CN105521336A - 一种生发乌发软丸及其制备工艺 - Google Patents
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Abstract
本发明属医药技术领域,涉及一种生发乌发软丸及其制备工艺。由黑豆、何首乌、熟地、生地、当归、鸡血藤、牡丹皮、白芍药、山萸肉、桑椹、女贞子、墨旱莲、枸杞子、补骨脂、牛膝、黑芝麻、决明子、菟丝子、麦冬、茯苓、合欢皮、柴胡、白蒺藜、防风、海藻酸钠、结冷胶、罗望子胶、凝结多糖、低聚异麦芽糖、黑糯米酒为原料制成,通过提取、滴制固化、118℃30分钟蒸汽灭菌和热凝固等工艺制得,具有显著生发乌发美发功能,剂型创新、口感时尚有趣。
Description
技术领域
本发明属于医药技术领域,特别涉及一种生发乌发软丸及其制备工艺。
背景技术
头发枯萎、发黄、早生白发、脱发是美容技术中需要面对的一大难题,而这些症状会给人们的外貌自信带来严重的伤害,亦是身体内出现健康问题的外在反映。
“七宝美髯丹”为传统中医治疗白发的著名方剂,出自清代医家汪昂所著的《医方集解》,由何首乌、茯苓、牛膝、当归、枸杞子、菟丝子、补骨脂组成,其中,何首乌要用米泔水浸、黑豆铺蒸、晒干,换豆再蒸,再晒干,如此九蒸九晒,补骨脂要用黑芝麻炒,茯苓以人乳制,其它药也要用酒制,制备工艺非常繁复。其方剂功效主要是补益肝肾、治肝肾不足而引起的须发早白、脱发,而对其它致病因素如血热生风、痰湿、情志等引起的脱发系列症状则无显著疗效,或根本不见效。
发明内容
本发明人在治疗发枯、早生白发、脱发的实践和探索中发现,在经济贫困的年代,人们由于饮食营养严重缺乏,肝肾不足的纯虚证患者居多,但在当代人群中,单纯性肝肾不足的患者显著减少,但多种致病因素叠加的患者则明显增多。所述多种致病因素包括:肝肾不足、血虚、血热化燥火、血热生风、细菌感染、虫虱感染等,尤其重要的一项致病因素是,由血脂高、血脂代谢失常引起的血脂痰湿郁结化火、阻塞经络、从而导致毛囊细胞营养供给和代谢不畅,这是当今常见的溢脂性脱发的关键致病因素,也是最为难治的脱发证,因为纯虚症可以通过补的方法给予补充、营养、提升、支持,使症状迅速得以改善,但血脂痰湿的阻塞,即中医的所谓具有胶结粘腻之性的实邪,是不易祛除的,这正是本发明需要突破的关键点。
脱发、白发、发枯、发黄这一系列症状虽然是一种外在表现的症状,同时它确实给患者心理健康带来很大的负面影响,但其作为同时反映了身体内在健康的异常讯号更应引起人们的重视。虽然多数患者由西医的体检数据中未必能发现病变的明确指标,但从中医的角度而论,其脏腑功能已出现亚健康状态,甚至是颇为严重的虚证,或虚实夹杂证,这一论断的正确性可以从客观上的外表症状作为最有说服力的佐证,从这种意义上说,中医“治未病”这种防微杜渐的保健及治病意识有着极为重要的现实意义和深远的启示、指导意义。本发明人正是通过对脱发、白发、发枯、发黄一系列症状的病因进行研究,并对“七宝美髯丹”这一传统方剂的药理、制药工艺进行深入的分析,经过反复组合、调整、创新、改良、试用,创建了一种新剂型的组方,并结合创新的制备工艺,制得一种生发乌发软丸,完成了本发明。
本发明的目的是这样实现的:
一种生发乌发软丸,由以下重量的原料制成:
(1)A组中药原料:
