CN103405490B - Compound medicine for preventing and treating infectious diseases of livestock and poultry and preparation method thereof - Google Patents
Compound medicine for preventing and treating infectious diseases of livestock and poultry and preparation method thereof Download PDFInfo
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- CN103405490B CN103405490B CN201310370450.5A CN201310370450A CN103405490B CN 103405490 B CN103405490 B CN 103405490B CN 201310370450 A CN201310370450 A CN 201310370450A CN 103405490 B CN103405490 B CN 103405490B
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Abstract
The invention discloses a compound medicine for preventing and treating infectious diseases of livestock and poultry. The compound medicine comprises the following raw material medicine components in parts by weight: 25-35 parts of gynostemma pentaphylla, 30-40 parts of honeysuckle, 8-13 parts of taurine, 5-10 parts of kanamycin sulfate, 2-6 parts of fructo-oligosaccharide and 10-25 parts of auxiliary materials. The compound medicine disclosed by the invention has the synergistic effects of treating both symptoms and root causes for inflammations of livestock and poultry, reducing the probability on drug resistance of pathogenic bacteria, and enhancing the curative effect, improves the sensitivity and antibacterial effect and reduces the pharmaceutical failure caused by diagnostic reasons. The rate of survival of livestock and poultry is raised from original 90% to over 95%, and the morbidity is reduced from original 78.33% to below 6%. The protection rate of vaccine (titer) is increased. The composition is safe and non-toxic, and the utilization ratio of feed is increased. The compound medicine is convenient to use and simple in process of preparation method, and has stronger market competitiveness and better economic and social benefits.
Description
Technical field
The invention belongs to veterinary drug technical field, relate to a kind of feed additive, specifically, relate to a kind ofly prevent and treat combination drug of poultry infectious disease and preparation method thereof.
Background technology
In recent years, the disease that poultry are caused by virus occupies very large ratio in poultry infectious disease, and the mortality of animals caused by it occupies the 2nd in all causes of disease, is only second to antibacterial, accounts for 36.8%.Overwhelming majority virosis is immunosuppressive disease, and cause immunity of organisms to decline, various mixed infection and Multi-organ failure syndrome occur secondary animal, make whole drove be in immunosuppressive condition; To other cause of disease susceptible, after mixed infection, symptom, pathological changes are not true to type; The immunne response ability of specific vaccine is declined or do not reacted, adds that medication is general, cause cause of disease drug resistance serious, cause immuning failure, overall resistance declines, growth retardation, constantly fragmentary dead, secondary multiple infection increases, conditionality pathogenic bacterium can cause serious disease, and sickness rate is in rising trend, particularly over the past two years, poultry bird flu and bird flu secondary or mixed infection sickness rate very high, make poultry M & M sharply increase.Livestock and poultry alimentary tract bacteriological infection is the disease that fowl often occurs, sick fowl shows as situation such as diarrhoea dysentery etc., and primarily of Gram-negative mattresses such as escherichia coli, Salmonella mattresses, single or mixed infection causes.Sick fowl undergrowth, morbidity rapidly.Show as diarrhoea, dysentery, row's white, Lycoperdon polymorphum Vitt, yellow or yellow green loose stool, what have is water sample, and sick fowl dehydration is serious, inflammatory reaction is serious, and may cause the too much phenomenon of electrolyte loss, occurs weak phenomenon, cause mortality rate very high, bring high risks to man of China livestock and poultry breeding industry.Take the monotherapy of general conventional means, medicine, often unsatisfactory curative effect, the economic loss caused is larger.
But current antiviral drugs major part is some Western medicine, they infect some diseases and have certain curative effect, such as, but also produce many toxic and side effects, also can produce certain damage to the cell that end is infected, the forbidding such as ribavirin, amantadine medicine also remains incessant after repeated prohibition simultaneously.Therefore the current developing direction for viral disease is that curative effect is certain, cost is low, has no side effect again, reduces as far as possible and takes in medicine to the harm of animal or human's body.
Chinese patent CN20lllO041260.X, is used for the treatment of the composition and method of making the same of fowl cholera.Be made up of following raw material by weight percentage: norfloxacin nicotinate 3-lO%, sulphuric acid celebrating great Lei element 3-lO%, taurine 5-l5%, sodium chloride 5%, potassium chloride 5%, surplus is anhydrous glucose.Adopt norfloxacin nicotinate and sulphuric acid to celebrate great Lei element to share, dual Synergistic antimicrobial, and the drug resistance probability effectively reducing pasteurellosis bacillus, improve sensitivity and antibacterial effect.Taurine have bring down a fever, antiinflammatory action, sodium chloride, potassium chloride electrolyte supplement, all medicines share and pass through rational proportion; to fowl cholera treating both the principal and secondary aspects of a disease; reduce pathogen drug resistance probability, strengthen curative effect, easy to use and reduce because of the phenomenon of medication failure of Diagnosis of Primary because causing.
