CN105535936A - Compound antibacterial preparation for treating pneumonia of foxes, martens and raccoon dogs - Google Patents
Compound antibacterial preparation for treating pneumonia of foxes, martens and raccoon dogs Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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Abstract
The invention relates to a compound antibacterial preparation for treating pneumonia of foxes, martens and raccoon dogs. The compound antibacterial preparation is prepared from, by mass, 1-15 parts of levofloxacin, 2-15 parts of colistin sulphate, 1-5 parts of honeysuckle flower extract, 2-5 parts of licorice root extract, 0.1-2 parts of medicine extract for relieving a cough and removing phlegm and the balance glucose. The compound antibacterial preparation is short in treatment course, fast in effect taking, small in dosage, small in side effect, high in healing rate, not likely to lead to relapse, simple in preparation method and low in price as the raw materials are easy to obtain.
Description
Technical field
The present invention relates to veterinary drug technical field, be specifically related to a kind of compounded antibiotic preparation for the treatment of fox, ermine and raccoon dog pneumonia.
Background technology
Due to flu, air is not pure and fresh, draw badly, overstrain, health are deficient in vitamin, respiratory tract infection and passive protective physical fitness is caused to decline, so that in respiratory tract or external microorganism (staphylococcus, streptococcus, escherichia coli, Klebsiella pneumoniae and mycete etc.) after incubation period after a while, the state of an illness is shown effect, make animal be subject to the invasion and attack of virus, bring out zoogenetic infection pneumonia.Animal pneumonia has rapid onset, infects the characteristic rapid, mortality rate is high, brings huge economic loss to raiser.Fur-bearing animal is different from poultry, and its time of raising and train is shorter, and still keep certain wild nature, not accessible, the diagnosis of disease is more difficult; If adopt general antibacterial Western medicine to carry out, there is the problem that healing degree is little, repeatability is strong.
Summary of the invention
For solving the problem, the invention provides a kind of therapeutic effect good, healing degree is high, not easily recurs, and preparation method is simple, and raw material is easy to get, the compounded antibiotic preparation of low-cost treatment fox, ermine and raccoon dog pneumonia.
Technical scheme of the present invention
Be used for the treatment of a compounded antibiotic preparation for fox, ermine and raccoon dog pneumonia, each component comprises following component by percent mass mark:
Further, each component comprises following component by percent mass mark:
Further, each component comprises following component by percent mass mark:
Further, each component comprises following component by percent mass mark:
Further, described eliminating phlegm and stopping cough medicine is dioxopromethazine, one in woods, ammonium chloride, ambroxol hydrochloride, acetylcysteine sent by pentoxyverine, dextromethorphan, phenylpropyl alcohol.
Further, a kind of preparation method being used for the treatment of the compounded antibiotic preparation of fox, ermine and raccoon dog pneumonia, is characterized in that, carries out as follows:
(1) take each component by formula;
(2) above each component is crossed 80-100 mesh sieve respectively;
(3) by each component premix 20-30 minute in mixer after sieving except glucose, then add the glucose mixing 30-40 minute of surplus, after mix homogeneously, namely obtain product.
Further, fox, ermine and raccoon dog hemorrhagic pneumonia, virus and antibacterial secondary infection pneumonia is used for the treatment of.
Wherein the main component of Flos Lonicerae extract is chlorogenic acid, the main component of Radix Glycyrrhizae extract is glycyrrhizic acid, the main component of apricot seed extract is amygdaloside, and the main component of Flos Chrysanthemi Indici extract is chrysanthanone, chrysanthemum glycoside etc., and the main component of Radix Isatidis extract is indigo, indirubin.The Main Function of described extract is anti-inflammation antiviral.
Levofloxacin: the one in quinolones, has broad-spectrum antibacterial action, antibacterial action is strong, and this medicine treatment respiratory tract infection, Genitourinary System Infection and skin soft-tissue infection etc. obtain good efficacy.Wherein high to bloodthirsty hemophilus influenza, mucositis mora bacterium, S. aureus L-forms and pneumococcal clearance rate, effective percentage and the bacteria clearance for the treatment of acute and chronic lower respiratory infection reach 80% ~ 100%.
Colistin sulfate: be basic polypeptide class antibiotic, is mainly used in infection and the promotion growth of animals or poultry of preventing and treating sensitive organism.Colistin sulfate can with cell membrane lipid albumen free phosphoric acid salt binding, make surface of cell membrane tension force reduce, permeability increase, cause endochylema to outflow, cell death.Colistin sulfate has high inhibition effect to gram negative bacteria (especially escherichia coli, Salmonella, bacillus pyocyaneus, Bacillus proteus and haemophilus etc.).
