CN105517989B - 大麻素类化合物的混合物及其制备和用途 - Google Patents
大麻素类化合物的混合物及其制备和用途 Download PDFInfo
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- CN105517989B CN105517989B CN201480048263.8A CN201480048263A CN105517989B CN 105517989 B CN105517989 B CN 105517989B CN 201480048263 A CN201480048263 A CN 201480048263A CN 105517989 B CN105517989 B CN 105517989B
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- 0 CCCCCc1cc(O)c([C@@]2C=C(C)CC[C@]2C(C)=C)c(O)c1C(O*)=O Chemical compound CCCCCc1cc(O)c([C@@]2C=C(C)CC[C@]2C(C)=C)c(O)c1C(O*)=O 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/50—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions decreasing the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
- C07C67/29—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by introduction of oxygen-containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Nutrition Science (AREA)
- Otolaryngology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pyrane Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13182788.3A EP2842933B1 (de) | 2013-09-03 | 2013-09-03 | Mischungen cannabinoider Verbindungen, deren Herstellung und Verwendung |
| EP13182788.3 | 2013-09-03 | ||
| PCT/EP2014/063872 WO2015032519A1 (de) | 2013-09-03 | 2014-06-30 | Mischungen cannabinoider verbindungen, deren herstellung und verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105517989A CN105517989A (zh) | 2016-04-20 |
| CN105517989B true CN105517989B (zh) | 2018-06-01 |
Family
ID=49117691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480048263.8A Active CN105517989B (zh) | 2013-09-03 | 2014-06-30 | 大麻素类化合物的混合物及其制备和用途 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9670133B2 (enExample) |
| EP (2) | EP2842933B1 (enExample) |
| JP (1) | JP6470289B2 (enExample) |
| CN (1) | CN105517989B (enExample) |
| BR (1) | BR112016004675B1 (enExample) |
| ES (2) | ES2547354T3 (enExample) |
| WO (1) | WO2015032519A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3150264A1 (de) * | 2015-09-30 | 2017-04-05 | Bionorica Ethics GmbH | Vakuumdestillation zur anreicherung von cbd |
| EP3455213B1 (en) * | 2016-05-13 | 2021-11-24 | Symrise AG | Method for purifying cannabinoid compounds via simulated moving bed chromatography |
| US10239808B1 (en) | 2016-12-07 | 2019-03-26 | Canopy Holdings, LLC | Cannabis extracts |
| CN106810426B (zh) * | 2016-12-29 | 2020-05-08 | 暨明医药科技（苏州）有限公司 | 一种大麻二酚的合成方法 |
| CN110869496A (zh) | 2017-05-10 | 2020-03-06 | 海湾医学公司 | 用于大麻素家族的戊烯化聚酮的重组生产系统 |
| AU2018287018B2 (en) * | 2017-06-20 | 2022-04-28 | University Of Guelph | Cannabidiolic acid esters compositions and uses thereof |
| EP3665145A1 (en) | 2017-08-07 | 2020-06-17 | Enantia, S.L. | A cocrystal of 2-[(1r,6r)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol |
| AU2018317939B2 (en) * | 2017-08-16 | 2021-06-03 | The University Of Sydney | Synthesis of phytocannabinoids including a decarboxylation step |
| AU2018317935A1 (en) * | 2017-08-16 | 2020-03-05 | The University Of Sydney | Synthesis of phytocannabinoids including a demethylation step |
| US11202771B2 (en) | 2018-01-31 | 2021-12-21 | Treehouse Biotech, Inc. | Hemp powder |
