JP6470289B2 - カンナビノイド化合物の組成物、その製造及び使用 - Google Patents

カンナビノイド化合物の組成物、その製造及び使用 Download PDF

Info

Publication number
JP6470289B2
JP6470289B2 JP2016539439A JP2016539439A JP6470289B2 JP 6470289 B2 JP6470289 B2 JP 6470289B2 JP 2016539439 A JP2016539439 A JP 2016539439A JP 2016539439 A JP2016539439 A JP 2016539439A JP 6470289 B2 JP6470289 B2 JP 6470289B2
Authority
JP
Japan
Prior art keywords
formula
compound
composition
compounds
residue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016539439A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016531919A (ja
Inventor
オスカー コッホ
オスカー コッホ
マルクス ルドルフ ゲッツ
マルクス ルドルフ ゲッツ
ヤン ローフト
ヤン ローフト
トビアス フェージング
トビアス フェージング
Original Assignee
シムライズ アーゲー
シムライズ アーゲー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by シムライズ アーゲー, シムライズ アーゲー filed Critical シムライズ アーゲー
Publication of JP2016531919A publication Critical patent/JP2016531919A/ja
Application granted granted Critical
Publication of JP6470289B2 publication Critical patent/JP6470289B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/658Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/50Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions decreasing the number of carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/28Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/29Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by introduction of oxygen-containing functional groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pyrane Compounds (AREA)
JP2016539439A 2013-09-03 2014-06-30 カンナビノイド化合物の組成物、その製造及び使用 Active JP6470289B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13182788.3 2013-09-03
EP13182788.3A EP2842933B1 (de) 2013-09-03 2013-09-03 Mischungen cannabinoider Verbindungen, deren Herstellung und Verwendung
PCT/EP2014/063872 WO2015032519A1 (de) 2013-09-03 2014-06-30 Mischungen cannabinoider verbindungen, deren herstellung und verwendung

Publications (2)

Publication Number Publication Date
JP2016531919A JP2016531919A (ja) 2016-10-13
JP6470289B2 true JP6470289B2 (ja) 2019-02-13

Family

ID=49117691

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016539439A Active JP6470289B2 (ja) 2013-09-03 2014-06-30 カンナビノイド化合物の組成物、その製造及び使用

Country Status (7)