黑豆24-40g、何首乌12-20g、熟地12-20g、生地12-20g、当归8-12g、鸡血藤3-5g、牡丹皮6-10g、白芍药6-10g、山萸肉8-16g、桑椹6-10g、女贞子6-10g、墨旱莲4-8g、枸杞子6-10g、补骨脂6-10g、牛膝4-8g、黑芝麻4g、决明子3-5g、菟丝子6-10g、麦冬8-12g、茯苓12-20g、合欢皮6-10g、柴胡4-8g、白蒺藜6-10g、防风4-8g;
(2)B组原料:
海藻酸钠4-6g、结冷胶0.8-1.6g、罗望子胶0.2-0.8g、凝结多糖16-20g、低聚异麦芽糖100-200g、黑糯米酒24-40g。
一种生发乌发软丸的制备工艺,在采用上述重量的原料的基础上,包括以下制备步骤:
(1)将A组中药原料中的熟地、生地用陶瓷刀切碎,然后将切碎的熟地、生地与A组原料中的其它所有原料混合,用粉碎机粉碎成粗粒,加A组中药原料总重量6-8倍的纯净水煮沸45分钟,120目过滤,得煎煮提取滤出液和药渣;
(2)在步骤(1)所得的药渣中加入药渣重量1-3倍的80度食用级酒精,50℃恒温避光浸渍2天,经200目压榨过滤,将滤出液经蒸馏回收乙醇后,得药渣浸渍提取液;
(3)将步骤(1)所得的煎煮提取滤出液和步骤(2)所得的药渣浸渍提取液合并,减压蒸发浓缩至100g,得浓缩提取物;
(4)将B组原料中的海藻酸钠加25倍重量的纯净水搅拌分散,放置30分钟;
(5)将B组原料中的结冷胶加60倍重量的纯净水搅拌分散,放置30分钟;
(6)将B组原料中的罗望子胶加50倍重量的纯净水搅拌分散,放置20分钟;
(7)将B组原料中的凝结多糖加13倍重量的18℃纯净水搅拌分散后,再搅拌10分钟;
(8)将步骤(3)所得的浓缩提取物和经过步骤(4)、(5)、(6)、(7)制作所得的原料全部混合一起,加入B组原料中的低聚异麦芽糖和黑糯米酒,添加纯净水至总重量为1000g,快速搅拌均匀,并迅速通过滴粒机滴于葡萄糖酸钙溶液中,形成圆粒状丸体,并让丸体在葡萄糖酸钙溶液中浸泡1-3分钟进行凝胶固化反应,捞起用无菌水冲去丸体表面的葡萄糖酸钙溶液,分装于达到食品卫生级标准的耐高温塑料杯中,用铝塑复合膜热封杯口,118℃30分钟蒸汽灭菌和热凝固,反压冷却,制得一种生发乌发软丸。
本发明的有益效果如下:
(1)本发明的A组中药原料,实际是一剂中药方剂,是本发明人根据多年的实践和研究,以“发为血之余”、“肾者,主蛰,封藏之本,精之处也,其华在发、其充在骨”,“肝主藏血”、“血热则生风”、“治风先治血,血行风自灭”等中医理论为指导,以现代科学对血脂、毛发生理的认识为切入点,参合古今和中西理论,启发新的中医“理、法、方”思维而研发的有效乌发生发新方剂,它的方义是这样的:当归、熟地、生地、鸡血藤、白芍药配合能养血活血和血以资生发之营养源;何首乌、山萸肉、黑豆、桑椹、菟丝子、女贞子滋养肝肾之阴与补骨脂、枸杞子提升肝肾阳气配合,加上墨旱莲、黑芝麻、牛膝强固肝肾,使肝肾这一生发之本精气充盈、恢复强壮;茯苓、麦冬养心而沟通心肾,使水火相济;柴胡、合欢皮升阳舒肝以愉情畅志;决明子苦甘微寒清肝、大肠经之热邪,使补肝而不致留邪;白蒺藜、防风配合能祛风,与上述养血活血和血凉血的药物配合,能增强熄风作用,避免头发为风燥所伤而致脱落,尤其重要的一点是,中医认为,肝属木,应自然界春生之气,只有保持其柔和、舒畅、升发、条达、既不抑郁也不亢奋的充和之象这样一种状态,才能发挥肝功能的正常生理作用,才能使血脂分解、代谢正常,由此启悟,本发明着重在补肝肾的同时,用柴胡、合欢皮、决明子、白蒺藜行气、清热、息风并佐以疏泄,使补肝肾药发挥出应有效力,从而使肝功能恢复和提高,在此前提下,何首乌、白芍药、桑椹、女贞子、枸杞子、决明子的降血脂和茯苓的除痰湿,以及白蒺藜、防风的祛风胜湿功能才能起作用,降血脂、疏通血脉、滋养头发才能实现。