Chinese patent CN20lllO041229.6, is used for the treatment of the composition and method of making the same of swine paratyphoid.Consisting of by weight percentage: florfenicol 3-lO%, soluble sulphathiazole 5-l5%, TMPl-5%, potassium chloride 5%, sodium bicarbonate 5-l5%, taurine 5-l5%, surplus is anhydrous glucose.Adopt florfenicol and soluble sulphathiazole to be disease-resistant ultimate constituent, outside the effective pathogenic microbe killing of decapacitation, improve the sensitivity of cause of disease, reduce the occurrence probability of drug resistance, and effective to secondary bacterial infection; TMP has remarkable potentiation to soluble sulphathiazole and florfenicol; Potassium chloride supplements the electrolyte loss because diarrhoea causes with high heat, and build up resistance, sodium bicarbonate can alleviate the side effect of soluble sulphathiazole, and prevention produces crystalluria; Taurine have bring down a fever, antiinflammatory, strengthen the effect of liver function.
Chinese patent CN20lOl0236436.2, is used for the treatment of the composition and method of making the same of chicken escherichia coli infection.Consisting of by weight percentage: amoxicillin 5-15%, ofloxacin 3-lO%, taurine 3-lO%, natrium carbonicum calcinatum 5%, surplus is anhydrous glucose.Compositions adopts amoxicillin and ofloxacin for cause of disease, effectively can kill escherichia coli, and the combination of two kinds of medicines, the occurrence probability of Drug Resistance of E. coli can be reduced, improve sensitivity, and other bacterial diseases to escherichia coli secondary infection, also there is good effect; The antiinflammatory action of taurine, the inflammation caused escherichia coli has the effect of quick antiinflammatory, and natrium carbonicum calcinatum is cosolvent, makes this product can be completely soluble in water, easy to use.All medicines share, and for cause of disease, disease, make this product can effectively resist cause of disease and clinical symptoms thereof, treating both the principal and secondary aspects of a disease.
Chinese patent CN2009l0305342.3, pharmaceutical composition for the treatment of livestock and poultry cold and its preparation method and application.Pharmaceutical composition, by weight the consisting of of percent: acetaminophen lO-20%, chlorphenamine O.1-O.5%, taurine 3-lO%, surplus is pharmaceutically acceptable adjuvant.The pharmaceutical composition for the treatment of livestock and poultry cold of the present invention, when flu occurs poultry, can be alleviated rapidly poultry high temperature, build up resistance, and effectively alleviates loss of appetite, accelerated breathing, death etc. that poultry influenza causes poultry.Can laying rate be increased, increase egg size, increase per day feed intake, improve food conversion ratio, also can relax peak descending process of laying eggs, reduce egg breakage rate.The hat temperature of heat stress laying hen, body temperature and breathing rate can be reduced and shorten the course of disease.
Along with the development of intensive culture industry, animal viral disease is serious harm husbandry sector not only, and some zoonosis also threatens human health.Due to the cytozoicus that virus is strict, antiviral drugs must optionally be destroyed or the virus of (outward) in T suppression cell, and to cell, does not at least produce fatal injury to the cell of end infection.The control of current poultry adopts Chinese herb prevention mostly, and the prescription of some classics has good effect, but due to herbal medicine efficacy slow, the course for the treatment of is longer, general medication just can take effect after 35 days, can not effective mitigate the disease rapidly, and the growth of poultry is often greatly affected.
Summary of the invention
Object of the present invention: being to overcome weak point of the prior art, providing a kind of and can prevent and treat combination drug of poultry infectious disease and preparation method thereof.
The present invention is achieved in that
Prevent and treat a combination drug for poultry infectious disease, comprise the former medicine component of following medicine and proportioning parts by weight are made: Herb Gynostemmae Pentaphylli 25-35 part, Flos Lonicerae 30-40 part, taurine 8-13 part, sulphuric acid kalamycin 5-10 part, oligofructose 2-6 part and adjuvant 10-25 part.