Country Link
US (1) US9670133B2 (enExample)
EP (2) EP2842933B1 (enExample)
JP (1) JP6470289B2 (enExample)
CN (1) CN105517989B (enExample)
BR (1) BR112016004675B1 (enExample)
ES (2) ES2547354T3 (enExample)
WO (1) WO2015032519A1 (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3150264A1 (de) * 2015-09-30 2017-04-05 Bionorica Ethics GmbH Vakuumdestillation zur anreicherung von cbd
DK3455213T3 (da) 2016-05-13 2022-03-07 Symrise Ag Fremgangsmåde til at oprense cannabinoid-forbindelser via simulated moving bed-kromatografi
US10239808B1 (en) 2016-12-07 2019-03-26 Canopy Holdings, LLC Cannabis extracts
CN106810426B (zh) * 2016-12-29 2020-05-08 暨明医药科技(苏州)有限公司 一种大麻二酚的合成方法
WO2018209143A1 (en) * 2017-05-10 2018-11-15 Baymedica, Inc. Recombinant production systems for prenylated polyketides of the cannabinoid family
US11440870B2 (en) 2017-06-20 2022-09-13 University Of Guelph Cannabidiolic acid esters compositions and uses thereof
CA3107566A1 (en) 2017-08-07 2019-02-14 Enantia, S.L. A cocrystal of 2-[(1r,6r)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol
EP3668829A4 (en) * 2017-08-16 2021-05-19 The University Of Sydney SYNTHESIS OF PHYTOCANNABINOIDS INCLUDING A DEMETHYLATION STEP
CN111183135A (zh) * 2017-08-16 2020-05-19 悉尼大学 包括脱羧步骤的植物大麻素的合成
EP3745884A1 (en) 2018-01-31 2020-12-09 Canopy Holdings, Llc Hemp powder
AU2019217673A1 (en) 2018-02-07 2020-09-24 Scf Pharma Inc. Polyunsaturated fatty acid monoglycerides, compositions, methods and uses thereof
US20220331235A1 (en) * 2018-02-19 2022-10-20 Fp Nutraceuticals, Llc Compositions for oral microadhesive dosage forms
ES2992095T3 (es) 2018-05-03 2024-12-09 Scf Pharma Inc Monoglicéridos de ácidos grasos poliinsaturados, composiciones y uso de los mismos para modular la composición de la microbiota de un sujeto
WO2019234728A1 (en) * 2018-06-04 2019-12-12 Al&Am Pharmachem Ltd. Cannabinolic acid derivatives and uses thereof
CN112292368B (zh) * 2018-06-28 2024-02-02 西姆莱斯有限公司 (+)-大麻素类的合成及其治疗作用
US20200035118A1 (en) 2018-07-27 2020-01-30 Joseph Pandolfino Methods and products to facilitate smokers switching to a tobacco heating product or e-cigarettes
US10897925B2 (en) 2018-07-27 2021-01-26 Joseph Pandolfino Articles and formulations for smoking products and vaporizers
CA3073093A1 (en) 2018-08-03 2020-02-06 Biomass Oil Separation Solutions, Llc Processes and apparatus for extraction of substances and enriched extracts from plant material
US11040932B2 (en) 2018-10-10 2021-06-22 Treehouse Biotech, Inc. Synthesis of cannabigerol
EP3873459A1 (en) 2018-10-31 2021-09-08 Enantia, S.L. Solid compositions of cocrystals of cannabinoids
EP3653596A1 (en) * 2018-11-14 2020-05-20 Indena S.p.A. Continuous flow synthesis of cannabidiol
JP2022516845A (ja) * 2018-12-25 2022-03-03 イーピーエム(アイピー), インコーポレイテッド 化粧品用または食用組成物のためのカンナビジオール酸エステル
CN109734591A (zh) * 2018-12-26 2019-05-10 江苏暨明医药科技有限公司 一种大麻二酚中间体及其制备方法与及应用
CN113840598B (zh) 2019-03-12 2024-07-05 Epm(Ip)公司 大麻素酸酯组合物及其用途
WO2020198874A1 (en) * 2019-04-04 2020-10-08 Scf Pharma Inc. Cannabidiolic acid monoglycerides, derivatives, and uses thereof
WO2020214574A1 (en) 2019-04-15 2020-10-22 Trustees Of Boston University One-step flow-mediated synthesis of cannabidiol (cbd) and derivatives
KR20220007078A (ko) * 2019-05-10 2022-01-18 베누비아 매뉴팩처링, 엘엘씨 칸나비디올 또는 칸나비디바린의 제조 방법 및 칸나비디올 또는 칸나비디바린 제조의 중간체
CN111943813B (zh) * 2019-05-17 2023-04-14 上海特化医药科技有限公司 大麻二酚类化合物的制备方法
GB201910389D0 (en) * 2019-07-19 2019-09-04 Gw Pharma Ltd Novel compounds, methods for their manufacture, and uses thereof
US12226390B2 (en) 2019-07-21 2025-02-18 Scf Pharma Inc. Cannabinoids compositions with polyunsaturated fatty acid monoglycerides, methods and uses thereof
US10799546B1 (en) 2019-07-26 2020-10-13 Biomass Oil Separation Solutions, Llc Modular, integrated process and apparatus for extracting, refining and remediating active substances from plant material
JP2022551066A (ja) * 2019-10-02 2022-12-07 キャノピー グロウス コーポレイション カンナビノイド誘導体
GB2588457B (en) * 2019-10-25 2022-12-21 Gw Res Ltd Cannabinoid compound
GB2588456B (en) * 2019-10-25 2023-02-01 Gw Res Ltd Cannabinoid compound
JP2023512578A (ja) * 2020-02-06 2023-03-27 ロンドン ファーマシューティカルズ アンド リサーチ コーポレーション Cアナビンオイド硫酸エステル、その塩及び用途
WO2021207605A1 (en) * 2020-04-10 2021-10-14 3Bc, Llc Methods for preparing cannabinoids and related instruments
GB202016536D0 (en) * 2020-10-19 2020-12-02 Aesica Pharmaceuticals Ltd Process
CN114507153B (zh) * 2020-11-17 2025-06-24 中国科学院上海药物研究所 一类间苯二酚化合物及其制备方法以及在神经系统疾病中的应用
EP4267122A4 (en) * 2020-12-24 2024-04-24 Buzzelet Development And Technologies Ltd Compositions comprising cannabinoid acid esters