Flos Lonicerae extract: extract from honeysuckle flower, principle active component is chlorogenic acid (chlorogenicacid) and Luteolin (Luteolin).For streptococcus, staphylococcus, Bacillus typhi, dysentery bacterium, large intestine and bacillus pyocyaneus, Diplococcus pneumoniae, bordetella pertussis, meningococcus etc., there is stronger antibacterial power; Be used for the inflammation that Resistant strain causes clinically, as treatment pulmonary tuberculosis complicated with respiratory tract infection, pneumonia, acute bacillary dysentery, diarrhoea, bacillary dysentery, various Medicine and Surgery inflammation.
Radix Glycyrrhizae extract: main component comprises: glycyrrhizin, glycyrrhizic acid, liquiritin, flavonoids of Glycyrrhiza etc.For yellow is to brownish-yellow powder.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription.Be used for the treatment of weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the diseases such as the anxious pain of gastral cavity abdomen, extremity contraction.
Apricot seed extract: main component is amygdaloside, has effect of sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation, for cough and asthma, fullness in the chest abundant expectoration, withered, the hot dry constipation in blood deficiency Tianjin.
Flos Chrysanthemi Indici extract: main component is chrysanthanone, chrysanthemum glycoside etc., and Main Function is anti-inflammation antiviral.
Radix Isatidis extract: main component is indigo glycoside (Indoxyl-β-glucoside), isatin (Isatin), indigo (Indigo), Isatan B (IsatanB) etc.Inhibitory action is had to various bacteria and virus, remarkable to staphylococcus aureus, escherichia coli, Bacillus typhi, Salmonella paratyphi, dysentery bacterium effect especially.
Above-mentioned five kinds of natural medicinal ingredients compatibilities use and there is no research report.
Usage and dosage of the present invention:
A kind of compounded antibiotic preparation for the treatment of fox, ermine and raccoon dog pneumonia of every 100 grams of the present invention mixes 120kg feedstuff, drinking water 150kg; Every 600-800 mink takes 100g the present invention every day, and 300-400 fox, recoon dog take 100g the present invention every day, take every day once, take 3-5 days continuously.Beneficial effect of the present invention:
Short treating period of the present invention, instant effect, consumption is few, and side effect is little, and healing degree is high, not easily recurs, and preparation method is simple, and raw material is easy to get, low price.
Detailed description of the invention
Table 1 is embodiments of the invention 1-6
Table 2 is comparative example 1-5 of the present invention
In the embodiment of the present invention and comparative example, each component is by percent mass mark, and the extract in embodiment and comparative example is directly buy, and manufacturer is: the permanent Easthome in Sichuan reaches bio tech ltd.
Flos Lonicerae extract product batch number is 150401, and Radix Glycyrrhizae extract product batch number is 150405, and Semen Armeniacae Amarum extract product batch number is 150501, and Flos Chrysanthemi Indici extract product batch number is 150301, and Radix Isatidis extract product batch number is 150305.
Mink, fox, recoon dog pneumonia infection clinical symptoms, cut open inspection change and diagnosis:
Clinical symptoms: during natural infection.In super acute or acute process.Can't see disease before dead, or dead before occur that appetite is absolutely useless, body temperature raises, asoscope is dry, takes action blunt, visual mucosa flushing, dyspnea, and in ventral breathing, the nostril that has flows out foam sample red liquid, and the rear mouth and nose that hold had flow out red blood foam.
Cut open inspection change: pulmonary congestion or diffuse hemorrhage, have several lobe of the lung to be sepia or peony liver sample consolidation as seen, cut and flow out a large amount of blood sample foam, serious is marble sample, drops in water; Liver enlargement, matter are crisp, congested; Spleen has petechia, infarction: kidney has petechia; There are rust content or blood sample liquid body in gastric portion, and spleen enlargement is hemorrhage, in dark red.Kidney hemorrhagic disease, in dark red.
Diagnosis: can tentative diagnosis be made according to epidemic characteristic, clinical symptoms and pathological change.
Animal experiment case one
Criterion of therapeutical effect is as follows:
Cure: clinical symptoms disappears completely, recover sick front state.
Effective: clinical symptoms disappears substantially.
Invalid: clinical symptoms without improvement, or has and increases the weight of trend, even dead.
The test case for the treatment of fox pneumonia infection
Select the fox 500 with pneumonia infection.Be divided into 10 groups at random, often organize 50, use the compounded antibiotic preparation of embodiment 1, embodiment 2, embodiment 5, embodiment 6, comparative example 1, comparative example 2, comparative example 3, comparative example 4, comparative example 5 respectively, the not medication of blank group.