The combination drug of above-described control poultry infectious disease, is made up of following former medicine component and proportioning parts by weight: Herb Gynostemmae Pentaphylli 30 parts, Flos Lonicerae 35 parts, taurine 10 parts, sulphuric acid kalamycin 8 parts, oligofructose 4 parts, white sugar 4 parts and adjuvant 15 parts.
Above-described adjuvant comprises starch or modified starch, dextrin, sodium carboxymethylcellulose pyce, ethyl cellulose, the third methylcellulose, Pulvis Talci, magnesium stearate, calcium phosphate and micropowder silica gel.
The combination drug of above-described control poultry infectious disease is tablet, granule and powder.
The preparation method of the combination drug of above-described control poultry infectious disease comprises: pulverized respectively by raw material, mixing, sieves, subpackage, and mounted box and vanning obtain powder product; Or by powder pelletize or film-making according to a conventional method, hot air drying, subpackage and outer package obtain granule or tablet.
This combination drug, per kilogram feedstuff adds 0.5-4%.
Effect of prescription Chinese medicine of the present invention and pharmacology thereof illustrate:
Herb Gynostemmae Pentaphylli: Herb Gynostemmae Pentaphylli (Herba Gynostemmatis Pentaphylli).Containing compositions such as protein, fat, dietary fiber, carbohydrate, calcium, phosphorus, ferrum, carotene, vitamin B1, vitamin B2, nicotinic acid, vitamin C and various trace elements in Herb Gynostemmae Pentaphylli stem and leaf.Bitter in the mouth; Micro-sweet; Cool in nature.Return lung; Spleen; Kidney channel.There is replenishing QI to invigorate the spleen, preventing phlegm from forming and stopping coughing, heat-clearing toxin-expelling functions.Cure mainly body void weak; Nephrasthenia emission; Leukopenia; Hyperlipemia; Viral hepatitis; Chronic gastroenteritis; Chronic tracheitis.
Flos Lonicerae: Flos Lonicerae (Lonicera Japonica), Flos Lonicerae is cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.
Taurine: taurine (Rine), chemical name is 2-hydrogen base ethyl sulfonic acid, be have simple chemical constitution containing sulfydryl acid, its weak solution is in neutral.Taurine has high chemical stability and low metabolic activity; extensively be present in people and mammiferous internal organs; one of most important hydrogen base acid; there is special pharmacological action and physiological function; can antiinflammatory, analgesia, antipyretic, blood sugar lowering, maintenance normal vision function, regulate nerve conduction, regulate lipid peptic ulcer bleeding; and participate in Endocrine Activity; increase contractile ability; improve the effect of immunocompetence and resisting fatigue, it is as medicine, food and feed additive and being widely used.
Sulphuric acid kalamycin: sulphuric acid kalamycin (kanamycin lution), another name: sulfate mono kalamycin, kalamycin and OK a karaoke club are pungent.White crystalline powder, belongs to broad-spectrum antibiotic, and to Grain-positive, negative bacteria has bacteriostasis, for escherichia coli, and aerobacteria, bacillus enteritidis, dysentery bacterium, enteritis coccus, the infection that drug resistance staphylococcus etc. causes.
Oligofructose: oligofructose (ructo oligosaccharide FOS), modern medicine study proves, directly edible or edible interpolation oligofructose, all has the absorption promoting mineral, synthesizes b vitamin, generates the absorption of nutrient substance, augment nutritional material; Maintain large intestine normal creepage of gastrointestinal functions, improve bowel movement function, anti-ly to treat constipation, intractable diarrhea effect, probiotics, particularly bacillus bifidus in increment body, suppress harmful bacteria or pathogenic bacterium, reaches microecological balance in body, improves effect of immunity of organisms.
White sugar: white sugar (Saccharum sinensis Roxb).Nature and flavor are sweet; Flat.Return spleen channel; Lung meridian.Have and middle emergency; Promote the production of body fluid and moisturize effect.Cure mainly middle void stomachache; Dry mouth is thirsty; Xeropulmonary cough.
Advantage of the present invention and good effect:
The taurine that the present invention adopts is one of most important hydrogen base acid; there is special pharmacological action and physiological function; antiinflammatory action, in digestive tract, does not damage gastrointestinal function, is conducive to the treatment of enteritis; maintain normal vision function, regulate nerve conduction, regulate lipid peptic ulcer bleeding; and participate in Endocrine Activity, increase contractile ability, improve the effect of immunocompetence and resisting fatigue; improve its utilization rate to feedstuff, thus promote the growth promoter of body.
