CN105534790A - Four-component eyesight-improving traditional Chinese medicinal toothpaste - Google Patents
Four-component eyesight-improving traditional Chinese medicinal toothpaste Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8164—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses four-component eyesight-improving traditional Chinese medicinal toothpaste. The toothpaste is prepared from the following raw materials in percentage by weight: 0.02-5 percent of Chinese wolfberry fruit extract, 0.02-5 percent of cassia seed extract, 0.02-5 percent of chrysanthemum extract, 0.02-5 percent of butterflybush flower extract, 20-60 percent of humectant, 18-50 percent of abrasive, 0.6-1.5 percent of a thickening agent, 0.1-2 percent of PVM/MA copolymer, 1.8-3 percent of surfactant, 0.15-0.3 percent of a sweetening agent, 0.15-0.5 percent of preservative, 0.8-1.5 percent of essence and the balance of deionized water which is added until the weight percentage reaches 100 percent. The traditional Chinese medicinal toothpaste is integrated with effects of clearing liver, improving eyesight and cleaning teeth, the application field of traditional Chinese medicines is expanded, and the health protection function of traditional Chinese medicines can be further achieved.
Description
Technical field
The present invention relates to a kind of toothpaste, be a kind of four taste Chinese medicine extract containing Fructus Lycii, Semen Cassiae, Flos Chrysanthemi and Flos Buddlejae specifically, there is the Chinese medicinal toothpaste of liver heat removing and eyesight improving effect, belong to oral cavity cleaning and nursing field.
Background technology
Along with the fast development of society, the rhythm of life of people is constantly accelerated, and various factors changes work and the living habit of people.Increasing people gets used to staying up late, or use computer and mobile phone for a long time, these undesirable elements can cause the poor circulation of around eyes to cause visual fatigue, cause the various visual problems such as ophthalmalgia, ophthalmic bloated, photophobia are shed tears, blurred vision, eyes are dry and astringent, bring white elephant to eyes, cover with one deck haze to soul.Eyes are windows of soul, and protection eyes are exactly our soul of protection.
There are multiple improving eyesight Chinese patent medicine or eyesight-improving health protection tea in the market, but the quickening of rhythm of life, many people have ignored these products.Toothpaste, as the product that disappear soon of oral cavity cleaning and nursing, is everyone daily indispensability, so add the Chinese medicine ingredients with improving eyesight effect in toothpaste, makes product can reach the dual function of cleaning oral cavity and eyesight-improving health care function.
Current oral cleaning nursing article market also there is not the Chinese medicinal toothpaste with improving eyesight effect, the improving eyesight toothpaste particularly simultaneously containing Fructus Lycii, Semen Cassiae, Flos Chrysanthemi and Flos Buddlejae four taste Chinese medicine extract.Four taste Chinese medicines are composite can play single medicinal material effect, can play again the synergistic function that the mutual compatibility of Chinese medicine produces.
Summary of the invention
The object of the present invention is to provide a kind of have liver heat removing and eyesight improving, cleaning teeth in one Chinese medicinal toothpaste, utilize the synergistic function of Fructus Lycii, Semen Cassiae, Flos Chrysanthemi and Flos Buddlejae four taste Chinese medicine extract, the application of developing China Chinese medicine, plays the health care of Chinese medicine better.
The object of the present invention is achieved like this:
A kind of four taste improving eyesight Chinese medicinal toothpastes, comprise active component and 85 ~ 99.2% matrix components of 0.8 ~ 15%.Described active component comprises wolfberry fruit extract, Semen Cassiae extract, Flos Chrysanthemi extract, Flos Buddlejae extract; Described matrix components comprises wetting agent, abrasive, thickening agent, Gantrez AN-119, surfactant, sweeting agent, antiseptic, essence and deionized water.
