CN203017432U - Flow type blood plasma virus inactivation equipment - Google Patents
Flow type blood plasma virus inactivation equipment Download PDFInfo
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- CN203017432U CN203017432U CN 201320030341 CN201320030341U CN203017432U CN 203017432 U CN203017432 U CN 203017432U CN 201320030341 CN201320030341 CN 201320030341 CN 201320030341 U CN201320030341 U CN 201320030341U CN 203017432 U CN203017432 U CN 203017432U
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Abstract
The utility model discloses flow type blood plasma virus inactivation equipment. The flow type blood plasma virus inactivation equipment comprises a box body, wherein at least two groups of ultraviolet lamp groups which are arranged symmetrically are fixedly arranged in the box body; and a blood plasma flowing pipe is fixedly arranged between the two groups of ultraviolet lamp groups, and a blood plasma input end and a blood plasma output end of the blood plasma flowing pipe are respectively arranged outside the box body. According to the flow type blood plasma virus inactivation equipment, the blood plasma can be continuously processed in batches, which is one of key steps of preparing universal virus inactivation blood plasma in a blood station and clinically treating viral diseases, and the treated sample blood plasma can be continuously received, so that compared with the unit blood plasma treatment manner, the batch treatment speed is faster, the operation is also simpler and more convenient, and the flow type blood plasma virus inactivation equipment is beneficial to wide popularization and application.
Description
Technical field
This utility model relates to a kind of Medical Instruments, particularly a kind of flow-type blood-plasma virus killing equipment.
Background technology
In medical field, inactivation of virus is mainly according to physics or chemical means dissolved destruction virus fat peplos or destroys nucleic acid and organize copying and transcribing of nucleic, so that virus loses appeal and destructive power.Present modal blood-plasma virus killing has two kinds of methods of physics and chemistry, and wherein chemical method has: S/D method, methylene blue method (MB), psoralen method and riboflavin photochemical method.Except the S/D method, the handled blood plasma of its excess-three kind mode is all unit blood plasma.
Wherein, the principle of the virus in riboflavin photochemical method deactivation blood plasma is: riboflavin is because of architectural characteristic, can embed in the nucleic acid of virus, under irradiation under ultraviolet ray, excite the transfer of its electronics, the guanine residue on oxidation nucleic acid, the nucleic acid of virus is modified and impaired, can not copy again and repair, thereby reach the effect of inactivation of viruses.It is the processing that the unit becomes pocket type that but existing riboflavin photochemical method is processed the form of blood plasma, pending blood plasma will be transferred to special illumination bag before processing in, add the riboflavin mixing in special environment, pave to certain thickness, be shelved on afterwards in deactivation equipment and process, the blood plasma after processing also will be shifted out from the illumination bag and could use.If in certain specific situation, need to feed back after the large batch of blood plasma that inactivation treatment is provided or autologous plasma deactivation, it just can't meet the demands.
The utility model content
The technical problems to be solved in the utility model is to provide a kind of flow-type blood-plasma virus killing equipment.This equipment becomes the bag processing to change the flow-type batch process into by the riboflavin method from unit, do not need the removal of photosensitizer, blood plasma is separated from the person, inactivation of virus " exsomatizes ", blood plasma after processing is also directly in the defeated object of bringing back to life, also can combine with blood separator, be used for viral disease patient's treatment and be used for removing virus.
For solving the problems of the technologies described above, this utility model adopts following technical proposals:
A kind of flow-type blood-plasma virus killing equipment, described equipment comprises a casing, is installed with the uviol lamp group that at least two groups are symmetrical set in described casing; Be installed with dismountable blood plasma flow duct between described two groups of uviol lamp groups, blood plasma input and the blood plasma outfan of described blood plasma flow duct are arranged on outside described casing respectively.
Further, described uviol lamp group comprises the UVB ultraviolet lamp tube of at least one 313nm spectral line and the UVA ultraviolet lamp tube of at least one 365nm spectral line.The purpose that ultraviolet lamp tube is set like this is: because general uv light irradiation insufficient strength is high, so the present invention adopts UVA and UVB associating irradiation blood plasma, and reaches certain exposure rate, guarantee deactivation.