本方剂融合了补肝肾、舒肝、愉悦情志、养血、活血、凉血、和血、熄风、行气、化湿、清热、降血脂、通经络的综合功能,这些功能之间是互相协调、互相促进并形成增效作用,且合理的制备工艺实质上已产生了中药炮制的作用,使药效得以杨长避短,并达到去毒副作用,正因为这样,才使本发明产品发挥出显著的生发乌发功能,达到理想的效果,这绝非单一药物或随意组方的药理作用所能达到的效果。
(2)传统方剂“七宝美髯丹”中,何首乌需要铺黑豆九蒸九晒,工艺非常繁复,耗时耗材,本发明将包括何首乌和黑豆在内的A组中药全部混合,打碎后加水煎煮,让其先融合和提取,再80度酒精经50℃较高温度的浸渍提取,使药渣中的醇溶性有效成份快速而充分地提取出来,并产生了制药去毒的作用,比传统“七宝美髯丹”中的酒制更有效,加上加入黑糯米酒滴制成软丸后,经118℃30分钟的高温处理,药物发生了进一步的反应,比传统九蒸九晒的效果更好,通过这样的处理,何首乌中的大黄素、大黄酚等化合物及其它未明的毒素因子被破坏失效,而降血脂、提高免疫功能、抗衰老等有益功能则显著提高,试验结果表明,本发明制品可使去肾上腺饥饿小鼠肝糖原含量增加≥7倍,而单纯采用水煎煮提取液的对照试验只增强2-3倍,本发明还简化了工艺,而这一工艺的创新对革新繁复的传统制药工艺也是一种有益的启示。采用纯净水煎煮中药,意在避免过度增加产品微量元素含量的浓度,更利于健康,还能使人体吸收更快。
(3)海藻酸钠溶液能在加入钙离子的情况下形成热不可逆性凝胶,结冷胶溶液也能在钙离子的作用下形成凝胶。结冷胶凝胶的风味释放性较好,低浓度的罗望子胶溶液有较好的流动性,罗望子胶溶液能与乙醇产生凝胶。本发明为实现用胶体将中药提取物进行包容、胶合而形成软丸,根据各种胶体的各自不同性质特点,以各取所长、协同增效、互补、相互制衡、实现对胶体的改性与重组的思维导向,进行了反复的、大量的调配试验,得出了最佳的组合配方及配比,其特出效果表现为:B组原料最终混合完成后,当迅速通过滴粒机滴于葡萄糖酸钙溶液中时,在滴粒的表面,海藻酸钠遇到钙离子后迅速反应形成一层固化薄层,通过对反应时间的恰当控制,获得理想的固化强度和薄层厚度,这一固化层的形成,能迅速包封住滴粒内部的中药提取物,避免泄漏损失,并初步形成丸粒体形状,实现了快速而有效的定形,同时,结冷胶也形成了一定的强度,罗望子胶将黑糯米酒有效络合,这时,软丸已基本形成较为稳定的丸粒形态,其后在装杯封口后的118℃30分钟蒸汽灭菌过程中,凝结多糖受热形成凝胶,冷却后,丸体形成一种稳定的外皮光滑致密,稍有脆性,核心部份软滑多汁,口感特别可口有趣的软丸。产品经高温灭菌,达到了商业无菌的卫生标准。低聚异麦芽糖能提供低热值的甜味,还能缓解和掩盖中药的气味。黑糯米酒既能起到炮制中药的作用,又能促进血液循环,使药力直达头发,其酒香味与低聚异麦芽糖配合后,与中药提取液形成了甜酒咖啡样略带微苦的风味口感,使人获得愉悦的享受感。B组原料中的四种胶体都是安全、富含膳食纤维的胶体,它们与中药的降脂功能部分产生协同增效作用,使降血脂功能更显著。