Toothpaste of the present invention, by weight percentage: the raw material components that described active component comprises: the wolfberry fruit extract of 0.02 ~ 5%, the Semen Cassiae extract of 0.02 ~ 5%, the Flos Chrysanthemi extract of 0.02 ~ 5%, the Flos Buddlejae extract of 0.02 ~ 5%;
The raw material components that described matrix components comprises: the wetting agent of 20 ~ 60%, the abrasive of 18 ~ 50%, the thickening agent of 0.6 ~ 1.5%, the Gantrez AN-119 of 0.1 ~ 2%, the surfactant of 1.8 ~ 3%, the sweeting agent of 0.15 ~ 0.3%, the antiseptic of 0.15 ~ 0.5%, the essence of 0.8 ~ 1.5%, deionized water is added into 100%.
Described wolfberry fruit extract is a kind of active component extracted from Fructus Lycii mellow fruit, comprises fructus lycii extracted solution or Fructus Lycii extraction powder, and preferred addition is 0.2% ~ 3%.
Described Semen Cassiae extract is a kind of active component extracted from the seed of Semen Cassiae, comprises Semen Cassiae extracting solution and Semen Cassiae extract powder, and preferred addition is 0.2% ~ 3%.
Described Flos Chrysanthemi extract is a kind of active component extracted from the dry capitulum of Flos Chrysanthemi, comprises chrysanthemum extract liquid and Flos Chrysanthemi extract powder, and preferred addition is 0.2% ~ 3%.
Described Flos Buddlejae extract is a kind of active component extracted from the dry flower and inflorescence thereof of loganiaceae plant Flos Buddlejae, and comprise Flos Buddlejae extracting solution and Flos Buddlejae extraction powder, preferred addition is 0.2% ~ 3%.
Described wetting agent is one or more mixture in sorbitol, glycerol, Polyethylene Glycol, propylene glycol.
Described abrasive is one or both mixture in calcium carbonate, calcium hydrogen phosphate, silicon dioxide.
Described thickening agent is one or more mixture in sodium carboxymethyl cellulose, hydroxyethyl-cellulose, xanthan gum, guar gum, carrageenan.
Described Gantrez AN-119 can improve active matter residence time in the oral cavity, improves the bioavailability of active matter.
Described surfactant is one or more mixture in sodium laurylsulfate, sodium lauroyl sarcosine, sodium lauroyl glutamate, cocoyl betanin.
Described sweeting agent is one or both mixture in saccharin sodium, acesulfame potassium.
Described antiseptic is one or more mixture in sodium benzoate, methyl hydroxybenzoate, ethyl hydroxybenzoate, propyl hydroxybenzoate, butyl hydroxybenzoate, methyl hydroxybenzoate sodium.
Other additive can also be comprised, as tetrasodium pyrophosphate, fluoride, titanium dioxide etc. in above-mentioned toothpaste.
Tool of the present invention has the following advantages and beneficial effect:
1, four taste Chinese medicine improving eyesight mechanism of the present invention emphasize particularly on different fields: Fructus Lycii invigorating the liver and kidney and improving eyesight, Flos Chrysanthemi wind-dispelling heat-dissipating and improving eyesight, and both compatibilities have yin nourishing hepatoprotective, effect of suppressing the hyperactive liver improving eyesight; Flos Buddlejae liver heat removing is nourished blood, improving acuity of vision and removing nebula, can adopting both clearing heat method and tonification method with Fructus Lycii compatibility, has effect of liver heat removing, tonifying liver, improving eyesight; Semen Cassiae liver heat removing and eyesight improving, with Flos Buddlejae compatibility, liver heat removing and eyesight improving effect is stronger.The composite synergistic function having played the mutual compatibility of Chinese medicine better and produced of four taste Chinese medicines.
2, Fructus Lycii, Semen Cassiae, Flos Chrysanthemi and Flos Buddlejae four taste Chinese medicine extract are carried out composite usage in toothpaste by the present invention first, both the activity of single medicinal material had been played, four taste Chinese medicines are made again to complement each other, Synergistic, with the addition of Gantrez AN-119 in mastic, the adhesive attraction that can produce by means of high molecular polymer and oral mucosa, makes the active component adhered on oral mucosa play a role lastingly simultaneously, improve the bioavailability of active matter, play liver heat removing and eyesight improving effect better.