The sulphuric acid kalamycin broad-spectrum antiseptic that the present invention adopts, for escherichia coli, aerobacteria, bacillus enteritidis, dysentery bacterium, enteritis coccus, the infection that drug resistance staphylococcus etc. causes, to Grain-positive, negative bacteria has bacteriostasis.
The oligofructose that the present invention adopts has the absorption promoting mineral, the absorption of synthesis b vitamin, generation nutrient substance, augment nutritional material, maintain large intestine normal creepage of gastrointestinal functions, improve bowel movement function, anti-ly to treat constipation, intractable diarrhea effect, probiotics in increment body, particularly bacillus bifidus, suppresses harmful bacteria or pathogenic bacterium, reaches microecological balance in body, improves effect of immunity of organisms, improve its utilization rate to feedstuff, thus promote the growth promoter of body.
Compositions of the present invention is compound preparation, Herb Gynostemmae Pentaphylli, Flos Lonicerae, taurine, sulphuric acid kalamycin and oligofructose share, the dual antagonism poultry of energy are to pathogenic bacteria, the synergism having treating both the principal and secondary aspects of a disease to all kinds of inflammation disease of poultry, reduce pathogen drug resistance probability, strengthen curative effect, improving sensitivity and antibacterial effect, reducing because of the phenomenon of medication failure of Diagnosis of Primary because causing; And can play a role in health care to poultry, build up one's resistance to disease, reduce and use antibiotic, survival rate is raised to 95% from former 90%, and sickness rate drops to 6% from former 78.33%, improves vaccine (titre) protective rate.Raw material sources are extensive, and cheap, safety non-toxic, does not develop immunity to drugs, and improves the utilization rate of feedstuff, easy to use, and preparation method technique is simple, have the stronger market competitiveness and good economic benefit and social benefit.
Detailed description of the invention
Be described in further detail the present invention below in conjunction with embodiment, listed embodiment is only the present invention is described and is never limited to the present invention.
Embodiment 1: the preparation of powder and on probation
One, raw material components and proportioning weight number:
Herb Gynostemmae Pentaphylli 3.0 kilograms, Flos Lonicerae 3.5 kilograms, taurine 1.0 kilograms, sulphuric acid kalamycin 0.8 kilogram, oligofructose 0.4 kilogram, white sugar 0.4 kilogram, 1.2 kilograms, calcium phosphate and Pulvis Talci 0.3 kilogram.
Two, preparation method
Raw material Herb Gynostemmae Pentaphylli, Flos Lonicerae are first pulverized; pulverizing Herb Gynostemmae Pentaphylli, Flos Lonicerae powder add taurine, sulphuric acid kalamycin, oligofructose, granulated sugar, calcium phosphate and Pulvis Talci again and add in mixer; mixing; pulverize; cross 100 mesh sieves; subpackage 5 grams/bag and 0.5 kilogram/bag, pack, mounted box and vanning obtain powder product.
Three, product beta test and effect
Adopt this example to prevent and treat the combination drug of poultry infectious disease, to try out respectively in XX chicken farm on July 15,13 days to 2012 May in 2012 and to merely hit chicken in 300 chickens and 260.Matched group 300 chickens and 260 chicken of merely hitting is fed Basic drawing; Chicken test group is at this powder combination drug of interpolation 1.0% in Basic drawing of feeding; Middle chicken test group is at this powder combination drug of interpolation 2.5% in Basic drawing of feeding; Addition manner is taken for being mixed in feedstuff.Test chicken all adopts stable breeding, and nipple drinking device supplies water, and hand fed also keeps free choice feeding, keeps good ventilation.Experimental period is 9 weeks, and daily management and health and epidemic prevention are carried out routinely, and timing is cleared up, and regularly carries out giving up interior sterilization.Duration of test, the death of itemized record chicken, morbidity and average body weights.Result of the test is in table 1.
Table 1:XX chicken farm result of the test
In the whole trial period, chicken test group and chicken test group food are normally, hair color light, and stool is normal; Wherein middle adult livability reaches 96.53%, survives middle chicken average weight gain 0.81 kilogram; Chicken survival rate 96.0%, survives chicken average weight gain 0.37 kilogram.Matched group food is abnormal, and hair color is brightless, defecates abnormal; Wherein middle adult livability reaches 89.6%, survives middle chicken average weight gain 0.59 kilogram; Chicken survival rate 88.0%, survives chicken average weight gain 0.26 kilogram.