| WO2019153073A1 (en) | 2018-02-07 | 2019-08-15 | Scf Pharma Inc. | Polyunsaturated fatty acid monoglycerides, compositions, methods and uses thereof |
| US20220331235A1 (en) * | 2018-02-19 | 2022-10-20 | Fp Nutraceuticals, Llc | Compositions for oral microadhesive dosage forms |
| EP3787614B1 (en) | 2018-05-03 | 2024-07-31 | SCF Pharma Inc. | Polyunsaturated fatty acid monoglycerides, compositions and use thereof for modulating a microbiota composition of a subject |
| WO2019234728A1 (en) * | 2018-06-04 | 2019-12-12 | Al&Am Pharmachem Ltd. | Cannabinolic acid derivatives and uses thereof |
| US11485700B2 (en) * | 2018-06-28 | 2022-11-01 | Symrise Ag | Synthesis of (+)-cannabinoids and their therapeutic effects |
| US20200035118A1 (en) | 2018-07-27 | 2020-01-30 | Joseph Pandolfino | Methods and products to facilitate smokers switching to a tobacco heating product or e-cigarettes |
| US10897925B2 (en) | 2018-07-27 | 2021-01-26 | Joseph Pandolfino | Articles and formulations for smoking products and vaporizers |
| WO2020028198A1 (en) | 2018-08-03 | 2020-02-06 | Biomass Oil Separation Solutions, Llc | Processes and apparatus for extraction of substances and enriched extracts from plant material |
| EP3864000A4 (en) | 2018-10-10 | 2022-08-10 | Treehouse Biosciences, Inc. | CANNABIGEROL SYNTHESIS |
| CN113905730B (zh) | 2018-10-31 | 2025-01-03 | 南迪亚公司 | 大麻素共晶体的固体组合物 |
| EP3653596A1 (en) * | 2018-11-14 | 2020-05-20 | Indena S.p.A. | Continuous flow synthesis of cannabidiol |
| WO2020136648A1 (en) * | 2018-12-25 | 2020-07-02 | Epm Group Inc. | Cannabidiolic acid esters for cosmetic or edible compositions |
| CN109734591A (zh) * | 2018-12-26 | 2019-05-10 | 江苏暨明医药科技有限公司 | 一种大麻二酚中间体及其制备方法与及应用 |
| JP2022524780A (ja) | 2019-03-12 | 2022-05-10 | イーピーエム（アイピー）， インコーポレイテッド | カンナビノイド酸エステル組成物およびその使用 |
| WO2020198874A1 (en) * | 2019-04-04 | 2020-10-08 | Scf Pharma Inc. | Cannabidiolic acid monoglycerides, derivatives, and uses thereof |
| US10981850B2 (en) | 2019-04-15 | 2021-04-20 | Trustees Of Boston University | One-step flow-mediated synthesis of cannabidiol (CBD) and derivatives |
| EP3966190A1 (en) * | 2019-05-10 | 2022-03-16 | Benuvia Manufacturing, LLC | Methods of manufacturing cannabidiol or cannabidivarin and intermediates of manufacturing cannabidiol or cannabidivarin |
| CN111943813B (zh) * | 2019-05-17 | 2023-04-14 | 上海特化医药科技有限公司 | 大麻二酚类化合物的制备方法 |
| GB201910389D0 (en) * | 2019-07-19 | 2019-09-04 | Gw Pharma Ltd | Novel compounds, methods for their manufacture, and uses thereof |
| US12226390B2 (en) | 2019-07-21 | 2025-02-18 | Scf Pharma Inc. | Cannabinoids compositions with polyunsaturated fatty acid monoglycerides, methods and uses thereof |
| US10799546B1 (en) | 2019-07-26 | 2020-10-13 | Biomass Oil Separation Solutions, Llc | Modular, integrated process and apparatus for extracting, refining and remediating active substances from plant material |
| JP2022551066A (ja) * | 2019-10-02 | 2022-12-07 | キャノピー グロウス コーポレイション | カンナビノイド誘導体 |
| GB2588456B (en) * | 2019-10-25 | 2023-02-01 | Gw Res Ltd | Cannabinoid compound |
| GB2588457B (en) * | 2019-10-25 | 2022-12-21 | Gw Res Ltd | Cannabinoid compound |