3, four taste improving eyesight Chinese medicinal toothpastes of the present invention, consumer can be made when cleaning oral cavity, improving eyesight active component is directly absorbed by oral mucosa and sublingual vein and enters blood circulation, avoid the Degradation of the first pass effect of liver and gastrointestinal enzyme and acid to the destruction of active matter, improve the degree of absorbing of active matter, play function of improving eyesight quickly.
4, four taste improving eyesight Chinese medicinal toothpastes of the present invention, add the approach that people absorb improving eyesight functional component, no longer be confined to food or health product, just liver heat removing and eyesight improving effect can be obtained while common oral cleaning-nursing, there is the feature of easy to use and convenient picked-up, expand the application of Chinese medicine, there is very strong practicality.
Detailed description of the invention
Below the simple statement of the health-care effect of several Chinese medicines that the present invention relates to:
Fructus Lycii is China's tradition rare Chinese medicine, have " red treasured " laudatory title, is rich in vegetable polysaccharides, protein, vitamins and other nutritious components, has improving eyesight effect, so be commonly called as " bright eye ".Deficiency of liver-blood can be treated, blurring of vision that deficiency of kidney-YIN causes and nyctalopia.The main active of Fructus Lycii is lycium barbarum polysaccharide, also has the nutritional labelings such as B-carotene, riboflavin, thiamine.Lycium barbarum polysaccharide is a kind of water-solubility protein polysaccharide, has the effect of immunity moderation, slow down aging, can improve the symptoms such as human-body fatigue, inappetence and blurred vision.The retinal photoreceptor of human body is made up of retinol and opsin, and in Fructus Lycii, contained abundant B-carotene can change into vitamin A in human body, and vitamin A can generate retinol, thus improves vision, prevents maculopathy.
Semen Cassiae is the dry mature seed of pulse family annual herb plant Semen Cassiae or little Semen Cassiae, is conventional improving eyesight Chinese crude drug, has effect of liver heat removing and eyesight improving, so be commonly called as " going back gb 1 ".Be mainly used in the puckery pain of conjunctival congestion, the many tear of photophobia, the diseases such as dizzy, poor vision of having a headache, Semen Cassiae can let out clearly liver and gall stagnated fire, again can dispelling wind and heat pathogens, for controlling conjunctival congestion and swelling pain key medicine.
Flos Chrysanthemi is feverfew, is used as medicine, is conventional Chinese medicine, has effect of wind-dispelling heat-dissipating, liver heat removing and eyesight improving, often drink chrysanthemum scented tea and have relieving restlessness of avoiding heat, the function of the improving eyesight that clears away heart-fire with flower.In Flos Chrysanthemi, main active is Flos Chrysanthemi flavone.There is heat-clearing and toxic substances removing, the effect of suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.
Flos Buddlejae is dry flower and the inflorescence thereof of loganiaceae plant Flos Buddlejae, sweet in the mouth, cold nature.Flos Buddlejae has effect of clearing away heat-damp and promoting diuresis, improving acuity of vision and removing nebula.Be used for the treatment of conjunctival congestion and swelling pain, many tear photophobia, nebula of looking unfamiliar film, the multiple ophthalmic such as blurring of vision.
Set forth the present invention further below by specific embodiment, but the use of these embodiments only for being described in more detail, and shall not be applied to and limit the present invention in any form.