(4)综上所述,本发明产品组方严谨,用药具备中医“君、臣、佐、使”的恰当配合,适应症侯面广,以现代理论对传统方剂及制备工艺进行有效的改良、充实、扩展、创新、突破,滋补与祛邪结合,药理功能协调性强,乌发、生发、美发效果显著,制备工艺具有创新、简化、优化、实用性强的特点,特别在产品形态即剂型上,也是对传统中成药剂型的一项新的突破,且口感时尚有趣,很适合现代人的时尚追求,产品保存、携带、食用方便,符合卫生要求。
具体实施方式
下面结合具体实施例对本发明作进一步说明。
实施例。
优选地,一种生发乌发软丸的制备,包括以下制备步骤:
1、称取以下重量的原料:
(1)A组中药原料:
黑豆32g、何首乌16g、熟地16g、生地16g、当归10g、鸡血藤4g、牡丹皮8g、白芍药8g、山萸肉12g、桑椹8g、女贞子8g、墨旱莲6g、枸杞子8g、补骨脂8g、牛膝6g、黑芝麻4g、决明子4g、菟丝子8g、麦冬10g、茯苓16g、合欢皮8g、柴胡6g、白蒺藜8g、防风6g;
(2)B组原料:
海藻酸钠5g、结冷胶1.2g、罗望子胶0.5g、凝结多糖18g、低聚异麦芽糖150g、黑糯米酒32g;
2、软丸的制备,在采用上述重量的原料的基础上,还包括以下制备步骤:
(1)将A组中药原料中的熟地、生地用陶瓷刀切碎,然后将切碎的熟地、生地与A组原料中的其它所有原料混合,用粉碎机粉碎成粗粒,加A组中药原料总重量6-8倍的纯净水煮沸45分钟,120目过滤,得煎煮提取滤出液和药渣;
(2)在步骤(1)所得的药渣中加入药渣重量1-3倍的80度食用级酒精,50℃恒温避光浸渍2天,经200目压榨过滤,将滤出液经蒸馏回收乙醇后,得药渣浸渍提取液;
(3)将步骤(1)所得的煎煮提取滤出液和步骤(2)所得的药渣浸渍提取液合并,减压蒸发浓缩至100g,得浓缩提取物;
(4)将B组原料中的海藻酸钠加25倍重量的纯净水搅拌分散,放置30分钟;
(5)将B组原料中的结冷胶加60倍重量的纯净水搅拌分散,放置30分钟;
(6)将B组原料中的罗望子胶加50倍重量的纯净水搅拌分散,放置20分钟;
(7)将B组原料中的凝结多糖加13倍重量的18℃纯净水搅拌分散后,再搅拌10分钟;
(8)将步骤(3)所得的浓缩提取物和经过步骤(4)、(5)、(6)、(7)制作所得的原料全部混合一起,加入B组原料中的低聚异麦芽糖和黑糯米酒,添加纯净水至总重量为1000g,快速搅拌均匀,并迅速通过滴粒机滴于葡萄糖酸钙溶液中,形成圆粒状丸体,并让丸体在葡萄糖酸钙溶液中浸泡1-3分钟进行凝胶固化反应,捞起用无菌水冲去丸体表面的葡萄糖酸钙溶液,分装于达到食品卫生级标准的耐高温塑料杯中,用铝塑复合膜热封杯口,118℃30分钟蒸汽灭菌和热凝固,反压冷却,制得一种生发乌发软丸。
应用例1:孙某,男,39岁,由于工作压力大,近日常感心身疲倦,心情烦闷,房事不举,早上起床发现头发大遍脱落,立即到医院进行体检,指标显示基本在正常范围内,服食西药两星期无效,改服本发明的软丸,每天4次,头5天每次服30g,后5天每次服20g、共服10天后,不但没有再出现明显脱发,反而在脱落的部位长出新发,再服两个月,头发恢复乌黑浓密。
应用例2:姚某,女,38岁,已满头白发,且发质枯萎无光泽,家庭无早生白发史,面容憔悴,常感腰膝酸软无力,诊其尺脉细弱无力,为肝肾亏损之症,应以丸剂持续地滋补为宜,予本发明软丸服食3个月,每天3次,每次15g,3个月后,面色出现红润,精神饱满,有50%白发有所转黑,发质恢复正常光泽。