Further, described uviol lamp group comprises the UVB ultraviolet lamp tube of at least two 313nm spectral lines and the UVA ultraviolet lamp tube of at least two 365nm spectral lines; The UVB ultraviolet lamp tube of described 313nm spectral line and the UVA ultraviolet lamp tube of the 365nm spectral line layout that is arranged alternately.
Every group of uviol lamp group is comprised of UVA and the UVB of 4 alternative arrangements at least, one group of uviol lamp group is positioned at above the blood plasma flow duct, another group uviol lamp group is positioned at below the blood plasma flow duct, be symmetrical set with the uviol lamp group above the blood plasma flow duct, design can better guarantee UVA ultraviolet lamp tube and UVB ultraviolet lamp tube associating irradiation blood plasma like this, guarantees inactivation of viruses.
Further, the blood plasma input of described blood plasma flow duct is provided with peristaltic pump; The blood plasma outfan of described blood plasma flow duct is provided with electromagnetic valve.The peristaltic pump adjustable speed is for the flow velocity of controlling blood plasma in the blood plasma flow duct; Electromagnetic valve is realized the on-off control of blood plasma outfan.
Further, S-type, the screw type of the blood plasma flow duct in described casing or Serpentis type.
The blood plasma flow duct purpose of design like this is, can guarantee that not only blood plasma flows the regular hour in flow duct; Its purpose also has: 1) can in less occupation of land space, have larger capacity; 2) plasma sample forms mobile whirlpool when flowing in flow duct, has reached the order ground that stirs in the time of mobile, and the illumination that the blood plasma in pipe is accepted is more even.
Further, described casing is camera bellows, and the front panel of described casing is openable drop front, and this front panel is provided with visual windows.
Further, also be provided with in described casing for the constant temperature fan of temperature in the control casing less than 37 ℃.Guarantee when plasma treatment temperature in casing, temperature in the blood plasma flow duct, most importantly the plasma sample temperature, do not get final product higher than 37 ℃ of the normal body temperature of people, and the high temperature when avoiding processing makes the albumen inactivation in blood plasma.
Further, described blood plasma flow duct is quartz ampoule; Described blood plasma flow duct also can adopt nanometer polymerization material film or other high nanometer polymerization soft material pipes of ultraviolet thoroughly.
Further, the pump speed of described peristaltic pump, the mobile blood plasma of controlling in the blood plasma flow duct flowed 6-10 minute in the range of exposures of uviol lamp group.
This utility model is compared with existing product, has following actively useful effect:
1, this utility model directly is placed in the blood plasma flow duct between at least two group uviol lamp groups, processing every batch of unit blood plasma again, disposable flowing process gets final product, thoroughly solved the difficult problem of processing unit blood plasma complex operation, and greatly simplified operating process, and the blood plasma flow duct is convenient to dismounting and cleaning.
2, this utility model is simple to operate, only need the blood plasma of required deactivation is got final product by the blood plasma input that sterile manner is connected to the blood plasma flow duct, and be paved with whole blood plasma flow duct, use the peristaltic pump coutroi velocity, make the blood plasma mobile 6-10min in the range of exposures of ultraviolet light that flows in the blood plasma flow duct, and sample gets final product after the blood plasma outfan is with the sterile manner reception ﹠ disposal, has greatly shortened inactivation time.
3, this utility model can make processed plasma flow move up, and has both reached the purpose that stirs, and has increased again the processing capacity, has thoroughly solved the inconvenience that in the prior art, cell processing blood plasma causes.
4, this utility model is to become bag to process from unit the riboflavin method to develop into the flow-type batch process, blood plasma after processing can be used for the blood station and prepare universal inactivation of virus blood plasma, also can combine with blood separator, be used for viral disease patient's treatment and be used for removing virus.
5, this utility model has been realized " exsomatizing " inactivation of virus, is that blood plasma is separated from the person, and then carries out deactivation, perhaps also can be supporting other equipment do external viral inactivation treatment.