The preparation method of embodiment 1, embodiment 2, embodiment 5, embodiment 6, comparative example 1, comparative example 2, comparative example 3, comparative example 4, comparative example 5:
(1) take each component by formula;
(2) above each component is crossed 90 mesh sieves respectively;
(3) by the premix 25 minutes in mixer of each component after sieving except glucose, then the glucose adding surplus mixes 35 minutes, namely obtains product after mix homogeneously.
Day dose is: feed by the present invention's every 100g mix fodder 120kg, drinking water 150kg, a 300-400 fox takes 100g the present invention every day, take every day once, take 5 days continuously.Reached the object of disease therapy by gastrointestinal absorption after oral.Assay is as follows:
Fox pneumonia infection experimental result treated by table 3
| Group | Sample size (only) | Do not heal quantity (only) | Do not heal rate |
| Embodiment 1 | 50 | 3 | 6％ |
| Embodiment 2 | 50 | 6 | 12％ |
| Embodiment 5 | 50 | 4 | 8％ |
| Embodiment 6 | 50 | 1 | 2％ |
| Comparative example 1 | 50 | 14 | 28％ |
| Comparative example 2 | 50 | 11 | 22％ |
| Comparative example 3 | 50 | 7 | 14％ |
| Comparative example 4 | 50 | 16 | 32％ |
| Comparative example 5 | 50 | 18 | 36％ |
| Blank group | 50 | 45 | 90％ |
In use, find no any untoward reaction, can clearly be found out by above-mentioned, the present invention takes safety, good effect, instant effect, is the good medicine for the treatment of fox pneumonia infection.
Animal experiment case two
Criterion of therapeutical effect is as follows:
Cure: clinical symptoms disappears completely, recover sick front state.
Effective: clinical symptoms disappears substantially.
Invalid: clinical symptoms without improvement, or has and increases the weight of trend, even dead.
The test case for the treatment of recoon dog pneumonia infection
Select the recoon dog 500 with pneumonia infection.Be divided into 10 groups at random, often organize 50, use the compounded antibiotic preparation of embodiment 1, embodiment 2, embodiment 5, embodiment 6, comparative example 1, comparative example 2, comparative example 3, comparative example 4, comparative example 5 respectively, the not medication of blank group.
The preparation method of embodiment 1, embodiment 2, embodiment 5, embodiment 6, comparative example 1, comparative example 2, comparative example 3, comparative example 4, comparative example 5:
(1) take each component by formula;
(2) above each component is crossed 100 mesh sieves respectively;
(3) by the premix 30 minutes in mixer of each component after sieving except glucose, then the glucose adding surplus mixes 40 minutes, namely obtains product after mix homogeneously.
Day dose is: take 100g the present invention every day by the present invention's every 100g mix fodder 120kg, drinking water 150kg, a 300-400 recoon dog, take every day once, take 5 days continuously.Reached the object of disease therapy by gastrointestinal absorption after oral.Assay is as follows:
Recoon dog pneumonia infection experimental result treated by table 4
| Group | Sample size (only) | Do not heal quantity (only) | Do not heal rate |
| Embodiment 1 | 50 | 1 | 2％ |
| Embodiment 2 | 50 | 6 | 12％ |
| Embodiment 5 | 50 | 3 | 6％ |
| Embodiment 6 | 50 | 0 | 0 |
| Comparative example 1 | 50 | 11 | 22％ |
| Comparative example 2 | 50 | 9 | 18％ |
| Comparative example 3 | 50 | 7 | 14％ |
| Comparative example 4 | 50 | 12 | 24％ |
| Comparative example 5 | 50 | 14 | 28％ |
| Blank group | 50 | 39 | 78％ |
In use, find no any untoward reaction, can clearly be found out by above-mentioned, the present invention takes safety, good effect, instant effect, is the good medicine for the treatment of recoon dog pneumonia infection.
Animal experiment case three
Criterion of therapeutical effect:
Cure: clinical symptoms disappears completely, recover sick front state.
Effective: clinical symptoms disappears substantially.
Invalid: clinical symptoms without improvement, or has and increases the weight of trend, even dead.
The test case for the treatment of mink pneumonia infection
Select the mink 400 with pneumonia infection.Be divided into 10 groups at random, often organize 40, use the compounded antibiotic preparation of embodiment 1, embodiment 2, embodiment 5, embodiment 6, comparative example 1, comparative example 2, comparative example 3, comparative example 4, comparative example 5 respectively, the not medication of blank group.