Following wolfberry fruit extract, Semen Cassiae extract, Flos Chrysanthemi extract and Flos Buddlejae extract can be extracting solution and/or extract powder, and are commercially available prod.
embodiment 1
A kind of four taste improving eyesight Chinese medicinal toothpastes, by weight percentage, comprise following raw material components:
Processing technology is as follows:
1) methyl hydroxybenzoate, propyl hydroxybenzoate, essence are added stirring and dissolving in container A after weighing;
2) Gantrez AN-119 is added in container B, with a small amount of PEG-4000 pre-dispersed evenly after add remaining PEG-4000 again;
3) deionized water is added in premix pot A, then saccharin sodium, acesulfame potassium, sodium lauroyl sarcosine, wolfberry fruit extract, Semen Cassiae extract, Flos Chrysanthemi extract, Flos Buddlejae extract is added, and stirring and dissolving, then the raw material in container B is added in premix pot A stir;
4) sorbitol is added in premix pot B;
5) calcium carbonate, silicon dioxide, sodium carboxymethyl cellulose, guar gum, sodium laurylsulfate are added in meal mixer;
6) liquid material in premix pot A and premix pot B is sucked Manufacturing medicine extract machine under vacuum conditions, then start scraper plate and stirring, suck the powder in meal mixer, open homogenizing after powder has entered, degassed 25 ~ 30 minutes of homogenizing;
7) vacuum outgas is after 25 ~ 30 minutes, sucks the raw material in container A, more degassed 10 minutes of homogenizing, can go out cream after the assay was approved.
embodiment 2
A kind of four taste improving eyesight Chinese medicinal toothpastes, by weight percentage, comprise following raw material components:
Processing technology is as follows:
1) methyl hydroxybenzoate, butyl hydroxybenzoate, essence are added stirring and dissolving in container A after weighing;
2) Gantrez AN-119 is added in container B, with a small amount of propylene glycol pre-dispersed evenly after add remaining propylene glycol again;
3) deionized water is added in premix pot A, then saccharin sodium, tetrasodium pyrophosphate, sodium lauroyl glutamate, wolfberry fruit extract, Semen Cassiae extract, Flos Chrysanthemi extract, Flos Buddlejae extract is added, and stirring and dissolving, then the raw material in container B is added in premix pot A stir;
4) glycerol, sorbitol are added in premix pot B;
5) calcium hydrogen phosphate, silicon dioxide, sodium carboxymethyl cellulose, xanthan gum, sodium laurylsulfate are added in meal mixer;
6) liquid material in premix pot A and premix pot B is sucked Manufacturing medicine extract machine under vacuum conditions, then start scraper plate and stirring, suck the powder in meal mixer, open homogenizing after powder has entered, degassed 25 ~ 30 minutes of homogenizing;
7) vacuum outgas is after 25 ~ 30 minutes, sucks the raw material in container A, more degassed 10 minutes of homogenizing, can go out cream after the assay was approved.
embodiment 3
A kind of four taste improving eyesight Chinese medicinal toothpastes, by weight percentage, comprise following raw material components:
Processing technology is as follows:
1) container A is added after being weighed by essence;
2) Gantrez AN-119 is added in container B, with a small amount of Polyethylene Glycol-600 pre-dispersed evenly after add remaining Polyethylene Glycol-600 again;
3) deionized water is added in premix pot A, then saccharin sodium, tetrasodium pyrophosphate, sodium benzoate, methyl hydroxybenzoate sodium, cocoyl betanin, sodium fluoride, wolfberry fruit extract, Semen Cassiae extract, Flos Chrysanthemi extract, Flos Buddlejae extract is added, and stirring and dissolving, then the raw material in container B is added in premix pot A stir;
4) sorbitol is added in premix pot B;
5) silicon dioxide, sodium carboxymethyl cellulose, carrageenan, sodium laurylsulfate, titanium dioxide are added in meal mixer;
6) liquid material in premix pot A and premix pot B is sucked Manufacturing medicine extract machine under vacuum conditions, then start scraper plate and stirring, suck the powder in meal mixer, open homogenizing after powder has entered, degassed 25 ~ 30 minutes of homogenizing;
7) vacuum outgas is after 25 ~ 30 minutes, sucks the raw material in container A, more degassed 10 minutes of homogenizing, can go out cream after the assay was approved.