6, utility model can be carried out continuous carrying out plasma treatment in batches, the continuous sample blood plasma to after processing receives, compare cell processing blood plasma, the speed of this batch process is faster, operate easier, therefore, this equipment with the deactivation that is virus, is with a wide range of applications in Blood Center, hospital or blood biological product companies.
Description of drawings
Fig. 1 is overall structure schematic diagram of the present utility model.
The specific embodiment
Below in conjunction with the description of drawings specific embodiment of the present utility model.
As shown in Figure 1, a kind of flow-type blood-plasma virus killing equipment, it comprises a casing 1, described casing 1 is camera bellows, the front panel 11 of this casing 1 is openable drop front, and this front panel 11 is provided with visual windows, is convenient to the situation in inspection box body outside to inside.
Be installed with at least two groups in described casing 1 and be the symmetrically arranged uviol lamp group 2 in up and down, symmetrical purpose of placing is: can guarantee that blood plasma can be shone up and down uniformly, avoid a side irradiation can not penetrate the thickness of blood plasma.Described uviol lamp group 2 comprises the UVB ultraviolet lamp tube 21 of two 313nm spectral lines and the UVA ultraviolet lamp tube 22 of two 365nm spectral lines; The UVB ultraviolet lamp tube 21 of described 313nm spectral line and the UVA ultraviolet lamp tube 22 of the 365nm spectral line layout that is arranged alternately.
Be installed with dismountable blood plasma flow duct 3 that is the Serpentis type between described two groups of uviol lamp groups 2, mobile 3 pipes of this blood plasma are quartz ampoule, and have certain capacity in pipe, and capacity can be adjusted with the difference of practical application; The blood plasma input 31 of described blood plasma flow duct 3 passes the right panel of described casing 1 and is arranged at outside casing 1, and the blood plasma outfan 32 of described blood plasma flow duct 3 passes the Left-Hand Panel of described casing 1 and is arranged at outside casing 1;
The blood plasma input 31 of described blood plasma flow duct 3 is provided with for the peristaltic pump 4 of controlling blood plasma flow duct 3 interior plasma flow rate, the pump speed of described peristaltic pump 4, and the mobile blood plasma of controlling in blood plasma flow duct 3 flowed 6-10 minute in the range of exposures of uviol lamp group 2; The blood plasma outfan 32 of described blood plasma flow duct 3 is provided with the electromagnetic valve 5 of realizing blood plasma outfan on-off control.
Also be provided with in described casing 1 for the constant temperature fan 6 of temperature in the control casing less than 37 ℃.
The step of this utility model in practical operation is as follows:
1, in the environment of aseptic lucifuge, pending blood plasma is added riboflavin solution, the final concentration that makes riboflavin is 50 μ mol/L, mixing, reaction 10min.
2, opening device medium ultraviolet lamp group 2 and constant temperature fan 6.
The container that 3, will fill pooled plasma is connected on blood plasma input 31 in aseptic mode.
4, open peristaltic pump 4 and import blood plasma, be paved with whole blood plasma flow duct 3.
5, open electromagnetic valve 5, control the flow velocity of peristaltic pump 4, allow blood plasma flow blood plasma flow duct 3 is interior, and guarantee that plasma sample is at the illumination range internal radiation of uviol lamp group 2 6-10min at least.
6, at blood plasma outfan 32 places, with aseptic mode reception ﹠ disposal plasma sample later, be the blood plasma after viral inactivation treatment.
7, after inactivation treatment is completed, blood plasma flow duct 3 can be removed, install again after the sterilization cleaning that carries out disinfection, reuse, or disposable use.
8, after the fluorescent tube performance degradation in uviol lamp group 2, also single the disassembling of light can be changed.
The word in the description orientation that adopts herein " on ", D score, " left side ", " right side " etc. be all for the convenience that illustrates based on the orientation shown in drawing in accompanying drawing, these orientation may be different due to the disposing way of device in actual device.