The preparation method of embodiment 1, embodiment 2, embodiment 5, embodiment 6, comparative example 1, comparative example 2, comparative example 3, comparative example 4, comparative example 5:
(1) take each component by formula;
(2) above each component is crossed 80 mesh sieves respectively;
(3) by the premix 20 minutes in mixer of each component after sieving except glucose, then the glucose adding surplus mixes 30 minutes, namely obtains product after mix homogeneously.
Day dose is: take 100g the present invention every day by the present invention's every 100g mix fodder 120kg, drinking water 150kg, a 600-800 mink, take every day once, take 5 days continuously.Reached the object of disease therapy by gastrointestinal absorption after oral.Assay is as follows:
Mink pneumonia infection experimental result treated by table 5
In use, find no any untoward reaction, can clearly be found out by above-mentioned, the present invention takes safety, good effect, instant effect, is the good medicine for the treatment of mink pneumonia infection.
To the above-mentioned explanation of the disclosed embodiments, professional and technical personnel in the field are realized or uses the present invention.To be apparent for those skilled in the art to the multiple amendment of these embodiments, General Principle as defined herein can without departing from the spirit or scope of the present invention, realize in other embodiments.Therefore, the present invention can not be restricted to these embodiments shown in this article, but will meet the widest scope consistent with principle disclosed herein and features of novelty.
Claims (7)
1. be used for the treatment of a compounded antibiotic preparation for fox, ermine and raccoon dog pneumonia, it is characterized in that, each component comprises following component by percent mass mark:
Levofloxacin 1 ~ 15,
Colistin sulfate 2 ~ 15,
Flos Lonicerae extract 1 ~ 5,
Radix Glycyrrhizae extract 2 ~ 5,
Eliminating phlegm and stopping cough medicine 0.1 ~ 2,
Glucose surplus.
2. a kind of compounded antibiotic preparation being used for the treatment of fox, ermine and raccoon dog pneumonia according to claim 1, it is characterized in that, each component comprises following component by percent mass mark:
Levofloxacin 1 ~ 15,
Colistin sulfate 2 ~ 15,
Flos Lonicerae extract 1 ~ 5,
Radix Glycyrrhizae extract 2 ~ 5,
Apricot seed extract 0.1 ~ 0.5,
Flos Chrysanthemi Indici extract 0.5 ~ 1.0,
Radix Isatidis extract 0.1 ~ 0.5,
Eliminating phlegm and stopping cough medicine 0.1 ~ 2,
Glucose surplus.
3. the compounded antibiotic preparation being used for the treatment of fox, ermine and raccoon dog pneumonia according to claim 1, is characterized in that, each component comprises following component by percent mass mark:
Levofloxacin 10,
Colistin sulfate 8,
Flos Lonicerae extract 3,
Radix Glycyrrhizae extract 3,
Eliminating phlegm and stopping cough medicine 0.8,
Glucose 75.2.
4. the compounded antibiotic preparation being used for the treatment of fox, ermine and raccoon dog pneumonia according to claim 2, is characterized in that, each component comprises following component by percent mass mark:
Levofloxacin 10,
Colistin sulfate 8,
Flos Lonicerae extract 3,
Radix Glycyrrhizae extract 3,
Apricot seed extract 0.2,
Flos Chrysanthemi Indici extract 0.8,
Radix Isatidis extract 0.3,
Eliminating phlegm and stopping cough medicine 0.8,
Glucose 73.9.
5. the compounded antibiotic preparation being used for the treatment of fox, ermine and raccoon dog pneumonia according to claim 1, it is characterized in that, described eliminating phlegm and stopping cough medicine is dioxopromethazine, one in woods, ammonium chloride, ambroxol hydrochloride, acetylcysteine sent by pentoxyverine, dextromethorphan, phenylpropyl alcohol.
6. the preparation method being used for the treatment of the compounded antibiotic preparation of fox, ermine and raccoon dog pneumonia according to any one of claim 1-5, is characterized in that, carries out as follows:
(1) take each component by formula;
(2) above each component is crossed 80-100 mesh sieve respectively;
(3) by each component premix 20-30 minute in mixer after sieving except glucose, then add the glucose mixing 30-40 minute of surplus, after mix homogeneously, namely obtain product.
7. the compounded antibiotic preparation being used for the treatment of fox, ermine and raccoon dog pneumonia according to claim 6, is characterized in that, is used for the treatment of fox, ermine and raccoon dog hemorrhagic pneumonia, virus and antibacterial secondary infection pneumonia.
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