embodiment 4
A kind of four taste improving eyesight Chinese medicinal toothpastes, by weight percentage, comprise following raw material components:
Processing technology is as follows:
1) methyl hydroxybenzoate, essence are added container A after weighing;
2) Gantrez AN-119 is added in container B, with a small amount of Polyethylene Glycol-600 pre-dispersed evenly after add remaining Polyethylene Glycol-600 again;
3) deionized water is added in premix pot A, then add saccharin sodium, sodium benzoate, wolfberry fruit extract, Semen Cassiae extract, Flos Chrysanthemi extract, Flos Buddlejae extract, and stirring and dissolving, then the raw material in container B is added in premix pot A stir;
4) sorbitol is added in premix pot B;
5) silicon dioxide, sodium carboxymethyl cellulose, carrageenan, sodium laurylsulfate, titanium dioxide are added in meal mixer;
6) liquid material in premix pot A and premix pot B is sucked Manufacturing medicine extract machine under vacuum conditions, then start scraper plate and stirring, suck the powder in meal mixer, open homogenizing after powder has entered, degassed 25 ~ 30 minutes of homogenizing;
7) vacuum outgas is after 25 ~ 30 minutes, sucks the raw material in container A, more degassed 10 minutes of homogenizing, can go out cream after the assay was approved.
clinical trial part
A kind of four taste improving eyesight Chinese medicinal toothpaste improving eyesight effect clinical trial investigation of the present invention:
Inclusive criteria: choose 60 people and use eye for a long time, the age, vision fatiguability person was study subject to have ophthalmalgia, ophthalmic bloated, photophobia is shed tears, blurred vision, eyes are dry and astringent etc. between 18 ~ 30 years old.
Test method: adopt control design between self and group, according to requirement that is random, double blinding, is divided into experimental group and matched group by the experimenter of symbol and condition.Experimental group uses the toothpaste of embodiment 2, and matched group uses not containing the toothpaste of improving eyesight Chinese medicine, and every day respectively brushes teeth once sooner or later, and squeeze 1.5 ~ 2cm mastic, Brushing time must not be less than 3 minutes at every turn.Continuous use carried out questionnaire survey and statistical result after 60 days, saw the following form shown in 1.
Table 1 survey result is added up
| Group | Number | Effectively | Invalid | Effective percentage % |
| Experimental group | 30 | 25 | 5 | 83.3％ |
| Matched group | 30 | 3 | 27 | 10％ |
As shown in Table 1, four taste improving eyesight Chinese medicinal toothpastes of the present invention, after continuously using 60 days, to ophthalmalgia, ophthalmic bloated, photophobia is shed tears, blurred vision, eyes are dry and astringent etc., and vision fatiguability person has significant improving eyesight effect, reaches desired design object.
What the present invention relates to is a kind of four taste improving eyesight Chinese medicinal toothpastes, above embodiment is just to limited elaboration of the present invention, and not limitation of the present invention, is not departing under the spirit and scope of the present invention condition, to the amendment that embodiment is done, all belong within the scope of the technology of the present invention.
Claims (10)
1. four taste improving eyesight Chinese medicinal toothpastes, comprise active component and 85 ~ 99.2% matrix components of 0.8 ~ 15%, it is characterized in that: described active component comprises wolfberry fruit extract, Semen Cassiae extract, Flos Chrysanthemi extract, Flos Buddlejae extract; Described matrix components comprises wetting agent, abrasive, thickening agent, Gantrez AN-119, surfactant, sweeting agent, antiseptic, essence and deionized water.
2. four taste improving eyesight Chinese medicinal toothpastes according to claim 1, it is characterized in that: the raw material components that described active component comprises: the wolfberry fruit extract of 0.02 ~ 5%, the Semen Cassiae extract of 0.02 ~ 5%, the Flos Chrysanthemi extract of 0.02 ~ 5%, the Flos Buddlejae extract of 0.02 ~ 5%;
The raw material components that described matrix components comprises: the wetting agent of 20 ~ 60%, the abrasive of 18 ~ 50%, the thickening agent of 0.6 ~ 1.5%, the Gantrez AN-119 of 0.1 ~ 2%, the surfactant of 1.8 ~ 3%, the sweeting agent of 0.15 ~ 0.3%, the antiseptic of 0.15 ~ 0.5%, the essence of 0.8 ~ 1.5%, deionized water is added into 100%.