In sum, embodiment described in the utility model only provides a kind of embodiment of the best, technology contents of the present utility model and technical characterstic disclose as above, however the content that the personage who is familiar with the technology still may disclose based on this utility model and do various replacement and the modifications that do not deviate from creation spirit of the present invention; Therefore, protection domain of the present utility model is not limited to the technology contents that embodiment discloses, therefore all equivalences of doing according to shape of the present utility model, structure and principle change, all is encompassed in protection domain of the present utility model.
Claims (9)
1. flow-type blood-plasma virus killing equipment, it is characterized in that: described equipment comprises a casing (1), is installed with the uviol lamp group (2) that at least two groups are symmetrical set in described casing (1); Be installed with dismountable blood plasma flow duct (3) between described two groups of uviol lamp groups (2), blood plasma input (31) and the blood plasma outfan (32) of described blood plasma flow duct (3) are arranged on outside described casing (1) respectively.
2. a kind of flow-type blood-plasma virus killing equipment according to claim 1, it is characterized in that: described uviol lamp group (2) comprises the UVB ultraviolet lamp tube (21) of at least one 313nm spectral line and the UVA ultraviolet lamp tube (22) of at least one 365nm spectral line.
3. a kind of flow-type blood-plasma virus killing equipment according to claim 1, it is characterized in that: described uviol lamp group (2) comprises the UVB ultraviolet lamp tube (21) of at least two 313nm spectral lines and the UVA ultraviolet lamp tube (22) of at least two 365nm spectral lines; The UVB ultraviolet lamp tube (21) of described 313nm spectral line and the UVA ultraviolet lamp tube (22) of the 365nm spectral line layout that is arranged alternately.
4. a kind of flow-type blood-plasma virus killing equipment according to claim 1, it is characterized in that: the blood plasma input (31) of described blood plasma flow duct (3) is provided with peristaltic pump (4); The blood plasma outfan (32) of described blood plasma flow duct (3) is provided with electromagnetic valve (5).
5. the described a kind of flow-type blood-plasma virus killing equipment of arbitrary claim according to claim 1 to 4 is characterized in that: the blood plasma flow duct (3) in described casing (1) is S-type, screw type or Serpentis type.
6. a kind of flow-type blood-plasma virus killing equipment according to claim 5, it is characterized in that: described casing (1) is camera bellows, and the front panel (11) of described casing (1) is openable drop front, and this front panel is provided with visual windows.
7. a kind of flow-type blood-plasma virus killing equipment according to claim 6, is characterized in that: also be provided with in described casing (1) for the constant temperature fan (6) of temperature in the control casing less than 37 ℃.
8. a kind of flow-type blood-plasma virus killing equipment according to claim 7 is characterized in that: described blood plasma flow duct (3) is quartz ampoule.
9. a kind of flow-type blood-plasma virus killing equipment according to claim 4 is characterized in that: the pump speed of described peristaltic pump (4), control mobile blood plasma in blood plasma flow duct (3) the range of exposures of uviol lamp group (2) in mobile 6-10 minute.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201320030341 CN203017432U (en) | 2013-01-21 | 2013-01-21 | Flow type blood plasma virus inactivation equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201320030341 CN203017432U (en) | 2013-01-21 | 2013-01-21 | Flow type blood plasma virus inactivation equipment |
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| CN203017432U true CN203017432U (en) | 2013-06-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201320030341 Expired - Lifetime CN203017432U (en) | 2013-01-21 | 2013-01-21 | Flow type blood plasma virus inactivation equipment |