以上所述实施例仅表达了本发明的较佳实施方式,其描述较为具体和详细,但并不能因此而理解对本发明专利范围的限制,本发明专利的保护范围以所附权利要求为准。
Claims (2)
1.一种生发乌发软丸,其特征在于,由以下重量的原料制成:
(1)A组中药原料:
黑豆24-40g
何首乌12-20g
熟地12-20g
生地12-20g
当归8-12g
鸡血藤3-5g
牡丹皮6-10g
白芍药6-10g
山萸肉8-16g
桑椹6-10g
女贞子6-10g
墨旱莲4-8g
枸杞子6-10g
补骨脂6-10g
牛膝4-8g
黑芝麻4g
决明子3-5g
菟丝子6-10g
麦冬8-12g
茯苓12-20g
合欢皮6-10g
柴胡4-8g
白蒺藜6-10g
防风4-8g;
(2)B组原料:
海藻酸钠4-6g
结冷胶0.8-1.6g
罗望子胶0.2-0.8g
凝结多糖16-20g
低聚异麦芽糖100-200g
黑糯米酒24-40g。
2.权利要求1所述的一种生发乌发软丸的制备工艺,其特征在于,在采用权利要求1所述重量的原料的基础上,包括以下制备步骤:
(1)将A组中药原料中的熟地、生地用陶瓷刀切碎,然后将切碎的熟地、生地与A组原料中的其它所有原料混合,用粉碎机粉碎成粗粒,加A组中药原料总重量6-8倍的纯净水煮沸45分钟,120目过滤,得煎煮提取滤出液和药渣;
(2)在步骤(1)所得的药渣中加入药渣重量1-3倍的80度食用级酒精,50℃恒温避光浸渍2天,经200目压榨过滤,将滤出液经蒸馏回收乙醇后,得药渣浸渍提取液;
(3)将步骤(1)所得的煎煮提取滤出液和步骤(2)所得的药渣浸渍提取液合并,减压蒸发浓缩至100g,得浓缩提取物;
(4)将B组原料中的海藻酸钠加25倍重量的纯净水搅拌分散,放置30分钟;
(5)将B组原料中的结冷胶加60倍重量的纯净水搅拌分散,放置30分钟;
(6)将B组原料中的罗望子胶加50倍重量的纯净水搅拌分散,放置20分钟;
(7)将B组原料中的凝结多糖加13倍重量的18℃纯净水搅拌分散后,再搅拌10分钟;
(8)将步骤(3)所得的浓缩提取物和经过步骤(4)、(5)、(6)、(7)制作所得的原料全
部混合一起,加入B组原料中的低聚异麦芽糖和黑糯米酒,添加纯净水至总重量为1000g,快速搅拌均匀,并迅速通过滴粒机滴于葡萄糖酸钙溶液中,形成圆粒状丸体,并让丸体在葡萄糖酸钙溶液中浸泡1-3分钟进行凝胶固化反应,捞起用无菌水冲去丸体表面的葡萄糖酸钙溶液,分装于达到食品卫生级标准的耐高温塑料杯中,用铝塑复合膜热封杯口,118℃30分钟蒸汽灭菌和热凝固,反压冷却,制得一种生发乌发软丸。
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CN106318772A (zh) * | 2016-08-19 | 2017-01-11 | 南京中脉科技发展有限公司 | 一种生物发酵养生保健酒及其制备方法 |
CN109266486A (zh) * | 2018-10-17 | 2019-01-25 | 安徽省福宁米业有限公司 | 一种补血养颜米酒及其制备方法 |
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