3. four taste improving eyesight Chinese medicinal toothpastes according to claim 2, it is characterized in that: described wolfberry fruit extract is the active component extracted from Fructus Lycii mellow fruit, comprise extracting solution and extract powder, preferred addition is 0.2% ~ 3%.
4. four taste improving eyesight Chinese medicinal toothpastes according to claim 2, it is characterized in that: described Semen Cassiae extract is the active component extracted from the seed of Semen Cassiae, comprise extracting solution and extract powder, preferred addition is 0.2% ~ 3%.
5. four taste improving eyesight Chinese medicinal toothpastes according to claim 2, it is characterized in that: described Flos Chrysanthemi extract is the active component extracted from the dry capitulum of Flos Chrysanthemi, comprise extracting solution and extract powder, preferred addition is 0.2% ~ 3%.
6. four taste improving eyesight Chinese medicinal toothpastes according to claim 2, it is characterized in that: described Flos Buddlejae extract is the active component extracted from the dry flower and inflorescence thereof of loganiaceae plant Flos Buddlejae, comprise extracting solution and extract powder, preferred addition is 0.2% ~ 3%.
7. four taste improving eyesight Chinese medicinal toothpastes according to claim 2, is characterized in that: described wetting agent is one or more mixture in sorbitol, glycerol, Polyethylene Glycol, propylene glycol;
Described abrasive is one or both mixture in calcium carbonate, calcium hydrogen phosphate, silicon dioxide;
Described thickening agent is one or more mixture in sodium carboxymethyl cellulose, hydroxyethyl-cellulose, xanthan gum, guar gum, carrageenan;
Described surfactant is one or more mixture in sodium laurylsulfate, sodium lauroyl sarcosine, sodium lauroyl glutamate, cocoyl betanin.
8. four taste improving eyesight Chinese medicinal toothpastes according to claim 2, is characterized in that: described Gantrez AN-119 can improve active matter residence time in the oral cavity, improve the bioavailability of active matter.
9. four taste improving eyesight Chinese medicinal toothpastes according to claim 2, is characterized in that: described sweeting agent is one or both mixture in saccharin sodium, acesulfame potassium; Described antiseptic is one or more mixture in sodium benzoate, methyl hydroxybenzoate, ethyl hydroxybenzoate, propyl hydroxybenzoate, butyl hydroxybenzoate, methyl hydroxybenzoate sodium.
10. four taste improving eyesight Chinese medicinal toothpastes according to claim 1, is characterized in that: can also comprise other additive in above-mentioned toothpaste, as tetrasodium pyrophosphate, fluoride, titanium dioxide etc.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107496263A (en) * | 2017-10-11 | 2017-12-22 | 付金龙 | Chinese medicinal toothpaste and preparation method thereof |
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| CN102246870A (en) * | 2010-05-21 | 2011-11-23 | 周兴兵 | Heat clearing and eyesight improving tea |
| CN105168059B (en) * | 2015-09-24 | 2017-12-26 | 名臣健康用品股份有限公司 | A kind of benefit good night refreshing Chinese medicinal toothpaste |
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| CN107496263A (en) * | 2017-10-11 | 2017-12-22 | 付金龙 | Chinese medicinal toothpaste and preparation method thereof |
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Effective date of registration: 20221021 Address after: 515834 Liannan Industrial Zone, Chenghai District, Shantou City, Guangdong Province Patentee after: Guangdong Mingchen Daily Chemical Co.,Ltd. Address before: 515834 Liannan Industrial Zone, Lianxia Town, Chenghai District, Shantou City, Guangdong Province Patentee before: MINGCHEN HEALTH Co.,Ltd. |