Embodiment 2: the preparation of granule and on probation
One, raw material components and proportioning weight number:
Herb Gynostemmae Pentaphylli 3.5 kilograms, Flos Lonicerae 3.0 kilograms, taurine 1.4 kilograms, sulphuric acid kalamycin 0.6 kilogram, oligofructose 0.6 kilogram, 0.8 kilogram, dextrin, Pulvis Talci 0.5 kilogram and dalcium biphosphate 0.5 kilogram.
Two, preparation method
Raw material Herb Gynostemmae Pentaphylli, Flos Lonicerae are first pulverized; pulverizing Herb Gynostemmae Pentaphylli, Flos Lonicerae powder add taurine, sulphuric acid kalamycin, oligofructose, dextrin, Pulvis Talci and dalcium biphosphate again and add in mixer; add water mixing; by comminutor pelletize according to a conventional method; 85 DEG C of hot air dryings; sieve, subpackage 10 grams/bag and 100 grams/bag, pack and vanning obtain granule product.
Three, product beta test and effect
Adopt this example to prevent and treat the combination drug of poultry infectious disease, in 20 days to 2012 July in 2012 on JIUYUE within 22, try out in 100 pigletss on XX pig farm, matched group 60 pigletss.Control group fed Basic drawing, add this granule combination drug of 2.0% in the Basic drawing that test group is fed, addition manner is taken for being mixed in feedstuff.Test piglets all adopts stable breeding, and hand fed also keeps free choice feeding, keeps good ventilation.Experimental period is 9 weeks, and daily management and health and epidemic prevention are carried out routinely, and timing is cleared up, and regularly carries out sterilization in pig house.Duration of test, the death of itemized record piglets, morbidity and average body weights.Result of the test is in table 2.
Table 2:XX kind pig farm result of the test
Whole trial period piglets test group food is normal, and the colour of skin is ruddy, and most piglets stool is normal, only has 6 to draw dysentery, survival rate 97.0%, survives piglets on average every net gain 82.4 kilograms.Matched group food is abnormal, and the colour of skin is not ruddy, and nearly half piglets stool is abnormal, and survival rate is 88.33%, survives piglets average weight gain 61.2 kilograms.
Claims (5)
1. prevent and treat a combination drug for poultry infectious disease, it is characterized in that: comprise the former medicine component of following medicine and proportioning parts by weight are made: Herb Gynostemmae Pentaphylli 25-35 part, Flos Lonicerae 30-40 part, taurine 8-13 part, sulphuric acid kalamycin 5-10 part, oligofructose 2-6 part and adjuvant 10-25 part.
2. a kind of combination drug preventing and treating poultry infectious disease according to claim 1, is characterized in that: be made up of following former medicine component and proportioning parts by weight: Herb Gynostemmae Pentaphylli 30 parts, Flos Lonicerae 35 parts, taurine 10 parts, sulphuric acid kalamycin 8 parts, oligofructose 4 parts, white sugar 4 parts and adjuvant 15 parts.
3. a kind of combination drug preventing and treating poultry infectious disease according to claim 1 and 2, is characterized in that: described adjuvant is: in starch or modified starch, dextrin, sodium carboxymethylcellulose pyce, ethyl cellulose, the third methylcellulose, Pulvis Talci, magnesium stearate, calcium phosphate and micropowder silica gel more than one.
4. a kind of combination drug preventing and treating poultry infectious disease according to claim 1 and 2, is characterized in that: the combination drug of described control poultry infectious disease is tablet, granule or powder.
5. a kind of combination drug preventing and treating poultry infectious disease according to claim 1 and 2, it is characterized in that: the preparation method of the combination drug of described control poultry infectious disease comprises: pulverized respectively by raw material, mixing, sieves, subpackage, mounted box and vanning obtain powder product; Or by powder pelletize or film-making according to a conventional method, hot air drying, subpackage and outer package obtain granule or tablet.
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| CN108157661A (en) * | 2017-12-30 | 2018-06-15 | 天津赫莱恩特生物科技有限公司 | A kind of feed addictive for improving antibody titer and preparation method thereof |
| CN108542931B (en) * | 2018-07-09 | 2021-01-05 | 南京农业大学 | Application of gynostemma pentaphylla in preparing medicament for resisting porcine epidemic diarrhea virus |
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| CN102847160B (en) * | 2012-09-07 | 2014-05-21 | 广东大华农动物保健品股份有限公司 | Compound quinolone injection for livestock, and preparation method thereof |
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