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| CN (1) | CN203017432U (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105561359A (en) * | 2016-02-02 | 2016-05-11 | 汪相伯 | Blood product treatment system based on riboflavin photochemical method |
| CN106492246A (en) * | 2016-12-23 | 2017-03-15 | 南京双威生物医学科技有限公司 | Ultraviolet inactivation system based on dual wavelength |
| CN106492245A (en) * | 2016-12-23 | 2017-03-15 | 中国人民解放军南京军区南京总医院 | Bloodborne pathogens inactivating device |
| CN107496950A (en) * | 2017-08-18 | 2017-12-22 | 广州市众为生物技术有限公司 | A kind of viral method in UV irradiation inactivation protein solution |
| CN107823658A (en) * | 2017-11-17 | 2018-03-23 | 武汉佰美斯医疗科技有限公司 | A kind of blood-plasma virus killing operating desk for being easy to illumination |
| CN108524969A (en) * | 2018-07-02 | 2018-09-14 | 苏州良辰生物医药科技有限公司 | A kind of virus inactivating device |
| CN108578728A (en) * | 2018-04-23 | 2018-09-28 | 北京铂鑫天然生物技术有限公司 | Blood-plasma virus killing instrument |
| CN108778357A (en) * | 2016-03-23 | 2018-11-09 | 泰尔茂株式会社 | Light irradiation device |
| CN110833627A (en) * | 2019-11-25 | 2020-02-25 | 四川南格尔生物科技有限公司 | Ultraviolet inactivation instrument |
| CN111770789A (en) * | 2017-12-29 | 2020-10-13 | 塞鲁斯公司 | System and method for treating biological fluids |
| CN111840596A (en) * | 2020-06-11 | 2020-10-30 | 南岳生物制药有限公司 | Riboflavin photochemical plasma inactivation device and control system and control method thereof |
| US11883544B2 (en) | 2019-06-28 | 2024-01-30 | Cerus Corporation | System and methods for implementing a biological fluid treatment device |
-
2013
- 2013-01-21 CN CN 201320030341 patent/CN203017432U/en not_active Expired - Lifetime
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105561359A (en) * | 2016-02-02 | 2016-05-11 | 汪相伯 | Blood product treatment system based on riboflavin photochemical method |
| CN109966574A (en) * | 2016-02-02 | 2019-07-05 | 汪相伯 | A kind for the treatment of of blood products system based on riboflavin photochemical method |
| CN108778357A (en) * | 2016-03-23 | 2018-11-09 | 泰尔茂株式会社 | Light irradiation device |
| CN106492246A (en) * | 2016-12-23 | 2017-03-15 | 南京双威生物医学科技有限公司 | Ultraviolet inactivation system based on dual wavelength |
| CN106492245A (en) * | 2016-12-23 | 2017-03-15 | 中国人民解放军南京军区南京总医院 | Bloodborne pathogens inactivating device |
| CN107496950B (en) * | 2017-08-18 | 2021-02-02 | 广州市众为生物技术有限公司 | Method for inactivating virus in protein solution by ultraviolet irradiation |
| CN107496950A (en) * | 2017-08-18 | 2017-12-22 | 广州市众为生物技术有限公司 | A kind of viral method in UV irradiation inactivation protein solution |
| CN107823658A (en) * | 2017-11-17 | 2018-03-23 | 武汉佰美斯医疗科技有限公司 | A kind of blood-plasma virus killing operating desk for being easy to illumination |
| CN111770789A (en) * | 2017-12-29 | 2020-10-13 | 塞鲁斯公司 | System and method for treating biological fluids |
| US11554185B2 (en) | 2017-12-29 | 2023-01-17 | Cerus Corporation | Systems and methods for treating biological fluids |
| CN108578728A (en) * | 2018-04-23 | 2018-09-28 | 北京铂鑫天然生物技术有限公司 | Blood-plasma virus killing instrument |
| CN108524969A (en) * | 2018-07-02 | 2018-09-14 | 苏州良辰生物医药科技有限公司 | A kind of virus inactivating device |
| US11883544B2 (en) | 2019-06-28 | 2024-01-30 | Cerus Corporation | System and methods for implementing a biological fluid treatment device |
| CN110833627A (en) * | 2019-11-25 | 2020-02-25 | 四川南格尔生物科技有限公司 | Ultraviolet inactivation instrument |
| CN111840596A (en) * | 2020-06-11 | 2020-10-30 | 南岳生物制药有限公司 | Riboflavin photochemical plasma inactivation device and control system and control method thereof |
| CN111840596B (en) * | 2020-06-11 | 2022-03-11 | 南岳生物制药有限公司 | Riboflavin photochemical plasma inactivation device and control system and control method thereof |
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| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20130626 |