| WO2021155474A1 (en) * | 2020-02-06 | 2021-08-12 | London Pharmaceuticals And Research Corporation | Cannabinoid sulfate esters, their salts and uses thereof |
| WO2021207605A1 (en) * | 2020-04-10 | 2021-10-14 | 3Bc, Llc | Methods for preparing cannabinoids and related instruments |
| GB202016536D0 (en) * | 2020-10-19 | 2020-12-02 | Aesica Pharmaceuticals Ltd | Process |
| CN120607456A (zh) * | 2020-11-17 | 2025-09-09 | 中国科学院上海药物研究所 | 一类间苯二酚化合物及其制备方法以及在神经系统疾病中的应用 |
| EP4267122A4 (en) * | 2020-12-24 | 2024-04-24 | Buzzelet Development And Technologies Ltd | Compositions comprising cannabinoid acid esters |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1547479A (zh) * | 2001-03-06 | 2004-11-17 | ��֢�о���˹��˹��Э�� | 由大麻提取物制成的药物组合物 |
| US20100298579A1 (en) * | 2009-04-29 | 2010-11-25 | Thc Pharm Gmbh | Process for preparing synthetic cannabinoids |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH473075A (de) * | 1966-11-04 | 1969-05-31 | Theodor Dr Petrzilka | Verfahren zur Herstellung von in 2-Stellung substituierten Resorcinderivaten |
| US5342971A (en) | 1992-12-29 | 1994-08-30 | The Australian National University | Process for the preparation of dibenzo[b,d]pyrans |
| DE102005028937B4 (de) | 2005-06-22 | 2009-07-23 | Bionorica Ag | Verfahren zur Herstellung von Dronabinol |
| EP1928853A4 (en) * | 2005-09-29 | 2011-02-16 | Amr Technology Inc | PROCESS FOR THE PRODUCTION OF DELTA-9-TETRAHYDROCANNABINOL |
-
2013
- 2013-09-03 EP EP13182788.3A patent/EP2842933B1/de not_active Not-in-force
- 2013-09-03 ES ES13182788.3T patent/ES2547354T3/es active Active
-
2014
- 2014-06-30 US US14/653,044 patent/US9670133B2/en active Active
- 2014-06-30 JP JP2016539439A patent/JP6470289B2/ja active Active
- 2014-06-30 CN CN201480048263.8A patent/CN105517989B/zh active Active
- 2014-06-30 ES ES14739086T patent/ES2738332T3/es active Active
- 2014-06-30 EP EP14739086.8A patent/EP3041815B1/de active Active
- 2014-06-30 BR BR112016004675-7A patent/BR112016004675B1/pt active IP Right Grant
- 2014-06-30 WO PCT/EP2014/063872 patent/WO2015032519A1/de not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1547479A (zh) * | 2001-03-06 | 2004-11-17 | ��֢�о���˹��˹��Э�� | 由大麻提取物制成的药物组合物 |
| US20100298579A1 (en) * | 2009-04-29 | 2010-11-25 | Thc Pharm Gmbh | Process for preparing synthetic cannabinoids |
Non-Patent Citations (1)
| Title |
|---|
| Synthesis of [alpha]-monoglycerides of aromatic acids;A. F. Artamonov, et al.;《Chemistry of Natural Compounds》;19991231;第35卷(第4期);第404-408页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2842933B1 (de) | 2015-07-29 |
| EP3041815A1 (de) | 2016-07-13 |
| ES2738332T3 (es) | 2020-01-22 |
| BR112016004675A2 (enExample) | 2017-08-01 |
| ES2547354T3 (es) | 2015-10-05 |
| JP6470289B2 (ja) | 2019-02-13 |
| CN105517989A (zh) | 2016-04-20 |
| JP2016531919A (ja) | 2016-10-13 |
| US9670133B2 (en) | 2017-06-06 |
| EP3041815B1 (de) | 2019-04-03 |
| US20150336874A1 (en) | 2015-11-26 |
| WO2015032519A1 (de) | 2015-03-12 |
| EP2842933A1 (de) | 2015-03-04 |
| BR112016004675B1 (pt) | 2023-03-07 |
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