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH473075A (de) * 1966-11-04 1969-05-31 Theodor Dr Petrzilka Verfahren zur Herstellung von in 2-Stellung substituierten Resorcinderivaten
US5342971A (en) 1992-12-29 1994-08-30 The Australian National University Process for the preparation of dibenzo[b,d]pyrans
CH695661A5 (de) * 2001-03-06 2006-07-31 Forsch Hiscia Ver Fuer Krebsfo Pharmazeutische Zusammensetzung.
DE102005028937B4 (de) 2005-06-22 2009-07-23 Bionorica Ag Verfahren zur Herstellung von Dronabinol
EP2578577A1 (en) * 2005-09-29 2013-04-10 Albany Molecular Research, Inc. Sulfonyl esters of tetrahydrocannabinol and derivatives thereof
DE102009019322A1 (de) * 2009-04-30 2010-11-11 The Health Concept Gmbh Verfahren zur Herstellung von Synthetischen Cannabinoiden

Also Published As

Publication number Publication date
US9670133B2 (en) 2017-06-06
EP3041815A1 (de) 2016-07-13
ES2738332T3 (es) 2020-01-22
CN105517989B (zh) 2018-06-01
EP3041815B1 (de) 2019-04-03
US20150336874A1 (en) 2015-11-26
ES2547354T3 (es) 2015-10-05
JP2016531919A (ja) 2016-10-13
EP2842933B1 (de) 2015-07-29
BR112016004675A2 (enExample) 2017-08-01
EP2842933A1 (de) 2015-03-04
CN105517989A (zh) 2016-04-20
WO2015032519A1 (de) 2015-03-12
BR112016004675B1 (pt) 2023-03-07

Similar Documents

Publication Publication Date Title
JP6470289B2 (ja) カンナビノイド化合物の組成物、その製造及び使用
US11964955B2 (en) Mixtures of cannabinoid compounds, and production and use thereof
JP6215230B2 (ja) イオンチャネルのモジュレーターとしてのピラン−スピロ環式ピペリジンアミド
EP2943467B1 (en) Benzylideneguanidine derivatives and therapeutic use for the treatment of protein misfolding diseases
JPH09503771A (ja) 治療剤
KR20200133259A (ko) Kv7 채널 활성화제 조성물 및 이의 사용 방법
MX2011001392A (es) Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de crf1.
JP2003511469A (ja) 抹消カンナビノイド受容体(cb2)選択的配位子
BRPI0608819B1 (pt) formas cristalinas de um derivado de imidazol
CN104161759B (zh) 阿那格雷及其衍生物的抗肿瘤用途
US7071205B2 (en) 5-cycloalkenyl 5H-chromeno[3,4-f]quinoline derivatives as selective progesterone receptor modulator compounds
WO2020001770A1 (en) Synthesis of (+)-cannabinoids and their therapeutic effects
CN108640921A (zh) 一种枸橼酸托法替布的制备方法
JP2009538270A (ja) 細胞複製破壊剤および病的状態を阻止する際のその使用
AU2006291060B2 (en) Sustained-release formulation comprising a glucuronate salt of a piperazine compound and uses thereof
AU2006291059A1 (en) Salicylate and gentisate salts of a piperazine compound
Edery US PATENT D ()(" UMENTS
US10272124B2 (en) Use of helminthostachys, ugonins or flavone-based compounds for the treatment or prevention of metabolic diseases
MX2008003258A (en) Salicylate and gentisate salts of a piperazine compound
MX2008003125A (en) Glucuronate salt of a piperazine compound
WO2011047597A1 (zh) 二羟基苯并吡喃酮化合物、其药物组合物及其预防和治疗骨折和骨质疏松的应用
HK1120497A (en) Salicylate and gentisate salts of a piperazine compound

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170629

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180423

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180723

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20190110

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20190117

R150 Certificate of patent or registration of utility model

Ref document number: 6470289

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250