107308515A (en) * | 2016-09-29 | 2017-11-03 | 中国人民解放军总医院 | The inactivation system of circulating tumor cell and application in a kind of blood |
| CN106492245A (en) * | 2016-12-23 | 2017-03-15 | 中国人民解放军南京军区南京总医院 | Bloodborne pathogens inactivating device |
| CN106492246A (en) * | 2016-12-23 | 2017-03-15 | 南京双威生物医学科技有限公司 | Ultraviolet inactivation system based on dual wavelength |
| CN108042858A (en) * | 2017-12-29 | 2018-05-18 | 武汉佰美斯医疗科技有限公司 | A kind of blood-plasma virus killing process data recording method |
| CN110639038A (en) * | 2019-10-14 | 2020-01-03 | 中国医学科学院输血研究所 | Equipment and method for inactivating blood component pathogens by riboflavin photochemical method |
| CN111840596B (en) * | 2020-06-11 | 2022-03-11 | 南岳生物制药有限公司 | Riboflavin photochemical plasma inactivation device and control system and control method thereof |
| CN111544296B (en) * | 2020-06-18 | 2024-03-12 | 四川省人民医院 | Light energy storage bag for blood products |
| CN112316166B (en) * | 2020-10-30 | 2022-07-12 | 中国医学科学院输血研究所 | Photochemical inactivation method for riboflavin of pathogen in biological liquid sample |
| CN114366831A (en) * | 2022-01-10 | 2022-04-19 | 南京双威生物医学科技有限公司 | Plasma pathogen inactivation treatment method based on riboflavin photochemical method |
| CN115350296A (en) * | 2022-08-30 | 2022-11-18 | 南京双威生物医学科技有限公司 | Blood pathogen inactivation treatment system based on riboflavin photochemical method |
| CN115948380A (en) * | 2023-03-10 | 2023-04-11 | 北京大有天弘科技有限公司 | Immune cell treatment method |
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| DE10031851B4 (en) * | 2000-07-04 | 2005-10-13 | Blutspendedienst der Landesverbände des Deutschen Roten Kreuzes Niedersachsen, Sachsen-Anhalt, Thüringen, Oldenburg und Bremen gGmbH | Photodynamic treatment and UV-B irradiation of a platelet suspension |
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| CN201192460Y (en) * | 2008-04-02 | 2009-02-11 | 上海输血技术有限公司 | Disposable light avoid type photosensitive agent storage releasing piece |
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| US8877060B2 (en) * | 2010-11-23 | 2014-11-04 | Biovec Transfusion, Llc | Methods for removing pathogens from a platelet preparation |
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| CN203017432U (en) * | 2013-01-21 | 2013-06-26 | 中国人民解放军总医院 | Flow type blood plasma virus inactivation equipment |
| CN104248643A (en) * | 2014-08-12 | 2014-12-31 | 中国人民解放军总医院 | Preparation device and preparation method of universal virus inactivation blood plasma |
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| CN105561359A (en) | 2016-05-11 |
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Effective date of registration: 20191121 Address after: 050035 no.502, unit 1, building 4, No.222 Xing'an Avenue, Shijiazhuang hi tech Zone, Shijiazhuang City, Hebei Province Co-patentee after: Wang Xiangbo Patentee after: Hebei PONEY Medical Technology Co Ltd Co-patentee after: Zhu Liguo Address before: Three transfusion room, 28 floor, outpatient building, PLA General Hospital, Fuxing Road, Beijing, Haidian District 100853 Co-patentee before: Zhu Liguo Patentee before: Wang Xiangbo |