CN105518022B - 具有嵌合表面蛋白的轮状病毒颗粒 - Google Patents

具有嵌合表面蛋白的轮状病毒颗粒 Download PDF

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CN105518022B
CN105518022B CN201480049500.2A CN201480049500A CN105518022B CN 105518022 B CN105518022 B CN 105518022B CN 201480049500 A CN201480049500 A CN 201480049500A CN 105518022 B CN105518022 B CN 105518022B
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rotavirus
protein
particles
adaptor
heterologous
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CN105518022A (zh
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P·R·道米策
N·格利高里夫
S·哈里森
J·潘
E·塞滕布里
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Novartis AG
Boston Childrens Hospital
Brandeis University
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Brandeis University
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    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
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    • C07K—PEPTIDES
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    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/42—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/50—Fusion polypeptide containing protease site
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12321—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12323—Virus like particles [VLP]
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    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12351—Methods of production or purification of viral material

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CN201480049500.2A 2013-07-08 2014-07-08 具有嵌合表面蛋白的轮状病毒颗粒 Active CN105518022B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13175637.1 2013-07-08
EP13175637 2013-07-08
PCT/EP2014/064652 WO2015004158A1 (en) 2013-07-08 2014-07-08 Rotavirus particles with chimeric surface proteins

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CN105518022A CN105518022A (zh) 2016-04-20
CN105518022B true CN105518022B (zh) 2020-08-18

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US (1) US10192025B2 (https=)
EP (1) EP3019518B1 (https=)
JP (1) JP6594306B2 (https=)
CN (1) CN105518022B (https=)
AU (1) AU2014289274B2 (https=)
CA (1) CA2916827C (https=)
ES (1) ES2733279T3 (https=)
MX (1) MX367150B (https=)
RU (1) RU2698049C2 (https=)
WO (1) WO2015004158A1 (https=)

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SMT202000101T1 (it) * 2008-10-10 2020-03-13 Childrens Medical Center Vaccino con trimero di env di hiv-1 stabilizzato biochimicamente
SG10201705880QA (en) 2013-01-07 2017-08-30 Beth Israel Deaconess Medical Ct Inc Stabilized human immunodeficiency virus (hiv) envelope (env) trimer vaccines and methods of using the same
EP3069730A3 (en) 2015-03-20 2017-03-15 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers
US9931394B2 (en) 2015-03-23 2018-04-03 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
EP3368068B1 (en) * 2015-10-30 2020-11-18 University of Copenhagen Virus like particle with efficient epitope display
MA44418B1 (fr) * 2017-03-02 2021-11-30 Intelligent Virus Imaging Inc Procédé permettant la mesure quantitative de contenu particulaire à l'aide d'une imagerie à l'état hydraté
CN109627295B (zh) * 2018-12-29 2020-08-04 四川大学 一种通用型狂犬病相关病毒g蛋白胞外段的制备方法
CN110144334B (zh) * 2019-05-05 2021-03-16 中国水产科学研究院长江水产研究所 一种共表达草鱼呼肠孤病毒外衣壳蛋白vp4和vp35的重组杆状病毒的制备方法和应用
CN110408637B (zh) * 2019-08-08 2020-12-25 中国水产科学研究院长江水产研究所 一种草鱼出血病酵母口服疫苗及应用
CN114316009B (zh) * 2020-09-29 2023-04-25 上海交通大学 一种能够结合多种病毒的蛋白及其应用
CN115044597A (zh) * 2022-07-22 2022-09-13 态创生物科技(广州)有限公司 基于噬菌体展示和蛋白酶切割的寡肽表达和提纯方法
CN116375878A (zh) * 2022-12-13 2023-07-04 遵义医科大学附属医院 嵌合流感病毒血凝素cH8/3及其构建、表达

Citations (1)

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CN102465137A (zh) * 2010-11-05 2012-05-23 上海生物制品研究所有限责任公司 表达轮状病毒类表达颗粒的毕赤酵母、其制备方法及用途

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EP0402354A4 (en) 1987-08-10 1991-03-20 The University Of Melbourne Molecular cloning of human rotavirus serotype 4 gene 9 encoding vp7, the major outer capsid neutralisation specific glycoprotein and expression of vp7 and fragments thereof for use in a vaccine
RU2215035C2 (ru) * 1991-12-06 2003-10-27 Уайтхэд институт фор биомедикл рисерч Рекомбинантный полиовирусный вектор (варианты), способ его получения (варианты), способ индукции иммунного ответа у индивидуума (варианты), способ получения белка (варианты), вакцинная композиция для терапии или профилактики инфекционных заболеваний (варианты)
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JP6594306B2 (ja) 2019-10-23
JP2016530236A (ja) 2016-09-29
MX2016000075A (es) 2016-07-19
US10192025B2 (en) 2019-01-29
AU2014289274A1 (en) 2016-02-18
WO2015004158A1 (en) 2015-01-15
MX367150B (es) 2019-08-07
CN105518022A (zh) 2016-04-20
EP3019518B1 (en) 2019-04-03
RU2016103770A3 (https=) 2018-07-25
ES2733279T3 (es) 2019-11-28
CA2916827A1 (en) 2015-01-15
US20160188790A1 (en) 2016-06-30
AU2014289274B2 (en) 2018-11-15
CA2916827C (en) 2021-11-02
RU2016103770A (ru) 2017-08-11
EP3019518A1 (en) 2016-05-18
RU2698049C2 (ru) 2019-08-21

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